| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jakub Wlodarczyk, Raja Bhattacharyya, Kim Dore, Gary P H Ho, Dale D O Martin, Rebeca Mejias, Karin Hochraine. Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 40. 2024-10-02. PMID:39358031. |
many proteins implicated in neurodegenerative diseases and associated neuronal dysfunction, including but not limited to amyloid precursor protein, β-secretase (bace1), postsynaptic density protein 95, fyn, synaptotagmin-11, mutant huntingtin, and mutant superoxide dismutase 1, undergo palmitoylation, and recent evidence suggests that altered palmitoylation contributes to the pathological characteristics of these proteins and associated disruption of cellular processes. |
2024-10-02 |
2024-10-05 |
Not clear |
| Subrata Pradhan, Keegan Bush, Nan Zhang, Raj K Pandita, Chi-Lin Tsai, Charlene Smith, Devon F Pandlebury, Sagar Gaikwad, Francis Leonard, Linghui Nie, Annie Tao, William Russell, Subo Yuan, Sanjeev Choudhary, Kenneth S Ramos, Cornelis Elferink, Yogesh P Wairkar, John A Tainer, Leslie M Thompson, Tej K Pandita, Partha S Sarka. Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345557. |
persistent dna double-strand breaks (dsbs) are enigmatically implicated in neurodegenerative diseases including huntington's disease (hd), the inherited late-onset disorder caused by cag repeat elongations in huntingtin (htt). |
2024-09-30 |
2024-10-02 |
Not clear |
| Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller, Weihan Huai, Tapan Biswas, Santi Mohan Mandal, Lisardo Boscá, Balaji Krishnan, Gourisankar Ghosh, Tapas Hazr. Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 39. 2024-09-19. PMID:39298485. |
huntington's disease (hd) and spinocerebellar ataxia type 3 (sca3) are the two most prevalent polyglutamine (polyq) neurodegenerative diseases, caused by cag (encoding glutamine) repeat expansion in the coding region of the huntingtin (htt) and ataxin-3 (atxn3) proteins, respectively. |
2024-09-19 |
2024-09-22 |
mouse |
| Ankita Deo, Rishita Ghosh, Snehal Ahire, Sayali Marathe, Amitabha Majumdar, Tania Bos. Two novel DnaJ chaperone proteins CG5001 and P58IPK regulate the pathogenicity of Huntington's disease related aggregates. Scientific reports. vol 14. issue 1. 2024-09-06. PMID:39242711. |
huntington's disease (hd) is a rare neurodegenerative disease caused due to aggregation of huntingtin (htt) protein. |
2024-09-06 |
2024-09-10 |
drosophila_melanogaster |
| Marina Sogorb-Gonzalez, Christian Landles, Nicholas S Caron, Anouk Stam, Georgina Osborne, Michael R Hayden, David Howland, Sander van Deventer, Gillian P Bates, Astrid Vallès, Melvin Ever. Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington disease models. Brain : a journal of neurology. 2024-08-18. PMID:39155061. |
huntington disease (hd) is a fatal neurodegenerative disease caused by a trinucleotide repeat expansion in exon 1 of the huntingtin gene (htt) resulting in toxic gain-of-function and cell death. |
2024-08-18 |
2024-08-21 |
mouse |
| Mohit Neema, Jordan L Schultz, Douglas R Langbehn, Amy L Conrad, Eric A Epping, Vincent A Magnotta, Peggy C Nopoulo. Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy. Annals of neurology. 2024-08-08. PMID:39115048. |
huntington's disease (hd) is a neurodegenerative disease caused by a triplet repeat expansion within the gene huntingtin (htt). |
2024-08-08 |
2024-08-10 |
Not clear |
| Shahin Ramazi, Maedeh Dadzadi, Mona Darvazi, Nasrin Seddigh, Abdollah Allahverd. Protein modification in neurodegenerative diseases. MedComm. vol 5. issue 8. 2024-08-06. PMID:39105197. |
this review elucidates the critical link between neurodegenerative diseases and specific posttranslational modifications, focusing on tau, app, α-synuclein, huntingtin protein, parkin, dj-1, and drp1. |
2024-08-06 |
2024-08-08 |
Not clear |
| Sarah Allen, Daniel O'Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette, Dimas Echeverria Moreno, Brianna Bramato, Nicholas McHugh, Ken Yamada, Neil Aronin, Marian DiFiglia, Anastasia Khvorov. mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs Nucleic acid therapeutics. 2024-07-18. PMID:39023561. |
mrna nuclear clustering leads to a difference in mutant huntingtin mrna and protein silencing by sirnas huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by cag repeat expansion in the first exon of the huntingtin gene ( |
2024-07-18 |
2024-07-20 |
Not clear |
| Harman Sharma, Sushma Koirala, Yee Lian Chew, Anna Konopk. DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration. Molecular neurobiology. 2024-07-08. PMID:38977621. |
this review focused on hallmark proteins involved in various neurodegenerative diseases, such as the microtubule-associated protein tau, tar dna/rna binding protein 43 (tdp-43), superoxide dismutase 1 (sod1), fused in sarcoma (fus), huntingtin (htt), α-synuclein, and β-amyloid precursor protein (app). |
2024-07-08 |
2024-07-12 |
Not clear |
| Tamara Raschka, Zexin Li, Heiko Gaßner, Zacharias Kohl, Jelena Jukic, Franz Marxreiter, Holger Fröhlic. Unraveling progression subtypes in people with Huntington's disease. The EPMA journal. vol 15. issue 2. 2024-06-06. PMID:38841617. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by a cag trinucleotide expansion in the huntingtin gene. |
2024-06-06 |
2024-06-08 |
Not clear |
| Sarah Allen, Daniel O'Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, Joseph Paquette, Dimas Echeverria Moreno, Brianna Bramato, Nicholas McHugh, Ken Yamada, Neil Aronin, Marian DiFiglia, Anastasia Khvorov. mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs bioRxiv : the preprint server for biology. 2024-05-23. PMID:38774633. |
mrna nuclear clustering leads to a difference in mutant huntingtin mrna and protein silencing by sirnas huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by cag repeat expansion in the first exon of the huntingtin gene ( |
2024-05-23 |
2024-05-27 |
Not clear |
| Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yan. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice. Cell death & disease. vol 15. issue 5. 2024-05-14. PMID:38744826. |
huntington's disease (hd) is a monogenic neurodegenerative disease, caused by the cag trinucleotide repeat expansion in exon 1 of the huntingtin (htt) gene. |
2024-05-14 |
2024-05-27 |
mouse |
| Javier Ojalvo-Pacheco, Sokhna M S Yakhine-Diop, José M Fuentes, Marta Paredes-Barquero, Mireia Niso-Santan. Role of TFEB in Huntington's Disease. Biology. vol 13. issue 4. 2024-04-26. PMID:38666850. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expansion of the cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2024-04-26 |
2024-04-28 |
Not clear |
| Adam Skeens, Chathuranga Siriwardhana, Sophia E Massinople, Michelle M Wunder, Zachary L Ellis, Kaitlyn M Keith, Tyler Girman, Shelli L Frey, Justin Legleite. The polyglutamine domain is the primary driver of seeding in huntingtin aggregation. PloS one. vol 19. issue 3. 2024-03-14. PMID:38483973. |
huntington's disease (hd) is a fatal, neurodegenerative disease caused by aggregation of the huntingtin protein (htt) with an expanded polyglutamine (polyq) domain into amyloid fibrils. |
2024-03-14 |
2024-03-17 |
caenorhabditis_elegans |
| Gerard Ross. Novel Pyrrolo-pyrazol-one Ligands of Alpha-Synuclein for Diagnosis of Parkinson's Disease. ACS medicinal chemistry letters. vol 15. issue 2. 2024-02-14. PMID:38352848. |
many neurodegenerative diseases are characterized by cellular deposits such as abeta, tau, alpha-synuclein, and huntingtin. |
2024-02-14 |
2024-02-16 |
human |
| b' Maria Grazia Maggio, Luana Billeri, Davide Cardile, Angelo Quartarone, Rocco Salvatore Calabr\\xc3\\xb. The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington\'s Disease: A Scoping Review. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255146.' |
huntington's disease is an autosomal dominant neurodegenerative disease caused by the repetition of cytosine, adenine, and guanine trinucleotides on the short arm of chromosome 4p16.3 within the huntingtin gene. |
2024-01-23 |
2024-01-25 |
Not clear |
| Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angel. Therapeutic advances in neural regeneration for Huntington's disease. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227527. |
huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the htt gene which is responsible for the production of the huntingtin (htt) protein. |
2024-01-16 |
2024-01-18 |
Not clear |
| Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt, Jan Kroon, Willeke M C van Roon-Mom, Onno C Meije. Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice. Experimental neurology. 2024-01-12. PMID:38216109. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by a mutation in the huntingtin gene. |
2024-01-12 |
2024-01-15 |
mouse |
| Chao Wu, Haoran Yin, Songdi Fu, Hanna Yoo, Min Zhang, Hyokeun Par. Altered anterograde axonal transport of mitochondria in cultured striatal neurons of a knock-in mouse model of Huntington's disease. Biochemical and biophysical research communications. vol 691. 2024-01-01. PMID:38029540. |
huntington's disease (hd) is a progressive genetic neurodegenerative disease caused by an abnormal expansion of a cytosine-adenine-guanine trinucleotide repeat in the huntingtin gene. |
2024-01-01 |
2024-01-05 |
mouse |
| Monika Chitre, Patrick Emer. ATXN2 is a target of N-terminal proteolysis. PloS one. vol 18. issue 12. 2023-12-21. PMID:38128014. |
other polyq-containing proteins such as atxn7 and huntingtin are associated with the development of neurodegenerative diseases when their n-terminal polyq domains are expanded. |
2023-12-21 |
2023-12-24 |
Not clear |