| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuzhu Zhang, Qian Mu, Zheng Zhou, Haibo Song, Yuan Zhang, Fei Wu, Miao Jiang, Fang Wang, Wen Zhang, Liang Li, Lei Shao, Xingli Wang, Shiwu Li, Lijun Yang, Qi Wu, Mingxiang Zhang, Dongqi Tan. Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction. PloS one. vol 11. issue 6. 2017-07-26. PMID:27355581. |
in addition, in a cell culture model, irisin restored ox-ldl-induced human umbilical vein endothelial cell dysfunction by reducing the levels of inflammatory genes via inhibiting the reactive oxygen species (ros)/ p38 mapk/ nf-κb signaling pathway activation and inhibiting cell apoptosis via up-regulating bcl-2 and down-regulating bax and caspase-3 expression. |
2017-07-26 |
2023-08-13 |
mouse |
| Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadi. The Antioxidative Fraction of White Mulberry Induces Apoptosis through Regulation of p53 and NFκB in EAC Cells. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936037. |
interestingly, apoptosis correlated with the upregulation of p53 and its target genes parp-1 and bax, and also with the down-regulation of nfκb and its target genes bcl-2 and bcl-xl. |
2017-07-26 |
2023-08-13 |
mouse |
| Yin He, Dehong Tan, Bing Bai, Zhaoxia Wu, Shujuan J. Epigallocatechin-3-gallate attenuates acrylamide-induced apoptosis and astrogliosis in rat cerebral cortex. Toxicology mechanisms and methods. vol 27. issue 4. 2017-07-26. PMID:28056603. |
analysis of dna fragmentation and protein expression of bax, bcl-2, caspase 3, and cytochrome c revealed that egcg inhibited acr-induced apoptosis. |
2017-07-26 |
2023-08-13 |
rat |
| Jun Wang, Yunjie Li, Fangfang Ma, Huifeng Zhou, Rong Ding, Binbin Lu, Li Zou, Junxia Li, Rugang L. Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28720068. |
in addition, we found that ectopic par-4 co-localized with cell surface grp78 and induced high expression of the endoplasmic reticulum proteins atf4 and bax, which activated the endoplasmic reticulum apoptosis pathway. |
2017-07-26 |
2023-08-13 |
mouse |
| Fanzhen Kong, Fang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanisms of IRE1α-ASK1 Pathway Reactions to Unfolded Protein Response in DRN Neurons of Post-Traumatic Stress Disorder Rats. Journal of molecular neuroscience : MN. vol 61. issue 4. 2017-07-24. PMID:28210980. |
2) increased expression of apoptosis-associated molecules bcl-2 and bax in drn neurons following sps challenge was revealed as a central mechanism, inducing apoptosis of drn neurons in ptsd rats. |
2017-07-24 |
2023-08-13 |
rat |
| Abdel Halim Harrath, Olga Østrup, Jan Rafay, Iveta Koničková Florkovičová, Jozef Laurincik, Alexander V Sirotki. Metabolic state defines the response of rabbit ovarian cells to leptin. Reproductive biology. vol 17. issue 1. 2017-07-19. PMID:27894742. |
isolated granulosa cells were cultured for 2days with and without leptin (100ng/ml), and the accumulation of various markers was evaluated using immunocytochemistry; i.e., cell proliferation (pcna and cyclin b1), apoptosis (bax), map/erk1,2 kinase (mapk), protein kinase a (pka), and igf-i. |
2017-07-19 |
2023-08-13 |
rabbit |
| Zhiwei Zhou, Xijian Lu, Jin Wang, Jia Xiao, Jing Liu, Feiyue Xin. microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling. Scientific reports. vol 6. 2017-07-18. PMID:27087117. |
the knockdown of the bim gene repressed the anisomycin-boosted apoptosis through the attenuation of the active bak and bax. |
2017-07-18 |
2023-08-13 |
human |
| Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hui Wan. A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631571. |
the expression levels of bax and p53 upregulated modulator of apoptosis were increased in h1299-p53(del) and 801d-p53(del) cells. |
2017-07-18 |
2023-08-13 |
human |
| Fei Liu, Wei-Lin Zhang, Hong-Zheng Meng, Zheng-Yu Cai, Mao-Wei Yan. Regulation of DMT1 on autophagy and apoptosis in osteoblast. International journal of medical sciences. vol 14. issue 3. 2017-07-17. PMID:28367088. |
apoptosis was evaluated by detecting the levels of cleaved caspase 3, bcl2, and bax with western blotting. |
2017-07-17 |
2023-08-13 |
Not clear |
| Eliza Rossi Komninou, Mariana Härter Remião, Caroline Gomes Lucas, William Borges Domingues, Andrea Cristina Basso, Denise Soledade Jornada, João Carlos Deschamps, Ruy Carlos Ruver Beck, Adriana Raffin Pohlmann, Vilceu Bordignon, Fabiana Kömmling Seixas, Vinicius Farias Campos, Silvia Stanisçuaski Guterres, Tiago Collare. Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model. PloS one. vol 11. issue 6. 2017-07-13. PMID:27310006. |
when compared to mel and mel-nc treatments at the same concentration (10-9 m), mel-lnc increased embryo cell number, decreased cell apoptosis and ros levels, down-regulated mrna levels of bax, casp3, and shc1 genes, and up-regulated mrna levels of cat and sod2 genes. |
2017-07-13 |
2023-08-13 |
cat |
| Yiran Yin, Lian Tang, Lei Sh. The metastasis suppressor gene KISS-1 regulates osteosarcoma apoptosis and autophagy processes. Molecular medicine reports. vol 15. issue 3. 2017-07-13. PMID:28075440. |
the mtt method was used to detect apoptosis by flow cytometry, and the mrna levels of apoptosis and autophagy markers caspase-3, bcl-2, bax, lc3 and beclin1 were assessed by rt-pcr. |
2017-07-13 |
2023-08-13 |
Not clear |
| Yaping Xie, Dan Yu, Jiahua Wu, Lin L. Protective effects of physiological testosterone on advanced glycation end product‑induced injury in human endothelial cells. Molecular medicine reports. vol 15. issue 3. 2017-07-13. PMID:28112379. |
early‑stage apoptosis was detected using flow cytometry with annexin v‑fluorescein isothiocyanate/propidium iodide double staining, and the expression levels of apoptosis‑associated proteins, b cell lymphoma‑2 (bcl‑2), bcl‑2‑associated x protein (bax) and caspase‑3, were determined using western blot analysis. |
2017-07-13 |
2023-08-13 |
human |
| Xin Zhou, Yansen Li, Zhaojian Li, Yun Cao, Fei Wang, ChunMei L. Effect of dietary zinc on morphological characteristics and apoptosis related gene expression in the small intestine of Bama miniature pigs. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28174029. |
we concluded that a diet with a pharmacological dose of zn increased the accumulation of zn and the expression of bax, cleaved caspase-3, and caspase-8, which might activate the apoptosis and lead to the marked injury of porcine small intestinal epithelium. |
2017-07-13 |
2023-08-13 |
Not clear |
| Xiaorui Fan, Huaming Xi, Zhen Zhang, Yajun Liang, Qinghong Li, Junping H. Germ cell apoptosis and expression of Bcl-2 and Bax in porcine testis under normal and heat stress conditions. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28279507. |
germ cell apoptosis and expression of bcl-2 and bax in porcine testis under normal and heat stress conditions. |
2017-07-13 |
2023-08-13 |
Not clear |
| Xiaorui Fan, Huaming Xi, Zhen Zhang, Yajun Liang, Qinghong Li, Junping H. Germ cell apoptosis and expression of Bcl-2 and Bax in porcine testis under normal and heat stress conditions. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28279507. |
the aim of this study was to examine whether an elevated ambient temperature (37-40°c) had an effect on the apoptosis of germ cells and the expression of bcl-2 and bax in porcine testis. |
2017-07-13 |
2023-08-13 |
Not clear |
| Xiaorui Fan, Huaming Xi, Zhen Zhang, Yajun Liang, Qinghong Li, Junping H. Germ cell apoptosis and expression of Bcl-2 and Bax in porcine testis under normal and heat stress conditions. Acta histochemica. vol 119. issue 3. 2017-07-13. PMID:28279507. |
this indicates that bcl-2 and bax may be involved in regulation of germ cell apoptosis induced by heat stress in boars. |
2017-07-13 |
2023-08-13 |
Not clear |
| Yifeng Liu, Yulin Jiang, Nian Wang, Qianni Jin, Feihu Ji, Changli Zhong, Zhiqiang Zhang, Junhong Yang, Xiangsen Ye, Tingmei Che. Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-11. PMID:28653874. |
additionally, fructose-1,6-bisphosphatase 1 promoted cell apoptosis by upregulating the levels of intracellular ros and expression of pro-apoptotic proteins such as cleaved parp, cleaved caspase 3, and bax and downregulating the levels of anti-apoptotic proteins such as parp, caspase 3, and bcl-2. |
2017-07-11 |
2023-08-13 |
Not clear |
| Noraziah Nordin, Mehran Fadaeinasab, Syam Mohan, Najihah Mohd Hashim, Rozana Othman, Hamed Karimian, Venus Iman, Noorlela Ramli, Hapipah Mohd Ali, Nazia Abdul Maji. Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway. PloS one. vol 11. issue 5. 2017-07-10. PMID:27136097. |
apoptosis was further confirmed via gene and protein expression levels, in which bcl-2 protein was down-regulated and bax protein was up-regulated. |
2017-07-10 |
2023-08-13 |
human |
| Liman Niu, Xueling Cui, Yan Qi, Dongxue Xie, Qian Wu, Xinxin Chen, Jingyan Ge, Zhonghui Li. Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice. PloS one. vol 11. issue 5. 2017-07-10. PMID:27224286. |
moreover, the results showed that the apoptosis of hepatocytes increased significantly, and apoptosis-associated proteins bax, cytochrome c and the cleaved caspase 3 expressions were up-regulated in ccl4-treated smad3-overexpressing mice as well. |
2017-07-10 |
2023-08-13 |
mouse |
| Zhiqiang Li, Yang Sun, Hongxing Wan, Fang Cha. [Overexpression of N-myc downstream regulated gene 2 (NDRG2) inhibits proliferation, migration and promotes apoptosis in SW480 rectal cancer cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 1. 2017-07-10. PMID:28031114. |
cell proliferation was detected in sw480 cells, sw480-ve cells and sw480-ndrg2 cells by mtt assay; cell migration distance in the three groups at 24, 48, 72 hours was tested by wound healing assay; apoptosis rate was determined in the three groups at 48 hours by flow cytometry; the expressions of bax, caspase-3, bcl-2 proteins in the three groups were examined by western blotting. |
2017-07-10 |
2023-08-13 |
human |