| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongming Huang, Junhua Li, Shaohua Du, Yanghua Tang, Ligang Huang, Luwei Xiao, Peijian Ton. FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. Oncotarget. vol 7. issue 26. 2018-01-12. PMID:27223089. |
fkbp14 knockdown decreased the protein levels of pcna, cdk1 and ccnb1 that promotes cell cycle, increased bax, caspase-3 and caspase-7 protein involved in promoting cell apoptosis, and increased kif4a expression as well as decreased smc4 and tmem33 proteins that contribute to cell invasion and adhesion. |
2018-01-12 |
2023-08-13 |
Not clear |
| Xian Lin, Ran Sun, Xiulan Zhao, Dongwang Zhu, Xueming Zhao, Qiang Gu, Xueyi Dong, Danfang Zhang, Yanhui Zhang, Yanlei Li, Baocun Su. C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling. Journal of molecular medicine (Berlin, Germany). vol 95. issue 1. 2018-01-12. PMID:27543492. |
high expression of c-myc increased bax expression in hypoxic conditions and induced cell apoptosis. |
2018-01-12 |
2023-08-13 |
Not clear |
| Hossein Haghir, Javad Hami, Nassim Lotfi, Mostafa Peyvandi, Simagol Ghasemi, Mehran Hossein. Expression of apoptosis-regulatory genes in the hippocampus of rat neonates born to mothers with diabetes. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:28078553. |
the results of the present study revealed that maternal hyperglycemia during gestational period may result in disturbances in the expression of bcl-2 and bax genes as two important genes in neuronal apoptosis regulation and induces the production of dns in the developing hippocampus of neonatal rats. |
2018-01-12 |
2023-08-13 |
rat |
| Chang-Hong Cheng, Sheng-Wei Luo, An-Li Wang, Zhi-Xun Gu. Molecular and immune response characterizations of a novel Bax inhibitor-1 gene in pufferfish, Takifugu obscurus. Fish physiology and biochemistry. vol 43. issue 4. 2018-01-12. PMID:28553691. |
bax inhibitor-1 (bi-1) is an anti-apoptotic protein that protects cells from endoplasmic reticulum stress-induced apoptosis. |
2018-01-12 |
2023-08-13 |
Not clear |
| E Raemy, S Montessuit, S Pierredon, A H van Kampen, F M Vaz, J-C Martino. Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell death and differentiation. vol 23. issue 7. 2018-01-10. PMID:26794447. |
during apoptosis, proapoptotic bax and bak trigger mitochondrial outer membrane (mom) permeabilization by a mechanism that is not yet fully understood. |
2018-01-10 |
2023-08-13 |
human |
| E Raemy, S Montessuit, S Pierredon, A H van Kampen, F M Vaz, J-C Martino. Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis. Cell death and differentiation. vol 23. issue 7. 2018-01-10. PMID:26794447. |
using these cells, we found that cl was not required for either tbid-induced bax activation, or for apoptosis in response to treatment with trail. |
2018-01-10 |
2023-08-13 |
human |
| Janina Dose, Almut Nebel, Stefanie Piegholdt, Gerald Rimbach, Patricia Huebb. Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27130033. |
therefore, we studied biomarkers of oxidative status (glutathione levels, 3-nitrotyrosine adducts, protein carbonyl concentration), er stress (xbp1(s), bip, ddit3), proteasome activity, mitochondrial function (respiratory complexes, atp levels and mitochondrial membrane potential as well as biomarkers of mitochondrial biogenesis, fission and fusion), autophagy (lc3, lamp2a), apoptosis (bcl2, bax, cycs) and dna damage in the liver of apoe targeted replacement (tr) mice and in huh7 hepatocytes overexpressing the apoe3 and the apoe4 isoform, respectively. |
2018-01-09 |
2023-08-13 |
mouse |
| Yunyan Pan, Yanling Zhang, Lijun Chen, Yan Liu, Yanlin Feng, Junyuan Ya. The Critical Role of Rab31 in Cell Proliferation and Apoptosis in Cancer Progression. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26245486. |
meanwhile, rab31 inhibits u87 and siha cell apoptosis, and decreased the bax and pig3 expression, but enhanced bcl2 expression. |
2018-01-08 |
2023-08-13 |
Not clear |
| Chang-Ae Shin, Hyun-Woo Cho, A-Ri Shin, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Ki. Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323820. |
notably, expression of cd40l augmented b-cell viability by inhibiting apoptosis through upregulated expression of the anti-apoptotic molecules bcl2, bcl-xl and bax. |
2018-01-08 |
2023-08-13 |
Not clear |
| Tao Fu, Yidi Liu, Qiong Wang, Zhen Sun, Hui Di, Weijia Fan, Mengyuan Liu, Jinhuan Wan. Overexpression of riboflavin transporter 2 contributes toward progression and invasion of glioma. Neuroreport. vol 27. issue 15. 2018-01-08. PMID:27584688. |
expression of proteins known to regulate cell cycle or apoptosis including p21, p27, bcl-2, and bax was notably altered in rft2-depleted cells. |
2018-01-08 |
2023-08-13 |
human |
| Yujing Huang, Deshang Xiong, Youhua Xu, Jie Yu, Ying Xian, E Ca. [Effect of the traditional Chinese medicine compound Yisui Lixue decoction on apoptosis of marrow cells in rats with myelodysplastic syndrome induced by
dimethyl benzanthracene]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 1. 2018-01-04. PMID:28216494. |
the peripheral blood cells, expressions of b-cell lymphoma-2 (bcl-2) and bcl-2 associated x protein (bax), apoptosis of bone marrow cells were measured.
results: the counts of peripheral leukocyte, erythrocyte, hemoglobin and platelet in the model+pbs group were significantly decreased compared with those in the control group (p<0.01), while the peripheral hemograms of the treatment groups were improved significantly compared with those in the model+pbs group (p<0.05 or p<0.01), especially in the model+high dose group (p<0.01). |
2018-01-04 |
2023-08-13 |
rat |
| Yujing Huang, Deshang Xiong, Youhua Xu, Jie Yu, Ying Xian, E Ca. [Effect of the traditional Chinese medicine compound Yisui Lixue decoction on apoptosis of marrow cells in rats with myelodysplastic syndrome induced by
dimethyl benzanthracene]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 1. 2018-01-04. PMID:28216494. |
conclusion: the traditional chinese medicine compound yisui lixue decoction can improve peripheral hemogram, decrease the expression of bax, increase the expression of bcl-2, and reduce the apoptosis of bone marrow cells. |
2018-01-04 |
2023-08-13 |
rat |
| Piyawadee Wicha, Jiraporn Tocharus, Adchara Janyou, Jinatta Jittiwat, Chatchawan Changtam, Apichart Suksamrarn, Chainarong Tocharu. Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model. PloS one. vol 12. issue 12. 2018-01-04. PMID:29220411. |
moreover, the hhc treatment also significantly decreased apoptosis, with a decrease in bax and cleaved caspase-3 and an increase in bcl-xl, which was in accordance with a decrease in the apoptotic neuronal cells. |
2018-01-04 |
2023-08-13 |
rat |
| Hong-Wei Wang, Wen-Peng Zhao, Jing Liu, Pan-Pan Tan, Cai Zhang, Bian-Hua Zho. Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice. Chemosphere. vol 186. 2018-01-02. PMID:28826138. |
the protein expression levels of apoptosis factors, including bax, bcl-2, casepase-3, casepase-9 and cytochrome c, and the mrna expression levels of antioxidant enzymes, including sod1, gsh-px1, cat and inducible nitric oxide synthase were measured by western blot and real-time pcr, respectively. |
2018-01-02 |
2023-08-13 |
mouse |
| Peng Duan, Chunhui Hu, Holly J Butler, Chao Quan, Wei Chen, Wenting Huang, Sha Tang, Wei Zhou, Meng Yuan, Yuqin Shi, Francis L Martin, Kedi Yan. Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways. Reproductive toxicology (Elmsford, N.Y.). vol 62. 2018-01-01. PMID:27109770. |
moreover, 60mg/kg np resulted in a significant reduction in fructose, fsh and lh; induced apoptosis related to oxidative stress; inhibited mrna and protein levels of bcl-2 and pcna; as well as the additional up-regulation of p53, bax, apaf-1, cytochrome c, cleaved-caspase-3, fas and fasl expression. |
2018-01-01 |
2023-08-13 |
rat |
| Cristina Corno, Simone Stucchi, Michelandrea De Cesare, Nives Carenini, Serena Stamatakos, Emilio Ciusani, Lucia Minoli, Eugenio Scanziani, Christian Argueta, Yosef Landesman, Nadia Zaffaroni, Laura Gatti, Paola Pereg. FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models. Biochemical pharmacology. vol 147. 2018-01-01. PMID:29155058. |
a modulation of proteins involved in apoptosis (p53, bax) and in cell cycle progression (p21 |
2018-01-01 |
2023-08-13 |
Not clear |
| Ukpong B Eyo, Samuel A Miner, Joshua A Weiner, Michael E Daile. Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26576723. |
the extent to which these changes in microglia are driven by developmental neuronal apoptosis was assessed in tissues from bax null mice lacking apoptosis. |
2017-12-29 |
2023-08-13 |
mouse |
| Xiao-Qiu Li, Jia-Tao Liu, Lu-Lu Fan, Yu Liu, Liang Cheng, Fang Wang, Han-Qing Yu, Jian Gao, Wei Wei, Hua Wang, Guo-Ping Su. Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy. Oncotarget. vol 7. issue 17. 2017-12-27. PMID:27029054. |
furthermore, exo-gf co-incubation with cisplatin increased autophagic activity and reduced apoptosis, as demonstrated by an upregulation of lc3-ii and bcl-2 protein levels and downregulation of p62 and bax protein levels. |
2017-12-27 |
2023-08-13 |
Not clear |
| Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yan. Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 95. issue 6. 2017-12-27. PMID:28662337. |
apoptosis in osteoarthritic cartilage tissues was attenuated by danshen, accompanied with increased expression of b cell lymphoma 2 (bcl-2) and decreased levels of bcl-2-associated x protein (bax). |
2017-12-27 |
2023-08-13 |
rabbit |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
we found 10 selected polymorphisms (p53 (rs1042522 and rs17878362), bcl2 (rs2279115), bax (rs1805419), bak1 (rs210132 and rs2227925), casp3 (rs1405937), casp7 (rs2227310), casp8 (rs1045485) and casp10 (rs13006529)) with a potential apoptosis effect in md patients compared to control population. |
2017-12-27 |
2023-08-13 |
Not clear |