All Relations between Tauopathies and Synucleinopathies

Publication Sentence Publish Date Extraction Date Species
Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. 2024-05-06 2024-05-08 mouse
Wen Li, Jia-Yi L. Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration. Translational neurodegeneration. vol 13. issue 1. 2024-03-26. PMID:38528629. we and other researchers have sequentially shown the cross-seeding phenomenon of α-synuclein (α-syn) and tau, reinforcing pathologies between synucleinopathies and tauopathies. 2024-03-26 2024-03-28 Not clear
Mingyue Jin, Shengming Wang, Xiaodie Gao, Zhenyou Zou, Shinji Hirotsune, Liyuan Su. Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843221. interestingly, the co-occurrence of α-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies, some of which share similarities in clinical manifestations. 2023-10-16 2023-11-08 mouse
Ana Ojeda, Valentina Cofré, Francisco Melo, Leonardo Caballero, Denis Fuentealba, Alberto Cornej. α-synuclein drives tau´s cytotoxic aggregates formation through hydrophobic interactions. ChemPlusChem. 2023-09-14. PMID:37708459. tau and α-synuclein are proteins involved in pathologies known as tauopathies and synucleinopathies, respectively. 2023-09-14 2023-10-07 Not clear
Nahuel N Foressi, Leandro Cruz Rodríguez, M Soledad Cele. Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies. Biochimica et biophysica acta. Proteins and proteomics. 2023-08-13. PMID:37574035. tauopathies and synucleinopathies are characterized by the aggregation of tau and α-synuclein (as) into amyloid structures, respectively. 2023-08-13 2023-08-16 Not clear
Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). 2023-07-10 2023-08-14 Not clear
Yixiang Jiang, Yan Lin, Senthilkumar Krishnaswamy, Ruimin Pan, Qian Wu, Leslie A Sandusky-Beltran, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Erin E Congdon, Einar M Sigurdsso. Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology. Science advances. vol 9. issue 19. 2023-05-10. PMID:37163602. intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. 2023-05-10 2023-08-14 mouse
Jolien Perneel, Manuela Neumann, Bavo Heeman, Simon Cheung, Marleen Van den Broeck, Sarah Wynants, Matt Baker, Cristina T Vicente, Júlia Faura, Rosa Rademakers, Ian R A Mackenzi. Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging. Acta neuropathologica. 2022-12-17. PMID:36527486. accumulation of tmem106b c-terminal immunoreactive (tmem-ir) material was a common finding in all the conditions evaluated, including frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp), alzheimer's disease, tauopathies, synucleinopathies and neurologically normal aging. 2022-12-17 2023-08-14 human
Shunsuke Koga, Keith A Josephs, Ikuko Aiba, Mari Yoshida, Dennis W Dickso. Neuropathology and emerging biomarkers in corticobasal syndrome. Journal of neurology, neurosurgery, and psychiatry. 2022-06-13. PMID:35697501. corticobasal degeneration (cbd) is one of the most common underlying pathologies of cbs, but other disorders, such as progressive supranuclear palsy (psp), alzheimer's disease (ad) and frontotemporal lobar degeneration with tdp-43 inclusions, are also associated with this syndrome.in this review, we describe common and rare neuropathological findings in cbs, including tauopathies, synucleinopathies, tdp-43 proteinopathies, fused in sarcoma proteinopathy, prion disease (creutzfeldt-jakob disease) and cerebrovascular disease, based on a narrative review of the literature and clinicopathological studies from two brain banks. 2022-06-13 2023-08-14 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. tau and mapt genetics in tauopathies and synucleinopathies. 2021-10-11 2023-08-13 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. abnormal tau can also be observed in secondary tauopathies such as alzheimer's disease (ad) and synucleinopathies such as parkinson's disease (pd). 2021-10-11 2023-08-13 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. mapt variations are a cause or risk factors for many tauopathies and synucleinopathies and are associated with certain clinical and pathological features in affected individuals. 2021-10-11 2023-08-13 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. understanding the role of mapt variations in tauopathies and synucleinopathies is therefore essential to elucidate the role of tau in the pathogenesis and phenotype of those disorders, and ultimately to develop targeted therapies. 2021-10-11 2023-08-13 Not clear
Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. in this review, we describe the role of mapt genetic variations in tauopathies and synucleinopathies, several genotype-phenotype and pathological features, and discuss their implications for the classification and treatment of those disorders. 2021-10-11 2023-08-13 Not clear
Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. thus, the tau + α-synuclein copolymer fibrils show robust transmission properties preferentially in rodent model of tauopathies but not in synucleinopathy, probably signifying an enhanced cooperative relationship between tau and α-synuclein in the tau seeding process. 2021-08-07 2023-08-13 mouse
Lindsay E Stoyka, Casey L Mahoney, Drake R Thrasher, Drèson L Russell, Anna K Cook, Anner T Harris, Ashwin Narayanan, Tiara P Janado, David G Standaert, Erik D Roberson, Laura A Volpicelli-Dale. Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33972291. reducing endogenous tau levels is protective in multiple models of alzheimer's disease (ad), tauopathies, and in some transgenic synucleinopathy mouse models. 2021-07-02 2023-08-13 mouse
Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeir. Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31105524. the coexistence of asyn and tau aggregates suggests a strong overlap between tauopathies and synucleinopathies. 2020-10-01 2023-08-13 Not clear
Elena Rodriguez-Vieitez, Henrietta M Nielse. Associations Between APOE Variants, Tau and α-Synuclein. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096038. while tau is a hallmark of alzheimer's disease (ad) and other non-ad tauopathies, and α-synuclein is the pathological feature of the spectrum of synucleinopathies including parkinson's disease (pd), parkinson's disease with dementia (pdd) and dementia with lewy bodies (dlb), the presence of co-pathologies is very frequent in all these diseases. 2020-04-08 2023-08-13 human
Alon Seifan, Christine A Ganzer, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R Jacobs, Molly Greenwald, Richard S Isaacso. Detecting Non-cognitive Features of Prodromal Neurodegenerative Diseases. Current aging science. vol 11. issue 4. 2020-03-30. PMID:30845903. prodromal neurodegenerative disease (nd) due to tauopathies such as alzheimer's disease (ad) and synucleinopathies (sn) such as parkinson's disease (pd) and dementia with lewy bodies (dlb) present subtly. 2020-03-30 2023-08-13 Not clear
Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousse. Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces. Scientific reports. vol 8. issue 1. 2019-11-20. PMID:30018327. α-synuclein fibrillar polymorphs, tau and aß 1-42 fibrillar assemblies have been shown to propagate, amplify and trigger the formation of protein deposits reminiscent of those present within the central nervous system of patients developing synucleinopathies, tauopathies and amyloid plaques after injection intracerebrally, intramuscularly, intraperitoneally or within the blood stream of model animals. 2019-11-20 2023-08-13 Not clear