| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandra E Johns, Arens Taga, Andriana Charalampopoulou, Sarah K Gross, Khalil Rust, Brett A McCray, Jeremy M Sullivan, Nicholas J Maragaki. Exploring P2X7 receptor antagonism as a therapeutic target for neuroprotection in an hiPSC motor neuron model. Stem cells translational medicine. 2024-10-17. PMID:39419765. |
the role of p2x7r has previously been explored in microglia and astrocytes within the context of neuroinflammation, however the presence of p2x7r on human motor neurons and its potential role in neurodegenerative diseases has not been the focus of the current literature. |
2024-10-17 |
2024-10-20 |
human |
| Verena Haage, John F Tuddenham, Alex Bautista, Charles C White, Frankie Garcia, Ronak Patel, Natacha Comandante-Lou, Victoria Marshe, Rajesh Kumar Soni, Peter A Sims, Vilas Menon, Andrew A Sproul, Philip L De Jage. HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416157. |
hdac inhibitors recapitulate human disease-associated microglia signatures disease-associated microglia (dam), initially described in mouse models of neurodegenerative diseases, have been classified into two related states; starting from a trem2-independent dam1 state to a trem2 dependent state termed dam2, with each state being characterized by the expression of specific marker genes |
2024-10-17 |
2024-10-19 |
mouse |
| Ryeong-Eun Kim, Darine Froy Mabunga, Kyung-Jun Boo, Dong Hyun Kim, Seol-Heui Han, Chan Young Shin, Kyoung Ja Kwo. GSP1-111 Modulates the Microglial M1/M2 Phenotype by Inhibition of Toll-like Receptor 2: A Potential Therapeutic Strategy for Depression. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408923. |
neuroinflammation plays a vital role in neurodegenerative diseases and neuropsychiatric disorders, and microglia and astrocytes chiefly modulate inflammatory responses in the central nervous system (cns). |
2024-10-16 |
2024-10-18 |
Not clear |
| Ting Li, Ana María Espinosa-Oliv. Editorial: Microglia in neurodegenerative diseases. Frontiers in cellular neuroscience. vol 18. 2024-10-09. PMID:39381504. |
editorial: microglia in neurodegenerative diseases. |
2024-10-09 |
2024-10-11 |
Not clear |
| Liqiang Wang, Xiaoyu Yuan, Qianyu Cai, Yutong Chen, Zhi Jia, Qiongmei Mai, Jie Liu, Yanan Li. Mitochondria-targeting Cu Colloids and surfaces. B, Biointerfaces. vol 245. 2024-10-04. PMID:39366108. |
mitochondria-targeting cu mitochondrial dysfunction in microglia has been implicated as a key pathogenesis of most neurodegenerative diseases including alzheimer's disease (ad). |
2024-10-04 |
2024-10-07 |
Not clear |
| Natallia Makarava, Tarek Safadi, Olga Bocharova, Olga Mychko, Narayan P Pandit, Kara Molesworth, Simone Baiardi, Li Zhang, Piero Parchi, Ilia V Baskako. Reactive microglia partially envelop viable neurons in prion diseases. The Journal of clinical investigation. 2024-10-03. PMID:39361421. |
the current work describes a new phenomenon of partial envelopment of neurons by reactive microglia in the context of an actual neurodegenerative disease, not a disease model. |
2024-10-03 |
2024-10-07 |
Not clear |
| Alexander P Young, Eileen M Denovan-Wrigh. Microglia-mediated neuron death requires TNF and is exacerbated by mutant Huntingtin. Pharmacological research. 2024-10-03. PMID:39362509. |
huntington's disease (hd) is a chronic neurodegenerative disease characterized by activated microglia and elevated concentrations of pro-inflammatory cytokines within the brain. |
2024-10-03 |
2024-10-07 |
Not clear |
| Sarah F McComish, Julia O'Sullivan, Adina Mac Mahon Copas, Magdalena Imiolek, Noreen T Boyle, Lucy A Crompton, Jon D Lane, Maeve A Caldwel. Reactive astrocytes generated from human iPSC are pro-inflammatory and display altered metabolism. Experimental neurology. 2024-10-02. PMID:39357593. |
a prominent risk factor for many neurodegenerative diseases is neuroinflammation which is the purview of glial cells, such as astrocytes and microglia. |
2024-10-02 |
2024-10-05 |
human |
| Justin You, Katarina Maksimovic, Mark N Metri, Anneka Schoeppe, Karin Chen, Jooyun Lee, Jhune Rizsan Santos, Mohieldin M M Youssef, Michael W Salter, Jeehye Par. Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS. Heliyon. vol 10. issue 18. 2024-09-26. PMID:39323783. |
microglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (als). |
2024-09-26 |
2024-09-28 |
mouse |
| Armin Bayati, Peter S McPherso. Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions. The Journal of biological chemistry. vol 300. issue 10. 2024-09-26. PMID:39233232. |
this, along with recent developments regarding the involvement of microglia and the immune system in neurodegenerative diseases, has brought about a new era in neurodegeneration: the role of proinflammatory cytokines on the nervous system, and their downstream effects on mitochondria, lysosomal degradation, and autophagy. |
2024-09-26 |
2024-09-29 |
Not clear |
| Jessica Greven, Joshua Wydra, Rory Greer, Cynthia Zhi, Christopher Camitta, Yuhua Song, Jennifer Alexander-Brett, Thomas John Bret. Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands. Research square. 2024-09-24. PMID:39315272. |
trem2 is a signaling receptor expressed on microglia that has emerged as an important drug target for alzheimer's disease and other neurodegenerative diseases. |
2024-09-24 |
2024-09-26 |
Not clear |
| Livia Zhou, Yafeng Wang, Yiran Xu, Yaodong Zhang, Changlian Zh. A comprehensive review of AAV-mediated strategies targeting microglia for therapeutic intervention of neurodegenerative diseases. Journal of neuroinflammation. vol 21. issue 1. 2024-09-20. PMID:39300451. |
a comprehensive review of aav-mediated strategies targeting microglia for therapeutic intervention of neurodegenerative diseases. |
2024-09-20 |
2024-09-22 |
Not clear |
| Livia Zhou, Yafeng Wang, Yiran Xu, Yaodong Zhang, Changlian Zh. A comprehensive review of AAV-mediated strategies targeting microglia for therapeutic intervention of neurodegenerative diseases. Journal of neuroinflammation. vol 21. issue 1. 2024-09-20. PMID:39300451. |
overall, aav-mediated targeting of microglia holds promise as a novel therapeutic approach for neurodegenerative diseases, offering the potential to modify disease progression and improve patient outcomes. |
2024-09-20 |
2024-09-22 |
Not clear |
| Mariagiovanna Di Chiano, Maria Teresa Rocchetti, Giuseppe Spano, Pasquale Russo, Caterina Allegretta, Giampaolo Milior, Raffaella Maria Gadaleta, Fabio Sallustio, Paola Pontrelli, Loreto Gesualdo, Carlo Avolio, Daniela Fiocco, Anna Gallon. Lactobacilli Cell-Free Supernatants Modulate Inflammation and Oxidative Stress in Human Microglia via NRF2-SOD1 Signaling. Cellular and molecular neurobiology. vol 44. issue 1. 2024-09-17. PMID:39287687. |
these findings confirmed that gut microorganisms' metabolites can play a relevant role in adjuvating the microglia cellular response against neuroinflammation and oxidative stress, which are known to cause neurodegenerative diseases. |
2024-09-17 |
2024-09-20 |
human |
| Alessandra Biff. Hematopoietic stem cell gene therapy to halt neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 21. issue 4. 2024-09-14. PMID:39276677. |
microglia play fundamental roles in multiple pathological primary and secondary processes affecting the central nervous system that ultimately result in neurodegeneration and for this reason they are considered as a key therapeutic target in several neurodegenerative diseases. |
2024-09-14 |
2024-09-18 |
Not clear |
| Wei Wei, Seyed Siyawasch Justus Lattau, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Lin Zhang, Irina Graf, Yaoyun Kuang, Xuan Zheng, Zhongnan Hao, Aurel Popa-Wagner, Stefan T Gerner, Sabine Huber, Manuel Nietert, Christian Klose, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Hua Liu, Dirk Fitzner, Thorsten R Doeppne. Dynamic Brain Lipid Profiles Modulate Microglial Lipid Droplet Accumulation and Inflammation Under Ischemic Conditions in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-10. PMID:39252446. |
lipid droplet (ld) accumulation in microglia results in a dysfunctional and pro-inflammatory state in the aged brain and worsens the outcome of neuroinflammatory and neurodegenerative diseases. |
2024-09-10 |
2024-09-13 |
mouse |
| Xi Fan, Hui Chen, Wei He, Jianmin Zhan. Emerging microglial biology highlights potential therapeutic targets for Alzheimer's disease. Ageing research reviews. 2024-09-01. PMID:39218078. |
these genetic risk factors suggest a critical role for microglia, highlighting their therapeutic potential in treating neurodegenerative diseases. |
2024-09-01 |
2024-09-04 |
Not clear |
| Borrajo An. Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200202. |
aged-related changes in microglia and neurodegenerative diseases: exploring the connection. |
2024-08-29 |
2024-09-01 |
Not clear |
| Borrajo An. Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200202. |
a better understanding of the involvement of microglia in neurodegenerative diseases such as alzheimer's and parkinson's is a critical topic for studying the role of inflammatory responses in disease progression. |
2024-08-29 |
2024-09-01 |
Not clear |
| Ifeoluwa Awogbindin, Michael Wanklin, Alexei Verkhratsky, Marie-Ève Trembla. Microglia in Neurodegenerative Diseases. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207709. |
microglia in neurodegenerative diseases. |
2024-08-29 |
2024-09-04 |
Not clear |