| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Hernández-Lorenzo, Fernando García-Gutiérrez, Ana Solbas-Casajús, Silvia Corrochano, Jordi A Matías-Guiu, Jose L Ayal. Genetic-based patient stratification in Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-05-01. PMID:38693203. |
we found three clusters defined mainly by genetic variants found in mapt, app, and apoe, considering known variants associated with ad and other neurodegenerative disease genetic architectures. |
2024-05-01 |
2024-05-04 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
a neurodegenerative disease is considered a primary tauopathy when mapt mutations/haplotypes are its primary cause and/or tau is the main pathological feature. |
2024-03-30 |
2024-04-02 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
we also found that rare and predicted damaging genetic variation in nominated cres was nominally depleted in dementia-affected individuals relative to control subjects, consistent with the hypothesis that variants that disrupt mapt enhancer activity, and thereby reduced mapt expression, may be protective against neurodegenerative disease. |
2024-01-17 |
2024-01-20 |
human |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Carmen Gasca-Salas, Clara Trompeta, Miguel López-Aguirre, Rafael Rodríguez Rojas, Jordi Clarimon, Oriol Dols-Icardo, Shaimaa El Bounasri, Pasqualina Guida, David Mata-Marín, Frida Hernández-Fernández, Connie Marras, Lina García-Cañamaque, Isabel Plaza de Las Heras, Ignacio Obeso, Lydia Vela, Beatriz Fernández-Rodrígue. Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2023-09-20. PMID:37726927. |
the microtubule-associated protein tau (mapt) h1 homozygosity (h1/h1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as parkinson's disease (pd). |
2023-09-20 |
2023-10-07 |
Not clear |
| Maurizio Callari, Martina Sola, Claudia Magrin, Andrea Rinaldi, Marco Bolis, Paolo Paganetti, Luca Colnaghi, Stéphanie Papi. Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response. Scientific data. vol 10. issue 1. 2023-09-20. PMID:37730697. |
tau (mapt) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. |
2023-09-20 |
2023-10-07 |
Not clear |
| Shelley L Forrest, Seojin Lee, Nasna Nassir, Ivan Martinez-Valbuena, Valerie Sackmann, Jun Li, Awab Ahmed, Maria Carmela Tartaglia, Lars M Ittner, Anthony E Lang, Mohammed Uddin, Gabor G Kovac. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy. Acta neuropathologica. 2023-06-24. PMID:37354322. |
microtubule-associated protein tau (mapt) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including progressive supranuclear palsy (psp). |
2023-06-24 |
2023-08-14 |
human |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
the microtubule-associated protein tau (mapt) is one of the proteins that are central to neurodegenerative diseases. |
2023-01-30 |
2023-08-14 |
Not clear |
| Brianne B Rogers, Shelby N Lauzon, M Natalie Davis, Lindsay F Rizzardi, Sara J Cooper, Richard M Myers, J Nicholas Cochra. Identification of cis-regulatory elements associated with MAPT expression in human induced pluripotent stem cell derived neural cells. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971147. |
tau is encoded by mapt and abnormal aggregates of tau are a hallmark of many neurodegenerative diseases. |
2021-12-31 |
2023-08-13 |
human |
| Ana Damianich, Carolina Lucia Facal, Javier Andrés Muñiz, Camilo Mininni, Mariano Soiza-Reilly, Magdalena Ponce De León, Leandro Urrutia, German Falasco, Juan Esteban Ferrario, María Elena Aval. Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:34059893. |
tauopathies are neurodegenerative diseases caused by the abnormal metabolism of the microtubule associated protein tau (mapt), which is highly expressed in neurons and critically involved in microtubule dynamics. |
2021-12-08 |
2023-08-13 |
mouse |
| Mandi Gandelman, Warunee Dansithong, Karla P Figueroa, Sharan Paul, Daniel R Scoles, Stefan M Puls. Staufen 1 amplifies proapoptotic activation of the unfolded protein response. Cell death and differentiation. vol 27. issue 10. 2021-11-08. PMID:32415281. |
staufen-1 (stau1) is an rna-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (psen1), microtubule-associated protein tau (mapt), huntingtin (htt), tar dna-binding protein-43 gene (tardbp), or c9orf72. |
2021-11-08 |
2023-08-13 |
Not clear |
| Faraz Ahmad, Hannah Mein, Yu Jing, Hu Zhang, Ping Li. Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study. International journal of molecular sciences. vol 22. issue 18. 2021-10-28. PMID:34575885. |
tauopathies refer to a group of neurodegenerative diseases with intracellular accumulation of hyperphosphorylated and aggregated microtubule-associated protein tau (mapt) in neurons and glial cells. |
2021-10-28 |
2023-08-13 |
mouse |
| Umesh K Jinwal, John Koren, John C O'Leary, Jeffrey R Jones, Jose F Abisambra, Chad A Dicke. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and cellular pharmacology. vol 2. issue 2. 2021-10-20. PMID:20523917. |
neurodegenerative diseases caused by abnormal accumulation of the microtubule associated protein tau (mapt, tau) are collectively called tauopathies. |
2021-10-20 |
2023-08-12 |
Not clear |
| Hoi-Khoanh Giong, Manivannan Subramanian, Kweon Yu, Jeong-Soo Le. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of International journal of molecular sciences. vol 22. issue 16. 2021-09-24. PMID:34445171. |
non-rodent genetic animal models for studying tauopathy: review of tauopathy refers to a group of progressive neurodegenerative diseases, including frontotemporal lobar degeneration and alzheimer's disease, which correlate with the malfunction of microtubule-associated protein tau (mapt) due to abnormal hyperphosphorylation, leading to the formation of intracellular aggregates in the brain. |
2021-09-24 |
2023-08-13 |
Not clear |
| Samantha L Strickland, Joseph S Reddy, Mariet Allen, Aurelie N'songo, Jeremy D Burgess, Morgane M Corda, Travis Ballard, Xue Wang, Minerva M Carrasquillo, Joanna M Biernacka, Gregory D Jenkins, Shubhabrata Mukherjee, Kevin Boehme, Paul Crane, John S Kauwe, Nilüfer Ertekin-Tane. MAPT haplotype-stratified GWAS reveals differential association for AD risk variants. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 7. 2021-06-01. PMID:32400971. |
mapt h1 haplotype is implicated as a risk factor for neurodegenerative diseases including alzheimer's disease (ad). |
2021-06-01 |
2023-08-13 |
Not clear |
| Kunie Ando, Robert De Decker, Cristina Vergara, Zehra Yilmaz, Salwa Mansour, Valérie Suain, Kristel Sleegers, Marie-Ange de Fisenne, Sarah Houben, Marie-Claude Potier, Charles Duyckaerts, Toshio Watanabe, Luc Buée, Karelle Leroy, Jean-Pierre Brio. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31925534. |
we have previously reported that soluble picalm protein level is reduced in correlation with abnormalities of autophagy markers in the affected brain areas of neurodegenerative diseases including ad, sporadic tauopathies and familial cases of frontotemporal lobar degeneration with tau-immunoreactive inclusions (ftld-tau) with mutations in the microtubule-associated protein tau (mapt) gene. |
2021-05-17 |
2023-08-13 |
mouse |
| M Catarina Silva, Stephen J Haggart. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255694. |
tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (mapt) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. |
2021-03-05 |
2023-08-13 |
Not clear |
| Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. |
disease-associated mutations in the tau-encoding mapt gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. |
2021-01-19 |
2023-08-13 |
mouse |