| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manel B Hammouda, María F Montenegro, Luis Sánchez-Del-Campo, Ons Zakraoui, Zohra Aloui, Ichrak Riahi-Chebbi, Habib Karoui, José Neptuno Rodríguez-López, Khadija Essafi-Benkhadi. Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells. Toxins. vol 8. issue 7. 2017-11-22. PMID:27399772. |
lebein induced a caspase-independent apoptotic program with apoptosis inducing factor (aif), bcl-2-associated x protein (bax) and bim overexpression together with downregulation of b-cell lymphoma-2 (bcl-2). |
2017-11-22 |
2023-08-13 |
human |
| Somanshu Banerjee, Chandra Mohini Chaturved. Apoptotic mechanism behind the testicular atrophy in photorefractory and scotosensitive quail: Involvement of GnIH induced p-53 dependent Bax-Caspase-3 mediated pathway. Journal of photochemistry and photobiology. B, Biology. vol 176. 2017-11-22. PMID:28992606. |
testicular apoptosis in the quail of different photoperiodic conditions was assessed by monitoring the alterations in the local testicular expression of gnrh-i, gnih, pro-apoptotic proteins (p53 and bax), inactive caspase (pro-caspase-3), executioner active-caspase-3 and inactive/uncleaved parp-1 (dna repair enzyme) and tunel analysis. |
2017-11-22 |
2023-08-13 |
Not clear |
| Chong Teik Tan, Qi-Ling Zhou, Yu-Chin Su, Nai Yang Fu, Hao-Chun Chang, Ran N Tao, Sunil K Sukumaran, Shairaz Baksh, Yee-Joo Tan, Kanaga Sabapathy, Chun-Dong Yu, Victor C Y. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320914. |
subsequent tbid recruitment to mitochondria, which is facilitated by its receptor mtch2 at the outer mitochondrial membrane (omm), is a critical step for commitment to apoptosis via the effector proteins bax or bak. |
2017-11-21 |
2023-08-13 |
mouse |
| Yan-Lin Guo, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Qiu Zhou, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Fen. The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-κB, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. vol 65. 2017-11-21. PMID:28428059. |
secondly, iron deficiency down-regulated the mrna levels of b-cell lymphoma-2 (bcl-2), myeloid cell leukemia 1 (mcl-1), and inhibitor of apoptosis protein (iap), and decreased activities and mrna levels of antioxidant enzymes, down-regulated the mrna levels of nf-e2-related factor 2 (nrf2) and tight junction complexes, and up-regulated mrna levels of cysteinyl aspartic acid-protease (caspase) -2, -3, -7, -8, -9, apoptotic protease activating factor-1 (apaf-1), bcl-2 associated x protein (bax), fas ligand (fasl), p38 mitogen-activated protein kinase (p38mapk), kelch-like ech-associating protein (keap) 1a, keap1b, claudin-12 and myosin light chain kinase (mlck), and increased malondialdehyde (mda), protein carbonyl (pc) and reactive oxygen species (ros) contents in head kidney and spleen of young grass carp (p < 0.05), indicating that iron deficiency impaired structural integrity in head kidney and spleen of fish. |
2017-11-21 |
2023-08-13 |
Not clear |
| Jiao Li, Xiaogan Wang, Yan Xie, Zhitao Ying, Weiping Liu, Lingyan Ping, Chen Zhang, Zhengying Pan, Ning Ding, Yuqin Song, Jun Zh. The mTOR kinase inhibitor everolimus synergistically enhances the anti-tumor effect of the Bruton's tyrosine kinase (BTK) inhibitor PLS-123 on Mantle cell lymphoma. International journal of cancer. vol 142. issue 1. 2017-11-21. PMID:28905990. |
simultaneous inhibition of btk and mtor resulted in marked induction of apoptosis and cell cycle arrest in the g1 phase, which were accompanied by upregulation of pro-apoptotic proteins (cleaved caspase-3, cleaved parp and bax), repression of anti-apoptotic proteins (mcl-1, bcl-xl and xiap), and downregulation of regulators of the g1/s phase transition (cdk2, cdk4, cdk6 and cyclin d1). |
2017-11-21 |
2023-08-13 |
mouse |
| Jufeng Xia, Yoshinori Inagaki, Jianjun Gao, Fanghua Qi, Peipei Song, Guohua Han, Tatsuo Sawakami, Bo Gao, Chuan Luo, Norihiro Kokudo, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Wei Tan. Combination of Cinobufacini and Doxorubicin Increases Apoptosis of Hepatocellular Carcinoma Cells through the Fas- and Mitochondria-Mediated Pathways. The American journal of Chinese medicine. vol 45. issue 7. 2017-11-21. PMID:28946772. |
the combination group induced more significant apoptosis by affecting proteins and rna of apoptosis-related elements, such as bcl-2, bax, bid, and cytochrome c. furthermore, cinobufacini, as a mixture of a number of components, had stronger apoptosis-inducing activity than particular individual components or a simple mixture of a few components. |
2017-11-21 |
2023-08-13 |
Not clear |
| Jae-Myung Yoo, Bo Dam Lee, Dai-Eun Sok, Jin Yuel Ma, Mee Ree Ki. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells. Redox biology. vol 11. 2017-11-20. PMID:28110215. |
moreover, nas suppressed glutamate-induced apoptosis by suppressing expression of aif, bax, calpain, cytochrome c and cleaved caspase-3, whereas it enhanced expression of bcl-2. |
2017-11-20 |
2023-08-13 |
mouse |
| Miaki Uzu, Hiromi Sato, Ayaka Shimizu, Yukihiro Shibata, Koichi Ueno, Akihiro Hisak. Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells. Journal of pharmacological sciences. vol 134. issue 2. 2017-11-16. PMID:28602541. |
connexin 43 enhances bax activation via jnk activation in sunitinib-induced apoptosis in mesothelioma cells. |
2017-11-16 |
2023-08-13 |
Not clear |
| Miaki Uzu, Hiromi Sato, Ayaka Shimizu, Yukihiro Shibata, Koichi Ueno, Akihiro Hisak. Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells. Journal of pharmacological sciences. vol 134. issue 2. 2017-11-16. PMID:28602541. |
in our previous work, cx43 was found to interact directly with bax and in the presence of sunitinib, lead to the bax-mediated apoptosis in mesothelioma cells. |
2017-11-16 |
2023-08-13 |
Not clear |
| Shiqi Cheng, WeiWei Gao, Xin Xu, Hengyi Fan, Yingang Wu, Fei Li, Jianning Zhang, Xingen Zhu, Yan Zhan. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain research bulletin. vol 127. 2017-11-13. PMID:27746369. |
in addition, mpss reduced neuronal apoptosis through increasing bcl-2 expression and reducing bax expression. |
2017-11-13 |
2023-08-13 |
mouse |
| Q Xu, Q-G Li, G-R Fan, Q-H Liu, F-L Mi, B Li. Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 2. 2017-11-13. PMID:28225864. |
fentanyl preconditioning may suppress cardiomyocyte apoptosis induced by i/r in rats by regulating bcl-2 and bax. |
2017-11-13 |
2023-08-13 |
rat |
| Song-Yi Park, Sophors Phorl, Suna Jung, Korm Sovannarith, Se-In Lee, Solhee Noh, Miae Han, Rema Naskar, Jae-Young Kim, Yun-Jaie Choi, Joo-Yong Le. HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation. Biochemical and biophysical research communications. vol 494. issue 1-2. 2017-11-13. PMID:29054408. |
deletion of hdac6 induces caspase-dependent apoptosis by promoting transactivation of bax and suppression of bcl-2. |
2017-11-13 |
2023-08-13 |
Not clear |
| Jung-Hye Choi, Hyerin Jeong, Kyung Lib Jan. Hepatitis B virus X protein suppresses all-trans retinoic acid-induced apoptosis in human hepatocytes by repressing p14 expression via DNA methylation. The Journal of general virology. vol 98. issue 11. 2017-11-13. PMID:29068287. |
as a result, hbx was able to impair the potential of atra to activate apoptosis-related molecules, including bax, p53-upregulated modulator of apoptosis, caspase-9, caspase-3 and poly (adp-ribose) polymerase. |
2017-11-13 |
2023-08-13 |
human |
| Fatima Abdelmutaal Ahmed Omer, Najihah Binti Mohd Hashim, Mohamed Yousif Ibrahim, Firouzeh Dehghan, Maizatulakmal Yahayu, Hamed Karimian, Landa Zeenelabdin Ali Salim, Syam Moha. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 11. 2017-11-13. PMID:29110583. |
caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for bcl-2, bax, caspase-3, and caspase-9 hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. |
2017-11-13 |
2023-08-13 |
human |
| Zhigang Fan, Yang Han, Yuanpeng Ye, Chao Liu, Hui Ca. l-carnitine preserves cardiac function by activating p38 MAPK/Nrf2 signalling in hearts exposed to irradiation. European journal of pharmacology. vol 804. 2017-11-10. PMID:28392465. |
cardiac systolic/diastolic functions were determined using invasive hemodynamic methods; myocyte apoptosis was assessed using the tunel assay; intracellular reactive oxygen species production was measured using dhe staining; and western blotting was used to evaluate the phosphorylation of p38mapk, phosphorylation of nrf2, and expression levels of ho1, nqo1, caspase3 and bax. |
2017-11-10 |
2023-08-13 |
mouse |
| Ke-Ying Zhang, Hui Xu, Le Du, Jun-Ling Xing, Bin Zhang, Qiang-Shan Bai, Yu-Qiao Xu, Yong-Chun Zhou, Jun-Ping Zhang, Yan Zhou, Gui-Rong Din. Enhancement of X-ray Induced Apoptosis by Mobile Phone-Like Radio-Frequency Electromagnetic Fields in Mouse Spermatocyte-Derived Cells. International journal of environmental research and public health. vol 14. issue 6. 2017-11-09. PMID:28590418. |
the findings suggested that rf exposure at sar of 3 w/kg did not affect apoptosis and proliferation in gc-1 cells by itself, but that it did enhance the effects of x-ray induced proliferation inhibition and apoptosis, in which b-cell lymphoma-2 (bcl-2) and bcl-2 associated x protein (bax) might be involved. |
2017-11-09 |
2023-08-13 |
mouse |
| Yanjie Chen, Yingxia Liang, Yan Zhan. [FcγRIis involved in lipopolysaccharide-induced apoptosis of PC12 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 6. 2017-11-07. PMID:28615096. |
compared to the control group, the protein and mrna expression of fcγri were upregulated, the expression levels of caspase-3, bcl-2 and bax proteins were elevated, and the apoptosis rate of pc12 cells was raised as well in the lps treated group. |
2017-11-07 |
2023-08-13 |
rat |
| Yanjie Chen, Yingxia Liang, Yan Zhan. [FcγRIis involved in lipopolysaccharide-induced apoptosis of PC12 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 6. 2017-11-07. PMID:28615096. |
compared to the lps treated group, the protein and mrna levels of fcγri were significantly lower along with significantly reduced expressions of caspase-3 and bax and inhibited cell apoptosis in the fcγrineutralizer treated group, while bcl-2 protein expression was upregulated. |
2017-11-07 |
2023-08-13 |
rat |
| Stephanie Bleicken, Annika Hantusch, Kushal Kumar Das, Tancred Frickey, Ana J Garcia-Sae. Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation. Nature communications. vol 8. issue 1. 2017-11-07. PMID:28706229. |
our study disentangles the hierarchy of bcl-2 complex formation in relation to their environment: bcl-xl association with cbid occurs in solution and in membranes, where the complex is stabilized, whereas bcl-xl binding to bax occurs only in membranes and with lower affinity than to cbid, leading instead to bax retrotranslocation.the permeabilization of the mitochondrial outer membrane to induce apoptosis is regulated by complex interactions between bcl-2 family members. |
2017-11-07 |
2023-08-13 |
Not clear |
| Y Nishida, A Maeda, M J Kim, L Cao, Y Kubota, J Ishizawa, A AlRawi, Y Kato, A Iwama, M Fujisawa, K Matsue, M Weetall, M Dumble, M Andreeff, T W Davis, A Branstrom, S Kimura, K Kojim. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood cancer journal. vol 7. issue 2. 2017-11-06. PMID:28211885. |
treatment with ptc596 reduced mcl-1 expression and triggered several molecular events consistent with induction of mitochondrial apoptosis: loss of mitochondrial membrane potential, bax conformational change, caspase-3 cleavage and phosphatidylserine externalization. |
2017-11-06 |
2023-08-13 |
Not clear |