| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tongyi Zhang, Xin Zhao, B T Thomas Yeo, Xiaoning Huo, Simon B Eickhoff, Ji Che. Leveraging Stacked Classifiers for Multi-task Executive Function in Schizophrenia Yields Diagnostic and Prognostic Insights. medRxiv : the preprint server for health sciences. 2024-12-16. PMID:39677485. |
ef assessments of inhibitory control (interference and response inhibitions), followed by working memory, evidently predicted schizophrenia diagnosis (area under the curve [auc]=0.87) and remission status (auc=0.81). |
2024-12-16 |
2024-12-21 |
Not clear |
| Tongyi Zhang, Xin Zhao, B T Thomas Yeo, Xiaoning Huo, Simon B Eickhoff, Ji Che. Leveraging Stacked Classifiers for Multi-task Executive Function in Schizophrenia Yields Diagnostic and Prognostic Insights. medRxiv : the preprint server for health sciences. 2024-12-16. PMID:39677485. |
the models highlighted the importance of interference inhibition or working memory updating in accurately identifying individuals with schizophrenia or those in remission. |
2024-12-16 |
2024-12-21 |
Not clear |
| Hang Wu, Xiongying Chen, Yinlong Li, Wan Zhao, Bofan Zhang, Caiying Luo, Xinyue Zhang, Jing Shi, Qiumei Zhang, Gao Li, Jun L. Impact of working memory training on brain network plasticity and genetic associations: insights from individual differences. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 12. 2024-12-10. PMID:39658543. |
working memory training resulted in specific brain changes that differed among individuals, which may be partially due to genetics, especially concerning single nucleotide polymorphisms related to schizophrenia. |
2024-12-10 |
2024-12-13 |
human |
| Aneri V Soni, Michael J Fran. Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605328. |
moreover, adaptive performance requires a dynamic range of dopaminergic signals to adjust striatal gating policies, providing a new interpretation of wm difficulties in patient populations such as parkinson's disease, adhd and schizophrenia. |
2024-11-28 |
2024-11-30 |
human |
| Li Li, Lina Wang, Han Wu, Bing Li, Weigang Pan, Wenqing Jin, Wen Wang, Yanping Ren, Chaomeng Liu, Xin M. Effects of parietal iTBS on resting-state effective connectivity within the frontoparietal network in patients with schizophrenia: An fMRI study. NeuroImage. Clinical. vol 45. 2024-11-28. PMID:39608227. |
although intermittent theta burst stimulation (itbs) has shown effectiveness in addressing working memory (wm) deficits in individuals with schizophrenia (sz), the current body of evidence is limited and the specific mechanisms involved remain unclear. |
2024-11-28 |
2024-12-01 |
Not clear |
| Anna S Huang, Ralf D Wimmer, Norman H Lam, Bin A Wang, Sahil Suresh, Maxwell J Roeske, Burkhard Pleger, Michael M Halassa, Neil D Woodwar. A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia. Cell reports. Medicine. 2024-11-08. PMID:39515319. |
task performance correlates with lateralized md-dlpfc functional connectivity, identifying a neural readout that predicts susceptibility to conflict during working memory in a larger independent schizophrenia cohort. |
2024-11-08 |
2024-11-16 |
human |
| Andreas Papassotiropoulos, Virginie Freytag, Nathalie Schicktanz, Christiane Gerhards, Amanda Aerni, Tamás Faludi, Ehssan Amini, Elia Müggler, Annette Harings-Kaim, Thomas Schlitt, Dominique J-F de Quervai. The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach. Molecular psychiatry. 2024-11-08. PMID:39516710. |
working memory (wm), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophrenia. |
2024-11-08 |
2024-11-17 |
Not clear |
| Takeshi Okuda, Sohei Kimoto, Rika Kawabata, Yufan Bian, Makoto Tsubomoto, Kazuya Okamura, John F Enwright, Mitsuru Kikuchi, David A Lewis, Takanori Hashimot. Alterations in inhibitory neuron subtype-selective transcripts in the prefrontal cortex: comparisons across schizophrenia and mood disorders. Psychological medicine. 2024-10-31. PMID:39478366. |
in schizophrenia (sz), impairments in cognitive functions, such as working memory, have been associated with alterations in certain types of inhibitory neurons that utilize the neurotransmitter |
2024-10-31 |
2024-11-02 |
Not clear |
| Xu Hu, Qingyu Zhu, Tianjie Lou, Qianqian Hu, Huashun Li, Yijia Xu, Xiaojie Niu, Li He, Hao Huang, Mengsheng Qiu, Ying Shen, Jie-Min Jia, Yanmei Ta. Pan-ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 45. 2024-10-30. PMID:39475641. |
disruption of erbb signaling, which is essential for peripheral myelination, has been genetically associated with schizophrenia and wm lesions in schizophrenic patients. |
2024-10-30 |
2024-11-02 |
mouse |
| Jiunn-Kae Wang, Prangya Parimita Sahu, Hsiao-Lun Ku, Yu-Hui Lo, Ying-Ru Chen, Che-Yin Lin, Philip Tsen. Enhancing visual working memory in schizophrenia: effects of frontoparietal theta tACS in low-performing patients. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-10-27. PMID:39461954. |
enhancing visual working memory in schizophrenia: effects of frontoparietal theta tacs in low-performing patients. |
2024-10-27 |
2024-10-29 |
Not clear |
| Ting Zhang, Chang Liu, Ning Zhong, Yichen Wang, Yiyun Huang, Xiaoqin Zhan. Advances in the Treatment of Cognitive Impairment in Schizophrenia: Targeting NMDA Receptor Pathways. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408997. |
cognitive impairment in schizophrenia encompasses a wide range of domains, including processing speed, episodic memory, working memory, and executive function. |
2024-10-16 |
2024-10-18 |
Not clear |
| Christin Schifani, Colin Hawco, Zafiris J Daskalakis, Tarek K Rajji, Benoit H Mulsant, Vinh Tan, Erin W Dickie, Iska Moxon-Emre, Daniel M Blumberger, Aristotle N Voinesko. Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Reduces Variability in Brain Function in Schizophrenia: Data From a Double-Blind, Randomized, Sham-Controlled Trial. Schizophrenia bulletin. 2024-10-07. PMID:39373168. |
we perform a secondary analysis using data from a double-blind randomized controlled 4-week trial of 20 hz active versus sham rtms to dorsolateral prefrontal cortex (dlpfc) during a working memory task in participants with schizophrenia. |
2024-10-07 |
2024-10-09 |
human |
| Dominique Arion, John F Enwright, Guillermo Gonzalez-Burgos, David A Lewi. Cell Type-Specific Profiles and Developmental Trajectories of Transcriptomes in Primate Prefrontal Layer 3 Pyramidal Neurons: Implications for Schizophrenia. The American journal of psychiatry. vol 181. issue 10. 2024-10-01. PMID:39350613. |
however, how the transcriptomes of these l3pn subtypes might shift during late postnatal development when working memory impairments emerge in individuals later diagnosed with schizophrenia is not known. |
2024-10-01 |
2024-10-03 |
monkey |
| Reut Komemi, Hana Tubenbaltt, Eiran V Harel, Mor Nahum, Lena Lipskaya-Velikovsk. Ecological virtual reality-based cognitive remediation among inpatients with schizophrenia: A pilot study. Schizophrenia research. Cognition. vol 38. 2024-09-16. PMID:39281321. |
twenty-three inpatients with schizophrenia (male: 33.3 ± 8.5; 4 female) completed 8, 20-min cr-evr sessions, with exercises training the cognitive abilities of inhibition, planning, working memory, shifting, self-initiation, persistence, and attention. |
2024-09-16 |
2024-09-19 |
human |
| Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A Feria Pliego, Rachita Yadav, Jing Liu, Patrick McGuinness, Johanna G Cobb, Muxiao Wang, Rajasekar Nagarajan, Jinrui Lyu, Vanessa Vongsouthi, Colin J Jackson, Elif Engin, Joseph T Coyle, Jaeweon Shin, Nathaniel W Hodgson, Takao K Hensch, Michael E Talkowski, Gregg E Homanics, Vadim Y Bolshakov, Christian Henneberger, Uwe Rudolp. An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Molecular psychiatry. 2024-08-30. PMID:39210012. |
using a chromosome-engineered allelic series in mice, we report that a triplication of the gene encoding the glycine-catabolizing enzyme glycine decarboxylase (gldc) - as found on a small supernumerary marker chromosome in patients with psychosis - reduces extracellular glycine levels as determined by optical fluorescence resonance energy transfer (fret) in dentate gyrus (dg) and suppresses long-term potentiation (ltp) in mpp-dg synapses but not in ca3-ca1 synapses, reduces the activity of biochemical pathways implicated in schizophrenia and mitochondrial bioenergetics, and displays deficits in schizophrenia-like behaviors which are in part known to be dependent on the activity of the dentate gyrus, e.g., prepulse inhibition, startle habituation, latent inhibition, working memory, sociability and social preference. |
2024-08-30 |
2024-09-04 |
mouse |
| Wenpeng Hou, Xiangqin Qin, Hang Li, Qi Wang, Yushen Ding, Xiongying Chen, Ru Wang, Fang Dong, Qijing Bo, Xianbin Li, Fuchun Zhou, Chuanyue Wan. Interaction between BDNF Val66Met polymorphism and mismatch negativity for working memory capacity in schizophrenia. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-08-22. PMID:39174571. |
both the brain-derived neurotrophic factor (bdnf) valine (val)/methionine (met) polymorphism and mismatch negativity (mmn) amplitude are reportedly linked to working memory impairments in schizophrenia. |
2024-08-22 |
2024-08-25 |
Not clear |
| Wenpeng Hou, Xiangqin Qin, Hang Li, Qi Wang, Yushen Ding, Xiongying Chen, Ru Wang, Fang Dong, Qijing Bo, Xianbin Li, Fuchun Zhou, Chuanyue Wan. Interaction between BDNF Val66Met polymorphism and mismatch negativity for working memory capacity in schizophrenia. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-08-22. PMID:39174571. |
the trial assessed the efficacy of transcranial direct current stimulation for enhancing working memory in clinically stable schizophrenia patients, who were randomly divided into three groups: dorsolateral prefrontal cortex stimulation, posterior parietal cortex stimulation, and sham stimulation groups. |
2024-08-22 |
2024-08-25 |
Not clear |
| Wenpeng Hou, Xiangqin Qin, Hang Li, Qi Wang, Yushen Ding, Xiongying Chen, Ru Wang, Fang Dong, Qijing Bo, Xianbin Li, Fuchun Zhou, Chuanyue Wan. Interaction between BDNF Val66Met polymorphism and mismatch negativity for working memory capacity in schizophrenia. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-08-22. PMID:39174571. |
as mmn has been considered a biomarker of n-methyl-d-aspartate receptor (nmdar) function, these data shed light on the complex interactions between bdnf and nmdar in terms of working memory in schizophrenia. |
2024-08-22 |
2024-08-25 |
Not clear |
| Selvameenatchi R, Ramya Rachel Jetty, Aruna Kaki, Suresh Kumar Gunapalli, Prasanna Kumar N, Arul Saravanan . Assessment of Cognitive Functions Among Remitted Patients of Schizophrenia and Bipolar Disorder: A Comparative Study. Cureus. vol 16. issue 7. 2024-08-12. PMID:39131022. |
schizophrenia patients showed poorer attention, working memory, and visual attention/task-switching compared to bipolar patients. |
2024-08-12 |
2024-08-14 |
Not clear |
| Elise Leroux, Laura Masson, Maxime Tréhout, Sonia Dollfu. Effects of Adapted Physical Activity on White Matter Integrity in Patients with Schizophrenia. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061450. |
schizophrenia is associated with changes in white matter (wm) integrity and with reduced life expectancy, in part because of the cardiometabolic side effects of antipsychotics. |
2024-07-27 |
2024-07-29 |
human |