| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Tang, Tian-Lun Yang, Zhen Zhang, Xiao-Gang Li, Qiao-Qing Zhong, Ting-Ting Zhao, Li Gon. MicroRNA-21 suppresses ox-LDL-induced human aortic endothelial cells injuries in atherosclerosis through enhancement of autophagic flux: Involvement in promotion of lysosomal function. Experimental cell research. vol 359. issue 2. 2017-10-10. PMID:28823833. |
the results showed that ox-ldl treatment significantly decreased haecs viability, increased caspase-3 activity, apoptosis ratio and bax protein expression, and reduced bcl-2 protein expression resulting in ec injuries. |
2017-10-10 |
2023-08-13 |
human |
| Hong-Mei Jia, Meng Yu, Li-Yan Ma, Hong-Wu Zhang, Zhong-Mei Zo. Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1064. 2017-10-10. PMID:28886478. |
the expressions of two apoptosis associated genes (bcl-2 and bax) and four genes (pnpla6, pla2g15, baat and gad1) related to the perturbed metabolic pathways were further investigated by quantitative real-time polymerase chain reaction (qrt-pcr). |
2017-10-10 |
2023-08-13 |
rat |
| Dan Li, Yang Lei, Jing Deng, Chanjuan Zhou, Yong Zhang, Wenjuan Li, Hua Huang, Shigang Cheng, Hongzhi Zhang, Liang Zhang, Rongzhong Huang, Xia Liu, Lihua Ma, Xiao Wang, Juan Li, Peng Xi. Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805250. |
in conclusion, hu-h1 inhibits cellular proliferation and promotes apoptosis in human oligodendrocytes via bax upregulation and bcl-2 downregulation. |
2017-10-06 |
2023-08-12 |
human |
| Dan Li, Yang Lei, Jing Deng, Chanjuan Zhou, Yong Zhang, Wenjuan Li, Hua Huang, Shigang Cheng, Hongzhi Zhang, Liang Zhang, Rongzhong Huang, Xia Liu, Lihua Ma, Xiao Wang, Juan Li, Peng Xi. Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805250. |
in contrast, strain v promotes cellular proliferation and inhibits apoptosis in human oligodendrocytes via bax downregulation and bcl-2 upregulation. |
2017-10-06 |
2023-08-12 |
human |
| Kai Jin, Lunliang Ruan, Jiujun Pu, Ailing Zhong, Fuchao Wang, Song Tan, Hua Huang, Jiamin Mou, Gang Yan. [Effect of metformin on proliferation and apoptosis of rat prolactinoma MMQ cells and related mechanisms]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 5. 2017-10-04. PMID:28502303. |
cck-8 assay was used to assess the cell proliferation ability; flow cytometry was used to analyze the cell cycle distribution and apoptosis; western blotting was performed to detect the expressions of ampkα1/2, p-ampkα, mtor, p-mtor, insulin like growth factor 1 receptor (igf-1r), erk1/2, p-erk1/2, akt, p-akt, p21, cdk4, cyclin d1, caspase-3, cleaved caspase-3(c-caspase-3), bcl-2 and bax. |
2017-10-04 |
2023-08-13 |
rat |
| Sarmila Nepali, Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Dae-Ki Kim, Young-Mi Le. Wheatgrass-Derived Polysaccharide Has Antiinflammatory, Anti-Oxidative and Anti-Apoptotic Effects on LPS-Induced Hepatic Injury in Mice. Phytotherapy research : PTR. vol 31. issue 7. 2017-10-04. PMID:28543910. |
wheatgrass-derived polysaccharide also attenuated hepatic cell death by modulating caspase-3 and apoptosis associated mitochondrial proteins, such as, b-cell lymphoma 2 (bcl-2) and bcl-2-associated x (bax). |
2017-10-04 |
2023-08-13 |
mouse |
| Shasha Song, Zhi Yi, Min Zhang, Min Mao, Li Fu, Xijuan Zhao, Zizhen Liu, Jiayin Gao, Weiwei Cao, Yumei Liu, Hengyuan Shi, Daling Zh. Hypoxia inhibits pulmonary artery endothelial cell apoptosis via the e-selectin/biliverdin reductase pathway. Microvascular research. vol 106. 2017-10-02. PMID:27033411. |
in addition, by examining the mitochondrial membrane potential and mitochondrial membrane proteins (bcl-2 and bax), we show that the mitochondrial-dependent apoptosis pathway was necessary for the e-selectin/bvr pathway inducing the anti-apoptotic effect of hypoxia in paecs. |
2017-10-02 |
2023-08-13 |
Not clear |
| Ievgeniia Burlaka, Linnéa M Nilsson, Lena Scott, Ulla Holtbäck, Ann-Christine Eklöf, Agnes B Fogo, Hjalmar Brismar, Anita Aperi. Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease. Kidney international. vol 90. issue 1. 2017-10-02. PMID:27217195. |
chronic ouabain treatment preserved renal function, protected from renal cortical apoptosis, up-regulated bax, down-regulated bcl-xl, and rescued from glomerular tubular disconnection and podocyte loss. |
2017-10-02 |
2023-08-13 |
rat |
| Yukai Xiang, Wen Ye, Chaohao Huang, Bin Lou, Jie Zhang, Dinglai Yu, Xince Huang, Bicheng Chen, Mengtao Zho. Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway. Biochemical and biophysical research communications. vol 487. issue 4. 2017-10-02. PMID:28455228. |
through researches brusatol was proved to inhibit growth and induce apoptosis in both patu-8988 and panc-1 cells by decreasing the expression level of bcl-2 and increasing the expression levels of bax, cleaved caspase-3. |
2017-10-02 |
2023-08-13 |
human |
| Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, Ali Nakhi, E V Venkat Shivaji Ramarao, Navneet Bung, Gopalakrishnan Bulusu, Manojit Pal, Devyani Halda. A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. Biochemical and biophysical research communications. vol 488. issue 3. 2017-10-02. PMID:28526414. |
further, 4bb treatment increased p53 acetylation, bax expression and induced caspase 3 cleavage suggesting that the death of hct116 colon cancer cells occur through intrinsic pathway of apoptosis. |
2017-10-02 |
2023-08-13 |
human |
| Ananga Ghosh, Amrita Sengupta, Guru Pavan Kumar Seerapu, Ali Nakhi, E V Venkat Shivaji Ramarao, Navneet Bung, Gopalakrishnan Bulusu, Manojit Pal, Devyani Halda. A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. Biochemical and biophysical research communications. vol 488. issue 3. 2017-10-02. PMID:28526414. |
overall, our results presents 4bb as a new class of human sirt1 inhibitor and suggest that inhibition of sirt1 by 4bb induces apoptosis of colon cancer cells at least in part via activating p53 by preventing p53 deacetylation, increasing bax expression and inducing caspases. |
2017-10-02 |
2023-08-13 |
human |
| Aubrey Converse, Chenan Zhang, Peter Thoma. Membrane Androgen Receptor ZIP9 Induces Croaker Ovarian Cell Apoptosis via Stimulatory G Protein Alpha Subunit and MAP Kinase Signaling. Endocrinology. vol 158. issue 9. 2017-10-02. PMID:28633436. |
testosterone treatment of croaker g/t cells increased intracellular zinc levels, mitogen-activated protein (map) kinase activity, caspase 3 activity, messenger rna levels of proapoptotic members bax, p53, and c-jun n-terminal kinase, and the incidence of apoptosis, similar to findings in mammalian cancer cells, but also increased cyclic adenosine monophosphate concentrations. |
2017-10-02 |
2023-08-13 |
human |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
to this end, we cloned full-length cdna sequences of bcl2 and three bax subtypes involved in apoptosis in p. fulvidraco, explored their mrna expressions in responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| Dan-Dan Li, Zhi Luo, Guang-Hui Chen, Yu-Feng Song, Chuan-Chuan Wei, Ya-Xiong Pa. Identification of apoptosis-related genes Bcl2 and Bax from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Gene. vol 633. 2017-09-29. PMID:28864113. |
for the first time, we characterized the full-length cdna sequences of bcl2 and three bax subtypes, determined their expression profiles and transcriptional responses to different zn exposure pathways, which would contribute to our understanding of the molecular basis of apoptosis, and also provide new insights into physiological responses to different zn exposure pathways. |
2017-09-29 |
2023-08-13 |
Not clear |
| Xiaomeng Ding, Xinxin Kou, Ye Zhang, Xiaoli Zhang, Guomei Cheng, Tianming Ji. Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression. Gene. vol 633. 2017-09-29. PMID:28864114. |
western blotting analysis of pcna, bcl-2 and bax confirmed the results of cell proliferation and apoptosis. |
2017-09-29 |
2023-08-13 |
mouse |
| Yelisetti Uma Mahesh, Henderson Rose Winnie Gibence, Sisinthy Shivaji, Brahmasani Sambasiva Ra. Effect of different cryo-devices on in vitro maturation and development of vitrified-warmed immature buffalo oocytes. Cryobiology. vol 75. 2017-09-27. PMID:28093199. |
the expression of oocyte secreting factors and their receptors (gdf9, bmp15, bmpr2, tgfbr1) and apoptosis related genes (bcl2, bax, p53, c-myc) were compared in vitrified-warmed oocytes after in vitro maturation. |
2017-09-27 |
2023-08-13 |
Not clear |
| Xiao Fu, Hongqing Wen, Li Jing, Yujuan Yang, Wenjuan Wang, Xuan Liang, Kejun Nan, Yu Yao, Tao Tia. MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway. Cancer science. vol 108. issue 4. 2017-09-26. PMID:28132399. |
western blots showed that mir-155-5p inactivated bax and caspase-9, but activated bcl-2 to inhibit apoptosis, and it activated mmp to promote migration and invasion via the pi3k/akt pathway. |
2017-09-26 |
2023-08-13 |
human |
| Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yoshio Tokumoto, Taira Kuroda, Masanori Abe, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hias. Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma. PloS one. vol 12. issue 5. 2017-09-26. PMID:28486557. |
conversely, anp32b overexpression decreased bad phosphorylation and upregulated bak, but did not induce apoptosis because bax expression was downregulated. |
2017-09-26 |
2023-08-13 |
Not clear |
| Yoshinori Ohno, Mitsuhito Koizumi, Hironao Nakayama, Takao Watanabe, Masashi Hirooka, Yoshio Tokumoto, Taira Kuroda, Masanori Abe, Shinji Fukuda, Shigeki Higashiyama, Teru Kumagi, Yoichi Hias. Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma. PloS one. vol 12. issue 5. 2017-09-26. PMID:28486557. |
anp32b modulates bad phosphorylation as well as bak and bax expression, resulting in regulation of apoptosis in hcc. |
2017-09-26 |
2023-08-13 |
Not clear |
| Harikrishnan Radhakrishnan, Katharina Ilm, Wolfgang Walther, Senji Shirasawa, Takehiko Sasazuki, Peter T Daniel, Bernhard Gillissen, Ulrike Stei. MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer letters. vol 403. 2017-09-26. PMID:28649004. |
this reduced mcl-1-mediated apoptosis sensitization was bax and bak dependent. |
2017-09-26 |
2023-08-13 |
Not clear |