| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A R Garcia-Rendueles, J S Rodrigues, M E R Garcia-Rendueles, M Suarez-Fariña, S Perez-Romero, F Barreiro, I Bernabeu, J Rodriguez-Garcia, L Fugazzola, T Sakai, F Liu, J Cameselle-Teijeiro, S B Bravo, C V Alvare. Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene. vol 36. issue 5. 2017-09-25. PMID:27452523. |
in normal thyroid cells, tgf-β/smad repressed the p27/cdkn1b gene, activating cdk2-dependent smad3 phosphorylation to induce p50 nfκb-dependent bax upregulation and apoptosis. |
2017-09-25 |
2023-08-13 |
human |
| Jie-Yi Du, Chen-Chen Jin, Guo-Hao Wang, Xiong-Qing Huang, Jian-Ding Cheng, Xue-Jun Wen, Xiao-Miao Zhao, Guan-Lei Wan. LNK deficiency aggravates palmitate-induced preadipocyte apoptosis. Biochemical and biophysical research communications. vol 490. issue 2. 2017-09-25. PMID:28526415. |
lnk specific sirna exacerbated palmitate-induced apoptosis and increased pro-apoptotic protein levels of cleaved caspase-3, bax and cytochrome c; while overexpression of lnk cdna exhibited significant anti-apoptotic effects. |
2017-09-25 |
2023-08-13 |
mouse |
| Xiaopeng An, Yuxuan Song, Jinxing Hou, Yue Zhang, Kaiwen Chen, Haidong Ma, Xinyan Zhao, Guang Li, Kexin Gao, Shan Wang, Binyun Cao, Yueyu Ba. Chi-miR-4110 promotes granulosa cell apoptosis by targeting Sma- and Mad-related protein 2 (Smad2) in the caprine ovary. PloS one. vol 12. issue 7. 2017-09-25. PMID:28704526. |
the increase in sp1 induces p53-upregulated modulator of apoptosis, which increases the relative abundance of bax and causes caprine gc apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |
| Meng-Yao An, Yan Li, Wen-Hua Chen, Ying Zhang, Yan-Na Wu, Kai Sun, Ying-Ying Pan, Yong-Qiang Yin, Jian-Shi Lo. Effects of non-invasive remote ischemic conditioning on rehabilitation after myocardial infarction. Biochemical and biophysical research communications. vol 488. issue 2. 2017-09-21. PMID:28479248. |
nric could inhibit cardiomyocytes apoptosis and reduce myocardium injury through raising the expression of bcl-2 and reduced the content of creatine kinase-mb, cardiac troponin i and bax. |
2017-09-21 |
2023-08-13 |
rat |
| Xueling Li, Jin Geng, Yuhan Chen, Fu Chen, Chen Liu, Qiwen Xu, Jinxuan Zhao, Jiaxin Hu, Jun Xie, Biao X. Exposure to particulate matter induces cardiomyocytes apoptosis after myocardial infarction through NFκB activation. Biochemical and biophysical research communications. vol 488. issue 1. 2017-09-21. PMID:28499868. |
tunel assay, flow cytometry and western blotting of caspase 3, bax and bcl-2 indicated that pm2.5 exposure could cause cellular apoptosis in vivo and in vitro. |
2017-09-21 |
2023-08-13 |
mouse |
| Tingting Lan, Hanchi Zhao, Bilu Xiang, Jun Wang, Yang Li. Suture compression induced midpalatal suture chondrocyte apoptosis with increased caspase-3, caspase-9, Bad, Bak, Bax and Bid expression. Biochemical and biophysical research communications. vol 489. issue 2. 2017-09-21. PMID:28549584. |
suture compression induced midpalatal suture chondrocyte apoptosis with increased caspase-3, caspase-9, bad, bak, bax and bid expression. |
2017-09-21 |
2023-08-13 |
mouse |
| Lei Yi, Xiaoqin Huang, Feng Guo, Zengding Zhou, Mengling Chang, Jiajun Tang, Jingning Hua. Lipopolysaccharide Induces Human Pulmonary Micro-Vascular Endothelial Apoptosis via the YAP Signaling Pathway. Frontiers in cellular and infection microbiology. vol 6. 2017-09-20. PMID:27807512. |
furthermore, inhibition of yap by small interfering rna (sirna) not only suppressed the lps-induced hpmec apoptosis but also regulated p73-mediated up-regulation of bax and down-regulation of bcl-2. |
2017-09-20 |
2023-08-13 |
human |
| Lei Yi, Xiaoqin Huang, Feng Guo, Zengding Zhou, Mengling Chang, Jiajun Tang, Jingning Hua. Lipopolysaccharide Induces Human Pulmonary Micro-Vascular Endothelial Apoptosis via the YAP Signaling Pathway. Frontiers in cellular and infection microbiology. vol 6. 2017-09-20. PMID:27807512. |
taken together, our results demonstrated that activation of the yap/p73/(bax and bcl-2)/caspase-3 signaling pathway played a critical role in lps-induced hpmec apoptosis. |
2017-09-20 |
2023-08-13 |
human |
| Uddin Md Nazim, Mohammad Rasheduzzaman, You-Jin Lee, Dai-Wu Seol, Sang-Youel Par. Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28178647. |
enhancement of trail-induced apoptosis by 5-fluorouracil requires activating bax and p53 pathways in trail-resistant lung cancers. |
2017-09-20 |
2023-08-13 |
human |
| Uddin Md Nazim, Mohammad Rasheduzzaman, You-Jin Lee, Dai-Wu Seol, Sang-Youel Par. Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28178647. |
taken together, the present study demonstrated that 5-fluorouracil enhances trail-induced apoptosis in trail-resistant lung adenocarcinoma cells by activating bax and p53, and also suggest that trail and 5-fluorouracil cotreatment can be used as an adequate therapeutic strategy for trail-resistant human cancers. |
2017-09-20 |
2023-08-13 |
human |
| Pei Li, Yibo Gan, Haoming Wang, Yuan Xu, Songtao Li, Lei Song, Chengmin Zhang, Yangbin Ou, Liyuan Wang, Qiang Zho. Role of the ERK1/2 pathway in osmolarity effects on nucleus pulposus cell apoptosis in a disc perfusion culture. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 1. 2017-09-19. PMID:27035885. |
np cell apoptosis was analyzed by tunel staining, caspase-3 activity, gene expression of bcl-2, bax and caspase-3 and protein expression of cleaved caspase-3, and cleaved parp. |
2017-09-19 |
2023-08-13 |
Not clear |
| Xiaoliang Li, Ping Xin, Changfu Wang, Zhibin Wang, Qiuhong Wang, Haixue Kuan. Mechanisms of Traditional Chinese Medicine in the Treatment of Mammary Gland Hyperplasia. The American journal of Chinese medicine. vol 45. issue 3. 2017-09-19. PMID:28359197. |
in this paper, we elaborate the mechanism of tcm in the treatment of mgh from the perspectives of sexual hormone levels, the expression of er and pr, hemorheology, free radical activity and lipid peroxidation, vegf and bfgf, cell proliferation activities, anti-apoptosis gene bcl-2, promoting apoptosis gene bax, erk, and tumor suppressor gene. |
2017-09-19 |
2023-08-13 |
Not clear |
| Qi Liu, Shouyu Hu, Yi He, Jiashu Zhang, Xiaona Zeng, Fengtao Gong, Li'na Lian. The protective effects of Zhen-Wu-Tang against cisplatin-induced acute kidney injury in rats. PloS one. vol 12. issue 6. 2017-09-19. PMID:28586398. |
furthermore, zwt downregulated apoptosis and fibrosis by modulating the expression levels of caspase-3, bax and alpha-smooth muscle actin (α-sma). |
2017-09-19 |
2023-08-13 |
rat |
| Jun Yang, Xinyu Zhao, Mei Tang, Lei Li, Yi Lei, Ping Cheng, Wenhao Guo, Yu Zheng, Wei Wang, Na Luo, Yong Peng, Aiping Tong, Yuquan Wei, Chunlai Nie, Zhu Yua. The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget. vol 8. issue 14. 2017-09-18. PMID:28423586. |
we further showed that puma induces mitochondrial dysfunction-mediated apoptosis and ros generation through functional bax in a ros generating enzyme- and caspase-independent manner irrespective of their p53 status, and results in activation of nrf2/ho-1 pathway. |
2017-09-18 |
2023-08-13 |
Not clear |
| Salma Malik, Kapil Suchal, Sana Irfan Khan, Jagriti Bhatia, Kamal Kishore, Amit Kumar Dinda, Dharamvir Singh Ary. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. American journal of physiology. Renal physiology. vol 313. issue 2. 2017-09-18. PMID:28566504. |
it also significantly prevented mapk activation, which inhibited inflammation (reduced tnf-α, il-6, and nf-κb expression) and apoptosis (increased expression of bcl-2 and decreased bax and caspase-3). |
2017-09-18 |
2023-08-13 |
rat |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
the results indicate that colistin had a stimulatory effect on the expression levels of the target genes and proteins involved in autophagy and apoptosis, including lc3-ii/i, p53, dram (damage-regulated autophagy modulator), puma (p53 upregulated modulator of apoptosis), bax, p-ampk (activated form of amp-activated protein kinase), and caspase-3. |
2017-09-15 |
2023-08-13 |
rat |
| U Heinicke, J Kupka, I Fichter, S Fuld. Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcoma. Oncogene. vol 35. issue 28. 2017-09-13. PMID:26616861. |
this shift toward proapoptotic bcl-2 proteins promotes activation of bax and bak as a critical event, as genetic silencing of bax or bak protects against jnj-26481585-induced apoptosis. |
2017-09-13 |
2023-08-13 |
mouse |
| Yongchang Guan, Wen Cheng, Cunyi Zou, Tingzhong Wang, Zhi Ca. Gremlin1 promotes carcinogenesis of glioma in vitro. Clinical and experimental pharmacology & physiology. vol 44. issue 2. 2017-09-13. PMID:27862197. |
meanwhile, grem1 silencing promoted apoptosis in u87-mg cells through the accumulation of bax, cleaved caspase-3, and cleaved poly (adp-ribose) polymerase (parp) as well as the downregulation of bcl-2. |
2017-09-13 |
2023-08-13 |
Not clear |
| Mark Phillippe, Sharareh Adel. Cell-free DNA release by mouse placental explants. PloS one. vol 12. issue 6. 2017-09-13. PMID:28622381. |
the cfdna release and cell death of trophoblast appears to involve components of the apoptosis signaling pathway as suggested by lps enhancement of placental caspase activity, suppression of cfdna release by a pan-caspase inhibitor and the trend toward increased bax protein expression. |
2017-09-13 |
2023-08-13 |
mouse |
| M Rada, E Vasileva, L Lezina, D Marouco, A V Antonov, S Macip, G Melino, N A Barle. Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene. vol 36. issue 7. 2017-09-12. PMID:27452519. |
both ectopic and endogenous hg9a augmented p53-dependent transcription of pro-apoptotic genes, including bax and puma, resulting in enhanced apoptosis and reduced colony formation. |
2017-09-12 |
2023-08-13 |
mouse |