| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Lin, Pengzhang Zhao, Guangchi Sun, Ning Liu, Jing J. SCG2 mediates blood-brain barrier dysfunction and schizophrenia-like behaviors after traumatic brain injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 17. 2024-09-03. PMID:39225388. |
furthermore, astrocytic scg2 knockout in the frontal cortex reduced bbb damage, mitigated inflammation, and inhibited schizophrenia after tbi. |
2024-09-03 |
2024-09-05 |
Not clear |
| Jan Postberg, Michèle Tina Schubert, Vincent Nin, Lukas Wagner, Martina Piefk. A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review. Neurogenetics. 2024-07-05. PMID:38967831. |
studies that met inclusion criteria were scrutinized, focusing on those with large sample sizes, analyses of both brain tissue and blood samples, investigation of frontal cortex markers, and a specific emphasis on schizophrenia and depressive disorders. |
2024-07-05 |
2024-07-11 |
human |
| Jan Postberg, Michèle Tina Schubert, Vincent Nin, Lukas Wagner, Martina Piefk. A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders - a systematic review. Neurogenetics. 2024-07-05. PMID:38967831. |
studies characterized by extensive sample sizes, analysis of brain tissue and blood samples, assessment of frontal cortex markers, and a focus on schizophrenia and depressive disorders yielded particularly noteworthy results. |
2024-07-05 |
2024-07-11 |
human |
| Bohan Zhu, Richard I Ainsworth, Zengmiao Wang, Zhengzhi Liu, Salvador Sierra, Chengyu Deng, Luis F Callado, J Javier Meana, Wei Wang, Chang Lu, Javier González-Maes. Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia. eLife. vol 12. 2024-04-23. PMID:38648100. |
antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia. |
2024-04-23 |
2024-04-26 |
human |
| Jennifer A Cale, Ethan J Chauhan, Joshua J Cleaver, Anthoio R Fusciardi, Sophie McCann, Hannah C Waters, Juš Žavbi, Madeleine V Kin. GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular neurobiology. 2024-02-16. PMID:38363536. |
gabaergic and inflammatory changes in the frontal cortex following neonatal pcp plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. |
2024-02-16 |
2024-02-18 |
rat |
| Smita Sahay, Nicholas Daniel Henkel, Christina Flora-Anabelle Vargas, Robert Erne McCullumsmith, Sinead Marie O'Donova. Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia. Brain sciences. vol 14. issue 1. 2024-01-22. PMID:38248228. |
activity of protein kinase a in the frontal cortex in schizophrenia. |
2024-01-22 |
2024-01-24 |
human |
| Smita Sahay, Nicholas Daniel Henkel, Christina Flora-Anabelle Vargas, Robert Erne McCullumsmith, Sinead Marie O'Donova. Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia. Brain sciences. vol 14. issue 1. 2024-01-22. PMID:38248228. |
specifically, 3'-5'-cyclic adenosine monophosphate (camp)-associated signaling pathways are coupled to the activation of neurotransmitter receptors and modulate cellular functions through the activation of protein kinase a (pka), an enzyme whose function is altered in the frontal cortex in schizophrenia. |
2024-01-22 |
2024-01-24 |
human |
| Brian Dean, James Duce, Qiao-Xin Li, Colin L Masters, Elizabeth Scar. Lower levels of soluble β-amyloid precursor protein, but not β-amyloid, in the frontal cortex in schizophrenia. Psychiatry research. vol 331. 2023-12-10. PMID:38071879. |
lower levels of soluble β-amyloid precursor protein, but not β-amyloid, in the frontal cortex in schizophrenia. |
2023-12-10 |
2023-12-17 |
Not clear |
| Rinako Tanaka, Kiyofumi Yamad. Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a Novel Drug Target. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958606. |
schizophrenia is one of the most serious psychiatric disorders and is characterized by reductions in both brain volume and spine density in the frontal cortex. |
2023-11-14 |
2023-11-20 |
mouse |
| Lejia Fan, Liangbing Liang, Yujue Wang, Xiaoqian Ma, Liu Yuan, Lijun Ouyang, Ying He, Zongchang Li, Chunwang Li, Xiaogang Chen, Lena Palaniyappa. Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-09-26. PMID:37752221. |
a subgroup of patients with schizophrenia is believed to have aberrant excess of glutamate in the frontal cortex; this subgroup is thought to show poor response to first-line antipsychotic treatments that focus on dopamine blockade. |
2023-09-26 |
2023-10-07 |
Not clear |
| Francesco Matriscian. Epigenetic regulation of metabotropic glutamate 2/3 receptors: Potential role for ultra-resistant schizophrenia? Pharmacology, biochemistry, and behavior. 2023-06-22. PMID:37348609. |
an epigenetic animal model of schizophrenia showed specific changes in promoter dna methylation activity of genes related to schizophrenia such as reelin, bdnf and gad67, and altered expression and function of mglu2/3 receptors in the frontal cortex. |
2023-06-22 |
2023-08-14 |
Not clear |
| Hiroki Shiwaku, Shingo Katayama, Mengxuan Gao, Kanoh Kondo, Yuri Nakano, Yukiko Motokawa, Saori Toyoda, Fuyuko Yoshida, Hiroaki Hori, Tetsuo Kubota, Kinya Ishikawa, Hiroshi Kunugi, Yuji Ikegaya, Hitoshi Okazawa, Hidehiko Takahash. Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia. Brain, behavior, and immunity. 2023-04-02. PMID:37004758. |
administration of anti-nrxn1α autoantibodies from patients with schizophrenia into the cerebrospinal fluid of mice reduced the number of spines/synapses in the frontal cortex and induced schizophrenia-related behaviors such as reduced cognition, impaired pre-pulse inhibition, and reduced social novelty preference. |
2023-04-02 |
2023-08-14 |
mouse |
| Xiaojian Jia, Jianhong Wang, Wentao Jiang, Zhi Kong, Huan Deng, Wentao Lai, Caihong Ye, Fen Guan, Peng Li, Min Zhao, Mei Yan. Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia. NeuroImage. Clinical. vol 36. 2022-12-13. PMID:36510408. |
common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia. |
2022-12-13 |
2023-08-14 |
Not clear |
| Rawan Alnafisah, Anna Lundh, Sophie M Asah, Julie Hoeflinger, Alyssa Wolfinger, Abdul-Rizaq Hamoud, Robert E McCullumsmith, Sinead M O'Donova. Altered purinergic receptor expression in the frontal cortex in schizophrenia. Schizophrenia (Heidelberg, Germany). vol 8. issue 1. 2022-11-14. PMID:36376358. |
altered purinergic receptor expression in the frontal cortex in schizophrenia. |
2022-11-14 |
2023-08-14 |
human |
| Alejandro Carrasco-Poves, Silvia Ruiz-Espana, Claudia Regio Brambilla, Irene Neuner, Ravichandran Rajkumar, Shukti Ramkiran, Christoph Lerche, David Morata. Analysis of New Biomarkers for the Study of Schizophrenia Following a Radiomics Approach on MR and PET Imaging. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2022. 2022-09-10. PMID:36086347. |
the precision results were obtained classifying schizophrenia both in mr images (89% area under the curve (auc) in the posterior cingulate cortex) and with pet images (82% auc in the frontal cortex), being linear svm and naive bayes the classification models with the highest predictive power. |
2022-09-10 |
2023-08-14 |
human |
| Hiroki Shiwaku, Shingo Katayama, Kanoh Kondo, Yuri Nakano, Hikari Tanaka, Yuki Yoshioka, Kyota Fujita, Haruna Tamaki, Hironao Takebayashi, Omi Terasaki, Yukihiro Nagase, Teruyoshi Nagase, Tetsuo Kubota, Kinya Ishikawa, Hitoshi Okazawa, Hidehiko Takahash. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell reports. Medicine. vol 3. issue 4. 2022-05-02. PMID:35492247. |
furthermore, the anti-ncam1 antibody purified from patients with schizophrenia interrupts ncam1-fyn interaction and inhibits phosphorylation of fak, mek1, and erk1 when introduced into the cerebrospinal fluid of mice and also reduces the number of spines and synapses in frontal cortex. |
2022-05-02 |
2023-08-13 |
mouse |
| Qianjin Wang, Honghong Ren, Chunwang Li, Zongchang Li, Jinguang Li, Hong Li, Lulin Dai, Min Dong, Jun Zhou, Jingqi He, Joseph O'Neill, Yanhui Liao, Ying He, Tieqiao Liu, Xiaogang Chen, Jinsong Tan. Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a Translational psychiatry. vol 12. issue 1. 2022-03-24. PMID:35322015. |
metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a studies of schizophrenia (scz) have associated auditory verbal hallucinations (avh) with structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex (mpfc). |
2022-03-24 |
2023-08-13 |
Not clear |
| Julio Rodriguez-López, Manuel Arrojo, Eduardo Paz, Mario Páramo, Javier Costa. Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31715283. |
to this goal, we predicted frontal cortex gene expression in one discovery sample, the largest gwas of schizophrenia from the psychiatric genomics consortium, using s-predixcan, and in one target sample, consisting of 625 schizophrenic patients and 819 controls from spain, using predixcan. |
2021-11-22 |
2023-08-13 |
Not clear |
| Xiaohui Wu, Junping Ye, Zhongju Wang, Cunyou Zha. Epigenetic Age Acceleration Was Delayed in Schizophrenia. Schizophrenia bulletin. vol 47. issue 3. 2021-11-22. PMID:33269797. |
furthermore, we observed that epigenetic age acceleration was significantly delayed in schizophrenia from the whole blood samples (aged 20-90 years) and brain frontal cortex tissues (aged 20-39 years). |
2021-11-22 |
2023-08-13 |
Not clear |
| Manuela R Kouakou, Darren Cameron, Eilis Hannon, Emma L Dempster, Jonathan Mill, Matthew J Hill, Nicholas J Bra. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 186. issue 6. 2021-11-10. PMID:34632689. |
here, we have used the assay for transposase-accessible chromatin with high-throughput sequencing (atac-seq) to map open chromatin (an index of active regulatory genomic regions) in bulk tissue, neun+ and neun- nuclei from the prenatal human frontal cortex, and tested enrichment of single-nucleotide polymorphism (snp) heritability for five neuropsychiatric disorders (autism spectrum disorder, attention deficit hyperactivity disorder [adhd], bipolar disorder, major depressive disorder, and schizophrenia) within these regions. |
2021-11-10 |
2023-08-13 |
human |