| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther P Jane, Daniel R Premkumar, Philip A Sutera, Jonathon M Cavaleri, Ian F Pollac. Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. Molecular carcinogenesis. vol 56. issue 4. 2017-09-12. PMID:27805285. |
treatment with ym155 increased the release of cytochrome c, smac/diablo and apoptosis inducing-factor, and promoted loss of mitochondrial membrane potential, activation of bax, recruitment of lc3-ii to the autophagosomes and apoptosis in bcl-xl silenced cells. |
2017-09-12 |
2023-08-13 |
Not clear |
| Patrick Y Lang, Gouri J Nanjangud, Marina Sokolsky-Papkov, Christine Shaw, Duhyeong Hwang, Joel S Parker, Alexander V Kabanov, Timothy R Gersho. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27803059. |
co-deletions of either p53 or bax and bak prevented apoptosis in atr-deleted cgnps, but failed to fully rescue cerebellar growth. |
2017-09-11 |
2023-08-13 |
mouse |
| Fangying Cao, Xiaoxiao Liu, Xiangrong Cao, Shaoping Wang, Kun Fu, Yejing Zhao, Fang Shen, Jinghua Li. Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system. Biochemical and biophysical research communications. vol 491. issue 3. 2017-09-11. PMID:28774557. |
knockdown of opg significantly impaired inhibition of fgf21 on apoptosis and the expression of pro-apoptotic genes including caspase-3 and bax and osteoblastic -promoting markers including alp, runx-2 and rankl. |
2017-09-11 |
2023-08-13 |
rat |
| Venkaiah Betapudi, Meenal Shukla, Ravi Alluri, Sergei Merkulov, Keith R McCra. Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 10. 2017-09-08. PMID:27402674. |
sirna knockdown of p56/lck promoted endothelial proliferation and blocked hka-induced apoptosis and activation of p53, bax, and bak. |
2017-09-08 |
2023-08-13 |
human |
| Wei Hu, Hongbo Wang, Zhenfeng Liu, Yanlu Liu, Rong Wang, Xiao Luo, Yifei Huan. Neuroprotective effects of lycopene in spinal cord injury in rats via antioxidative and anti-apoptotic pathway. Neuroscience letters. vol 642. 2017-09-08. PMID:28163080. |
besides, the sci group showed decreased protein expression of bcl-2 and mitochondrial cytochrome c, increased protein expression of cytosolic cytochrome c, cleaved caspase-9, cleaved caspase-3 and bax, and increased tunel-positive cell numbers, which indicated that sci could induce cell apoptosis. |
2017-09-08 |
2023-08-13 |
rat |
| P-H Liao, H-H Hsu, T-S Chen, M-C Chen, C-H Day, C-C Tu, Y-M Lin, F-J Tsai, W-W Kuo, C-Y Huan. Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury. Oncogene. vol 36. issue 14. 2017-09-07. PMID:27748761. |
we observed that hdaci induced ros accumulation in cells and apoptosis via promotion of the cfl-1 interaction with bax and cfl-1 translocation to the mitochondria, resulting in cytochrome c release. |
2017-09-07 |
2023-08-13 |
Not clear |
| Emma C Watson, Monica N Koenig, Zoe L Grant, Lachlan Whitehead, Evelyn Trounson, Grant Dewson, Leigh Coulta. Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis. Development (Cambridge, England). vol 143. issue 16. 2017-09-05. PMID:27471260. |
we generated mice in which ec apoptosis was blocked by tissue-specific deletion of the apoptosis effector proteins bak and bax. |
2017-09-05 |
2023-08-13 |
mouse |
| Rishi Bhardwaj, S N Sanyal, Kim Vaiphei, Vandita Kakkar, Parneet Kaur Deol, Indu Pal Kaur, Tranum Kau. Sesamol Induces Apoptosis by Altering Expression of Bcl-2 and Bax Proteins and Modifies Skin Tumor Development in Balb/c Mice. Anti-cancer agents in medicinal chemistry. vol 17. issue 5. 2017-09-05. PMID:27539478. |
sesamol induces apoptosis by altering expression of bcl-2 and bax proteins and modifies skin tumor development in balb/c mice. |
2017-09-05 |
2023-08-13 |
mouse |
| Rashmi Bharti, Goutam Dey, Indranil Banerjee, Kaushik Kumar Dey, Sheetal Parida, B N Prashanth Kumar, Chandan Kanta Das, Ipsita Pal, Manabendra Mukherjee, Mridula Misra, Anjan K Pradhan, Luni Emdad, Swadesh K Das, Paul B Fisher, Mahitosh Manda. Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy. Cancer letters. vol 388. 2017-09-05. PMID:28025102. |
enhanced apoptosis in breast cancer cells was detected in sst-dnl treated groups as monitored by cell cycle analysis and changes in expression level of apoptotic/anti-apoptotic proteins bcl-2, bax, cleaved caspase 3 and parp. |
2017-09-05 |
2023-08-13 |
mouse |
| Shiwei Liu, Fang Du, Xin Li, Mingming Wang, Ruixue Duan, Jiaxin Zhang, Yaru Wu, Qi Zhan. Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells. PloS one. vol 12. issue 4. 2017-09-05. PMID:28394923. |
irisin also promoted ins-1 cell proliferation via the erk and p38 mapk signaling pathways, protected the cells from high-glucose-induced apoptosis by regulating the expression of caspases, bad, bax, bcl-2 and bcl-xl, and improved pancreatic β cell function. |
2017-09-05 |
2023-08-13 |
rat |
| R Bharti, G Dey, P K Ojha, S Rajput, S K Jaganathan, R Sen, M Manda. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene. vol 35. issue 30. 2017-09-01. PMID:26616855. |
in vitro apoptosis was induced by this drug in breast cancer cells as verified by increased sub-g1 population, live/dead assay, cell cytotoxicity and presence of terminal deoxynucleotidyl transferase dutp nick end labeling (tunel)-positive cells, as well as downregulation of antiapoptotic proteins bcl-2 and bcl-xl and upregulation of apoptotic protein bax. |
2017-09-01 |
2023-08-13 |
Not clear |
| Prashanta Kumar Panda, Birendra Behera, Biswa Ranjan Meher, Durgesh Nandini Das, Subhadip Mukhopadhyay, Niharika Sinha, Prajna Paramita Naik, Bibhas Roy, Joyjyoti Das, Subhankar Paul, Tapas K Maiti, Rajesh Agarwal, Sujit K Bhuti. Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27182794. |
additionally, it observed that agg-induced autophagic cell death in bax knock down (bax-kd) and 5-fu resistant hela cells, confirming as an alternate cell killing pathway to apoptosis. |
2017-09-01 |
2023-08-13 |
human |
| Rasika R Hudlikar, Varadha Balaji Venkadakrishnan, Rajiv Kumar, Rahul A Thorat, Sadhana Kannan, Arvind D Ingle, Saral Desai, Girish B Maru, Manoj B Mahimka. Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27377358. |
pbps down-regulated the b(a)p and nnk-induced cell proliferation (diminished pcna expression, proliferation index, and bcl-2 expression) and enhanced apoptosis (increased bax expression and apoptotic index) potentially through phosphorylation of p38 and akt. |
2017-09-01 |
2023-08-13 |
mouse |
| K Matsuura, N-J Huang, K Cocce, L Zhang, S Kornblut. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. vol 36. issue 12. 2017-09-01. PMID:27721409. |
this function of bax is enhanced by the moap-1 (modulator of apoptosis protein 1) protein in response to dna damage. |
2017-09-01 |
2023-08-13 |
Not clear |
| Thomas P Garner, Denis E Reyna, Amit Priyadarshi, Hui-Chen Chen, Sheng Li, Yang Wu, Yogesh Tengarai Ganesan, Vladimir N Malashkevich, Emily H Cheng, Evripidis Gavathioti. An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Molecular cell. vol 63. issue 3. 2017-08-30. PMID:27425408. |
following a pro-apoptotic trigger, cytosolic bax is activated and translocates to the mitochondria to initiate mitochondrial dysfunction and apoptosis. |
2017-08-30 |
2023-08-13 |
Not clear |
| Thomas P Garner, Denis E Reyna, Amit Priyadarshi, Hui-Chen Chen, Sheng Li, Yang Wu, Yogesh Tengarai Ganesan, Vladimir N Malashkevich, Emily H Cheng, Evripidis Gavathioti. An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Molecular cell. vol 63. issue 3. 2017-08-30. PMID:27425408. |
our data support a model whereby the degree of apoptosis induction is regulated by the conformation of cytosolic bax and identify an unprecedented mechanism of cytosolic bax inhibition. |
2017-08-30 |
2023-08-13 |
Not clear |
| Guanglin Shi, Qian Wang, Xiaoyu Zhou, Jun Li, Hua Liu, Jun Gu, Haiying Wang, Yi Wu, Liang Ding, Songshi Ni, Zhiyuan Tan. Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics. Acta biochimica et biophysica Sinica. vol 49. issue 4. 2017-08-29. PMID:28338770. |
key factors, such as apaf1, bax, gadd45a, p21, pml, and ypel3, which are related to cell cycle arrest, senescence, and apoptosis, were measured at different time points after incubation with wogonin. |
2017-08-29 |
2023-08-13 |
human |
| Xuexue Zhu, Yuetao Zhou, Weiwei Cai, Haijian Sun, Liying Qi. Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway. Biochemical and biophysical research communications. vol 491. issue 2. 2017-08-29. PMID:28647373. |
we also established that silencing of salusin-β with adenoviruse-mediated shrna reduced high glucose-induced apoptosis by up-regulating bcl-2 expression and down-regulating bax and caspase-3 expressions. |
2017-08-29 |
2023-08-13 |
human |
| Yunhu Yu, Fang Cao, Qishan Ran, Fei Wan. Long non-coding RNA Gm4419 promotes trauma-induced astrocyte apoptosis by targeting tumor necrosis factor α. Biochemical and biophysical research communications. vol 491. issue 2. 2017-08-29. PMID:28688761. |
overexpression of gm4419 in injury-treated astrocytes increased protein expressions of tnf-α, bax, cleaved caspase-3 and cleaved caspase-9, decreased levels of bcl-2 and cyclind1, and significantly led to cellular apoptosis. |
2017-08-29 |
2023-08-13 |
Not clear |
| Li Xu, Qiuling Fan, Xu Wang, Xue Zhao, Lining Wan. Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells. Cell death & disease. vol 7. issue 11. 2017-08-28. PMID:27809300. |
in the present study, ages induced mitochondrial depolarization and led to mitochondrial-dependent apoptosis in mesangial cells, as shown by the loss of the mitochondrial membrane potential; increased bax processing; increased caspase-9, caspase-3 and parp cleavage; and decreased bcl-2 expression. |
2017-08-28 |
2023-08-13 |
Not clear |