| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hana Cho, Bo Young Choi, Young-Hee Shin, Sang Won Suh, Seung Bum Par. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS chemical neuroscience. 2023-11-28. PMID:38014902. |
tau protein aggregation and propagation in neurons and surrounding microglia are well-known risk factors for neurodegenerative diseases. |
2023-11-28 |
2023-11-29 |
Not clear |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
recent research suggests that baicalein has potential to reduce neuroinflammation and prevent neurodegenerative diseases by affecting microglia, while the specific molecular mechanism of baicalein in regulating microglia in the treatment of ad is still unclear. |
2023-11-25 |
2023-11-28 |
mouse |
| Ilaria Piano, Arianna Votta, Patrizia Colucci, Francesca Corsi, Sara Vitolo, Chiara Cerri, Dario Puppi, Michele Lai, Jos\\xc3\\xa9 Fernando Maya-Vetencourt, Massimiliano Leigheb, Chiara Gabellini, Elisabetta Ferrar. Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine. Scientific reports. vol 13. issue 1. 2023-11-18. PMID:37978212. |
microglia chronic activation is a hallmark of several neurodegenerative diseases, including the retinal ones, possibly contributing to their etiopathogenesis. |
2023-11-18 |
2023-11-20 |
Not clear |
| E Richard Stanley, Fabrizio Biundo, \\xc5\\x9e\\xc3\\xb6len G\\xc3\\xb6khan, Violeta Chit. Differential regulation of microglial states by colony stimulating factors. Frontiers in cellular neuroscience. vol 17. 2023-11-15. PMID:37964794. |
recent studies have emphasized the role of microglia in the progression of many neurodegenerative diseases. |
2023-11-15 |
2023-11-20 |
mouse |
| Maria A Boylan, Andrew Pincetic, Gary Romano, Nadine Tatton, Sara Kenkare-Mitra, Arnon Rosentha. Targeting Progranulin as an Immuno-Neurology Therapeutic Approach. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958929. |
loss-of-function (lof) mutations causing decreased levels of progranulin (pgrn), an immune regulatory protein, lead to dysfunctional microglia and are associated with multiple neurodegenerative diseases, including frontotemporal dementia caused by the progranulin gene ( |
2023-11-14 |
2023-11-20 |
Not clear |
| Edward S Wickstead, Bradley T Elliott, Sarah Pokorny, Christopher Biggs, Stephen J Getting, Simon McArthu. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NF\\xce\\xbaB Activity. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958978. |
neuroinflammation driven primarily by microglia directly contributes to neuronal death in many neurodegenerative diseases. |
2023-11-14 |
2023-11-20 |
Not clear |
| Shilauni Dadwal, Michael T Henek. Microglia heterogeneity in health and disease. FEBS open bio. 2023-11-09. PMID:37945346. |
in this review, we discuss the latest advances in the field of microglia research, focusing specifically on the origin and subpopulations of microglia, the populations of microglia types in the brains of patients with neurodegenerative diseases, and how microglia are regulated in the healthy cns. |
2023-11-09 |
2023-11-20 |
human |
| Julie J Ahn, Robert H Miller, Yusra Isla. Isolation of Pure Astrocytes and Microglia from the Adult Mouse Spinal Cord For In Vitro Assays and Transcriptomic Studies. Journal of visualized experiments : JoVE. issue 200. 2023-11-06. PMID:37930016. |
astrocytes and microglia play pivotal roles in central nervous system development, injury responses, and neurodegenerative diseases. |
2023-11-06 |
2023-11-08 |
mouse |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases. |
2023-10-31 |
2023-11-08 |
Not clear |
| Tingting Han, Yuxiang Xu, Lin Sun, Makoto Hashimoto, Jianshe We. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural regeneration research. vol 19. issue 6. 2023-10-31. PMID:37905870. |
this review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases, including alzheimer's disease, huntington's chorea, and parkinson's disease. |
2023-10-31 |
2023-11-08 |
Not clear |
| Yonghae Son, In-Jun Yeo, Jin-Tae Hong, Seong-Kug Eo, Dongjun Lee, Koanhoi Ki. Side-Chain Immune Oxysterols Induce Neuroinflammation by Activating Microglia. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894967. |
the activation of microglia and subsequent neuroinflammation elicited by the immune oxysterols can contribute to the development of neurodegenerative diseases. |
2023-10-30 |
2023-11-08 |
mouse |
| Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodi. Cell-Type-Specific Mitochondrial Quality Control in the Brain: A Plausible Mechanism of Neurodegeneration. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833867. |
during aging, activated microglia undergo phenotypic alterations that can lead to neuroinflammation, which is a well-accepted event in the pathogenesis of neurodegenerative diseases. |
2023-10-14 |
2023-10-15 |
Not clear |
| Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodi. Cell-Type-Specific Mitochondrial Quality Control in the Brain: A Plausible Mechanism of Neurodegeneration. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37833867. |
several common mechanisms are shared by genetically or pathologically distinct neurodegenerative diseases, such as excitotoxicity, mitochondrial deficits and oxidative stress, protein misfolding and translational dysfunction, autophagy and microglia activation. |
2023-10-14 |
2023-10-15 |
Not clear |
| Deqiang Fu, Xingyue Liang, Yuxuan Jiang, Jieping Liu, Xiaosi Lin, Quan Yang, Xue Chen, Ping Huang, Wei Wang, Wenlin W. Iron blocks autophagic flux and induces autophagosomes accumulation in microglia. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-30. PMID:37777083. |
meanwhile, abnormal autophagy in microglia is closely related to the occurrence of neurodegenerative diseases. |
2023-09-30 |
2023-10-07 |
Not clear |
| Alejandro Lillo, Joan Serrano-Mar\\xc3\\xadn, Jaume Lillo, Iu Ra\\xc3\\xafch, Gemma Navarro, Rafael Franc. Differential Gene Expression in Activated Microglia Treated with Adenosine A Cells. vol 12. issue 18. 2023-09-28. PMID:37759436. |
differential gene expression in activated microglia treated with adenosine a microglial activation often accompanies the plastic changes occurring in the brain of patients with neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
Not clear |
| Daniele Lana, Giada Magni, Elisa Landucci, Gary L Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannin. Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761971. |
phenomic microglia diversity as a druggable target in the hippocampus in neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
rat |
| Qin Fan, Yue-Zhang Wu, Xiao-Xi Jia, Ruhan A, Chu-Mou Liu, Wei-Wei Zhang, Zhi-Yue Chao, Dong-Hua Zhou, Yuan Wang, Jia Chen, Kang Xiao, Cao Chen, Qi Shi, Xiao-Ping Don. Increased Gal-3 Mediates Microglia Activation and Neuroinflammation via the TREM2 Signaling Pathway in Prion Infection. ACS chemical neuroscience. 2023-09-28. PMID:37769016. |
galectin 3 (gal-3) is one of the major elements for activating microglia and mediating neuroinflammation in some types of neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
Not clear |
| Samar F Darwish, Abdullah M M Elbadry, Amir S Elbokhomy, Ghidaa A Salama, Rania M Salam. The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. Frontiers in aging. vol 4. 2023-09-25. PMID:37744008. |
the dual face of microglia (m1/m2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
Not clear |
| Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. |
microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. |
2023-09-22 |
2023-10-07 |
Not clear |
| Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Che. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal transduction and targeted therapy. vol 8. issue 1. 2023-09-22. PMID:37735487. |
microglia activation is observed in various neurodegenerative diseases. |
2023-09-22 |
2023-10-07 |
Not clear |