| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo Dong, Shusen Yang, Xuefei Cao, Nannan Yu, Jiangbo Yu, Xiufen Q. Low shear stress‑induced autophagy alleviates cell apoptosis in HUVECs. Molecular medicine reports. vol 15. issue 5. 2017-11-02. PMID:28350133. |
in addition, it was observed that huvecs treated with lss underwent apoptotic death, by monitoring the rate of apoptosis and the expression of apoptosis regulator bax (bax) and apoptosis regulator bcl‑2 (bcl‑2) (by flow cytometry and wb) and the lss‑induced apoptosis in huvecs, that was significantly alleviated by pretreatment with rapamycin, partially via a decrease in the level of bax and an increase in the level of bcl‑2. |
2017-11-02 |
2023-08-13 |
human |
| Guo Dong, Shusen Yang, Xuefei Cao, Nannan Yu, Jiangbo Yu, Xiufen Q. Low shear stress‑induced autophagy alleviates cell apoptosis in HUVECs. Molecular medicine reports. vol 15. issue 5. 2017-11-02. PMID:28350133. |
pretreatment of huvecs with cq markedly increased lss‑induced apoptosis, which was associated with an increased expression of bax and a decreased expression of bcl‑2. |
2017-11-02 |
2023-08-13 |
human |
| Srinivasan Periasamy, Chuan-Teng Liu, Se-Ping Chien, Ying-Chien Chen, Ming-Yie Li. Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury. The Journal of nutritional biochemistry. vol 37. 2017-11-01. PMID:27619544. |
apoptosis was evaluated by p53, caspase-3, bcl-2, bax and cyto-c expression. |
2017-11-01 |
2023-08-13 |
mouse |
| Seok Soon Park, Eunjin Jwa, Seol Hwa Shin, Eun Jin Ju, Intae Park, Jhang Ho Pak, Jung Jin Hwang, Dong-Hyung Cho, B Moon Kim, Sung-Bae Kim, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Cho. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. The international journal of biochemistry & cell biology. vol 83. 2017-11-01. PMID:27923747. |
ibulocydine sensitizes human hepatocellular carcinoma cells to trail-induced apoptosis via calpain-mediated bax cleavage. |
2017-11-01 |
2023-08-13 |
human |
| Seok Soon Park, Eunjin Jwa, Seol Hwa Shin, Eun Jin Ju, Intae Park, Jhang Ho Pak, Jung Jin Hwang, Dong-Hyung Cho, B Moon Kim, Sung-Bae Kim, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Cho. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. The international journal of biochemistry & cell biology. vol 83. 2017-11-01. PMID:27923747. |
interestingly, the combination treatment induced cleavage of bax, which was translocated to mitochondria upon induction of apoptosis. |
2017-11-01 |
2023-08-13 |
human |
| Seok Soon Park, Eunjin Jwa, Seol Hwa Shin, Eun Jin Ju, Intae Park, Jhang Ho Pak, Jung Jin Hwang, Dong-Hyung Cho, B Moon Kim, Sung-Bae Kim, Jung Shin Lee, Si Yeol Song, Seong-Yun Jeong, Eun Kyung Cho. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. The international journal of biochemistry & cell biology. vol 83. 2017-11-01. PMID:27923747. |
finally, pre-treatment of hcc cells with a calpain inhibitor effectively blocked ib plus trail-induced cleavage of bax and apoptosis. |
2017-11-01 |
2023-08-13 |
human |
| Wei Li, K N Yu, Jie Ma, Jie Shen, Cheng Cheng, Fangjian Zhou, Zhiming Cai, Wei Ha. Non-thermal plasma induces mitochondria-mediated apoptotic signaling pathway via ROS generation in HeLa cells. Archives of biochemistry and biophysics. vol 633. 2017-10-31. PMID:28893509. |
furthermore, ntp exposure suppressed bcl-2 expression, enhanced bax expression and translocation to mitochondria, activated mitochondria-mediated apoptotic pathway, followed by the release of cytochrome c. further studies showed that ntp treatment led to ros generation, whereas blockade of ros generation by n-acetyl-l-cysteine (nac, ros scavengers) significantly prevented ntp-induced mitochondrial alteration and subsequent apoptosis of hela cells via suppressing bax translocation, cytochrome c and caspase-3 activation. |
2017-10-31 |
2023-08-13 |
Not clear |
| Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A Bartholdy, Loren D Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathioti. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer cell. vol 32. issue 4. 2017-10-31. PMID:29017059. |
direct activation of bax by btsa1 overcomes apoptosis resistance in acute myeloid leukemia. |
2017-10-31 |
2023-08-13 |
human |
| Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A Bartholdy, Loren D Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathioti. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer cell. vol 32. issue 4. 2017-10-31. PMID:29017059. |
the bcl-2 family protein bax is a central mediator of apoptosis. |
2017-10-31 |
2023-08-13 |
human |
| Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A Bartholdy, Loren D Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathioti. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer cell. vol 32. issue 4. 2017-10-31. PMID:29017059. |
we report the discovery of btsa1, a pharmacologically optimized bax activator that binds with high affinity and specificity to the n-terminal activation site and induces conformational changes to bax leading to bax-mediated apoptosis. |
2017-10-31 |
2023-08-13 |
human |
| Denis E Reyna, Thomas P Garner, Andrea Lopez, Felix Kopp, Gaurav S Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris A Bartholdy, Loren D Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathioti. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer cell. vol 32. issue 4. 2017-10-31. PMID:29017059. |
btsa1-induced bax activation effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. |
2017-10-31 |
2023-08-13 |
human |
| Nazir M Khan, Mohammad Y Ansari, Tariq M Haqq. Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway. Journal of cellular biochemistry. vol 118. issue 3. 2017-10-30. PMID:27669541. |
chondrocyte apoptosis was evaluated by propidium iodide (pi) staining using flowcytometry, expression of bax by western blotting, gene expression by taqman assays and caspase 3/7 activity was measured using a luminescence-based assay. |
2017-10-30 |
2023-08-13 |
human |
| Ning Yang, Michael Weinfeld, Hélène Lemieux, Ben Montpetit, Ing Swie Gopin. Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell death & disease. vol 8. issue 2. 2017-10-27. PMID:28151485. |
ros production was critical for bax activation and subsequent apoptosis. |
2017-10-27 |
2023-08-13 |
Not clear |
| Ting-Hong Ye, Fang-Fang Yang, Yong-Xia Zhu, Ya-Li Li, Qian Lei, Xue-Jiao Song, Yong Xia, Ying Xiong, Li-Dan Zhang, Ning-Yu Wang, Li-Feng Zhao, Hong-Feng Gou, Yong-Mei Xie, Sheng-Yong Yang, Luo-Ting Yu, Li Yang, Yu-Quan We. Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis. Cell death & disease. vol 8. issue 1. 2017-10-26. PMID:28055016. |
moreover, western blot analysis demonstrated that the occurrence of its apoptosis was correlated with the activation of bax and cleaved caspase-3, and decreased the expression of bcl-2. |
2017-10-26 |
2023-08-13 |
Not clear |
| Yan Liu, Tingting Bi, Wei Dai, Gang Wang, Liqiang Qian, Quangen Gao, Genhai She. Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells. Technology in cancer research & treatment. vol 15. issue 3. 2017-10-25. PMID:26009496. |
in addition, smmc-7721 xenograft tumors were established in male nude balb/c mice, and oxymatrine was intravenously administered to evaluate the anticancer capacity in vivo our results showed that oxymatrine inhibited the proliferation and induced apoptosis of hep-g2 and smmc-7721 cells in a dose-dependent manner in vitro furthermore, the rna and protein expression of bax and caspase 3 levels were significantly upregulated, whereas the expression of bcl-2 was downregulated. |
2017-10-25 |
2023-08-13 |
mouse |
| Chunwei Lu, Jun Ma, Dingfang Ca. Pachymic acid inhibits the tumorigenicity of gastric cancer cells by the mitochondrial pathway. Anti-cancer drugs. vol 28. issue 2. 2017-10-25. PMID:27792037. |
pa induced cell apoptosis by regulating the expressions of apoptosis-related proteins (caspase-3, parp, bcl-2, and bax) and suppressing the mitochondrial capacity of gc cell lines in vitro in a dose-dependent manner. |
2017-10-25 |
2023-08-13 |
human |
| Jingquan Gao, Hongmei Wu, Yonggang Cao, Shuang Liang, Caihong Sun, Peng Wang, Ji Wang, Hongli Sun, Lijie W. Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. The Journal of nutritional biochemistry. vol 35. 2017-10-23. PMID:27469996. |
the results showed that maternal feeding of dha to the prenatal exposed to vpa (1) prevented vpa-induced learning and memory impairment but did not change social-related behavior, (2) increased total dha content in offspring plasma and hippocampus, (3) rescued vpa-induced neuronal loss and apoptosis of pyramidal cells in hippocampal ca1, (4) influenced the content of malondialdehyde and glutathione and the activities of superoxide dismutase and glutathione in the hippocampus, (5) altered levels of apoptosis-related proteins (bcl-2, bax and caspase-3) and inhibited the activity of caspase-3 in offspring hippocampus and (6) enhanced relative levels of p-camkii and p-creb proteins in the hippocampus. |
2017-10-23 |
2023-08-13 |
rat |
| Joseph D Unsay, Katia Cosentino, Katharina Sporbeck, Ana J García-Sáe. Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. Biochimica et biophysica acta. Biomembranes. vol 1859. issue 1. 2017-10-23. PMID:27755971. |
during apoptosis, bid is cleaved (cbid) and translocates to the mom, where it activates bax. |
2017-10-23 |
2023-08-13 |
Not clear |
| Nan Zhang, Yan Huang, Fengbo Wu, Yinbo Zhao, Xiang Li, Pengfei Shen, Lu Yang, Yan Luo, Li Yang, Gu H. Codelivery of a miR-124 Mimic and Obatoclax by Cholesterol-Penetratin Micelles Simultaneously Induces Apoptosis and Inhibits Autophagic Flux in Breast Cancer in Vitro and in Vivo. Molecular pharmaceutics. vol 13. issue 7. 2017-10-20. PMID:27266580. |
mir-124-m-oba induced higher levels of mitochondrial apoptosis via bax and caspase-9 activation. |
2017-10-20 |
2023-08-13 |
human |
| Melek Karaca, Rinku Dutta, Yildiz Ozsoy, Ram I Mahat. Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer. Molecular pharmaceutics. vol 13. issue 6. 2017-10-19. PMID:26981724. |
remarkable increase in parp cleavage and bax proved increased apoptosis by this combination formulation compared to individual micelles. |
2017-10-19 |
2023-08-13 |
mouse |