| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingying Zhang, Xianmei Zhou, Jiping Zh. Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis. Oncotarget. vol 7. issue 46. 2018-02-08. PMID:27801673. |
bea promoted cell apoptosis, stimulated the expression of bax and caspase-3 and inhibited bcl-2 protein expression in a dose-dependent manner. |
2018-02-08 |
2023-08-13 |
mouse |
| Xiaoli Liu, Jinhu Dong, Wangyu Cai, Ying Pan, Ruili Li, Bing L. The Effect of Thymoquinone on Apoptosis of SK-OV-3 Ovarian Cancer Cell by Regulation of Bcl-2 and Bax. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 27. issue 8. 2018-02-08. PMID:28692636. |
the effect of thymoquinone on apoptosis of sk-ov-3 ovarian cancer cell by regulation of bcl-2 and bax. |
2018-02-08 |
2023-08-13 |
Not clear |
| Xiaoli Liu, Jinhu Dong, Wangyu Cai, Ying Pan, Ruili Li, Bing L. The Effect of Thymoquinone on Apoptosis of SK-OV-3 Ovarian Cancer Cell by Regulation of Bcl-2 and Bax. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 27. issue 8. 2018-02-08. PMID:28692636. |
we also want to explore the mechanism of these influences on the cells' apoptosis by bcl-2 and bax gene. |
2018-02-08 |
2023-08-13 |
Not clear |
| Lin Chen, Zhiping Ren, Xinbing Wei, Shuaishuai Wang, Yimeng Wang, Yanyan Cheng, Hua Gao, Huiqing Li. Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt. European journal of pharmacology. vol 815. 2018-02-08. PMID:28844872. |
our results showed that administration of losartan significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the protein level of cleaved caspase-3, cytochrom c and bax, and increasing the level of bcl-2 both in vivo and in vitro. |
2018-02-08 |
2023-08-13 |
rat |
| Huina Jia, Juan Ye, Jing You, Xiaoyan Shi, Wenyi Kang, Tianxiao Wan. Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system. Oncology reports. vol 37. issue 5. 2018-02-07. PMID:28440458. |
meanwhile, cbs knockdown caused multiple effects, including apoptosis of smmc-7721 cells, an increase in the bcl-2-associated x protein (bax)/b cell lymphoma/leukemia (bcl-2) ratio, activation of caspase-3 and polyadp-ribose polymerase (parp), when compared with the scramble sirna (sc sirna)-transfected groups. |
2018-02-07 |
2023-08-13 |
human |
| Laura Lucarini, Lucia Magnelli, Nicola Schiavone, Alfonso Crisci, Alessio Innocenti, Luca Puccetti, Fabio Cianchi, Sara Peri, Claudiu T Supuran, Laura Papucci, Emanuela Masin. Plasmatic carbonic anhydrase IX as a diagnostic marker for clear cell renal cell carcinoma. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-02-07. PMID:29251173. |
bcl-2 and bax, and the activity of caspase-3, evaluated in tissue biopsies from patients, were congruent with resistance to apoptosis in ccrccs with respect to healthy controls, respectively. |
2018-02-07 |
2023-08-13 |
human |
| Te-Yu Kao, Chia-Jung Tsai, Yu-Jing Lan, Yun-Wei Chian. The role of conformational heterogeneity in regulating the apoptotic activity of BAX protein. Physical chemistry chemical physics : PCCP. vol 19. issue 14. 2018-02-06. PMID:28345702. |
while activation of bax is required for initiating mitochondria-mediated apoptosis, the underlying mechanisms remain unsettled. |
2018-02-06 |
2023-08-13 |
Not clear |
| Yue Liu, Zhen-Gang Tang, Yi Lin, Xin-Guo Qu, Wei Lv, Guo-Bin Wang, Cai-Li L. Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-02-05. PMID:28528183. |
quercetin treatment also induced apoptosis via deregulating the expression of apoptotic genes, including bax and bcl-2, and arrested cell cycle at g2/m phases. |
2018-02-05 |
2023-08-13 |
human |
| Gui-Yun Xu, Xiao-Jun Tan. Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-κB and Bcl-2 signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-02-05. PMID:28531805. |
the pro-apoptotic proteins of bax and bid were up-regulated, accompanied with caspase cleavage, leading to apoptosis. |
2018-02-05 |
2023-08-13 |
mouse |
| Xue Liang, Peiyan Kong, Jin Wang, Yulin Xu, Chunfang Gao, Guozhen Gu. Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells. Journal of pharmacological sciences. vol 135. issue 1. 2018-02-05. PMID:28927780. |
the combination of specific inhibitors of erk1/2, jnk or pi3k/akt pathway and metformin further promoted cell apoptosis and the up-regulation of p21, bax, bad, cleaved caspase-3 and -9 as well as the down-regulation of bcl-2 mediated by metformin alone, but inhibition of p38 pathway exhibited the opposite results. |
2018-02-05 |
2023-08-13 |
human |
| Yong-Tao Duan, Ruo-Jun Man, Dan-Jie Tang, Yong-Fang Yao, Xiang-Xiang Tao, Chen Yu, Xin-Yi Liang, Jigar A Makawana, Mei-Juan Zou, Zhong-Chang Wang, Hai-Liang Zh. Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents. Scientific reports. vol 6. 2018-02-02. PMID:27138035. |
cellular studies have revealed that the induction of apoptosis by compound 7 was associated with a collapse of mitochondrial membrane potential, accumulation of reactive oxygen species, alterations in the expression of some cell cycle-related proteins (cyclin b1, cdc25c, cdc2, p21) and some apoptosis-related proteins (bax, parp, bcl-2, caspase3). |
2018-02-02 |
2023-08-13 |
human |
| Hui Teng, Qun Huang, Lei Che. Inhibition of cell proliferation and triggering of apoptosis by agrimonolide through MAP kinase (ERK and p38) pathways in human gastric cancer AGS cells. Food & function. vol 7. issue 11. 2018-02-01. PMID:27747355. |
in addition, it was found that agrimonolide-induced cell apoptosis was associated with the increase in the (bcl-2 associated x protein, bax)/(b-cell lymphoma-2, bcl-2) ratio and the activation of cleaved caspase-3. |
2018-02-01 |
2023-08-13 |
human |
| Hassan Nazari, Abolfazl Shirazi, Naser Shams-Esfandabadi, Azita Afzali, Ebrahim Ahmad. The effect of amniotic membrane stem cells as donor nucleus on gene expression in reconstructed bovine oocytes. The International journal of developmental biology. vol 60. issue 4-6. 2018-01-31. PMID:27389982. |
the expression pattern of genes involved in self-renewal and pluripotency (pou5f1, sox2, nanog), imprinting (igf2, igf2r), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), and apoptosis (bax, bcl2) were evaluated in nt and ivf derived embryos. |
2018-01-31 |
2023-08-13 |
cattle |
| Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yua. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutrition research (New York, N.Y.). vol 36. issue 11. 2018-01-31. PMID:27865619. |
in vitro studies showed that treatment of triple negative breast cancer (tnbc) mda-mb-231 cells with se-pfps (1) inhibited cell growth dose-dependently by arresting cells at g2 phase via inhibiting cdc25c-cyclinb1/cdc2 pathway; (2) caused apoptosis associated with increased p53, bax, puma and noxa, decreased bcl2, increased bax/bcl2 ratio and increased activities of caspases 3/9, suggesting its effect on p53-mediated cytochrome c-caspase pathway. |
2018-01-31 |
2023-08-13 |
mouse |
| Yuan Wang, Yan Wang, Gui-Rong L. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. vol 7. issue 32. 2018-01-30. PMID:27472391. |
silencing trpc1 or trpc3 countered the lysopc-induced increase of ca2+ influx and apoptosis, and the pro-apoptotic proteins bax and cleaved caspase-3 and decrease of the anti-apoptotic protein bcl-2 and the survival kinase pakt. |
2018-01-30 |
2023-08-13 |
human |
| Yuan Wang, Yan Wang, Gui-Rong L. TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells. Oncotarget. vol 7. issue 32. 2018-01-30. PMID:27472391. |
these results demonstrate the novel information that trpc1/trpc3 channels mediate lysopc-induced ca2+ influx and apoptosis via activating the pro-apoptotic proteins bax and cleaved caspase-3 and inhibiting the anti-apoptotic protein bcl-2 and the survival kinase pakt in human coronary artery smcs, which implies that trpc1/trc3 channels may be the therapeutic target of lysopc-induced disorders such as atherosclerosis. |
2018-01-30 |
2023-08-13 |
human |
| Bruna Isabela Biazi, Thalita Alves Zanetti, Adrivanio Baranoski, Amanda Cristina Corveloni, Mário Sérgio Mantovan. Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. Basic & clinical pharmacology & toxicology. vol 121. issue 4. 2018-01-30. PMID:28256105. |
rt-qpcr showed that c-ner down-regulated genes related to apoptosis (bak1, bax, capn1, casp8, casp9, parp1 and tp53), cell cycle (ccnd1, ccne1, cdk1 and cdk2), xenobiotic metabolism (cyp2d6 and cyp3a4) and paraptosis (igf1r receptor). |
2018-01-30 |
2023-08-13 |
human |
| Renato Franco, Giosuè Scognamiglio, Elena Valentino, Michela Vitiello, Antonio Luciano, Giuseppe Palma, Claudio Arra, Elvira La Mantia, Luigi Panico, Valentina Tenneriello, Antonello Pinto, Ferdinando Frigeri, Gaetana Capobianco, Gerardo Botti, Laura Cerchia, Annarosaria De Chiara, Monica Fedel. PATZ1 expression correlates positively with BAX and negatively with BCL6 and survival in human diffuse large B cell lymphomas. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27494852. |
therefore, we propose patz1 as a new prognostic marker of dlbcls, which may act as a tumor suppressor by enhancing apoptosis through inhibiting and enhancing transcription of bcl6 and bax, respectively. |
2018-01-29 |
2023-08-13 |
mouse |
| Han Liu, Chunlei Yu, Tianjiao Xu, Xiaojie Zhang, Miaoxian Don. Synergistic protective effect of paeoniflorin and β-ecdysterone against rotenone-induced neurotoxicity in PC12 cells. Apoptosis : an international journal on programmed cell death. vol 21. issue 12. 2018-01-29. PMID:27688248. |
pf and β-ecd cooperate to attenuate the rotenone-induced apoptosis by decrease in bax expression, caspase-9 activity, and caspase-3 activity. |
2018-01-29 |
2023-08-13 |
Not clear |
| Quadri Afnan, Peerzada J Kaiser, Rather A Rafiq, Lone A Nazir, Shashi Bhushan, Subhash C Bhardwaj, Rajat Sandhir, Sheikh A Tasdu. Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway. Experimental dermatology. vol 25. issue 6. 2018-01-26. PMID:26836460. |
furthermore, ga inhibited uv-b-mediated apoptosis by attenuating translocation of bax from the cytosol to mitochondria, thus preserving mitochondrial integrity. |
2018-01-26 |
2023-08-13 |
mouse |