| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Ting Liu, Fen-Fen Peng, Hong-Yu Li, Xiao-Wen Chen, Wang-Qiu Gong, Wen-Jing Chen, Yi-Hua Chen, Pei-Lin Li, Shu-Ting Li, Zhao-Zhong Xu, Hai-Bo Lon. Metadherin facilitates podocyte apoptosis in diabetic nephropathy. Cell death & disease. vol 7. issue 11. 2017-08-28. PMID:27882943. |
the inhibition of mtdh expression, using small interfering rna, but not mtdh overexpression, was shown to inhibit hg-induced mpc5 apoptosis and p38 mapk pathway, and bax and cleaved caspase 3 expression. |
2017-08-28 |
2023-08-13 |
mouse |
| Xian Jiang, Li Li, Zhengxin Ying, Chenjie Pan, Shaoqiang Huang, Lin Li, Miaomiao Dai, Bo Yan, Ming Li, Hui Jiang, She Chen, Zhiyuan Zhang, Xiaodong Wan. A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway. Molecular cell. vol 63. issue 2. 2017-08-25. PMID:27447985. |
here we report the discovery of a small molecule that efficiently blocks bim-induced apoptosis after bax is activated on the mitochondria. |
2017-08-25 |
2023-08-13 |
rat |
| Bo Guo, Wenjing Wang, Zhenghao Zhao, Qian Li, Kaiyue Zhou, Lingyu Zhao, Lumin Wang, Juan Yang, Chen Huan. Rab14 Act as Oncogene and Induce Proliferation of Gastric Cancer Cells via AKT Signaling Pathway. PloS one. vol 12. issue 1. 2017-08-23. PMID:28107526. |
when we overexpressed rab14 in sgc-7901 cells or silenced rab14 in bgc-823 cells, we found that rab14 could modify cell growth, cell cycle or apoptosis, which accompanied with an obvious regulation of ccnd1, cdk2 and bax involving in akt signaling pathway. |
2017-08-23 |
2023-08-13 |
human |
| Min Liang, Aiqing Li, Aiju Lou, Xifang Zhang, Youyuan Chen, Lei Yang, Yumin Li, Shenglin Yang, Fan Fan Ho. Advanced oxidation protein products promote NADPH oxidase-dependent β-cell destruction and dysfunction through the Bcl-2/Bax apoptotic pathway. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 7. 2017-08-23. PMID:28263293. |
exposure of cultured rat β-cells (ins-1) to aopps induced an increase in bax expression, caspase-3 activity, and apoptosis as well as a decrease in bcl-2 expression in a dose- and time-dependent manner. |
2017-08-23 |
2023-08-13 |
rat |
| In-Hu Hwang, Junsoo Park, Jung Min Kim, Seung Il Kim, Jong-Soon Choi, Kyung-Bok Lee, Sung Ho Yun, Min-Goo Lee, Soo Jung Park, Ik-Soon Jan. Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27247127. |
this decreased bcl2-associated x protein (bax) activation, leading to marked protection against high glucose-induced apoptosis. |
2017-08-22 |
2023-08-13 |
human |
| In-Hu Hwang, Junsoo Park, Jung Min Kim, Seung Il Kim, Jong-Soon Choi, Kyung-Bok Lee, Sung Ho Yun, Min-Goo Lee, Soo Jung Park, Ik-Soon Jan. Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27247127. |
bax subfamily proteins induced apoptosis through caspase-3. |
2017-08-22 |
2023-08-13 |
human |
| In-Hu Hwang, Junsoo Park, Jung Min Kim, Seung Il Kim, Jong-Soon Choi, Kyung-Bok Lee, Sung Ho Yun, Min-Goo Lee, Soo Jung Park, Ik-Soon Jan. Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27247127. |
thus, tspan2 might have induced bax translocation and caspase-3 activation in pancreatic β cells, thereby promoting the apoptosis of rnakt-15 cells by regulating the jnk/β-catenin pathway in response to high glucose concentrations. |
2017-08-22 |
2023-08-13 |
human |
| b' Janusz Godlewski, Bartlomiej E Krazinski, Anna E Kowalczyk, Jolanta Kiewisz, Jacek Kiezun, Przemyslaw Kwiatkowski, Agnieszka Sliwi\\xc5\\x84ska-Jewsiewicka, Piotr W Wierzbicki, Zbigniew Kmie\\xc4\\x8. Expression and Prognostic Significance of Anticancer research. vol 37. issue 6. 2017-08-21. PMID:28551630.' |
expression and prognostic significance of histone acetyltransferase e1a-binding protein p300 (ep300), tumor protein p53 (tp53) and b-cell lymphoma-2-associated x protein (bax) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. |
2017-08-21 |
2023-08-13 |
Not clear |
| Ko-Jen Li, Cheng-Han Wu, Chieh-Yu Shen, Yu-Min Kuo, Chia-Li Yu, Song-Chou Hsie. Membrane Transfer from Mononuclear Cells to Polymorphonuclear Neutrophils Transduces Cell Survival and Activation Signals in the Recipient Cells via Anti-Extrinsic Apoptotic and MAP Kinase Signaling Pathways. PloS one. vol 11. issue 6. 2017-08-18. PMID:27258015. |
total membrane transfer from cd4+ t to pmns delayed pmn apoptosis by suppressing the extrinsic apoptotic molecules, bax, myc and caspase 8. |
2017-08-18 |
2023-08-13 |
human |
| Jian-Hua Xu, Wei-Hua Chang, Hang-Wei Fu, Wei-Qun Shu, Tao Yuan, Ping Che. Upregulated long non-coding RNA LOC90784 promotes cell proliferation and invasion and is associated with poor clinical features in HCC. Biochemical and biophysical research communications. vol 490. issue 3. 2017-08-18. PMID:28651931. |
knockdown of lncrna loc90784 expression inhibited proliferation and induced apoptosis and cell cycle arrest by promoting bax and repressing cdk4 and cyclin d1 protein expression; it also inhibited invasion and migration by repressing mmp2 and mmp9 expression in hcc cells. |
2017-08-18 |
2023-08-13 |
Not clear |
| Yong Joo Park, Chang-Ik Choi, Kyu Hyuck Chung, Ki Hyun Ki. Pharbilignan C induces apoptosis through a mitochondria-mediated intrinsic pathway in human breast cancer cells. Bioorganic & medicinal chemistry letters. vol 26. issue 19. 2017-08-15. PMID:27575473. |
plc induced apoptosis in mda-mb 231 cells with down regulation of bcl-2 and up-regulation of bax expression. |
2017-08-15 |
2023-08-13 |
human |
| Michał Szewczuk, Karolina Boguszewska, Marta Żebrowska, Ewa Balcerczak, Marta Stasiak, Maria Świątkowska, Katarzyna Błaszczak-Świątkiewic. Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-08-15. PMID:28752801. |
the apoptosis was confirmed by generation of bax gene and protein and reduction of bcl2 gene and protein. |
2017-08-15 |
2023-08-13 |
Not clear |
| Jong Cheon Joo, Jung Hoo Hwang, Eunbi Jo, Young-Rang Kim, Dae Joon Kim, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jan. Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma. Oncotarget. vol 8. issue 7. 2017-08-11. PMID:28099944. |
foxo3a sirna downregulated bax protein and attenuated a549 apoptosis, indicating that the cav1-mediated jnk/foxo3a pathway induces the apoptosis of a549 lung cancer cells. |
2017-08-11 |
2023-08-13 |
mouse |
| Yanhao Cheng, Chao Dai, Jian Zhan. SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death. Acta biochimica Polonica. vol 64. issue 2. 2017-08-11. PMID:28567457. |
linalool decreased mitochondrial oxygen consumption rate, increased the expression of bax and bak, reduced the expression of bcl-2 and bcl-xl, and increased the activities of caspase 3 and caspase 9, leading to increase of apoptosis. |
2017-08-11 |
2023-08-13 |
Not clear |
| b' Nadia Casatta, Fabrizio Stefani, Luigi Vigan\\xc3\\xb. Hepatic gene expression profiles of a non-model cyprinid (Barbus plebejus) chronically exposed to river sediments. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 196. 2017-08-09. PMID:28286098.' |
we investigated a set of 24 genes involved in xenobiotic biotransformation (cyp1a, gstα, ugt), antioxidant defense (gpx, sod, cat, hsp70), trace metal exposure (mt-i, mt-ii), dna repair (xpa, xpc), apoptosis (bax, casp3), growth (igf2), and steroid (erα, erβ1, erβ2, ar, vtg) and thyroid (dio1, dio2, trα, trβ, nis) hormone signaling pathways. |
2017-08-09 |
2023-08-13 |
cat |
| Ruobing Wang, Qinglei Sun, Fangzhou Xia, Zeli Chen, Jiangchun Wu, Yuelu Zhang, Jiajun Xu, Lin Li. Methane rescues retinal ganglion cells and limits retinal mitochondrial dysfunction following optic nerve crush. Experimental eye research. vol 159. 2017-08-09. PMID:28336261. |
the retinal apoptosis was measured by terminal-deoxy-transferase-mediated dutp nick end labeling (tunel) assay and the expression of apoptosis-related factors, such as phosphorylated bcl-2-associated death promoter (pbad), phosphorylated glycogen synthase kinase-3β (pgsk-3β), bcl-2 associated x protein (bax) and bcl-2 extra large (bcl-xl). |
2017-08-09 |
2023-08-13 |
rat |
| Ruobing Wang, Qinglei Sun, Fangzhou Xia, Zeli Chen, Jiangchun Wu, Yuelu Zhang, Jiajun Xu, Lin Li. Methane rescues retinal ganglion cells and limits retinal mitochondrial dysfunction following optic nerve crush. Experimental eye research. vol 159. 2017-08-09. PMID:28336261. |
as expected, methane also remarkably inhibited the retinal neural apoptosis, such as the fewer tunel-positive cells in ganglion cell layer, accompanied by the up-regulations of anti-apoptotic factors (pgsk-3β, pbad, bcl-xl) and the down-regulation of pro-apoptotic factor (bax). |
2017-08-09 |
2023-08-13 |
rat |
| Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T Daniel, Bernhard F Gillissen, Klaus Schulze-Osthoff, Frank Essman. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. Journal of cell science. vol 129. issue 11. 2017-08-08. PMID:27076518. |
bok is a genuine multi-bh-domain protein that triggers apoptosis in the absence of bax and bak. |
2017-08-08 |
2023-08-13 |
Not clear |
| Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T Daniel, Bernhard F Gillissen, Klaus Schulze-Osthoff, Frank Essman. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. Journal of cell science. vol 129. issue 11. 2017-08-08. PMID:27076518. |
the pro-apoptotic multidomain bcl-2 proteins bax and bak (also known as bak1) are considered the gatekeepers of the intrinsic pathway of apoptosis by triggering the mitochondrial release of cytochrome c the role of the third bax- and bak-homologous multidomain protein bok, however, is still unresolved. |
2017-08-08 |
2023-08-13 |
Not clear |
| Stephanie Einsele-Scholz, Silke Malmsheimer, Katrin Bertram, Daniel Stehle, Janina Johänning, Marianne Manz, Peter T Daniel, Bernhard F Gillissen, Klaus Schulze-Osthoff, Frank Essman. Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. Journal of cell science. vol 129. issue 11. 2017-08-08. PMID:27076518. |
as cells doubly deficient for bax and bak are largely resistant to various apoptotic stimuli, it has been proposed that bok is either dispensable for apoptosis or that its role is dependent on bax and bak. |
2017-08-08 |
2023-08-13 |
Not clear |