| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dianlong Chong, Linyan Ma, Fang Liu, Zhirui Zhang, Surong Zhao, Qiang Huo, Pei Zhang, Hailun Zheng, Hao Li. Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. Anti-cancer drugs. vol 28. issue 8. 2017-12-06. PMID:28816773. |
it was also observed that bax expression increased, whereas bcl-2 expression reduced, which were indicative of mitochondria-dependent apoptosis. |
2017-12-06 |
2023-08-13 |
mouse |
| Shuqing Liu, Chunmei Guo, Jiasheng Wang, Bo Wang, Houbao Qi, Ming-Zhong Su. ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun. Oncotarget. vol 7. issue 13. 2017-12-05. PMID:26908448. |
although bax and bcl-2 levels increased in shrna-anxa11-transfected hca-p, anxa11 downregulation showed no clear effect on hca-p apoptosis. |
2017-12-05 |
2023-08-13 |
Not clear |
| Ling-Ai Hu, Yu-Kun Sun, Hong-Sheng Zhang, Jin-Guo Zhang, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway. Bioscience reports. vol 36. issue 3. 2017-12-05. PMID:27166426. |
we observed that apoptosis in h9c2 was associated with increased bax, cytochrome c, caspase-3, decreased bcl-2 activity after 24 h of h2o2 exposure. |
2017-12-05 |
2023-08-13 |
rat |
| Ling-Ai Hu, Yu-Kun Sun, Hong-Sheng Zhang, Jin-Guo Zhang, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway. Bioscience reports. vol 36. issue 3. 2017-12-05. PMID:27166426. |
these findings indicated for the first time that pretreatment of h9c2 cells with catalpol can be against h2o2-induced apoptosis, and the protective effect of catalpol involves the mitochondrial-dependent caspase pathway and is associated with increased bcl-2 and decreased bax expression. |
2017-12-05 |
2023-08-13 |
rat |
| Fenfen Ma, Wenwen Li, Xinghui Li, Ba Hieu Tran, Rinkiko Suguro, Ruijuan Guan, Cuilan Hou, Huijuan Wang, Aijie Zhang, Yichun Zhu, YiZhun Zh. Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats. Bioscience reports. vol 36. issue 6. 2017-12-05. PMID:27780890. |
in addition, pemf treatment also reduced the apoptosis of myocardial cells by up-regulating the expression of anti-apoptosis protein b-cell lymphoma 2 (bcl-2) and down-regulating the expression of pro-apoptosis protein (bax). |
2017-12-05 |
2023-08-13 |
rat |
| Kartick Patra, Samarjit Jana, Arnab Sarkar, Subrata Karmakar, Jagannath Jana, Mradu Gupta, Gopeswar Mukherjee, Utpal Chandra De, Deba Prasad Mandal, Shamee Bhattacharje. Parkia javanica Extract Induces Apoptosis in S-180 Cells via the Intrinsic Pathway of Apoptosis. Nutrition and cancer. vol 68. issue 4. 2017-12-04. PMID:27144503. |
a decline in the relative fluorescence emission upon staining s-180 cells with rhodamine 123 (rh 123), enhanced expression of cytosolic cyt c and mitochondrial bax, and inhibition of apoptosis in the presence of caspase-9 inhibitor in pje-treated cells indicated intrinsic pathway of apoptosis. liver function test and hepatic antioxidant enzymes demonstrated non-toxicity of pje. |
2017-12-04 |
2023-08-13 |
Not clear |
| Katia Cosentino, Ana J García-Sáe. Bax and Bak Pores: Are We Closing the Circle? Trends in cell biology. vol 27. issue 4. 2017-12-04. PMID:27932064. |
bax and its homolog bak are key regulators of the mitochondrial pathway of apoptosis. |
2017-12-04 |
2023-08-13 |
Not clear |
| Katia Cosentino, Ana J García-Sáe. Bax and Bak Pores: Are We Closing the Circle? Trends in cell biology. vol 27. issue 4. 2017-12-04. PMID:27932064. |
these discoveries reveal an unexpected molecular mechanism in which bax (and likely bak) dimers assemble into oligomers with an even number of molecules that fully or partially delineate pores of different sizes to permeabilize the mitochondrial outer membrane (mom) during apoptosis. |
2017-12-04 |
2023-08-13 |
Not clear |
| Jian Sun, Tao Wei, Shuzhi Bai, Hongtao Zhao, Xiaoqin Liu, Jinfeng Yu, Li Li, Gaochen Song, Hairong Luan, Changqing X. Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction. Molecular and cellular biochemistry. vol 431. issue 1-2. 2017-12-04. PMID:28281186. |
using acute myocardial infarction rat models, we found that a combination therapy of casr inhibition and embryonic stem cell (esc) transplantation after acute myocardial infarction (ami) leads to a dramatic reduction in the infarct size; a significant increase in the maximum rising and falling rate (+dp/dtmax and -dp/dtmax, respectively) of left ventricular pressure; a significant decrease in left ventricular end-diastolic pressure; a significant decrease in the mrna expression level of casr, bax, bcl-2, cleaved caspase-3, cleaved caspase-9, p-erk, p-jnk and p-p38 protein together with apoptosis indexes in the c and e groups; and a significant decrease in ctnt levels as well as ldh and ck activity. |
2017-12-04 |
2023-08-13 |
mouse |
| Ming Yuan, Liwei Zhang, Fei You, Jingyu Zhou, Yongjiang Ma, Feifei Yang, Ling Ta. MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40. Molecular and cellular biochemistry. vol 431. issue 1-2. 2017-12-04. PMID:28281187. |
furthermore, we observed hypoxia stimulation significantly augmented apoptosis accompanied by a decrease in the expression of bcl-2 and an increase in the expression of bax, caspase-3, and caspase-9. |
2017-12-04 |
2023-08-13 |
Not clear |
| Jun Wang, Yan Cheng, Xiaoran Yin, Jie Wu, Yumei Luo, Jing Wu, Jia Di, Dong Liu, Yahui Huang, Rong Zhang, Jun Zhan. Globular adiponectin inhibits leptin-stimulated esophageal adenocarcinoma cell proliferation via adiponectin receptor 2-mediated suppression of UHRF1. Molecular and cellular biochemistry. vol 431. issue 1-2. 2017-12-04. PMID:28285359. |
silence of uhrf1 increased the expression of cleaved caspase 3 and 9 and bax, reduced the expression of bcl-2, promoted apoptosis, and inhibited cell proliferation in oe 19 cells. |
2017-12-04 |
2023-08-13 |
Not clear |
| Brian Koss, Jeremy Ryan, Amit Budhraja, Katherine Szarama, Xue Yang, Madhavi Bathina, Michael H Cardone, Zaneta Nikolovska-Coleska, Anthony Letai, Joseph T Opferma. Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines. Oncotarget. vol 7. issue 10. 2017-12-01. PMID:26862853. |
here we demonstrate that this panel of cell lines can determine the specificity of bh3-mimetics to individual anti-apoptotic bcl-2 family members (bcl-2, bcl-xl, bcl-w, bfl-1, and mcl-1), demonstrate whether cell death is due to the induction of apoptosis (bax and bak-dependent), and faithfully assess the efficacy of bh3-mimetic small molecules in pre-clinical mouse models. |
2017-12-01 |
2023-08-13 |
mouse |
| Amal Salah, Chayma Bouaziz, Alexandre Prola, Julie Pires Da Silva, Hassen Bacha, Salwa Abid-Essefi, Christophe Lemair. Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress. Journal of toxicology and environmental health. Part A. vol 80. issue 23-24. 2017-12-01. PMID:29165056. |
further, the genetic deficiency of the pro-apoptotic protein bax protected cells against ctn-induced apoptosis, indicating that bax is required for ctn-mediated toxicity. |
2017-12-01 |
2023-08-13 |
human |
| Qiuxia Liao, Rui Zhang, Xiaoyu Wang, Weiwei Nian, Lulu Ke, Wei Ouyang, Zigui Zhan. Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells. Environmental toxicology and pharmacology. vol 54. 2017-11-30. PMID:28697452. |
fluoride poisoning induced severe cell injuries, such as decreased pc12 cell activity, enhanced cell apoptosis, high c-fos, camkii, and bax mrna expression levels. |
2017-11-30 |
2023-08-13 |
Not clear |
| Jingmei Luo, Li Yu, Guangcheng Xie, Dan Li, Meng Su, Xuerong Zhao, Luanying D. Study on the mitochondrial apoptosis pathways of small cell lung cancer H446 cells induced by Trichinella spiralis muscle larvae ESPs. Parasitology. vol 144. issue 6. 2017-11-29. PMID:28073393. |
the results of flow cytometry testing indicate a clear apoptosis trend in h446 cells co-cultured with esps for 24 h. reverse transcription polymerase chain reaction and western blotting results showed increased expression of pro-apoptosis genes bax, cyt-c, apaf-1, caspase-9 and caspase-3, compared with the negative control group, and decreased the expression of anti-apoptosis genes bcl-2 and livin. |
2017-11-29 |
2023-08-13 |
Not clear |
| Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Czabota. Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. Molecular cell. vol 68. issue 4. 2017-11-29. PMID:29149594. |
certain bh3-only proteins transiently bind and activate bak and bax, initiating their oligomerization and the permeabilization of the mitochondrial outer membrane, a pivotal step in the mitochondrial pathway to apoptosis. |
2017-11-29 |
2023-08-13 |
human |
| Yu-Wen Zhuang, Cun-En Wu, Jin-Yong Zhou, Xu Chen, Jian Wu, Shan Jiang, Hai-Yan Peng, Xi Zou, Jia-Yun Liu, Da-Peng Wu, Tao Gong, Ming-Hao Qi, Tian Xue, Shen-Lin Liu, Hui Ca. Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3β/β-catenin pathway. Cancer science. vol 108. issue 11. 2017-11-28. PMID:28803443. |
solasodine was also found to fuel caspase-cascade reaction and increase the ratio between bax and bcl-2 so as to induce crc cell apoptosis. |
2017-11-28 |
2023-08-13 |
human |
| Hongyu Jie, Yi He, Xuechan Huang, Qingyou Zhou, Yanping Han, Xing Li, Yongkun Bai, Erwei Su. Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis. Oncotarget. vol 7. issue 15. 2017-11-27. PMID:27027357. |
we also provided evidence that nec-1 promoted apoptosis by reducing the expression of the anti-apoptotic protein mcl-1 and increasing the expression of pro-apoptotic protein bax. |
2017-11-27 |
2023-08-13 |
mouse |
| Wei Li, Xiangqi Wu, Minghui Li, Zhimei Wang, Bing Li, Xinliang Qu, Shaoliang Che. Cardamonin Alleviates Pressure Overload-induced Cardiac Remodeling and Dysfunction Through Inhibition of Oxidative Stress. Journal of cardiovascular pharmacology. vol 68. issue 6. 2017-11-27. PMID:27560458. |
moreover, cardamonin significantly abrogated the expression of bax, apoptosis inducing factor, cytochrome c, and caspase-3 and caspase-9 and enhanced the expression of bcl-2 and bcl-xl. |
2017-11-27 |
2023-08-13 |
Not clear |
| Sana Moshari, Vahid Nejati, Gholamreza Najafi, Mazdak Raz. Nanomicelle curcumin-induced DNA fragmentation in testicular tissue; Correlation between mitochondria dependent apoptosis and failed PCNA-related hemostasis. Acta histochemica. vol 119. issue 4. 2017-11-24. PMID:28385400. |
in conclusion, the nmcm by reducing the testicular endocrine status, down-regulating bcl-2 expression and by enhancing the bax and caspase-3 expression initiates the intrinsic apoptosis pathway. |
2017-11-24 |
2023-08-13 |
rat |