| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingfeng Guo, Yingying Lei, Liwei Liu, Zhenzhen Wen, Bo Zhang, Jincun Fang, Guohui Liang, Qikun Guo, Jing Pen. MHY1485 promotes adriamycin sensitivity in HepG2 cells by inhibiting autophagy. Functional & integrative genomics. vol 24. issue 1. 2024-02-02. PMID:38306005. |
the hepg2/adm cell line and hepg2 cells were treated with mhy1485 and adm, respectively, and the proliferation and apoptosis of hcc cells were detected using cck8, clone formation, flow cytometry, and 5-ethynyl-2'-deoxyuridine staining assays. |
2024-02-02 |
2024-02-04 |
Not clear |
| Peipei Wang, Shitong Min, Congliang Chen, Junmei Hu, Dapeng Wei, Xia Wan. Phytohemagglutinin from Phaseolus vulgaris enhances the lung cancer cell chemotherapy sensitivity by changing cell membrane permeability. Journal of natural medicines. 2024-01-24. PMID:38265611. |
our results demonstrated that the pha significantly enhanced the sensitivity of lung cancer cells to ddp and adm, and western blot showed that pha combined with ddp or adm enhance cytotoxic effects by inhibiting autophagy and promoting apoptosis. |
2024-01-24 |
2024-01-26 |
Not clear |
| Mengqi Li, Ting Li, Tingting Jin, Yi Chen, Lan Cheng, Qiheng Liang, Simiao Yan, Tingting Li, Qingzhen Ran, Wanqun Che. Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis. Molecular biology reports. 2023-10-25. PMID:37878207. |
t-box transcription factor 3(tbx3) is a transcription factor that can regulate cell proliferation, apoptosis, invasion, and migration in different tumor cells; however, its role in adenomyosis (adm) has not been previously studied. |
2023-10-25 |
2023-11-08 |
Not clear |
| Bowen Wu, Peng Li, Eryue Qiu, Jian Che. Metformin alleviates adriamycin resistance of osteosarcoma by declining YY1 to inhibit MDR1 transcriptional activity. BMC pharmacology & toxicology. vol 24. issue 1. 2023-10-12. PMID:37828612. |
met dramatically enhanced adm cytotoxicity and accelerated apoptosis of mg-63/adm cells. |
2023-10-12 |
2023-10-15 |
Not clear |
| Bei Xie, Lei Zhao, Zhewen Zhang, Cunmin Zhou, Ye Tian, Yingying Kang, Jing Chen, Hulai Wei, Linjing L. CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells. BMC cancer. vol 23. issue 1. 2023-10-09. PMID:37814227. |
our results furtherly proved that inhibition of mir-1246 could significantly enhance drug sensitivity to adriamycin (adm), induce cell cycle arrest at g0/g1 phase, promote cell apoptosis, and relieve its suppression on cadm1 in k562/adm and hl-60/rs cells. |
2023-10-09 |
2023-10-15 |
Not clear |
| Yongmei Yin, Yu Xin, Feng Zhang, Donghao An, Hui Fan, Mengyao Qin, Jinxin Xia, Tao Xi, Jing Xion. Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40. Neoplasia (New York, N.Y.). vol 39. 2023-03-17. PMID:36931039. |
overexpression of bhlhe40 resensitized resistant cells to adm, promoted cell apoptosis in vitro and suppressed tumor growth in vivo, whereas bhlhe40 knockdown induced resistance to adm in parental cells. |
2023-03-17 |
2023-08-14 |
human |
| Yanming Liu, Feiyue Zhang, Qi Sun, Lichao Lian. Adalimumab combined with erythropoietin improves recovery from spinal cord injury by suppressing microglial M1 polarization-mediated neural inflammation and apoptosis. Inflammopharmacology. 2023-01-15. PMID:36642757. |
hence, this study aimed to explore the effect of adm with or without erythropoietin (epo) on microglial polarization, neuroinflammation, neural apoptosis, and functional recovery in sci. |
2023-01-15 |
2023-08-14 |
Not clear |
| Cui Liu, Li Liu, Yanping Huang, Ruiming Shi, Yue Wu, Intan Hakimah Binti Ismai. Contribution of IL-33/ILC2-mediated Th2 cytokines during the progression of minimal change disease. International immunopharmacology. vol 114. 2022-12-17. PMID:36527879. |
it was found that pan-induced kidney jury, inflammation, oxidative stress and apoptosis were severer than adm, and il-33 treatment significantly alleviated the above injuries in pan and adm-induced mcd rat model. |
2022-12-17 |
2023-08-14 |
rat |
| Rania Nagi Abd-Ellatif, Nahla Anas Nasef, Hemat El-Sayed El-Horany, Marwa Nagy Emam, Reham Lotfy Younis, Rehab E Abo El Gheit, Walaa Elseady, Doaa A Radwan, Yasser Mostafa Hafez, Ahmad Eissa, Alshimaa Aboalsoud, Rania H Shalaby, Marwa Mohamed Ate. Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36498902. |
adm administration improved the biochemical parameters of dox-induced nephrotoxicity, significantly reduced oxidative damage markers and inflammatory mediators, and suppressed both apoptosis and pyroptosis. |
2022-12-11 |
2023-08-14 |
human |
| Jian-Hua Zhou, Xia-Lian Zhu, Ming-Yong Li, You-Wen Luo, Zhi-Min Yang, Li Wang, Tao Tong, Song-Lin Qin, Bo-Long Liu, Bing-Hai Chen, Wei H. Local adrenomedullin gene delivery inhibits Leydig cell dysfunction by rescuing steroidogenic enzymes in vivo. Andrologia. 2022-08-09. PMID:35942817. |
our previous studies demonstrated that adm exerts a restorative effect on steroidogenesis in lps-treated primary rat leydig cells by attenuating oxidative stress, inflammation and apoptosis. |
2022-08-09 |
2023-08-14 |
rat |
| Xiaobei Zhang, Xiaokun Wang, Xiaofeng Liu, Weihao Luo, Hongwei Zhao, Yiqing Yin, Kuibin X. Myocardial protection of propofol on apoptosis induced by anthracycline by PI3K/AKT/Bcl-2 pathway in rats. Annals of translational medicine. vol 10. issue 10. 2022-06-20. PMID:35722399. |
the aim of the study was to evaluate the protective effects of propofol on phosphatidylinositol 3 kinase/protein kinase b/b cell lymphoma 2 (pi3k/akt/bcl-2) pathway in cardiomyocyte apoptosis induced by doxorubicin [adriamycin (adm)] of rat cardiomyocytes |
2022-06-20 |
2023-08-14 |
rat |
| Michael P Marciel, Asmi Chakraborty, Nikita U Bhalerao, Susan L Belli. ST6Gal1 Contributes to Pancreatic Cancer Initiation by Promoting Pancreatitis-Induced Acinar to Ductal Metaplasia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552860. |
pancreatitis causes acinar cell apoptosis, however some cells undergo adm and acquire regenerative capabilities essential for tissue healing. |
2022-05-13 |
2023-08-13 |
mouse |
| Xiaoqin Jiang, Huizhen Li, Yu Fang, Chuanliang X. LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB-mediated p53 ubiquitination. Environmental toxicology. 2022-02-25. PMID:35213076. |
downregulation of pvt1 suppressed adm-resistant bc cell proliferation and invasion, promoted apoptosis, and increased sensitivity to adm, while pvt1 overexpression promoted adm-sensitive bc cell growth and their resistance to adm. further study uncovered that pvt1 could interact with and promote mouse double minute 2 (mdm2) expression, and upregulated mdm2-mediated aurora kinase b (aurkb). |
2022-02-25 |
2023-08-13 |
mouse |
| Meng Wang, Fan Zhan, Hui Cheng, Qinglin L. Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980780. |
cell viability test represented that gna could improve the sensitivity of hepatoma drug-resistant cell line bel-7402/adm to adriamycin (adm), and further study by 4',6-diamidino-2-phenylindole (dapi) staining and flow cytometry found that gna could improve the effect of adm on promoting apoptosis in bel-7402/adm cells, and the activation of apoptosis-related protein was significantly increased, and the ratio of bax to bcl-2 was significantly increased. |
2022-01-04 |
2023-08-13 |
Not clear |
| Meng Wang, Fan Zhan, Hui Cheng, Qinglin L. Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980780. |
gna inhibit protective autophagy in bel-7402/adm cells and promote the role of adm in inducing apoptosis, thereby increasing adm sensitivity to bel-7402/adm cells, and the effect of gna inhibition of autophagy may be achieved by inhibiting the degradation of autophagosomes. |
2022-01-04 |
2023-08-13 |
Not clear |
| Jingjing Chen, Peng Shi, Jinghua Zhang, Yufeng Li, Jie Ma, Yudong Zhang, Hong Li. CircRNA_0044556 diminishes the sensitivity of triple‑negative breast cancer cells to adriamycin by sponging miR‑145 and regulating NRAS. Molecular medicine reports. vol 25. issue 2. 2021-12-16. PMID:34913063. |
following adm treatment, the effects of circrna_0044556 on the viability, adm resistance, apoptosis and migration of tnbc cells were investigated by cell function experiments (cell counting kit‑8, flow cytometry and transwell assays). |
2021-12-16 |
2023-08-13 |
Not clear |
| Jing Ke, Kan Ni, Huimin Xue, Jia L. RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells. Oncology letters. vol 23. issue 1. 2021-12-07. PMID:34868364. |
in addition, the results of the mtt assay revealed that the overexpression of rbm38 enhanced the resistance of mcf-7/a cells to adm, promoted invasiveness, as determined using a transwell assay, inhibited the apoptosis of resistant cells, as determined using flow cytometry, and accelerated cell cycle progression from the g |
2021-12-07 |
2023-08-13 |
Not clear |
| Jie Ding, Xiaochun Zhang, Jianan Xue, Le Fang, Chunmei Ban, Bin Song, Lili W. CircNPM1 strengthens Adriamycin resistance in acute myeloid leukemia by mediating the miR-345-5p/FZD5 pathway. Central-European journal of immunology. vol 46. issue 2. 2021-11-13. PMID:34764785. |
circnpm1 silence or mir-345-5p restoration repressed colony formation, cell migration and invasion, contributed to cell apoptosis and cell cycle arrest, and weakened adriamycin (adm) resistance of aml cells. |
2021-11-13 |
2023-08-13 |
Not clear |
| Zheng-Xiao Ouyang, Xian-An L. Inhibitory effects of tamoxifen and doxorubicin, alone and in combination, on the proliferation of the MG63 human osteosarcoma cell line. Oncology letters. vol 6. issue 4. 2021-10-21. PMID:24137447. |
the combination of tam and adm significantly enhanced the inhibitory effect, partly through the enhanced sensitivity of the cells to adm by tam, which caused the inhibition of cell proliferation and apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Zhijun Wuxiao, Hua Wang, Qunhao Su, Haiyan Zhou, Min Hu, Shi Tao, Lu Xu, Yu Chen, Xinbao Ha. MicroRNA‑145 promotes the apoptosis of leukemic stem cells and enhances drug‑resistant K562/ADM cell sensitivity to adriamycin via the regulation of ABCE1. International journal of molecular medicine. vol 46. issue 4. 2021-06-29. PMID:32945355. |
taken together, the findings of the present study demonstrate that the overexpression of mir‑145 promotes leukemic stem cell apoptosis and enhances the sensitivity of k562/adm cells to adm by inhibiting abce1. |
2021-06-29 |
2023-08-13 |
Not clear |