| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ksenia V Lapshina, Irina V Ekimov. Aquaporin-4 and Parkinson's Disease. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338949. |
it also highlights future directions that can help study the role of aqp4 in the functioning of the protective mechanisms of the brain during the development of pd and other neurodegenerative diseases. |
2024-02-10 |
2024-02-12 |
human |
| Luca Sacchi, Marina Arcaro, Tiziana Carandini, Anna Margherita Pietroboni, Giorgio Giulio Fumagalli, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Caterina Visconte, Manuela Pintus, Giorgio Conte, Valeria Elisa Contarino, Elio Scarpini, Fabio Triulzi, Daniela Galimberti, Andrea Arigh. Association between enlarged perivascular spaces and cerebrospinal fluid aquaporin-4 and tau levels: report from a memory clinic. Frontiers in aging neuroscience. vol 15. 2023-08-07. PMID:37547746. |
our aim was to investigate the relationship between neurodegenerative diseases and two putative glymphatic system biomarkers: aqp4 and epvs. |
2023-08-07 |
2023-08-14 |
Not clear |
| Alaa Alghanimy, Conor Martin, Lindsay Gallagher, William M Holme. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PloS one. vol 18. issue 3. 2023-03-15. PMID:36920936. |
therefore, enhancing aqp4 function might protect against neurodegenerative diseases such as alzheimer's disease (ad), in which the accumulation of harmful proteins and solutes is a hallmark feature. |
2023-03-15 |
2023-08-14 |
rat |
| Xiaohui Sun, Qing Tian, Zhengjie Yang, Yumei Li, Chengqian Li, Binghui Hou, Anmu Xi. Association of AQP4 single nucleotide polymorphisms (rs335929 and rs2075575) with Parkinson's disease: a case-control study. Neuroscience letters. 2023-01-10. PMID:36626962. |
genetic variation in the aqp4 gene has therefore been hypothesized to be associated with genetic susceptibility to neurodegenerative diseases. |
2023-01-10 |
2023-08-14 |
Not clear |
| Yue Zhang, Jianguo Feng, Cehua Ou, Xue Zhou, Yonghong Lia. AQP4 mitigates chronic neuropathic pain-induced cognitive impairment in mice. Behavioural brain research. 2023-01-03. PMID:36596395. |
the ubiquitous expression of aqp4 in astrocytes throughout the central nervous system is altered in the neurodegenerative disease. |
2023-01-03 |
2023-08-14 |
mouse |
| Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. |
aquaporin-4 (aqp4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2022-09-17 |
2023-08-14 |
human |
| Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimbert. Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation. Alzheimer's research & therapy. vol 14. issue 1. 2022-09-17. PMID:36115967. |
significantly higher levels of aqp4 were found in ad and ftd patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between aqp4 and total tau levels was found. |
2022-09-17 |
2023-08-14 |
human |
| b' Canhong Yang, Sisi Qin, Jiafa Zhang, Yuanyuan Wang, Huan Li, Tianming L\\xc3\\xb. Sulforaphane Upregulates Cultured Mouse Astrocytic Aquaporin-4 Expression through p38 MAPK Pathway. Journal of healthcare engineering. vol 2022. 2022-08-22. PMID:35991296.' |
recent studies have demonstrated that the specific water channel protein, aquaporin-4 (aqp4), plays a role in the pathogenesis of neurodegenerative diseases involving protein clearance system. |
2022-08-22 |
2023-08-14 |
mouse |
| Paul A Soden, Aria R Henderson, Esak Le. A Microfluidic Model of AQP4 Polarization Dynamics and Fluid Transport in the Healthy and Inflamed Human Brain: The First Step Towards Glymphatics-on-a-Chip. Advanced biology. 2022-08-03. PMID:35922370. |
dysfunction of the aquaporin-4 (aqp4)-dependent glymphatic waste clearance pathway has recently been implicated in the pathogenesis of several neurodegenerative diseases. |
2022-08-03 |
2023-08-14 |
human |
| Mootaz M Salman, Philip Kitchen, Andrea Halsey, Marie Xun Wang, Susanna Tornroth-Horsefield, Alex C Conner, Jerome Badaut, Jeffrey J Iliff, Roslyn M Bil. Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis. Brain : a journal of neurology. 2021-11-05. PMID:34499128. |
given the difficulties in developing pore-blocking aqp4 inhibitors, targeting aqp4 subcellular localization opens up new treatment avenues for cns oedema, neurovascular and neurodegenerative diseases, and provides a framework to address fundamental questions about water homeostasis in health and disease. |
2021-11-05 |
2023-08-13 |
Not clear |
| Yoichiro Abe, Natsumi Ikegawa, Keitaro Yoshida, Kyosuke Muramatsu, Satoko Hattori, Kenji Kawai, Minetaka Murakami, Takumi Tanaka, Wakami Goda, Motohito Goto, Taichi Yamamoto, Tadafumi Hashimoto, Kaoru Yamada, Terumasa Shibata, Hidemi Misawa, Masaru Mimura, Kenji F Tanaka, Tsuyoshi Miyakawa, Takeshi Iwatsubo, Jun-Ichi Hata, Takako Niikura, Masato Yasu. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32398151. |
aquaporin-4 (aqp4) has been suggested to be involved in the pathogenesis of neurodegenerative diseases including alzheimer's disease (ad), which may be due to the modulation of neuroinflammation or the impairment of interstitial fluid bulk flow system in the central nervous system. |
2021-05-31 |
2023-08-13 |
mouse |
| Jin Young Kim, Hye Jeong Oh, Yuntae Kim, Jin Myoung Seo. Sporadic amyotrophic lateral sclerosis with seropositive neuromyelitis optica spectrum disorder: A case report. Medicine. vol 100. issue 16. 2021-04-26. PMID:33879715. |
neuromyelitis optica spectrum disorder (nmosd) is a severe inflammatory disorder of the central nervous system with an autoantibody against aquaporin-4 protein (aqp4), and amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease. |
2021-04-26 |
2023-08-13 |
Not clear |
| Andrea Arighi, Andrea Di Cristofori, Chiara Fenoglio, Stefano Borsa, Marianna D'Anca, Giorgio Giulio Fumagalli, Marco Locatelli, Giorgio Carrabba, Anna Margherita Pietroboni, Laura Ghezzi, Tiziana Carandini, Annalisa Colombi, Marta Scarioni, Milena Alessandra De Riz, Maria Serpente, Paolo Maria Rampini, Elio Scarpini, Daniela Galimbert. Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease? Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156164. |
this study indicates the potential role of aqp4 and glymphatic system in neurodegenerative diseases pathophysiology. |
2020-09-18 |
2023-08-13 |
Not clear |
| Sara Marie Ulv Larsen, Hans-Peter Landolt, Wolfgang Berger, Maiken Nedergaard, Gitte Moos Knudsen, Sebastian Camillo Hols. Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep. PLoS biology. vol 18. issue 5. 2020-07-20. PMID:32369477. |
the human aqp4 gene harbors several single nucleotide polymorphisms (snps) associated with aqp4 expression, brain-water homeostasis, and neurodegenerative diseases. |
2020-07-20 |
2023-08-13 |
human |
| Shuang Zou, Yu-Long Lan, Hongjin Wang, Bo Zhang, Yan-Guo Su. The potential roles of aquaporin 4 in amyotrophic lateral sclerosis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 40. issue 8. 2020-01-13. PMID:30980198. |
besides its function in water and ion homeostasis, aqp4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. |
2020-01-13 |
2023-08-13 |
Not clear |
| Masato Yasu. [Aquaporin4 (AQP4) in brain disorder]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 153. issue 5. 2019-08-13. PMID:31092756. |
here i will discuss about the roles of aqp4 in neurodegenerative diseases and introduce new knowledge regarding to "glymphatic system". |
2019-08-13 |
2023-08-13 |
Not clear |
| Hiroko Ikeshima-Kataok. Neuroimmunological Implications of AQP4 in Astrocytes. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27517922. |
finally, the author would like to hypothesize on aqp4's role in interaction between reactive astrocytes and reactive microglial cells, which might occur in neurodegenerative diseases. |
2017-04-17 |
2023-08-13 |
mouse |
| Eva Küppers, Corinna Gleiser, Veronica Brito, Britta Wachter, Thorsten Pauly, Bernhard Hirt, Stephan Grissme. AQP4 expression in striatal primary cultures is regulated by dopamine--implications for proliferation of astrocytes. The European journal of neuroscience. vol 28. issue 11. 2009-02-20. PMID:19046364. |
these results demonstrate a clear-cut involvement of aqp4 in the regulation of proliferation and implicate that modulation of aqp4 could be used therapeutically in the treatment of neurodegenerative diseases as well as in the regulation of reactive astrogliosis by preventing or reducing the glia scar formation, thus improving regeneration following ischemia or other trauma. |
2009-02-20 |
2023-08-12 |
Not clear |