| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Liu, Yunli Tong, Xia Yang, Fangyuan Li, Liang Zheng, Wenqin Liu, Jinjun Wu, Rilan Ou, Guiyu Zhang, Ming Hu, Zhongqiu Liu, Linlin L. Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer. Pharmacological research. vol 111. 2017-12-26. PMID:27268146. |
in a549 and h1299 cells, magnolol and pm remarkably induced cell apoptosis by arresting the cell cycle in the g0/g1 phase while simultaneously activating various pro-apoptotic signals, including trail-r2 (dr5), bax, caspase 3, cleaved caspase 3, and cleaved parp. |
2017-12-26 |
2023-08-13 |
Not clear |
| Pascale Krejbich-Trotot, Essia Belarbi, Miora Ralambondrainy, Chaker El-Kalamouni, Wildriss Viranaicken, Pierre Roques, Philippe Desprès, Gilles Gade. The growth of arthralgic Ross River virus is restricted in human monocytic cells. Virus research. vol 225. 2017-12-22. PMID:27637347. |
mitochondrial bax localisation and parp cleavage) were observed in infected mm6 cells indicating that rrv can trigger apoptosis at late infection times. |
2017-12-22 |
2023-08-13 |
human |
| Ke-Wang Luo, Wei Chen, Wing-Yin Lung, Xia-Yun Wei, Bao-Hui Cheng, Zhi-Ming Cai, Wei-Ren Huan. EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9. The Journal of nutritional biochemistry. vol 41. 2017-12-22. PMID:28040581. |
western blot confirmed that egcg induced apoptosis in sw780 cells by activation of caspases-8, -9 and -3, bax, bcl-2 and parp. |
2017-12-22 |
2023-08-13 |
mouse |
| Yuwei Han, Tingting Zhang, Jingyuan Su, Yuan Zhao, Chenchen, Wang, Xiaoming L. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 40. 2017-12-22. PMID:28342702. |
moreover, api treatment inhibited sah-induced the expression of bax and caspase-3, significantly reduced neuronal apoptosis. |
2017-12-22 |
2023-08-13 |
rat |
| Buyun Kim, Ki Yong Lee, Byoungduck Par. Crocin Suppresses Constitutively Active STAT3 Through Induction of Protein Tyrosine Phosphatase SHP-1. Journal of cellular biochemistry. vol 118. issue 10. 2017-12-21. PMID:28295507. |
finally, crocin downregulated the expression of stat3-mediated gene products including anti-apoptotic (bcl-2), pro-apoptotic (bax), invasive (cxcr4), angiogenic (vegf), and cell cycle regulator (cyclin d1), which are correlated with suppression of proliferation, the accumulation of cells in sub-g1 phase of cell cycle, and induction of apoptosis. |
2017-12-21 |
2023-08-13 |
human |
| Parminder K Ajji, Marley J Binder, Ken Walder, Munish Pur. Balsamin induces apoptosis in breast cancer cells via DNA fragmentation and cell cycle arrest. Molecular and cellular biochemistry. vol 432. issue 1-2. 2017-12-21. PMID:28378131. |
firstly, the induction of apoptosis in human breast cancer mcf-7 and bt549 cells showed that balsamin-induced apoptosis involved increases in caspase-3 and caspase-8 activity, upregulation of bax, bid, and bad, and downregulation of bcl-2 and bcl-xl. |
2017-12-21 |
2023-08-13 |
human |
| Julia Ariza, José A González-Reyes, Laura Jódar, Alberto Díaz-Ruiz, Rafael de Cabo, José Manuel Villalb. Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2. Free radical biology & medicine. vol 95. 2017-12-19. PMID:27016073. |
apoptosis in nrf2ko mefs was associated with a decrease of bcl-2 but not bax levels, and with the release of the mitochondrial pro-apoptotic factors cytochrome c and aif. |
2017-12-19 |
2023-08-13 |
mouse |
| Lijuan Shi, Zhihua Zhang, Lin Li, Christian Hölsche. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behavioural brain research. vol 327. 2017-12-19. PMID:28342971. |
apoptosis was reduced as shown in the reduced ratio of pro-apoptotic bax to anti- apoptotic bcl-2 levels. |
2017-12-19 |
2023-08-13 |
rat |
| Ziying Lin, Wenya Xu, Chunyan Li, Yahong Wang, Lawei Yang, Bao'an Zou, Shenglan Gao, Weimin Yao, Zeqing Song, Gang Li. β-8-Oxoguanine DNA Glycosylase Overexpression Reduces Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis Through the JNK Signaling Pathway in Human Bronchial Epithelial Cells. DNA and cell biology. vol 36. issue 12. 2017-12-19. PMID:29227732. |
additionally, knocking down ogg1 enhanced oxidative damage-induced apoptosis and mitochondrial dysfunction, whereas the overexpression of β-ogg1 had the opposite effects and led to the downregulation of bax and parp. |
2017-12-19 |
2023-08-13 |
human |
| Takeshi Moriishi, Ryo Fukuyama, Toshihiro Miyazaki, Tatsuya Furuichi, Masako Ito, Toshihisa Komor. Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 31. issue 7. 2017-12-15. PMID:26852895. |
the bcl2 family proteins, bcl2 and bclxl, suppress apoptosis by preventing the release of caspase activators from mitochondria through the inhibition of bax subfamily proteins. |
2017-12-15 |
2023-08-13 |
mouse |
| Xi Peng, Zhengqiang Yu, Na Liang, Xiaofeng Chi, Xiaochong Li, Min Jiang, Jing Fang, Hengmin Cui, Weimin Lai, Yi Zhou, Shan Zho. The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1. Oncotarget. vol 7. issue 11. 2017-12-14. PMID:26933817. |
(2) the excessive apoptosis involved the mitochondrial pathway (up-regulation of bax, bak, cytc and down-regulation of bcl-2 and bcl-xl) and death receptor pathway (up-regulation of fasl, fas and fadd). |
2017-12-14 |
2023-08-13 |
Not clear |
| Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Ton. The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma. Investigational new drugs. vol 35. issue 1. 2017-12-14. PMID:27785591. |
the treatment inhibited proliferation and clonogenicity, increased the apoptosis rate and the number of cells in the s phase (p < 0.05), as well as the expression of p53, p21, and bax, and decreased cyclin a, survivin and bcl-2 proteins. |
2017-12-14 |
2023-08-13 |
Not clear |
| H Kocic, I Arsic, M Stankovic, D Tiodorovic, V Ciric, G Koci. Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture of skin fibroblasts. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28954469. |
our current study was aimed to explore the effect of l-arginine on skin fibroblast (l929) signaling pathways involved in cell proliferation (akt-pakt kinase, erk/perk1/2 kinase, jnk/pjnk kinase and pstat-1), apoptosis (bcl2 and bax) and immune defense (nf-κb and cd26). |
2017-12-14 |
2023-08-13 |
Not clear |
| Mozhgan Moshrefi, Adel Spotin, Hossein Samadi Kafil, Mahmoud Mahami-Oskouei, Behzad Baradaran, Ehsan Ahmadpour, Behzad Mansoor. Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite. Parasitology research. vol 116. issue 8. 2017-12-12. PMID:28560572. |
tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by leishmania major, by activation of bax and caspase-3: a possible survival mechanism for the parasite. |
2017-12-12 |
2023-08-13 |
Not clear |
| Xiao-Ting Huang, Shao-Jie Yue, Chen Li, Yan-Hong Huang, Qing-Mei Cheng, Xiao-Hong Li, Cai-Xia Hao, Ling-Zhi Wang, Jian-Ping Xu, Ming Ji, Chen Chen, Dan-Dan Feng, Zi-Qiang Lu. A Sustained Activation of Pancreatic NMDARs Is a Novel Factor of β-Cell Apoptosis and Dysfunction. Endocrinology. vol 158. issue 11. 2017-12-12. PMID:28938426. |
nmda specifically induces the mitochondrial-dependent pathway of apoptosis in β-cells through upregulation of the proapoptotic bim and bax, and downregulation of antiapoptotic bcl-2. |
2017-12-12 |
2023-08-13 |
Not clear |
| Aktarul Islam Siddique, Vijay Mani, Senbagarani Renganathan, Rajagopal Ayyanar, Ananthi Nagappan, Nalini Namasivaya. Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis. Chemico-biological interactions. vol 278. 2017-12-12. PMID:29108773. |
concordantly aa also induced apoptosis by downregulating the expression of bcl-2 and upregulating bax, cytochrome c, caspase-3 and -9 in the dmh-alone-exposed rats. |
2017-12-12 |
2023-08-13 |
rat |
| Jing-Jing Zhang, Yi Zhu, Chuang Yang, Xian Liu, Yun-Peng Peng, Kui-Rong Jiang, Yi Miao, Ze-Kuan X. Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27074573. |
yin yang-1 increases apoptosis through bax activation in pancreatic cancer cells. |
2017-12-11 |
2023-08-13 |
Not clear |
| Jing-Jing Zhang, Yi Zhu, Chuang Yang, Xian Liu, Yun-Peng Peng, Kui-Rong Jiang, Yi Miao, Ze-Kuan X. Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27074573. |
we found that overexpression of yy1 promoted apoptosis and increased the expression and mitochondrial localization of the pro-apoptotic bax protein in pancreatic cancer cell lines. |
2017-12-11 |
2023-08-13 |
Not clear |
| Jing-Jing Zhang, Yi Zhu, Chuang Yang, Xian Liu, Yun-Peng Peng, Kui-Rong Jiang, Yi Miao, Ze-Kuan X. Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27074573. |
moreover, yy1 promoted pancreatic cancer cell apoptosis through bax transcriptional activation and subsequent translocation of bax to the mitochondrial membrane, leading to cytochrome c release, and caspase activation.yy1 and bax are co-expressed in pancreatic cancer tissues and higher bax expression predicts better outcomes for patients. |
2017-12-11 |
2023-08-13 |
Not clear |
| Nouf Mohamed Al-Rasheed, Laila Mohamed Fadda, Hala A Attia, Hanaa Mahmoud Ali, Nawal Mohamed Al-Rashee. Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-α, TGF-β, Smad-2, and AKT pathways. Journal of biochemical and molecular toxicology. vol 31. issue 5. 2017-12-11. PMID:28000380. |
quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing bax, hif1-α, tgf-β, smad-2, and akt pathways. |
2017-12-11 |
2023-08-13 |
rat |