| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiang Li, Yang Sun, Hongxing Wan, Fang Cha. [Overexpression of N-myc downstream regulated gene 2 (NDRG2) inhibits proliferation, migration and promotes apoptosis in SW480 rectal cancer cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 1. 2017-07-10. PMID:28031114. |
conclusion overexpression of ndrg2 can inhibit the proliferation, reduce cell migration, and promote cell apoptosis by regulating the expressions of bcl-2, bax and caspase-3 proteins in sw480 cells. |
2017-07-10 |
2023-08-13 |
human |
| Xiao Ding, Lei Yu, Chongyang Ge, Haitian M. Protective effect of DHEA on hydrogen peroxide-induced oxidative damage and apoptosis in primary rat Leydig cells. Oncotarget. vol 8. issue 10. 2017-07-07. PMID:28212544. |
meanwhile, pre-treatment with dhea inhibited h2o2-induced leydig cells early apoptosis which mainly by reducing the pro-apoptotic protein bax and caspases-9, caspases-3 mrna levels. |
2017-07-07 |
2023-08-13 |
rat |
| Na Guo, Zuojia Liu, Wenjing Zhao, Erkang Wang, Jin Wan. Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling. PloS one. vol 11. issue 5. 2017-07-06. PMID:27223122. |
furthermore, apy606 treatment directly inhibited ras-gtp and the downstream activation of mapk, which resulted in the down-regulation of anti-apoptotic protein bcl-2, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (bax, cytosolic cytochrome c and caspase 3) and of cyclin-dependent kinase 2 and cyclin a, e. these data suggest that impairing ras-mapk signaling is a novel mechanism of action for apy606 during therapeutic intervention in pancreatic cancer. |
2017-07-06 |
2023-08-13 |
human |
| Duc Duy Vo, Isabelle Rouaud, Francoise Le Devehat, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, Joël Boustie, René Gré. Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic Systems Against B16-F10 Melanoma Cancer Cells. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 12. issue 5. 2017-07-04. PMID:26825069. |
cancer cells can develop the ability to avoid apoptosis through the upregulation and/or down regulation of such proteins bax, bcl-xl or mcl-1, especially during chemoresistance progress. |
2017-07-04 |
2023-08-13 |
Not clear |
| Zhu Chao, Tian Liuyang, Li Nan, Chen Qi, Cai Zhongqi, Li Yang, Liu Yuq. Mitochondrial tRNA mutation with high-salt stimulation on cardiac damage: underlying mechanism associated with change of Bax and VDAC. American journal of physiology. Heart and circulatory physiology. vol 311. issue 5. 2017-06-30. PMID:27638882. |
expression of the voltage-dependent anion channel (vdac) and the apoptosis regulator bax were highest in the shr + m + nacl group (p < 0.05), which also showed evidence of vdac and bax colocalization (p < 0.05). |
2017-06-30 |
2023-08-13 |
rat |
| Zhu Chao, Tian Liuyang, Li Nan, Chen Qi, Cai Zhongqi, Li Yang, Liu Yuq. Mitochondrial tRNA mutation with high-salt stimulation on cardiac damage: underlying mechanism associated with change of Bax and VDAC. American journal of physiology. Heart and circulatory physiology. vol 311. issue 5. 2017-06-30. PMID:27638882. |
overall, these data suggest that mitochondrial trna mutation with high-salt stimulation can aggravate cardiac damage, potentially because of increased expression and interaction between bax and vdac and increased reactive oxygen species formation and initiation of apoptosis. |
2017-06-30 |
2023-08-13 |
rat |
| Huanyin Li, Lan Zheng, Yanqing Mo, Qi Gong, Aihua Jiang, Jing Zha. Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy. PloS one. vol 11. issue 12. 2017-06-29. PMID:27941998. |
meanwhile apoptosis related proteins bax and atf2 were involved in desminopathy patients and desminopathy rat model, but not bcl-2, bcl-xl or hk2.vdac1 and desmin are closely relevant in the tissue splices of deminopathies patients and rats with desminopathy at protein lever. |
2017-06-29 |
2023-08-13 |
rat |
| Zhaoxia Yu, Aisa Rayile, Xiangyang Zhang, Ying Li, Qiang Zha. Ulinastatin protects against lipopolysaccharide-induced cardiac microvascular endothelial cell dysfunction via downregulation of lncRNA MALAT1 and EZH2 in sepsis. International journal of molecular medicine. vol 39. issue 5. 2017-06-29. PMID:28405676. |
then, cell permeability was evaluated by transendothelial electrical resistance, reactive oxygen species (ros) levels were assessed by 2,7-dichlorofluorescein diacetate, cell apoptosis was detected using annexin v-fitc apoptosis detection kit, and the expression levels of bcl-2, bax, caspase-3, metastasis-associated lung adenocarcinoma transcript 1 (malat1) and ezh2 were detected by rt-qpcr and/or western blotting. |
2017-06-29 |
2023-08-13 |
rat |
| Qianqian Jiang, Yu Pan, Yupeng Cheng, Huiling Li, Hui L. Protection of rat liver against hepatic ischemia-reperfusion injury by a novel selenocysteine-containing 7-mer peptide. Molecular medicine reports. vol 14. issue 3. 2017-06-27. PMID:27431272. |
the results of the current study suggest that the 7‑mer peptide protected the liver against hepatic i‑r injury via suppression of oxygen‑derived free radicals and regulation of bcl‑2 and bax expression, which are involved in the apoptosis of liver cells. |
2017-06-27 |
2023-08-13 |
rat |
| Liyun Xu, Yanlin Chen, Siyang Wen, Yan'e DU, Xi Tang, Manran Li. [Knockdown of Drosha promotes chemosensitivity of epirubicin for gastric cancer MGC-803 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 9. 2017-06-27. PMID:27609577. |
after the treatment with ic50 epirubicin, the apoptosis rate of each cell group was determined by flow cytometry; the expressions of apoptosis-related proteins caspase-3, caspase-9, bax, bcl-2 were assessed by western blotting. |
2017-06-27 |
2023-08-13 |
Not clear |
| Liyun Xu, Yanlin Chen, Siyang Wen, Yan'e DU, Xi Tang, Manran Li. [Knockdown of Drosha promotes chemosensitivity of epirubicin for gastric cancer MGC-803 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 9. 2017-06-27. PMID:27609577. |
after the cells were treated with 0.5 mg/l(ic50) epirubicin, the apoptosis rate of mgc-803 cells was raised, the protein expressions of caspase-3 , caspase-9 and bax were significantly upregulated and bcl-2 was downregulated. |
2017-06-27 |
2023-08-13 |
Not clear |
| Jianzhong Cheng, Shaozeng Ma, Guanghua Yang, Lisen Wang, Wei Ho. The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-06-27. PMID:28095393. |
125i particle implantation therapy markedly suppressed rabbit vx2 transplanted tumor cell proliferation, promoted tumor regression, induced tumor cell apoptosis, reduced bcl-2 expression, and upregulated bax expression level (p<0.05). |
2017-06-27 |
2023-08-13 |
rabbit |
| Mürüde Dagdelen, Muzaffer Temur, Özgür Yılmaz, Tamer Altındag, Turan Uslu, Pelin Özün Özba. Placental bed apoptosis is increased in pregnant women with pre-eclampsia versus normotensive pregnant women. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 36. issue 8. 2017-06-26. PMID:27565440. |
apoptosis in syncytiotrophoblasts, syncytial cluster, extravillous cytotrophoblast, and decidual and stromal cells were evaluated by caspase-3, bax and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labelling (tunel) immunohistochemical methods. |
2017-06-26 |
2023-08-13 |
Not clear |
| Katharine J Goodall, Megan L Finch-Edmondson, Joanne van Vuuren, George C Yeoh, Ian E Gentle, James E Vince, Paul G Ekert, David L Vaux, Bernard A Callu. Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins. PloS one. vol 11. issue 11. 2017-06-26. PMID:27806040. |
apoptosis mediated by bax or bak is usually thought to be triggered by bh3-only members of the bcl-2 protein family. |
2017-06-26 |
2023-08-13 |
Not clear |
| Antonella Muscella, Carla Vetrugno, Luca Giulio Cossa, Giovanna Antonaci, Francesco De Nuccio, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Santo Marsigliant. In Vitro and In Vivo Antitumor Activity of [Pt(O,O'-acac)(γ-acac)(DMS)] in Malignant Pleural Mesothelioma. PloS one. vol 11. issue 11. 2017-06-26. PMID:27806086. |
ptac2s was more efficacious than cisplatin also in inducing apoptosis characterized by: (a) mitochondria depolarization, (b) increase of bax expression and its cytosol-to-mitochondria translocation and decrease of bcl-2 expression, (c) activation of caspase-7 and -9. |
2017-06-26 |
2023-08-13 |
human |
| Zhi-Jun Ou, Jing Chen, Wei-Ping Dai, Xiang Liu, Yin-Ke Yang, Yan Li, Ze-Bang Lin, Tian-Tian Wang, Ying-Ying Wu, Dan-Hong Su, Tian-Pu Cheng, Zhi-Ping Wang, Jun Tao, Jing-Song O. 25-Hydroxycholesterol impairs endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase. American journal of physiology. Endocrinology and metabolism. vol 311. issue 4. 2017-06-23. PMID:27600825. |
endothelial cell apoptosis was monitored by tunel staining and caspase-3 activity, and expression of bcl-2, bax, cleaved caspase-9, and cleaved caspase-3 were detected by immunoblot analysis. |
2017-06-23 |
2023-08-13 |
rat |
| Yuanyuan Tang, Mao Xie, Neng Jiang, Feifei Huang, Xiao Zhang, Ruishan Li, Jingjing Lu, Shijie Liao, Yun Li. Icarisid II inhibits the proliferation of human osteosarcoma cells by inducing apoptosis and cell cycle arrest. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-06-22. PMID:28621234. |
the cell apoptotic rate increased in a dose-dependent manner after treatment with icarisid ii for 48 h. icarisid ii induced apoptosis by upregulating bax, downregulating bcl-2, and activating apoptosis-related proteins, including cleaved caspase-3, caspase-7, caspase-9, and poly (adp-ribose) polymerase. |
2017-06-22 |
2023-08-13 |
human |
| Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang H. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. vol 107. 2017-06-21. PMID:26976669. |
with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tmcao) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (il-1β), bax and p53 expression and upregulating anti-apoptotic protein bcl-2 level. |
2017-06-21 |
2023-08-13 |
mouse |
| Shao-Ze Wu, Lu-Yuan Tao, Jiao-Ni Wang, Zhi-Qiang Xu, Jie Wang, Yang-Jing Xue, Kai-Yu Huang, Jia-Feng Lin, Lei Li, Kang-Ting J. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxidative medicine and cellular longevity. vol 2017. 2017-06-21. PMID:28392886. |
in vivo, amifostine pretreatment alleviated i/r injury and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase (sod) and reduced malondialdehyde (mda) in myocardial tissues, increased bcl2 expression, decreased bax expression, lower cleaved caspase-3 level, fewer tunel positive cells, and fewer dhe-positive cells in heart. |
2017-06-21 |
2023-08-13 |
mouse |
| Nemat Ali, Summya Rashid, Sana Nafees, Syed Kazim Hasan, Ayaz Shahid, Ferial Majed, Sarwat Sultan. Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chemico-biological interactions. vol 272. 2017-06-20. PMID:28479099. |
cga inhibited cox-2, inos, bax, bcl-2 and caspases 3, 9 mediated inflammation and apoptosis, and improve the histology induced by mtx. |
2017-06-20 |
2023-08-13 |
human |