All Relations between TDP-43 Proteinopathies and prosencephalon

Publication Sentence Publish Date Extraction Date Species
Julio A Alfieri, Natalia S Pino, Lionel M Iga. Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 46. 2015-02-09. PMID:25392493. we have previously shown in mice that inducible overexpression of a cytoplasmically localized form of tdp-43 (tdp-43-\xce\x94nls) in forebrain neurons evokes neuropathological changes that recapitulate several features of tdp-43 proteinopathies. 2015-02-09 2023-08-13 mouse
Ashley Cannon, Baoli Yang, Joshua Knight, Ian M Farnham, Yongjie Zhang, Charles A Wuertzer, Simon D'Alton, Wen-lang Lin, Monica Castanedes-Casey, Linda Rousseau, Brittany Scott, Michael Jurasic, John Howard, Xin Yu, Rachel Bailey, Matthew R Sarkisian, Dennis W Dickson, Leonard Petrucelli, Jada Lewi. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22539017. these results suggest that neurons in the developing forebrain are extremely sensitive to tdp-43 overexpression and that timing of tdp-43 overexpression in transgenic mice must be considered when distinguishing normal roles of tdp-43, particularly as they relate to development, from its pathogenic role in ftld-tdp and other tdp-43 proteinopathies. 2012-09-24 2023-08-12 mouse