| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabio Moda, Arianna Ciullini, Ilaria Linda Dellarole, Annalisa Lombardo, Nicole Campanella, Giuseppe Bufano, Federico Angelo Cazzaniga, Giorgio Giaccon. Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exception. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919089. |
finally, aggregates of tdp-43, typically associated with ftld and amyotrophic lateral sclerosis (als), have been observed in ad, progressive supranuclear palsy (psp), corticobasal degeneration (cbd), msa, dlb, and other neurodegenerative diseases. |
2023-11-02 |
2023-11-08 |
human |
| Sanjesh Kumar, Siva Prasad Pand. Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions. Current molecular medicine. 2023-10-25. PMID:37877564. |
dementia in neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb) is a progressive neurological condition affecting millions worldwide. |
2023-10-25 |
2023-11-08 |
human |
| Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, In\\xc3\\xa9s Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Mar\\xc3\\xada Trinidad Herrero, Miquel Vila, Jos\\xc3\\xa9 A Obeso, Erwan Bezard, Benjamin Deha. Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain. NPJ Parkinson's disease. vol 9. issue 1. 2023-09-19. PMID:37726343. |
aggregation of \xce\xb1-synuclein (\xce\xb1-syn) is the cornerstone of neurodegenerative diseases termed synucleinopathies, which include parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-09-19 |
2023-10-07 |
monkey |
| Manuel Flores-Leon, Tiago Fleming Outeir. More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy. Acta neuropathologica. 2023-07-08. PMID:37421475. |
the accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as alzheimer's disease, parkinson's disease (pd), and dementia with lewy bodies (dlb). |
2023-07-08 |
2023-08-14 |
Not clear |
| Katherine Fodder, Rohan de Silva, Thomas T Warner, Concei\\xc3\\xa7\\xc3\\xa3o Bettencour. The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-06-29. PMID:37386505. |
aberrant dna methylation, the most widely studied epigenetic modification, has been associated with many neurodegenerative diseases, including ad, pd, dlb and msa, and recent findings highlight aberrant dna methylation in oligodendrocyte/myelin-related genes. |
2023-06-29 |
2023-08-14 |
Not clear |
| Linjuan Feng, Hsuan Lo, Zhaoxiang Hong, Jiahao Zheng, Yuhong Yan, Zucheng Ye, Xiaochun Chen, Xiaodong Pa. Microglial LRRK2-mediated NFATc1 attenuates \\xce\\xb1-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation. Glia. 2023-06-10. PMID:37300531. |
synucleinopathies refer to a range of neurodegenerative diseases caused by abnormal \xce\xb1-synuclein (\xce\xb1-syn) deposition, including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-06-10 |
2023-08-14 |
mouse |
| Camilla Christina Pedersen, Anastasia Ushakova, Ragnhild Eide Skogseth, Guido Alves, Ole-Bj\\xc3\\xb8rn Tysnes, Dag Aarsland, Johannes Lange, Jodi Maple-Gr\\xc3\\xb8de. Inflammatory Biomarkers in Newly Diagnosed Patients With Parkinson Disease and Related Neurodegenerative Disorders. Neurology(R) neuroimmunology & neuroinflammation. vol 10. issue 4. 2023-05-31. PMID:37258413. |
neuroinflammation also plays a role in related neurodegenerative diseases, such as dementia with lewy bodies (dlb) and alzheimer disease (ad). |
2023-05-31 |
2023-08-14 |
Not clear |
| Youngsoon Yang, Eva Bagyinszky, Seong Soo A A. Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37176125. |
taken together, neurodegenerative diseases such as ad, pd, dlb and ftd may share several common hallmarks (cognitive and motor impairment, associated with abnormal protein aggregates). |
2023-05-14 |
2023-08-14 |
Not clear |
| Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivianna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderso. Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease. vol 9. issue 1. 2023-05-11. PMID:37169750. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) are progressive neurodegenerative diseases characterized by the accumulation of misfolded \xce\xb1-synuclein in the form of lewy pathology. |
2023-05-11 |
2023-08-14 |
Not clear |
| Alejandra Coll\\xc3\\xada, Alex Iranzo, M\\xc3\\xb3nica Serradell, Amaia Mu\\xc3\\xb1oz-Lopetegi, Gerard May\\xc3\\xa0, Joan Santamar\\xc3\\xada, Raquel S\\xc3\\xa1nchez-Valle, Carles Gai. Former participation in professional football as an occupation in patients with isolated REM sleep behavior disorder leading to a synucleinopathy: a case-control study. Journal of neurology. 2023-03-20. PMID:36939930. |
isolated rem sleep behavior disorder (irbd) represents an early manifestation of neurodegenerative diseases including parkinson disease (rbd) and dementia with lewy bodies (dlb). |
2023-03-20 |
2023-08-14 |
Not clear |
| Suman Dutta, Simon Hornung, Hash Brown Taha, Karl Biggs, Ibrar Siddique, Lea M Chamoun, Hedieh Shahpasand-Kroner, Carter Lantz, Marcos Herrera-Vaquero, Nadia Stefanova, Joseph A Loo, Gal Bita. Development of a Novel Electrochemiluminescence ELISA for Quantification of \\xce\\xb1-Synuclein Phosphorylated at Ser ACS chemical neuroscience. 2023-03-15. PMID:36920792. |
development of a novel electrochemiluminescence elisa for quantification of \xce\xb1-synuclein phosphorylated at ser synucleinopathies are a group of neurodegenerative diseases including parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2023-03-15 |
2023-08-14 |
Not clear |
| Matthias Schmitz, Niccol\\xc3\\xb2 Candelise, Sezgi Canaslan, Hermann C Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zer. \\xce\\xb1-Synuclein conformers reveal link to clinical heterogeneity of \\xce\\xb1-synucleinopathies. Translational neurodegeneration. vol 12. issue 1. 2023-03-14. PMID:36915212. |
\xce\xb1-synucleinopathies, such as parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded \xce\xb1-synuclein (\xce\xb1syn), referred to as lewy bodies or oligodendroglial cytoplasmic inclusions (papp-lantos bodies). |
2023-03-14 |
2023-08-14 |
Not clear |
| Joseph R Phillips, Elie Matar, Kaylena A Ehgoetz Martens, Ahmed A Moustafa, Glenda M Halliday, Simon J G Lewi. Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria. Brain sciences. vol 12. issue 12. 2022-12-23. PMID:36552054. |
dementia with lewy bodies (dlb) is an insidious neurodegenerative disease characterised by a precipitous decline in cognition, sleep disturbances, motor impairment and psychiatric features. |
2022-12-23 |
2023-08-14 |
Not clear |
| Sinead Gaubert, Claire Hourregue, Fran\\xc3\\xa7ois Mouton-Liger, P\\xc3\\xa9rine Millot, M\\xc3\\xa9lanie Franco, Elodie Amar-Bouaziz, Dag Aarsland, Jacques Hugon, Claire Paque. Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A Mini-Review. Neuroscience and biobehavioral reviews. 2022-09-09. PMID:36084847. |
dementia with lewy bodies (dlb) is a neurodegenerative disease linked to abnormal accumulation of phosphorylated \xce\xb1-synuclein. |
2022-09-09 |
2023-08-14 |
Not clear |
| Michiyo Iba, Ross A McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Maslia. Aging exacerbates the brain inflammatory micro-environment contributing to \\xce\\xb1-synuclein pathology and functional deficits in\\xc2\\xa0a mouse model of DLB/PD. Molecular neurodegeneration. vol 17. issue 1. 2022-09-05. PMID:36064424. |
although \xc9\x91-synuclein (\xc9\x91-syn) spreading in age-related neurodegenerative diseases such as parkinson's disease (pd) and dementia with lewy bodies (dlb) has been extensively investigated, the role of aging in the manifestation of disease remains unclear. |
2022-09-05 |
2023-08-14 |
mouse |
| Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kaye. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies. Brain pathology (Zurich, Switzerland). 2022-09-02. PMID:36054524. |
here, we have investigated the immunological and biochemical properties of aggregated tau species in different brain cell types in tau-induced neurodegenerative diseases such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2022-09-02 |
2023-08-14 |
mouse |
| Olivier Bousiges, Fr\\xc3\\xa9d\\xc3\\xa9ric Blan. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35742814. |
dementia with lewy bodies (dlb) is a common form of cognitive neurodegenerative disease. |
2022-06-24 |
2023-08-14 |
Not clear |
| Joan Prats-Climent, Maria Teresa Gandia-Ferrero, Irene Torres-Espallardo, Lourdes \\xc3\\x81lvarez-Sanchez, Bego\\xc3\\xb1a Mart\\xc3\\xadnez-Sanchis, Consuelo Ch\\xc3\\xa1fer-Peric\\xc3\\xa1s, Ignacio G\\xc3\\xb3mez-Rico, Leonor Cerd\\xc3\\xa1-Alberich, Fernando Aparici-Robles, Miquel Baquero-Toledo, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-\\xc3\\x81lvarez, Luis Mart\\xc3\\xad-Bonmat\\xc3\\xa. Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of medical systems. vol 46. issue 8. 2022-06-17. PMID:35713815. |
the purpose of this project is to develop and validate a deep learning (dl) fdg pet imaging algorithm able to identify patients with any neurodegenerative diseases (alzheimer's disease (ad), frontotemporal degeneration (ftd) or dementia with lewy bodies (dlb)) among patients with mild cognitive impairment (mci). |
2022-06-17 |
2023-08-14 |
human |
| Joan Prats-Climent, Maria Teresa Gandia-Ferrero, Irene Torres-Espallardo, Lourdes \\xc3\\x81lvarez-Sanchez, Bego\\xc3\\xb1a Mart\\xc3\\xadnez-Sanchis, Consuelo Ch\\xc3\\xa1fer-Peric\\xc3\\xa1s, Ignacio G\\xc3\\xb3mez-Rico, Leonor Cerd\\xc3\\xa1-Alberich, Fernando Aparici-Robles, Miquel Baquero-Toledo, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-\\xc3\\x81lvarez, Luis Mart\\xc3\\xad-Bonmat\\xc3\\xa. Artificial Intelligence on FDG PET Images Identifies Mild Cognitive Impairment Patients with Neurodegenerative Disease. Journal of medical systems. vol 46. issue 8. 2022-06-17. PMID:35713815. |
this dataset contained 90 subjects with mci, 71 of them developed a neurodegenerative disease (64 ad, 4 ftd and 3 dlb) while 19 did not associate any neurodegenerative disease. |
2022-06-17 |
2023-08-14 |
human |
| Sindhu Menon, Sabrina Armstrong, Amir Hamzeh, Naomi P Visanji, Sergio Pablo Sardi, Anurag Tando. Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies. Frontiers in neurology. vol 13. 2022-05-26. PMID:35614915. |
\xce\xb1-synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases generically known as synucleinopathies, including parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2022-05-26 |
2023-08-13 |
Not clear |