| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian Yang, Qi-Ming Zhong, Mei-Qing Song, Li-Guo Tong, Chong-Zhi Ba. Exosomes derived from Danshen decoction-pretreated bone marrow mesenchymal stem cells alleviate myocardial infarction via anti-apoptosis and up-regulation of autophagy. Heliyon. vol 10. issue 18. 2024-09-30. PMID:39347388. |
on the 7th, 14th and 28th days, serum ck, ldh, α-hbdh, alt, and ast were measured and electrocardiogram changes were monitored to identify cardiac function; triphenyltetrazolium chloride staining, hematein&eosin staining, masson trichrome staining and transmission electron microscope were adopted to analyze infarct area, cardiac morphology, histopathology, and fibrosis and cardiomyocyte ultrastructure; tunel assay, real-time pcr and western blot were performed to detect cardiomyocyte apoptosis and autophagy. |
2024-09-30 |
2024-10-02 |
rat |
| Alireza Shahmohammadi, Seyed-Mohamad-Sadegh Mirahmadi, Ali-Mohammad Rousta, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Protective effect of sinomenine against CCl4-induced acute liver injury through regulation of mitochondrial biogenesis. Naunyn-Schmiedeberg's archives of pharmacology. 2024-09-16. PMID:39283527. |
sinomenine pretreatment significantly lowered alt and ast, mda, il-6, apoptosis intensity, and tnf-α and restored mitochondrial biogenesis besides enhancement of sod, sirtuin-1, and ampk. |
2024-09-16 |
2024-09-19 |
Not clear |
| Hussam A Bukhari, Muhammad Afzal, Fahad A Al-Abbasi, Ryan A Sheikh, May M Alqurashi, Azizah Salim Bawadood, Sami I Alzarea, Abdulaziz Alamri, Nadeem Sayyed, Imran Kazm. In vivo and computational investigation of butin against alloxan-induced diabetes via biochemical, histopathological, and molecular interactions. Scientific reports. vol 14. issue 1. 2024-09-04. PMID:39232184. |
various diabetic parameters (blood glucose, insulin, hba1c), lipid profile, inflammatory (tnf-α, il-1β, il-6 and nf-κb), antioxidant enzymes (cat, sod and gsh), oxidative stress indicators (mda), apoptosis marker (caspase-3), hepatic markers (alt and ast), and histopathological changes were assessed. |
2024-09-04 |
2024-09-08 |
human |
| Xu Xiaomin, Lu Fang, Wang Yu, Liu Shumi. Investigation on the mechanism of hepatotoxicity of dictamnine on juvenile zebrafish by integrating metabolomics and transcriptomics. Gene. 2024-08-18. PMID:39154970. |
the results showed that the liver function indexes such as alt and ast were affected after the exposure treatment with dictamnine, and the hepatic damage, lipid droplet formation, and increased apoptosis were observed in zebrafish by he, oil red o(oro), and acridine orange hydrochloride(ao)staining. |
2024-08-18 |
2024-08-21 |
zebrafish |
| Xuan Shen, Wenxing Zheng, Xinna Du, Yuping Chen, Xianping Song, Liucai Yang, Qi Yua. The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH. Scientific reports. vol 14. issue 1. 2024-07-26. PMID:39060563. |
in vivo and in vitro experiments revealed that knocking down c5ar1 in liver significantly reduced liver weight ratio and serum alt and ast levels and attenuated inflammatory cell infiltration and cell apoptosis in the liver of nash mice as well as enhanced the efferocytotic ability of liver macrophages, suggesting that c5ar1 may play a crucial role in the efferocytosis of liver macrophages. |
2024-07-26 |
2024-07-29 |
mouse |
| Zhenkun Xiong, Zhenhua Li, Xueqin Sima, Zhi Zen. Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1/2-FOS pathway. Ecotoxicology and environmental safety. vol 281. 2024-07-04. PMID:38964056. |
ast, through its antioxidant action, was able to significantly reduce the increase in reactive oxygen species (ros) levels induced by tbph, the increased expression of apoptosis markers, and the activation of the erk1/2-fos signaling pathway, alleviating tbph-induced apoptosis in hippocampal neurons and improving neurobehavioral outcomes. |
2024-07-04 |
2024-07-11 |
mouse |
| Zhenkun Xiong, Zhenhua Li, Xueqin Sima, Zhi Zen. Astaxanthin reduces TBPH-induced neurobehavioral deficits in mice by the ROS-ERK1/2-FOS pathway. Ecotoxicology and environmental safety. vol 281. 2024-07-04. PMID:38964056. |
these findings suggest that ast may alleviate the neurotoxicity of tbph by modulating molecular events related to apoptosis and the erk1/2-fos signaling pathway. |
2024-07-04 |
2024-07-11 |
mouse |
| Hadis Elyasi, Masoud Ghanbari, Farshad Nadr. Investigation of the Adverse Health Effects of Cell Phone Radiation and Propose Solutions to Minimize Them: A Systematic Review. Indian journal of occupational and environmental medicine. vol 28. issue 1. 2024-05-24. PMID:38783888. |
the result revealed that exposure to cell phone radiation can lead to disturb in the metabolic activity of the cerebellum by increasing the migration of granulosa cells, decrease the water around the fetus in pregnant women, decrease in the number of blood plates, increasing levels of alt and ast that they are the key biomarkers of liver damage, decrease of phagocytosis and induced apoptosis of neutrophils, changes at the level of glucose and even at the microscopic level of pancreas this may be a predisposing factor for diabetes, increment in tissue temperature in all depth of the brain tissue, emf increase the volume, weight, and atresia follicles of the ovaries of the children, also it can cause oxidative stress, dna fragmentation, etc. |
2024-05-24 |
2024-05-27 |
Not clear |
| Xiao Zhang, Silong Yuan, Hui Fan, Wei Zhang, Honggang Zhan. Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner. Chemico-biological interactions. 2024-05-01. PMID:38692452. |
the results suggested that lie could decrease ast and alt levels in serum, ameliorate histopathological changes and inhibit cell apoptosis in mice with lps-induced septic liver injury. |
2024-05-01 |
2024-05-04 |
mouse |
| Zhi Qin, Min Zho. [Tanshinone Ⅱ_A inhibits ferroptosis via Nrf2 signaling pathway to protect liver in rats of non-alcoholic fatty liver disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 6. 2024-04-15. PMID:38621946. |
the result showed that tsⅡ_a significantly reduced the content of mda, ast, alt, tc, and tg in the serum, increased the activity of sod, decreased the apoptosis rate, lipid deposition, ros, and iron deposition in the liver tissue, up-regulated the expression of nrf2, ho-1, fsp1, gpx, and bcl-2, and inhibited the expression of bax in the liver tissue of nafld rats. |
2024-04-15 |
2024-04-18 |
rat |
| Qiwen Yu, Jiye Li, Mengwei Cui, Chaopeng Mei, Qianqian He, Xiaoxiao D. 6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway. Scientific reports. vol 14. issue 1. 2024-04-02. PMID:38565569. |
the results show that 6-gingerol decreased serum alanine aminotransferase (alt), aspartate aminotransferase (ast) levels, liver necrosis, inflammatory cytokines il-1β, il-6, mcp-1, tnf-α expression, ly6g+ inflammatory cell infiltration, protein phosphorylation of nf-κb signaling pathway, terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) positive cells, cell apoptosis rate, the protein expression of pro-apoptotic protein bax and c-caspase3, increased cell viability, and expression of anti-apoptotic protein bcl-2. |
2024-04-02 |
2024-04-05 |
mouse |
| Lidan Zhang, Ge Kuang, Xia Gong, Rui Huang, Zizuo Zhao, Yan Li, Jingyuan Wan, Bin Wan. Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice. Transplant immunology. 2024-03-14. PMID:38484898. |
the results showed that plasma aminotransferase (alt), aspartate aminotransferase (ast), hepatocyte apoptosis, oxidative stress, and inflammatory cell infiltration significantly increased in hiri mice. |
2024-03-14 |
2024-03-17 |
mouse |
| Ling Liu, Jun Liu, Junshuai Wang, Yu Chen, Gang Li. Ulinastatin protects against myocardial ischemia/reperfusion injury in rats via Rho/ROCK signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279430. |
the myocardial infarction area in the ir group was markedly larger than that in the c group (p<0.01) but was significantly reduced after ulinastatin treatment (p<0.05), and the ir group had higher levels of ast, ctni, ck-mb and ldh than c group, but the levels of those indexes were significantly reduced after ulinastatin treatment.the cardiomyocyte apoptosis was increased in the ir group compared with that in the c group, while it was decreased in the ur group in comparison with that in the ir group. |
2024-01-27 |
2024-01-29 |
rat |
| Chenglong Fei, Lei Liu, Hedong Qi, Yuyang Peng, Jingfen Han, Chunru Wang, Xue L. Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration. ACS applied materials & interfaces. 2024-01-24. PMID:38267397. |
the regulation of hepatic inflammation contributes to inhibiting inflammatory cytokines-induced hepatocyte apoptosis, decreasing the serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) contents and thus ameliorating immune-mediated hepatic injury. |
2024-01-24 |
2024-01-27 |
mouse |
| Min Wu, Xudong Liu, Qiwen Yu, Jihua Shi, Wenzhi Guo, Shuijun Zhan. Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway. European journal of pharmacology. 2023-12-18. PMID:38110141. |
serum alt and ast levels, and h&e staining were used to measure liver damage; mda content, superoxide dismutase and glutathione activities, and dihydroethidium staining were used to measure oxidative stress; mrna expression levels of tumor necrosis factor-α, interleukin(il)-1β, il-6, mcp-1, and ly6g staining were used to measure inflammatory response; and protein expression of bax, bcl-2, c-caspase3, and terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling staining were used to measure apoptosis. |
2023-12-18 |
2023-12-21 |
mouse |
| Yanli Zou, Ting Zhan, Jiaxi Liu, Jie Tan, Weijie Liu, Shasha Huang, Yisan Cai, Ming Huang, Xiaodong Huang, Xia Tia. CXCL6 promotes the progression of NAFLD through regulation of PPARα. Cytokine. vol 174. 2023-12-06. PMID:38056250. |
after transfecting nafld cells with sirna targeting cxcl6 (si-cxcl6), a series of functional experiments were carried out, and these data indicated that the inhibition of cxcl6 reduced intracellular lipid deposition, decreased ast, alt and tg level, facilitate cell proliferation and suppress their apoptosis. |
2023-12-06 |
2023-12-10 |
Not clear |
| Jingwen Yu, Bingtao Mu, Minfang Guo, Chunyun Liu, Tao Meng, Yuqing Yan, Lijuan Song, Jiezhong Yu, Gajendra Kumar, Cungen M. Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes. Folia neuropathologica. vol 61. issue 3. 2023-10-11. PMID:37818688. |
ast iv improved paralysis and pathology of eae by inhibiting the neurotoxic m1 microglia/macrophage phenotype, promoting m2 phenotype, shifting astrocytes towards a neuroprotective a2 phenotype, and protecting neurons from apoptosis through inhibition of tlr4/myd88/nf-kb signalling pathway. |
2023-10-11 |
2023-10-15 |
Not clear |
| Ming Chen, Jing Luo, Hongwu Ji, Wenkui Song, Di Zhang, Weiming Su, Shucheng Li. The Preventive Mechanism of Anserine on Tert-Butyl Hydroperoxide-Induced Liver Injury in L-02 Cells via Regulating the Keap1-Nrf2 and JNK-Caspase-3 Signaling Pathways. Marine drugs. vol 21. issue 9. 2023-09-27. PMID:37755089. |
the l-02 cells were pretreated with anserine (10, 20, and 40 mmol/l) and then induced with 400 μmol/l of tbhp for 4 h. the results showed that the survival rates of l-02 cells and the contents of gsh were significantly increased with the pretreatment of anserine; the activities of alanine aminotransferase (alt) and aspartate aminotransferase (ast) in the extracellular fluid were sharply decreased; and the formation of reactive oxygen species (ros), nuclear fragmentation, and apoptosis were significantly inhibited. |
2023-09-27 |
2023-10-07 |
human |
| Ning Liu, Xiaohong Lyu, Xianglin Zhang, Fan Zhang, Yiming Chen, Gang L. Astaxanthin attenuates cognitive deficits in Alzheimer's disease models by reducing oxidative stress via the SIRT1/PGC-1α signaling pathway. Cell & bioscience. vol 13. issue 1. 2023-09-14. PMID:37710272. |
therefore, this study aimed to investigate and validate the protective effect of ast on neuronal senescence and apoptosis caused by oxidative stress induced by aβ25-35 peptide, with the goal of preventing the onset of cognitive dysfunction. |
2023-09-14 |
2023-10-07 |
Not clear |
| Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wan. Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-12. PMID:37699317. |
in this study, we released that ast could attenuate cigarette smoke-induced dna damage and apoptosis in vivo and in vitro. |
2023-09-12 |
2023-10-07 |
mouse |