| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
moreover, by comparing single filament to paired filament structures within tauopathies we find a consistent change in the side-chain orientations with respect to the alpha carbon atoms at the area of interaction. |
2024-03-30 |
2024-04-02 |
Not clear |
| Goonho Park, Ke Xu, Leon Chea, Kyle Kim, Lance Safarta, Keon-Hyoung Song, Jian Wu, Soyoung Park, Hyejung Min, Nobuhiko Hiramatsu, Jaeseok Han, Jonathan H Li. Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation. The Journal of biological chemistry. 2022-12-23. PMID:36563857. |
population studies implicate eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3), better known as perk (protein kinase r-like endoplasmic reticulum kinase), as a genetic risk factor in several tauopathies. |
2022-12-23 |
2023-08-14 |
Not clear |
| Shauna H Yuan, Nobuhiko Hiramatsu, Qing Liu, Xuehan Victoria Sun, David Lenh, Priscilla Chan, Karen Chiang, Edward H Koo, Aimee W Kao, Irene Litvan, Jonathan H Li. Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Human molecular genetics. vol 27. issue 22. 2019-05-09. PMID:30137327. |
eif2ak3 (eukaryotic translation initiation factor 2 alpha kinase 3), also known as perk (protein kinase r-like endoplasmic reticulum kinase), was identified by genome-wide association study as a genetic risk factor in several tauopathies. |
2019-05-09 |
2023-08-13 |
human |
| Jean-Marie Sontag, Viyada Nunbhakdi-Craig, Lisa Montgomery, Erland Arning, Teodoro Bottiglieri, Estelle Sonta. Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 45. 2008-12-31. PMID:18987184. |
our results suggest that counteracting the neuronal loss of lcmt-1 and b(alpha) could be beneficial for all tauopathies and folate-dependent disorders of the cns. |
2008-12-31 |
2023-08-12 |
mouse |