| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhijiang Gu, Shaoxun Li, Jiyu Liu, Xiaotian Zhang, Cong Pang, Lianshu Ding, Changchun Ca. Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke. Biochemical and biophysical research communications. vol 724. 2024-06-08. PMID:38851140. |
protection of blood-brain barrier by endothelial dapk1 deletion after stroke. |
2024-06-08 |
2024-06-11 |
Not clear |
| Jinyoung Won, Seunghoon Lee, Zeeshan Ahmad Khan, Jeonghyun Choi, Tae Ho Lee, Yonggeun Hon. Suppression of DAPK1 reduces ischemic brain injury through inhibiting cell death signaling and promoting neural remodeling. Brain research. 2023-09-24. PMID:37742938. |
this research shows that dapk1 drives cell death, its activation exacerbates functional recovery after cerebral ischemia and shows that oxazolone-based di could be an excellent candidate for stroke and ischemic injury intervention. |
2023-09-24 |
2023-10-07 |
mouse |
| Priti Talwar, Pratibha Singh, Palaniyandi Ravana. Structure-Based Virtual Screening and Discovery of New Bi-functional DAPK1 Inhibitors. Molecular biotechnology. 2023-06-23. PMID:37351834. |
recently, a new signaling complex death-associated protein kinase 1 (dapk1)-n-methyl d-aspartate receptor subtype 2b (nr2b) engaged in the neuronal death cascade was identified where it was found that after stroke injury, n-methyl-d-aspartate glutamate (nmda) receptors interact with dapk1 through nr2b subunit and lead to excitotoxicity via overactivation of nmda receptors. |
2023-06-23 |
2023-08-14 |
Not clear |
| Tayebeh Noori, Samira Shirooie, Antoni Sureda, Eduardo Sobarzo-Sanchez, Ahmad Reza Dehpour, Marianela Saldías, Esra Küpeli Akko. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochemical research. 2022-06-08. PMID:35674928. |
dysregulation of dapk1 in the brain is involved in the developing neurological diseases such as stroke. |
2022-06-08 |
2023-08-14 |
human |
| Tayebeh Noori, Samira Shirooie, Antoni Sureda, Eduardo Sobarzo-Sanchez, Ahmad Reza Dehpour, Marianela Saldías, Esra Küpeli Akko. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochemical research. 2022-06-08. PMID:35674928. |
due to the role of dapk1 in neurological disorders, the aim of this article was to investigate the role of dapk1 in stroke and its modulation by natural compounds. |
2022-06-08 |
2023-08-14 |
human |
| Tayebeh Noori, Samira Shirooie, Antoni Sureda, Eduardo Sobarzo-Sanchez, Ahmad Reza Dehpour, Marianela Saldías, Esra Küpeli Akko. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochemical research. 2022-06-08. PMID:35674928. |
regulation of dapk1 by natural products: an important target in treatment of stroke. |
2022-06-08 |
2023-08-14 |
human |
| Tayebeh Noori, Samira Shirooie, Antoni Sureda, Eduardo Sobarzo-Sanchez, Ahmad Reza Dehpour, Marianela Saldías, Esra Küpeli Akko. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochemical research. 2022-06-08. PMID:35674928. |
natural products can function in a variety of ways, including reducing cerebral edema, reducing brain endothelial cell death, and inhibiting tnfα and interleukin-1β (il-1β) through regulating the dapk1 signal against stroke. |
2022-06-08 |
2023-08-14 |
human |
| Shan Wang, Keng Chen, Jia Yu, Xiaojiao Wang, Qiang Li, Fei Lv, Huiyong Shen, Lei Pe. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Experimental neurology. vol 329. 2020-12-24. PMID:32277960. |
although the substrates of dapk1 and molecular signal in stroke have been gradually discovered, the modulation of dapk1 itself is still unclear. |
2020-12-24 |
2023-08-13 |
mouse |
| Ying Su, Man-Fei Deng, Wan Xiong, Ao-Ji Xie, Jifeng Guo, Zhi-Hou Liang, Bo Hu, Jian-Guo Chen, Xiongwei Zhu, Heng-Ye Man, Youming Lu, Dan Liu, Beisha Tang, Ling-Qiang Zh. MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease. Biological psychiatry. vol 85. issue 9. 2020-03-30. PMID:30718039. |
death-associated protein kinase 1 (dapk1) is a widely distributed serine/threonine kinase that is critical for cell death in multiple neurological disorders, including alzheimer's disease and stroke. |
2020-03-30 |
2023-08-13 |
Not clear |
| Pratibha Singh, Priti Talwa. Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN) substrate recognition motifs. Journal of molecular graphics & modelling. vol 77. 2018-07-24. PMID:28858643. |
recently, a new signaling complex death associated protein kinase 1 (dapk1) ̶ n-methyl-d-aspartate receptor subtype 2b (nmdar2b or nr2b) engaged in the neuronal death cascade was identified and it was found that after stroke injury, n-methyl-d-aspartate glutamate (nmda) receptors interact with dapk1 through nr2b subunit and lead to excitotoxicity via over-activation of nmda receptors. |
2018-07-24 |
2023-08-13 |
Not clear |
| Shan Wang, Xiangde Shi, Hao Li, Pei Pang, Lei Pei, Huiyong Shen, Youming L. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Molecular neurobiology. vol 54. issue 6. 2018-04-09. PMID:27447806. |
dapk1 signaling pathways in stroke: from mechanisms to therapies. |
2018-04-09 |
2023-08-13 |
Not clear |
| Lei Pei, Shan Wang, Huijuan Jin, Linlin Bi, Na Wei, Honglin Yan, Xin Yang, Chengye Yao, Mengmeng Xu, Shu Shu, Yu Guo, Huanhuan Yan, Jianhua Wu, Hao Li, Pei Pang, Tian Tian, Qing Tian, Ling-Qiang Zhu, You Shang, Youming L. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:25995053. |
we found that dapk1 phosphorylates tau protein at ser262 (ps(262)) in cortical neurons of stroke mice. |
2016-07-18 |
2023-08-13 |
mouse |
| Lei Pei, Shan Wang, Huijuan Jin, Linlin Bi, Na Wei, Honglin Yan, Xin Yang, Chengye Yao, Mengmeng Xu, Shu Shu, Yu Guo, Huanhuan Yan, Jianhua Wu, Hao Li, Pei Pang, Tian Tian, Qing Tian, Ling-Qiang Zhu, You Shang, Youming L. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:25995053. |
a novel mechanism of spine damages in stroke via dapk1 and tau. |
2016-07-18 |
2023-08-13 |
mouse |
| Lei Pei, Shan Wang, Huijuan Jin, Linlin Bi, Na Wei, Honglin Yan, Xin Yang, Chengye Yao, Mengmeng Xu, Shu Shu, Yu Guo, Huanhuan Yan, Jianhua Wu, Hao Li, Pei Pang, Tian Tian, Qing Tian, Ling-Qiang Zhu, You Shang, Youming L. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:25995053. |
here, we report that a direct interaction of dapk1 with tau causes spine loss and subsequently neuronal death in a mouse model with stroke. |
2016-07-18 |
2023-08-13 |
mouse |
| Lei Pei, Shan Wang, Huijuan Jin, Linlin Bi, Na Wei, Honglin Yan, Xin Yang, Chengye Yao, Mengmeng Xu, Shu Shu, Yu Guo, Huanhuan Yan, Jianhua Wu, Hao Li, Pei Pang, Tian Tian, Qing Tian, Ling-Qiang Zhu, You Shang, Youming L. A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 11. 2016-07-18. PMID:25995053. |
either genetic deletion of dapk1 kinase domain (kd) in mice (dapk1-kd(-/-)) or blocking dapk1-tau interaction by systematic application of a membrane permeable peptide protects spine damages and improves neurological functions against stroke insults. |
2016-07-18 |
2023-08-13 |
mouse |
| Xiaoxi Wang, Lei Pei, Honglin Yan, Zhongping Wang, Na Wei, Shan Wang, Xin Yang, Qing Tian, Youming L. Intervention of death-associated protein kinase 1-p53 interaction exerts the therapeutic effects against stroke. Stroke. vol 45. issue 10. 2015-01-26. PMID:25139875. |
death-associated protein kinase 1 (dapk1) interacts with the tumor suppressor gene p53 via a direct binding of a death domain of dapk1 to a dna-binding motif (dm) of p53 (p53dm) and converges multiple cell death pathways in stroke. |
2015-01-26 |
2023-08-13 |
Not clear |
| Weihong Tu, Xin Xu, Lisheng Peng, Xiaofen Zhong, Wenfeng Zhang, Mangala M Soundarapandian, Cherine Balel, Manqi Wang, Nali Jia, Wen Zhang, Frank Lew, Sic Lung Chan, Yanfang Chen, Youming L. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. vol 140. issue 2. 2010-02-25. PMID:20141836. |
dapk1 interaction with nmda receptor nr2b subunits mediates brain damage in stroke. |
2010-02-25 |
2023-08-12 |
mouse |
| Weihong Tu, Xin Xu, Lisheng Peng, Xiaofen Zhong, Wenfeng Zhang, Mangala M Soundarapandian, Cherine Balel, Manqi Wang, Nali Jia, Wen Zhang, Frank Lew, Sic Lung Chan, Yanfang Chen, Youming L. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. vol 140. issue 2. 2010-02-25. PMID:20141836. |
thus, dapk1 physically and functionally interacts with the nmda receptor nr2b subunit at extrasynaptic sites and this interaction acts as a central mediator for stroke damage. |
2010-02-25 |
2023-08-12 |
mouse |