| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roselle Gélinas, Chloé Lévesque, Julie Thompson Legault, Marie-Eve Rivard, Louis Villeneuve, Catherine Laprise, John D Riou. Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC). Frontiers in genetics. vol 15. 2024-05-06. PMID:38706791. |
leigh syndrome french canadian type (lsfc) is a recessive neurodegenerative disease characterized by tissue-specific deficiency in cytochrome c oxidase (cox), the fourth complex in the oxidative phosphorylation system. |
2024-05-06 |
2024-05-08 |
human |
| Yihan Hu, Kejia Hu, Huan Song, Yudi Pawitan, Fredrik Piehl, Fang Fan. Infections among individuals with multiple sclerosis, Alzheimer's disease and Parkinson's disease. Brain communications. vol 5. issue 2. 2023-04-03. PMID:37006328. |
the relative risk of infections after a diagnosis of neurodegenerative disease was estimated using stratified cox models, with adjustment for differences in baseline characteristics. |
2023-04-03 |
2023-08-14 |
Not clear |
| Natasha Irrera, Alessandra Bitt. Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases. Neural regeneration research. vol 12. issue 7. 2020-09-29. PMID:28852388. |
evidence for using a dual cox 1/2 and 5-lox inhibitor in neurodegenerative diseases. |
2020-09-29 |
2023-08-13 |
Not clear |
| Miho Shukuri, Aya Mawatari, Masahiro Ohno, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe, Hirotaka Ono. Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 2. 2016-06-14. PMID:26585055. |
cyclooxygenase (cox), a prostanoid-synthesizing enzyme, is considered to be involved in the neuroinflammatory process of neurodegenerative diseases. |
2016-06-14 |
2023-08-13 |
mouse |
| Melinda M Mulvihill, Daniel K Nomur. Therapeutic potential of monoacylglycerol lipase inhibitors. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:23142242. |
both cannabinoids, like marijuana, that exert anti-inflammatory action through stimulating cannabinoid receptors, and cyclooxygenase (cox) inhibitors, like aspirin, that suppress pro-inflammatory eicosanoid production have shown beneficial outcomes in mouse models of neurodegenerative diseases and cancer. |
2013-04-17 |
2023-08-12 |
mouse |
| Jun-Peng Gao, Shan Sun, Wen-Wei Li, Hong Zhao, Ding-Fang Ca. [COX plays a pivotal role in the progressive neuronal loss in neurodegenerative diseases]. Sheng li ke xue jin zhan [Progress in physiology]. vol 39. issue 3. 2012-11-26. PMID:18819488. |
[cox plays a pivotal role in the progressive neuronal loss in neurodegenerative diseases]. |
2012-11-26 |
2023-08-12 |
Not clear |
| Susanne Arnol. Cytochrome c oxidase and its role in neurodegeneration and neuroprotection. Advances in experimental medicine and biology. vol 748. 2012-09-06. PMID:22729864. |
a hallmark of neurodegenerative diseases, such as alzheimer's and parkinson's diseases, and stroke is a malfunction of mitochondria including cytochrome c oxidase (cox), the terminal enzyme complex of the respiratory chain. |
2012-09-06 |
2023-08-12 |
human |
| Susanne Arnol. Cytochrome c oxidase and its role in neurodegeneration and neuroprotection. Advances in experimental medicine and biology. vol 748. 2012-09-06. PMID:22729864. |
thus, cox is a crucial factor in etiology, progression, and prevalence of numerous human neurodegenerative diseases and represents an important target for developing diagnostic and therapeutic tools against those diseases. |
2012-09-06 |
2023-08-12 |
human |
| Saba Aid, Nishant Parikh, Sara Palumbo, Francesca Bosett. Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation. Neuroscience letters. vol 478. issue 3. 2010-10-08. PMID:20451580. |
neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases and cyclooxygenases (cox)-1 and -2 are key regulators of innate immune responses. |
2010-10-08 |
2023-08-12 |
mouse |
| Harikesh Kalonia, Puneet Kumar, Anil Kumar, Bimla Nehr. Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. Neurotoxicology. vol 31. issue 2. 2010-06-16. PMID:20043943. |
recently, cyclooxygenase (cox) inhibitors have been implicated as a neuroprotectant in the treatment of various neurodegenerative diseases. |
2010-06-16 |
2023-08-12 |
rat |
| Zhengyi Li, Dong-Young Choi, Eun-Joo Shin, Randy L Hunter, Chun Hui Jin, Myung-Bok Wie, Min Soo Kim, Seok Joo Park, Guoying Bing, Hyoung-Chun Ki. Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity. Neuroscience letters. vol 445. issue 1. 2009-04-14. PMID:18760329. |
therefore, dual inhibition of cox and lox with phenidone represents a promising new candidate for anti-inflammatory drug therapy, and may provide a novel therapeutic approach for inflammation-related neurodegenerative diseases including pd. |
2009-04-14 |
2023-08-12 |
Not clear |
| Anke Huss, Adrian Spoerri, Matthias Egger, Martin Röösl. Residence near power lines and mortality from neurodegenerative diseases: longitudinal study of the Swiss population. American journal of epidemiology. vol 169. issue 2. 2009-02-09. PMID:18990717. |
cox proportional hazard models were used to analyze the relation of living in the proximity of 220-380 kv power lines and the risk of death from neurodegenerative diseases, with adjustment for a range of potential confounders. |
2009-02-09 |
2023-08-12 |
Not clear |
| Keiko Nishio, Akiko Fukuhara, Yo Omata, Yoshiro Saito, Shuuhei Yamaguchi, Hisatoyo Kato, Yasukazu Yoshida, Etsuo Nik. Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Bioorganic & medicinal chemistry. vol 16. issue 24. 2009-01-09. PMID:18976930. |
there is increasing evidence indicating that free radicals and oxygenases such as cyclooxygenase (cox) and lipoxygenase (lox) are related to the onset and development of neurodegenerative diseases. |
2009-01-09 |
2023-08-12 |
Not clear |
| K D Rainsfor. Anti-inflammatory drugs in the 21st century. Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612044. |
the discovery of the cox isoforms led to establishing their importance in many non-arthritic or non-pain states where there is an inflammatory component to pathogenesis, including cancer, alzheimer's and other neurodegenerative diseases. |
2007-08-06 |
2023-08-12 |
Not clear |
| Juan C Mayo, Rosa M Sainz, Dun-Xian Tan, Rüdiger Hardeland, Josefa Leon, Carmen Rodriguez, Russel J Reite. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. Journal of neuroimmunology. vol 165. issue 1-2. 2005-09-08. PMID:15975667. |
the inducible isoform of cox, namely cox-2, plays a critical role in the inflammatory response and its over-expression has been associated with several pathologies including neurodegenerative diseases and cancer. |
2005-09-08 |
2023-08-12 |
Not clear |
| J Xu, M Chalimoniuk, Y Shu, A Simonyi, A Y Sun, F A Gonzalez, G A Weisman, W G Wood, G Y Su. Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents. Prostaglandins, leukotrienes, and essential fatty acids. vol 69. issue 6. 2004-08-11. PMID:14623498. |
upregulation and activation of phospholipases a2 (pla2) and cyclooxygenases (cox) leading to prostaglandin e2(pge2) production have been implicated in a number of neurodegenerative diseases. |
2004-08-11 |
2023-08-12 |
rat |
| M Asanuma, I Miyazaki, N Ogaw. Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases. Current pharmaceutical design. vol 10. issue 6. 2004-06-21. PMID:14965332. |
in this article, various pharmacological effects of nsaids except their inhibitory action on cox are reviewed, and possible neuroprotective effects of nsaids have been discussed on neurodegenerative diseases, especially parkinson's disease. |
2004-06-21 |
2023-08-12 |
Not clear |
| Z-H Feng, T-G Wang, D-D Li, P Fung, B C Wilson, B Liu, Syed F Ali, R Langenbach, J-S Hon. Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra. Neuroscience letters. vol 329. issue 3. 2002-10-28. PMID:12183047. |
cyclooxygenases (cox), key enzymes in prostanoid biosynthesis, may represent important therapeutic targets in various neurodegenerative diseases. |
2002-10-28 |
2023-08-12 |
mouse |
| Z Zhu, J Yao, T Johns, K Fu, I De Bie, C Macmillan, A P Cuthbert, R F Newbold, J Wang, M Chevrette, G K Brown, R M Brown, E A Shoubridg. SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Nature genetics. vol 20. issue 4. 1998-12-21. PMID:9843204. |
these data suggest a role for surf1 in the biogenesis of the cox complex and define a new class of gene defects causing human neurodegenerative disease. |
1998-12-21 |
2023-08-12 |
human |