| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah M Mosaad, Sawsan A Zaitone, Abdelazim Ibrahim, Amani A El-Baz, Dina M Abo-Elmatty, Yasser M Moustaf. Celecoxib aggravates cardiac apoptosis in L-NAME-induced pressure overload model in rats: Immunohistochemical determination of cardiac caspase-3, Mcl-1, Bax and Bcl-2. Chemico-biological interactions. vol 272. 2017-06-20. PMID:28526264. |
celecoxib aggravates cardiac apoptosis in l-name-induced pressure overload model in rats: immunohistochemical determination of cardiac caspase-3, mcl-1, bax and bcl-2. |
2017-06-20 |
2023-08-13 |
rat |
| Meiyang Xi, Xiaojian Wang, Jun Ge, Dali Yi. N'-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFκB/IL-6/STAT3 pathway. Biochemical and biophysical research communications. vol 477. issue 2. 2017-06-19. PMID:27311853. |
moreover, this polyphenol suppressed p-stat3 production as well as its downstream proteins response for apoptosis, such as bcl-2 and bax. |
2017-06-19 |
2023-08-13 |
mouse |
| Chao Chang, Kun Wang, Sheng-Nan Zhou, Xue-Dong Wang, Jin-E W. Protective Effect of Saccharomyces boulardii on Deoxynivalenol-Induced Injury of Porcine Macrophage via Attenuating p38 MAPK Signal Pathway. Applied biochemistry and biotechnology. vol 182. issue 1. 2017-06-19. PMID:27878744. |
in addition, s. boulardii significantly alleviated don-induced phosphorylation and mrna expression of p38 and further increased the expression of apoptosis regulation genes bcl-xl and bcl-2 and inhibited the activation of bax. |
2017-06-19 |
2023-08-13 |
Not clear |
| Antonio Serapio-Palacios, Fernando Navarro-Garci. EspC, an Autotransporter Protein Secreted by Enteropathogenic Escherichia coli, Causes Apoptosis and Necrosis through Caspase and Calpain Activation, Including Direct Procaspase-3 Cleavage. mBio. vol 7. issue 3. 2017-06-15. PMID:27329750. |
espc induces apoptosis through the mitochondrial apoptotic pathway by provoking (i) a decrease in the expression levels of antiapoptotic protein bcl-2, (ii) translocation of the proapoptotic protein bax from cytosol to mitochondria, (iii) cytochrome c release from mitochondria to the cytoplasm, (iv) loss of mitochondrial membrane potential, (v) caspase-9 activation, (vi) cleavage of procaspase-3 and (vii) an increase in caspase-3 activity, (viii) parp proteolysis, and (ix) nuclear fragmentation and an increase in the sub-g1 population. |
2017-06-15 |
2023-08-13 |
Not clear |
| Li-Tzong Chen, Chiung-Tong Chen, Weir-Torn Jiaang, Tsai-Yun Chen, Joseph H Butterfield, Neng-Yao Shih, John Tsu-An Hsu, Hui-You Lin, Sheng-Fung Lin, Hui-Jen Tsa. BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia. Molecular cancer therapeutics. vol 15. issue 10. 2017-06-15. PMID:27512117. |
the compound induced apoptosis by the mitochondrial intrinsic pathway through upregulation of proapoptotic proteins bax and bak and caspase 8 and 9 activation in c-kit mutant kasumi-1 cells. |
2017-06-15 |
2023-08-13 |
mouse |
| Mohammed Amir Husain, Hassan Mubarak Ishqi, Tarique Sarwar, Sayeed Ur Rehman, Mohammad Tabis. Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse. Gene. vol 621. 2017-06-15. PMID:28412457. |
bax, a pro-apoptotic member of bcl-2 family regulates apoptosis through homodimerization/heterodimerization with bcl-2. |
2017-06-15 |
2023-08-13 |
mouse |
| Xin Qi, Brandon Davis, Yung-Hsiao Chiang, Emily Filichia, Austin Barnett, Nigel H Greig, Barry Hoffer, Yu Lu. Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27317935. |
however, in da-p53ko mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), we found that the induction of bax and p53 up-regulated modulator of apoptosis (puma) mrna and protein levels by mptp were diminished in both striatum and substantia nigra of these mice. |
2017-06-14 |
2023-08-13 |
mouse |
| Xiaocui Tian, Jianhua Peng, Jianjun Zhong, Mei Yang, Jinwei Pang, Jie Lou, Minghang Li, Ruidi An, Qian Zhang, Lu Xu, Zhi Don. β-Caryophyllene protects in vitro neurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury. Journal of neurochemistry. vol 139. issue 5. 2017-06-14. PMID:27565895. |
bcp pre-treatment prior to the initiation of ogd/r significantly (i) decreased bbb permeability and neuronal apoptosis, (ii) mitigated oxidative stress damage and the release of inflammatory cytokines, (iii) down-regulated bax expression, metalloproteinase-9 activity and expression, and (iv) up-regulated claudin-5, occludin, zo-1, growth-associated protein-43 and bcl-2 expression. |
2017-06-14 |
2023-08-13 |
Not clear |
| Weiwei Qin, Bei Ren, Shanshan Wang, Shujun Liang, Baiqiu He, Xiaoji Shi, Liying Wang, Jingyu Liang, Feihua W. Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. Vascular pharmacology. vol 85. 2017-06-13. PMID:27473516. |
furthermore, we demonstrated that apigenin and naringenin reduced high glucose-increased apoptosis, bax expression, caspase-3 activity and phosphorylation of nf-κb in endothelial cells. |
2017-06-13 |
2023-08-13 |
rat |
| Shin Hee Hong, Kang Jun Yoon, Key-Hwan Lim, Yun Jung Um, Jin Gu Cho, Young Joon Jo, Sang Gyu Par. Tauroursodeoxycholic acid improves viability of artificial RBCs. Biochemical and biophysical research communications. vol 478. issue 4. 2017-06-13. PMID:27596970. |
tauroursodeoxycholic acid (tudca) is known to prevent apoptosis through the bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation. |
2017-06-13 |
2023-08-13 |
Not clear |
| Jian-Nan Li, Ye Yu, Yan-Fei Zhang, Zhi-Meng Li, Guang-Zhi Cai, Ji-Yu Gon. Synergy of Raddeanin A and cisplatin induced therapeutic effect enhancement in human hepatocellular carcinoma. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28219642. |
interestingly, the molecule signals correlated to tumor cell apoptosis containing both of p53 and bax are simultaneously activated, but bcl-2 and survivin are all depressed in mrna level. |
2017-06-13 |
2023-08-13 |
human |
| Dan Sun, Fei Yan. Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. Biochemical and biophysical research communications. vol 486. issue 2. 2017-06-13. PMID:28302481. |
hearts were taken from mice after 4 weeks, and cell apoptosis in myocardial tissue was detected using tunel method; fresh mitochondria were taken and changes in oxygen consumption rate (ocr) and respiratory control rate (rcr) of mitochondria in each group were detected using bio-energy metabolism tester, and change in mitochondrial membrane potential (mmp) of myocardial tissue was detected via jc-1 staining; the expressions and changes in bcl-2, bax, sirt3, pgc-1α and acetylated pgc-1α in myocardial tissue were detected by western blot. |
2017-06-13 |
2023-08-13 |
mouse |
| Ji-Liang Zhang, Christopher Laurence Souders, Nancy D Denslow, Christopher J Martyniu. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). Toxicology and applied pharmacology. vol 327. 2017-06-13. PMID:28450151. |
there were no changes in transcripts related to apoptosis (bcl2, bax, casp3, casp7), but we did observe a decrease in mrna levels for catalase (cat) in fish exposed to each dose, supporting an oxidative stress response. |
2017-06-13 |
2023-08-13 |
cat |
| Na-Na Tao, Ji-Hua Ren, Hua Tang, Long-Kuan Ran, Hong-Zhong Zhou, Bo Liu, Ai-Long Huang, Juan Che. Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma. Biochemical and biophysical research communications. vol 485. issue 4. 2017-06-12. PMID:28238784. |
we previously reported that sirt6 potentiated apoptosis evasion in hepatocellular carcinoma by inhibiting both bax expression and mitochondrial translocalization. |
2017-06-12 |
2023-08-13 |
Not clear |
| Tianen Zhou, Yanran Liang, Longyuan Jiang, Tao Yu, Chaotao Zeng, Enxiang Ta. Mild hypothermia protects against oxygen glucose deprivation/reoxygenation-induced apoptosis via the Wnt/β-catenin signaling pathway in hippocampal neurons. Biochemical and biophysical research communications. vol 486. issue 4. 2017-06-12. PMID:28365156. |
mild hypothermia also caused the down regulation of the expression of apoptosis promoting proteins (bax cleaved caspase-3), up-regulated the expression of apoptosis inhibiting proteins (bcl-2), and ameliorated ogd/r injury-induced apoptosis. |
2017-06-12 |
2023-08-13 |
Not clear |
| Federica Rizzo, Dario Ronchi, Sabrina Salani, Monica Nizzardo, Francesco Fortunato, Andreina Bordoni, Giulia Stuppia, Roberto Del Bo, Daniela Piga, Romana Fato, Nereo Bresolin, Giacomo P Comi, Stefania Cort. Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons. Human molecular genetics. vol 25. issue 19. 2017-06-09. PMID:27506976. |
p53, bax, caspase 8, cleaved caspase 3, and the anti-apoptotic marker bcl2) demonstrated that cmt2a-mns are more resistant to apoptosis than wild-type mns. |
2017-06-09 |
2023-08-13 |
human |
| Mohd Ishtiaq Anasir, Sofia Caria, Michael A Skinner, Marc Kvansaku. Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039. The Journal of biological chemistry. vol 292. issue 22. 2017-06-09. PMID:28411240. |
our findings suggest that fpv039 is a pan-bcl-2 protein inhibitor that can engage all host bh3-only proteins, as well as bcl-2-associated x, apoptosis regulator (bax) and bcl-2 antagonist/killer (bak) proteins to inhibit premature apoptosis of an infected host cell. |
2017-06-09 |
2023-08-13 |
Not clear |
| Xuan Gao, Jun Zhang, Qiang Xu, Zun Huang, Yiyue Wang, Qi She. Hyaluronic acid-coated cationic nanostructured lipid carriers for oral vincristine sulfate delivery. Drug development and industrial pharmacy. vol 43. issue 4. 2017-06-08. PMID:28043185. |
the expressions of apoptosis related protein caspase-3, caspase-9, bax and bcl-2 were estimated by western blot assay in mcf-7 cells, and ha-nlcs exhibited the strongest effect in promoting cell apoptosis. |
2017-06-08 |
2023-08-13 |
rat |
| Chandrashekhar Dasari, Dattu Prasad Yaghnam, Reinhard Walther, Ramesh Ummann. Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-κB transactivation in LNCaP cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 5. 2017-06-08. PMID:28466782. |
overexpression of tpd52 protected lncap cells from apoptosis through elevated anti-apoptotic proteins xiap, bcl-2, and cyclin d1, whereas bax was downregulated. |
2017-06-08 |
2023-08-13 |
Not clear |
| Shigemi Matsuyama, James Palmer, Adam Bates, Izmarie Poventud-Fuentes, Kelvin Wong, Justine Ngo, Mieko Matsuyam. Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 12. 2017-06-06. PMID:27302174. |
ku70 is essential for non-homologous end joining pathway for dna double strand break repair, and bax plays an important role in apoptosis. |
2017-06-06 |
2023-08-13 |
mouse |