All Relations between Neurodegenerative Diseases and microglial cell

Publication Sentence Publish Date Extraction Date Species
Sanaz Keshavarz Shahbaz, Khadije Koushki, Samaneh Keshavarz Hedayati, Alice P McCloskey, Prashant Kesharwani, Yazdan Naderi, Amirhossein Sahebka. Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases. Medicinal research reviews. 2024-07-20. PMID:39031446. through triggering release of inflammatory cytokines, chemokines and proteases, microglia can however precipitate neurological damage-a significant factor in neurodegenerative diseases. 2024-07-20 2024-07-24 Not clear
Frida Lind-Holm Mogensen, Carole Sousa, Corrado Ameli, Katja Badanjak, Sandro L Pereira, Arnaud Muller, Tony Kaoma, Djalil Coowar, Andrea Scafidi, Suresh K Poovathingal, Maria Tziortziou, Paul M A Antony, Nathalie Nicot, Aurélien Ginolhac, Daniela M Vogt Weisenhorn, Wolfgang Wurst, Aurélie Poli, Petr V Nazarov, Alexander Skupin, Anne Grünewald, Alessandro Michelucc. PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation. Journal of neuroinflammation. vol 21. issue 1. 2024-07-17. PMID:39014482. specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including parkinson's disease (pd). 2024-07-17 2024-07-19 Not clear
Cory A Diemler, Michael MacLean, Sarah E Heuer, Amanda A Hewes, Olivia J Marola, Richard T Libby, Gareth R Howel. Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma. Frontiers in aging neuroscience. vol 16. 2024-07-17. PMID:39015474. in recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. 2024-07-17 2024-07-19 mouse
Irina Kerkis, Álvaro Prieto da Silva, Rodrigo Pinheiro Arald. The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions. Frontiers in immunology. vol 15. 2024-07-17. PMID:39015561. elevated il-6 levels in the central nervous system worsen neuroinflammation in neurodegenerative diseases by activating microglia and astrocytes and releasing pro-inflammatory cytokines and neurotoxic molecules. 2024-07-17 2024-07-19 Not clear
Jian Shen, Wenjia Lai, Zeyang Li, Wenyuan Zhu, Xue Bai, Zihao Yang, Qingsong Wang, Jianguo J. SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024-07-15. PMID:39008037. microglia, the main innate immune cells in the central nervous system, are key drivers of neuroinflammation, which plays a crucial role in the pathogenesis of neurodegenerative diseases. 2024-07-15 2024-07-18 Not clear
Andrew Baumgartner, Max Robinson, Todd Golde, Suman Jaydev, Sui Huang, Jennifer Hadlock, Cory Fun. Fokker-Planck diffusion maps of multiple single cell microglial transcriptomes reveals radial differentiation into substates associated with Alzheimer's pathology. bioRxiv : the preprint server for biology. 2024-07-15. PMID:38979220. the identification of microglia subtypes is important for understanding the role of innate immunity in neurodegenerative diseases. 2024-07-15 2024-07-18 Not clear
Mateusz Chmielarz, Beata Sobieszczańska, Kamila Środa-Pomiane. Metabolic Endotoxemia: From the Gut to Neurodegeneration. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000116. microglia, guarding the central nervous system, are the first line of defense and respond to endotoxin with activation, which may contribute to the development of neurodegenerative diseases. 2024-07-13 2024-07-15 human
Wanxian Luo, Chuanhui Xu, Linxi Li, Yunxiang Ji, Yezhong Wang, Yingjia Li, Yongyi Y. Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming. Neural regeneration research. vol 20. issue 4. 2024-07-11. PMID:38989955. journal/nrgr/04.03/01300535-202504000-00032/figure1/v/2024-07-06t104127z/r/image-tiff microglia, the primary immune cells within the brain, have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system, including parkinson's disease. 2024-07-11 2024-07-13 mouse
Emilia Petillo, Valeria Veneruso, Gianluca Gragnaniello, Lorenzo Brochier, Enrico Frigerio, Giuseppe Perale, Filippo Rossi, Andrea Cardia, Alessandro Orro, Pietro Veglianes. Targeted therapy and deep learning insights into microglia modulation for spinal cord injury. Materials today. Bio. vol 27. 2024-07-08. PMID:38975239. microglia, the central nervous system's immune sentinels, are known to be promising therapeutic targets in both sci and neurodegenerative diseases. 2024-07-08 2024-07-11 Not clear
Christine A Bowen, Hai M Nguyen, Young Lin, Pritha Bagchi, Aditya Natu, Claudia Espinosa-Garcia, Erica Werner, Rashmi Kumari, Amanda Dabdab Brandelli, Prateek Kumar, Brendan R Tobin, Levi Wood, Victor Faundez, Heike Wulff, Nicholas T Seyfried, Srikant Rangaraj. Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia. Molecular & cellular proteomics : MCP. 2024-06-27. PMID:38936775. in neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (dam). 2024-06-27 2024-06-30 Not clear
Yan-Li Huang, Zhao-Qiong Zh. Current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases. Ibrain. vol 10. issue 2. 2024-06-25. PMID:38915946. current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases. 2024-06-25 2024-06-27 Not clear
Yan-Li Huang, Zhao-Qiong Zh. Current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases. Ibrain. vol 10. issue 2. 2024-06-25. PMID:38915946. sevoflurane can activate microglia, increase the expression of inflammatory factors through various inflammatory signaling pathways, release inflammatory mediators to cause oxidative stress, damage nerve tissues, and eventually develop into neurodegenerative diseases. 2024-06-25 2024-06-27 Not clear
Yan-Li Huang, Zhao-Qiong Zh. Current status of sevoflurane anesthesia in association with microglia inflammation and neurodegenerative diseases. Ibrain. vol 10. issue 2. 2024-06-25. PMID:38915946. in this article, the relationship between sevoflurane anesthesia and microglia inflammation expression and the occurrence of neurodegenerative diseases is reviewed as follows. 2024-06-25 2024-06-27 Not clear
Abhishek Kumar Verma, Shea Lowery, Li-Chin Lin, Eazhisaivallabi Duraisami, Juan E Abrahante Lloréns, Qiang Qiu, Marco Hefti, C Ron Yu, Mark W Albers, Stanley Perlma. Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895239. rnaseq analysis unveiled persistent microglia activation, as found in human neurodegenerative diseases. 2024-06-19 2024-06-21 mouse
Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridg. Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging. Journal of neuroinflammation. vol 21. issue 1. 2024-06-06. PMID:38840206. single cell analyses attributed the aging-associated sex dimorphism to more abundant disease-associated microglia (dam) in old female mice than old male mice, and evaluation of an alzheimer's disease mouse model revealed that the metabolic and complement changes are also apparent in the context of neurodegenerative disease and are strongest in the neuroprotective dam2 subset. 2024-06-06 2024-06-08 mouse
Mai M Anwar, Leonor Pérez-Martínez, Gustavo Pedraza-Alv. Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets. Immunological investigations. 2024-06-05. PMID:38836373. the traditional classification of microglia as ramified, m1 (proinflammatory), or m2 (anti-inflammatory) phenotypes is overly simplistic, failing to capture the wide range of recently identified microglial phenotypes in various brain regions affected by neurodegenerative diseases. 2024-06-05 2024-06-07 Not clear
Mai M Anwar, Leonor Pérez-Martínez, Gustavo Pedraza-Alv. Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets. Immunological investigations. 2024-06-05. PMID:38836373. recognizing the heterogeneity of microglial phenotypes in diseased states can unveil novel therapeutic strategies for targeting microglia in neurodegenerative diseases. 2024-06-05 2024-06-07 Not clear
Chenyuan Zhai, Zun Wang, Jili Cai, Lu Fang, Xiangzhe Li, Kunmao Jiang, Ying Shen, Yu Wang, Xingjun Xu, Wentao Liu, Tong Wang, Qi W. Repeated trans-spinal magnetic stimulation promotes microglial phagocytosis of myelin debris after spinal cord injury through LRP-1. Experimental neurology. 2024-06-03. PMID:38830500. recent studies have begun to reveal critical roles for professional phagocytes in the central nervous system, microglia, and their receptors in the control of myelin debris in neurodegenerative disease. 2024-06-03 2024-06-06 rat
Abhirami K Iyer, Lisa Vermunt, Farzaneh S Mirfakhar, Miguel Minaya, Mariana Acquarone, Rama Krishna Koppisetti, Arun Renganathan, Shih-Feng You, Emma P Danhash, Anthony Verbeck, Grant Galasso, Scott M Lee, Jacob Marsh, Alissa L Nana, Salvatore Spina, William W Seeley, Lea T Grinberg, Sally Temple, Charlotte E Teunissen, Chihiro Sato, Celeste M Karc. Cell autonomous microglia defects in a stem cell model of frontotemporal dementia. medRxiv : the preprint server for health sciences. 2024-05-27. PMID:38798451. however, across neurodegenerative diseases, there is strong evidence for active involvement of immune cells like microglia in driving disease pathophysiology. 2024-05-27 2024-05-31 human
Amy Gathings, Vandana Zaman, Narendra L Banik, Azizul Haqu. Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson's Disease and Aging. Biomedicines. vol 12. issue 5. 2024-05-25. PMID:38791036. activated microglia have been implicated in the pathology of many neurodegenerative diseases, including pd, that initiate inflammatory responses, leading to neuron death. 2024-05-25 2024-05-27 Not clear