| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T Daniel, Bernhard F Gillissen, Klaus Schulze-Osthoff, Frank Essman. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. Journal of cell science. vol 129. issue 11. 2017-08-08. PMID:27076518. |
here, we demonstrate, in several cell systems, that bok efficiently induces cytochrome c release and apoptosis even in the complete absence of both bak and bax. |
2017-08-08 |
2023-08-13 |
Not clear |
| Dang Tang, Cheng Wang, Yongjun Gao, Jun Pu, Jiang Long, Wei X. Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway. Neuroscience letters. vol 632. 2017-08-08. PMID:27581524. |
after 24h of reperfusion, the results showed that deep hypothermia decreased the neural apoptosis, and significantly suppressed overexpression of bax, cytc, caspase 3, caspase 9 and cleaved parp-1, and inhibited the reduction of bcl-2 expression. |
2017-08-08 |
2023-08-13 |
Not clear |
| Patricia Gomez-Bougie, Maxime Halliez, Philippe Moreau, Catherine Pellat-Deceunynck, Martine Amio. Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis. Cancer letters. vol 383. issue 2. 2017-08-08. PMID:27697610. |
bak but not bax was found to contribute to thapsigargin-induced apoptosis. |
2017-08-08 |
2023-08-13 |
Not clear |
| Hengdao Liu, Hui Peng, Shuhua Chen, Yanwei Liu, Hong Xiang, Ruifang Chen, Wei Chen, Shaoli Zhao, Pan Chen, Hongwei L. S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway. Biochemical and biophysical research communications. vol 490. issue 3. 2017-08-08. PMID:28676392. |
the expression of mitochondrial apoptosis related protein bax increased and bcl-2 decreased in high glucose-induced huvecs. |
2017-08-08 |
2023-08-13 |
human |
| Yong Xin Li, Lin Run, Tao Shi, Yong Jian Zhan. CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-β1/ERK1/2 signaling pathway. Biochemical and biophysical research communications. vol 490. issue 4. 2017-08-08. PMID:28688765. |
meanwhile, ctrp9 strikingly promoted hypoxia-mediated cell apoptosis as reflected by upregulation of bax and downregulation of bcl-2, as well as enhanced caspase 3 activity. |
2017-08-08 |
2023-08-13 |
human |
| Bo Shi, Ying Li, Xiuli Wang, Yi Yang, Dan Li, Xin Liu, Xianghong Yan. Silencing of hypoxia inducible factor-1α by RNA interference inhibits growth of SK-NEP-1 Wilms tumour cells in vitro, and suppresses tumourigenesis and angiogenesis in vivo. Clinical and experimental pharmacology & physiology. vol 43. issue 6. 2017-08-07. PMID:27015631. |
in addition, reduction of hif-1α expression induced apoptosis in sk-nep-1 cells, which was accompanied by increased levels of cleaved caspase-3, cleaved poly (adp-ribose) polymerase (parp) and bax as well as downregulation of bcl-2 in the cells. |
2017-08-07 |
2023-08-13 |
mouse |
| Eduardo B Dornelles, Bayard D Goncalves, Karen Lilian Schott, Fernanda Barbisan, Tais C Unfer, Werner G Glanzner, Alencar K Machado, Francine C Cadona, Veronica Farina Azzolin, Marco Aurélio Echart Montano, John Griner, Ivana B M da Cru. Cytotoxic effects of moderate static magnetic field exposure on human periphery blood mononuclear cells are influenced by Val16Ala-MnSOD gene polymorphism. Environmental science and pollution research international. vol 24. issue 5. 2017-08-07. PMID:28004364. |
in addition, apoptosis induction has been analyzed by flow cytometry as well as bcl-2-associated x protein (bax), b-cell lymphoma 2 (bcl-2), and caspases 8 and 3 gene expression. |
2017-08-07 |
2023-08-13 |
human |
| Feng Zhang, Junfeng Zhu, Jiajia Li, Fangbing Zhu, Pingping Zhan. IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival. Gene. vol 627. 2017-08-07. PMID:28579269. |
in addition, irf2 knockdown induces apoptosis of aml cells by regulating the apoptotic effectors bcl-2, bax and caspase 3. |
2017-08-07 |
2023-08-13 |
human |
| Xue Tian, Hae Seong Song, Young Mi Cho, Bongkyun Park, Yoon-Jae Song, Sunphil Jang, Se Chan Kan. Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells. Medicine. vol 96. issue 30. 2017-08-07. PMID:28746210. |
sle treatment decreased the viability of lncap cells and increased bax expression while suppressing the expression of pro-caspases-8/9/3, parp, bid, and bcl-2, thereby inducing apoptosis in lncap cells. |
2017-08-07 |
2023-08-13 |
Not clear |
| Daniela Lorenzo, Alejandra Duarte, Juliana Mundiñano, Paula Berguer, Irene Nepomnaschy, Isabel Piazzo. A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells. PloS one. vol 11. issue 9. 2017-08-04. PMID:27603942. |
the involvement of the intrinsic pathway was clearly indicated by: i) alterations in mitochondrial membrane potential (ΔΨm) both in murine and human lymphoma cells exposed to ppl; ii) decreased levels of apoptosis in the presence of caspase-9 inhibitor; iii) significant increases of bim and bax protein levels and downregulation of bcl-2; iv) the translocation from the cytoplasm to the mitochondria of bax and bim pro-apoptotic proteins and its inhibition by caspase-9 inhibitor but not by caspase-8 inhibitor and v) the translocation of bcl-2 protein from the mitochondria to the cytosol and its inhibition by caspase-9 inhibitor but not by caspase-8 inhibitor. |
2017-08-04 |
2023-08-13 |
human |
| Lin Chen, Li Cheng, Xinbing Wei, Zheng Yuan, Yanmei Wu, Shuaishuai Wang, Zhiping Ren, Xinyong Liu, Huiqing Li. Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice. Neurochemical research. vol 42. issue 4. 2017-08-04. PMID:28005221. |
our further findings confirmed treatment of cxc195 at the dose of 10 mg/kg significantly inhibited the apoptosis by decreasing the level of cleaved caspase-3 and bax, and increasing the level of bcl-2 in 6-ohda-lesioned mice. |
2017-08-04 |
2023-08-13 |
mouse |
| Q Wang, Y Shi, H J Butler, J Xue, G Wang, P Duan, H Zhen. Role of delta-like ligand-4 in chemoresistance against docetaxel in MCF-7 cells. Human & experimental toxicology. vol 36. issue 4. 2017-08-03. PMID:27334972. |
overexpression of dll4 could significantly attenuate the cytotoxic effects of doc by increasing bcl-2 expression, while decreasing bax expression, apoptosis rate and dna damage. |
2017-08-03 |
2023-08-13 |
human |
| Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, Grażyna Ewa Pta. Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PloS one. vol 12. issue 1. 2017-08-03. PMID:28076382. |
likely, this accumulation of damaged organelles led to uncontrolled apoptosis in scnt placentae, as demonstrated by the high number of apoptotic bodies, fragmented cytoplasm, condensed chromatin, lack of integrity of the nuclear membrane and the perturbed mrna expression of apoptotic genes (bcl2 and bax). |
2017-08-03 |
2023-08-13 |
Not clear |
| Santosh Kumar Singh, Saswati Banerjee, Edward P Acosta, James W Lillard, Rajesh Sing. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget. vol 8. issue 10. 2017-08-01. PMID:28212547. |
the combined drug treatment up-regulates the pro-apoptotic genes (bax, bid, and bak), cleaved parp and down regulates the anti-apoptotic genes (mcl-1, bcl-2, bcl-xl) promoting apoptosis. |
2017-08-01 |
2023-08-13 |
Not clear |
| Robert F Gahl, Pallavi Dwivedi, Nico Tjandr. Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27763642. |
bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis. |
2017-07-31 |
2023-08-13 |
Not clear |
| Yu-Ching Huang, Ming-Shiun Tsai, Pei-Chi Hsieh, Jheng-Hong Shih, Tsu-Shing Wang, Yi-Chun Wang, Ting-Hui Lin, Sue-Hong Wan. Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. Toxicology and applied pharmacology. vol 329. 2017-07-31. PMID:28558962. |
in terms of cell death, galangin administration reduced levels of p53, pro-apoptotic bax and activated caspase-3 to inhibit the cisplatin-induced apoptosis. |
2017-07-31 |
2023-08-13 |
mouse |
| Andrew J Crowther, Jennifer K Ocasio, Fang Fang, Jessica Meidinger, Jaclyn Wu, Allison M Deal, Sha X Chang, Hong Yuan, Ralf Schmid, Ian Davis, Timothy R Gersho. Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway. Cancer research. vol 76. issue 11. 2017-07-28. PMID:27197166. |
deletion of bax, which blocked apoptosis downstream of p53, was sufficient to render tumors radiation resistant. |
2017-07-28 |
2023-08-13 |
mouse |
| Vidal Jarauta, Paula Jaime, Oscar Gonzalo, Diego de Miguel, Ariel Ramírez-Labrada, Luis Martínez-Lostao, Alberto Anel, Julián Pardo, Isabel Marzo, Javier Nava. Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. Cancer letters. vol 382. issue 1. 2017-07-28. PMID:27565383. |
carfilzomib induced apoptosis essentially by the intrinsic pathway, through the up-regulation of puma and noxa proteins followed by the interaction of puma, noxa and bim with bax and of noxa with bak. |
2017-07-28 |
2023-08-13 |
mouse |
| Lindsay Hollander, Xiaojia Guo, Heino Velazquez, John Chang, Robert Safirstein, Harriet Kluger, Charles Cha, Gary V Desi. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer research. vol 76. issue 13. 2017-07-27. PMID:27197188. |
mechanistic investigations showed that increased apoptosis in tumor cells was temporally related to p38 mapk-mediated bax activation and that increased cell growth arrest was associated with elevated expression of the cell-cycle inhibitor p21. |
2017-07-27 |
2023-08-13 |
Not clear |
| Zhi Pan, Yingcai Niu, Yini Liang, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway. Neurotoxicity research. vol 30. issue 3. 2017-07-26. PMID:27229883. |
in the present study, pretreatment with β-ecd significantly reduced 6-ohda-induced apoptosis of sh-sy5y cells by a mitochondria-dependent pathway, as indicated by downregulation of bax and puma (p53 upregulated modulator of apoptosis) expression, suppressing ΔΨm loss, inhibiting cytochrome c release, and attenuating caspase-9 activation. |
2017-07-26 |
2023-08-13 |
Not clear |