| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Yiguan Zhang, Jiajiu Shaw, Frederick A Valeriote, Subhash C Gauta. Mycotoxin verrucarin A inhibits proliferation and induces apoptosis in prostate cancer cells by inhibiting prosurvival Akt/NF-kB/mTOR signaling. Journal of experimental therapeutics & oncology. vol 11. issue 4. 2017-10-19. PMID:27849335. |
vc-a also induced apoptosis in cap cells as characterized by the cleavage of poly (adp-ribose) polymerase (parp-1), procaspases-3, -8 and -9 and the inhibition of bcl-2 family proteins that regulate apoptosis (bcl-2, bcl-xl, bax, bak and bad). |
2017-10-19 |
2023-08-13 |
Not clear |
| Ya Xiang, Fangnong Lai, Guifang He, Yapeng Li, Leilei Yang, Wei Shen, Heqiang Huo, Jun Zhu, Hongyi Dai, Yugang Zhan. Alleviation of Rosup-induced oxidative stress in porcine granulosa cells by anthocyanins from red-fleshed apples. PloS one. vol 12. issue 8. 2017-10-19. PMID:28850606. |
anthocyanins inhibit rosup-induced apoptosis by increasing expression of antiapoptotic protein bcl-2 and suppressing the expression of pro-apoptotic protein bax. |
2017-10-19 |
2023-08-13 |
cat |
| Enyara R Morais, Katia C Oliveira, Renato G de Paula, Alice M M Ornelas, Érika B C Moreira, Fernanda Rafacho Badoco, Lizandra G Magalhães, Sergio Verjovski-Almeida, Vanderlei Rodrigue. Effects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni. PloS one. vol 12. issue 9. 2017-10-18. PMID:28898250. |
finally, we showed the down-regulation of bax pro-apoptotic gene, as well as up-regulation of two apoptosis inhibitor genes, iap1 and bre1, and in contrast, down-regulation of apaf-1 apoptotic activator, thus suggesting that apoptosis is deregulated in s. mansoni exposed to mg-132. |
2017-10-18 |
2023-08-13 |
Not clear |
| Eliza Drwal, Agnieszka Rak, Adam Grochowalski, Tomasz Milewicz, Ewa Lucja Gregoraszczu. Cell-specific and dose-dependent effects of PAHs on proliferation, cell cycle, and apoptosis protein expression and hormone secretion by placental cell lines. Toxicology letters. vol 280. 2017-10-17. PMID:28803881. |
in the preset study we measured the concentrations of 16 priority pahs in maternal blood and placental tissue by using the gc-ms/ms system, and investigated the effects of selected pahs (naphthalene, anthracene, phenanthrene, pyrene) and mixtures on bewo and jeg-3 human placental cell line proliferation (alamar blue), cytotoxicity (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (xtt), lactate dehydrogenase (ldh), acid phosphatase (ap), endocrine activity (progesterone and estradiol secretion) and apoptosis (cyclin a1, cyclin d2, cdk 2, cdk 4, bcl-xl, bax, and caspase-3 protein expression). |
2017-10-17 |
2023-08-13 |
human |
| Chia-Hui Huang, Yuan-Chin Lee, Ying-Jung Chen, Liang-Jun Wang, Yi-Jun Shi, Long-Sen Chan. Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. Toxicology and applied pharmacology. vol 334. 2017-10-17. PMID:28867437. |
quinacrine induces the apoptosis of human leukemia u937 cells through foxp3/mir-183/β-trcp/sp1 axis-mediated bax upregulation. |
2017-10-17 |
2023-08-13 |
human |
| Chia-Hui Huang, Yuan-Chin Lee, Ying-Jung Chen, Liang-Jun Wang, Yi-Jun Shi, Long-Sen Chan. Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. Toxicology and applied pharmacology. vol 334. 2017-10-17. PMID:28867437. |
quinacrine-induced apoptosis of u937 cells was accompanied with ros generation, mitochondrial depolarization, and bax upregulation. |
2017-10-17 |
2023-08-13 |
human |
| Chia-Hui Huang, Yuan-Chin Lee, Ying-Jung Chen, Liang-Jun Wang, Yi-Jun Shi, Long-Sen Chan. Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation. Toxicology and applied pharmacology. vol 334. 2017-10-17. PMID:28867437. |
together, our data indicate that quinacrine-induced apoptosis of u937 cells is mediated by mitochondrial alterations triggered by foxp3/mir-183/β-trcp/sp1 axis-mediated bax upregulation. |
2017-10-17 |
2023-08-13 |
human |
| Nicola J Darling, Kathryn Balmanno, Simon J Coo. ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. PloS one. vol 12. issue 9. 2017-10-17. PMID:28931068. |
indeed, cells that lack the key executioner proteins bax and bak are protected from er stress-induced apoptosis. |
2017-10-17 |
2023-08-13 |
Not clear |
| Kai-Lee Wang, Shih-Min Hsia, Jiun-Yih Yeh, Shao-Chi Cheng, Paulus S Wang, Shyi-Wu Wan. Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells. PloS one. vol 8. issue 6. 2017-10-16. PMID:23840656. |
evodiamine inhibited the proliferation of mcf-7 and mda-mb-231 cells in a concentration-dependent manner with concentration of 1×10(-6) and 1×10(-5) m. evodiamine also induced apoptosis via up-regulation of caspase 7 activation, parp cleavage (bik and bax expression). |
2017-10-16 |
2023-08-12 |
human |
| Lei Liu, Li-Min Mu, Yan Yan, Jia-Shuan Wu, Ying-Jie Hu, Ying-Zi Bu, Jing-Ying Zhang, Rui Liu, Xue-Qi Li, Wan-Liang L. The use of functional epirubicin liposomes to induce programmed death in refractory breast cancer. International journal of nanomedicine. vol 12. 2017-10-16. PMID:28615943. |
mechanistic studies revealed that the liposomes could target the mitochondria, activate the apoptotic enzymes caspase 8, 9, and 3, upregulate the proapoptotic protein bax while downregulating the antiapoptotic protein mcl-1, and induce the generation of reactive oxygen species (ros) through an apoptosis cascade. |
2017-10-16 |
2023-08-13 |
mouse |
| Margaret E Maes, Cassandra L Schlamp, Robert W Nickell. Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. PloS one. vol 12. issue 9. 2017-10-16. PMID:28880942. |
live-cell imaging to measure bax recruitment kinetics to mitochondria during apoptosis. |
2017-10-16 |
2023-08-13 |
Not clear |
| Margaret E Maes, Cassandra L Schlamp, Robert W Nickell. Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. PloS one. vol 12. issue 9. 2017-10-16. PMID:28880942. |
bax fusion proteins behave like endogenous bax during apoptosis. |
2017-10-16 |
2023-08-13 |
Not clear |
| Yahong Wang, Ting Chen, Haili Huang, Yun Jiang, Lawei Yang, Ziying Lin, Huijuan He, Tie Liu, Bin Wu, Jie Chen, David W Kamp, Gang Li. miR-363-3p inhibits tumor growth by targeting PCNA in lung adenocarcinoma. Oncotarget. vol 8. issue 12. 2017-10-13. PMID:28423618. |
additionally, mir-363-3p enhances cell apoptosis, whereas mir-363-3p inhibitor prevents apoptosis and leads to downregulation of bax and bak expression. |
2017-10-13 |
2023-08-13 |
mouse |
| Monika Hułas-Stasiak, Piotr Dobrowolski, Bożena Pawlikowska-Pawlęga, Ewa Tomaszewska, Siemowit Muszyńsk. The effects of dexamethasone administered during pregnancy on the postpartum spiny mouse ovary. PloS one. vol 12. issue 8. 2017-10-13. PMID:28827819. |
the expression of proteins related to apoptosis (caspase-3, bax, bcl-2) and autophagy (beclin1, lamp1) as well as pcna and gr receptors were evaluated by western-blot. |
2017-10-13 |
2023-08-13 |
mouse |
| Gabriella Mamede Andrade, Juliano Coelho da Silveira, Claudia Perrini, Maite Del Collado, Samuel Gebremedhn, Dawit Tesfaye, Flávio Vieira Meirelles, Felipe Pereci. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PloS one. vol 12. issue 9. 2017-10-13. PMID:28922408. |
using pi3k-akt responsive genes, we showed decreased foxo3a levels and bax levels in lower quality groups, indicating changes in cell cycle progression, oxidative response and apoptosis. |
2017-10-13 |
2023-08-13 |
cattle |
| Laura Fozzatti, Jeong Won Park, Li Zhao, Mark C Willingham, Sheue-Yann Chen. Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer. PloS one. vol 8. issue 6. 2017-10-10. PMID:23840792. |
tumor cell proliferation was inhibited by increased expression of cyclin-dependent kinase inhibitor 1 (p21(waf1/cip1); cdkn1a), and apoptosis was activated by elevated expression of pro-apoptotic bcl-associated x (bax). |
2017-10-10 |
2023-08-12 |
mouse |
| Lei Chen, Yue Meng, Qi Sun, Zhongyu Zhang, Xiaoqing Guo, Xiaotong Sheng, Guihua Tai, Hairong Cheng, Yifa Zho. Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. Cell death & disease. vol 7. issue 8. 2017-10-10. PMID:27512955. |
on a cellular mechanistic level, ck downregulated cell survival proteins including mcl-1, bcl-2, surviving, x-linked inhibitor of apoptosis protein and fas-associated death domain-like il-1-converting enzyme-inhibitory protein, upregulated cell pro-apoptotic proteins including bax, tbid and cytochrome c, and induced the cell surface expression of trail death receptor dr5. |
2017-10-10 |
2023-08-13 |
human |
| Fuqian Wang, Jie Jiang, Song Hu, Haoran Ma, Hucheng Zhu, Qingyi Tong, Lu Cheng, Xincai Hao, Geng Zhang, Yonghui Zhan. Secondary metabolites from endophytic fungus Chaetomium sp. induce colon cancer cell apoptotic death. Fitoterapia. vol 121. 2017-10-10. PMID:28652012. |
in addition, 3 induced apoptosis via caspase-3 induction and parp cleavage, concomitantly with the increase of bax and decrease of bcl-2. |
2017-10-10 |
2023-08-13 |
Not clear |
| Mohammad Dalla. A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Archives of physiology and biochemistry. vol 123. issue 5. 2017-10-10. PMID:28699791. |
this concomitant treatment acted by increasing the activity of major antioxidant enzymes (sod and gpx), decreasing the levels of inflammatory markers including tnf-α, il-6 as well as levels of bcl-2 and caspase-3 and downregulating mrna levels of bax and p53, markers of apoptosis. |
2017-10-10 |
2023-08-13 |
rat |
| Sarmita Jana, Dipak Patel, Shweta Patel, Kapil Upadhyay, Jaymesh Thadani, Rahul Mandal, Santasabuj Das, Ranjitsinh Devka. Anthocyanin rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction. PloS one. vol 12. issue 8. 2017-10-10. PMID:28763488. |
also, the mrna levels of enzymatic antioxidants (sod and catalase) and apoptotic genes (bax and bcl-2) in arce+iso treated group were similar to the control group suggesting that arce pretreatment prevents iso induced depletion of enzymatic antioxidants and apoptosis. |
2017-10-10 |
2023-08-13 |
rat |