| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mansour Haidar, Benjamin Schmid, Agustín Ruiz, Andreas Ebneth, Alfredo Cabrera-Socorr. Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch. Stem cell research. vol 77. 2024-05-04. PMID:38703665. |
late-onset alzheimer's disease (ad) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the apoe locus. |
2024-05-04 |
2024-05-07 |
Not clear |
| Laura Hernández-Lorenzo, Fernando García-Gutiérrez, Ana Solbas-Casajús, Silvia Corrochano, Jordi A Matías-Guiu, Jose L Ayal. Genetic-based patient stratification in Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-05-01. PMID:38693203. |
we found three clusters defined mainly by genetic variants found in mapt, app, and apoe, considering known variants associated with ad and other neurodegenerative disease genetic architectures. |
2024-05-01 |
2024-05-04 |
Not clear |
| Young Jun Park, Hye-Young Shin, Jong-Il Ki. Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population. Scientific reports. vol 14. issue 1. 2024-04-18. PMID:38637538. |
apolipoprotein e (apoe) is a multifaceted protein with roles in lipid metabolism, neurobiology, and neurodegenerative diseases. |
2024-04-18 |
2024-04-21 |
Not clear |
| Guillermo Santos-Sánchez, Eduardo Ponce-España, Ana Isabel Álvarez-López, Justo Pedroche, María Del Carmen Millán-Linares, María-Soledad Fernández-Pachón, Patricia Judith Lardone, Ivan Cruz-Chamorro, Antonio Carrillo-Vic. A lupin protein hydrolysate protects the central nervous system from oxidative stress in WD-fed ApoE Molecular nutrition & food research. 2024-02-03. PMID:38308501. |
a lupin protein hydrolysate protects the central nervous system from oxidative stress in wd-fed apoe oxidative stress plays a crucial role in neurodegenerative diseases like parkinson's and alzheimer's. |
2024-02-03 |
2024-02-05 |
human |
| Ayse Dondu, Metin Caliskan, Seda Orenay-Boyaciogl. Link Between Obsessive-Compulsive Disorder and ApoE Gene Polymorphisms. Neuropsychiatric disease and treatment. vol 20. 2024-01-30. PMID:38288269. |
the most studied gene in neurodegenerative diseases is apolipoprotein e (apoe) gene, and apoe ɛ4 allele in particular. |
2024-01-30 |
2024-02-01 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Samran Sheriff, Sina Shadfar, Matthew Fitzhenry, Ardeshir Amirkhani, Veer Gupta, Ghasem H Salekdeh, Paul A Haynes, Stuart L Graham, Mehdi Mirzae. Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases. Aging and disease. vol 14. issue 4. 2023-12-28. PMID:37199411. |
the apoe ε4 allele is also associated with retinal neurodegenerative diseases however in contrast to ad, it is considered protective in amd, likewise apoe e2 allele, which is a protective factor for ad, has been implicated as a risk factor for amd and glaucoma. |
2023-12-28 |
2023-12-30 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Samran Sheriff, Sina Shadfar, Matthew Fitzhenry, Ardeshir Amirkhani, Veer Gupta, Ghasem H Salekdeh, Paul A Haynes, Stuart L Graham, Mehdi Mirzae. Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases. Aging and disease. vol 14. issue 4. 2023-12-28. PMID:37199411. |
this review summarizes the evidence on the effects of apoe in retinal neurodegenerative diseases and discusses the overlapping molecular pathways in ad. |
2023-12-28 |
2023-12-30 |
Not clear |
| Wenhua Yi, De Lv, Yue Sun, Jingyu Mu, Xuejing L. Role of APOE in glaucoma. Biochemical and biophysical research communications. vol 694. 2023-12-25. PMID:38145596. |
the apolipoprotein e (apoe) gene is closely related to the genetic risk of numerous neurodegenerative diseases and has become a hot topic in the field of neurodegenerative disease research in recent years. |
2023-12-25 |
2023-12-28 |
Not clear |
| Ian A Windham, Sarah Cohe. The cell biology of APOE in the brain. Trends in cell biology. 2023-10-07. PMID:37805344. |
the e4 variant of apoe is a major genetic risk factor for alzheimer's disease (ad) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which apoe4 drives disease are still unclear. |
2023-10-07 |
2023-10-15 |
mouse |
| Linda G Yang, Zachary M March, Roxan A Stephenson, Priyanka S Naraya. Apolipoprotein E in lipid metabolism and neurodegenerative disease. Trends in endocrinology and metabolism: TEM. 2023-06-25. PMID:37357100. |
variants of the lipid transport protein, apolipoprotein e (apoe), modulate risk and resilience in several neurodegenerative diseases including late-onset alzheimer's disease (load). |
2023-06-25 |
2023-08-14 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Samran Sheriff, Sina Shadfar, Matthew Fitzhenry, Ardeshir Amirkhani, Veer Gupta, Ghasem H Salekdeh, Paul A Haynes, Stuart L Graham, Mehdi Mirzae. Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases. Aging and disease. 2023-05-10. PMID:37163427. |
the apoe ε4 allele is also associated with retinal neurodegenerative diseases however in contrast to ad, it is considered protective in amd, likewise apoe e2 allele, which is a protective factor for ad, has been implicated as a risk factor for amd and glaucoma. |
2023-05-10 |
2023-08-14 |
Not clear |
| Morteza Abyadeh, Vivek Gupta, Joao A Paulo, Samran Sheriff, Sina Shadfar, Matthew Fitzhenry, Ardeshir Amirkhani, Veer Gupta, Ghasem H Salekdeh, Paul A Haynes, Stuart L Graham, Mehdi Mirzae. Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases. Aging and disease. 2023-05-10. PMID:37163427. |
this review summarizes the evidence on the effects of apoe in retinal neurodegenerative diseases and discusses the overlapping molecular pathways in ad. |
2023-05-10 |
2023-08-14 |
Not clear |
| Matthias Jung, Carla Hartmann, Toni Ehrhardt, Lisa-Maria Peter, Chaudhry Luqman Abid, Bernadette Harwardt, Jana Hirschfeld, Claudia Claus, Undine Haferkamp, Ole Pless, Marina Nastainczyk-Wulf, Astrid Kehlen, Dietmar Schlote, Insa S Schroder, Dan Rujesc. Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease. Stem cell research. vol 69. 2023-03-31. PMID:37001364. |
late-onset alzheimer disease (load) is the most frequent neurodegenerative disease, and the apoe ε4 allele is the most prominent risk factor for load. |
2023-03-31 |
2023-08-14 |
human |
| Courtney M Kloske, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Adam M Brickman, Guojun Bu, Jessica Dennison, Mary D Gearon, Alison M Goate, Christian Haass, Michael T Heneka, William T Hu, Lenique K L Huggins, Nahdia S Jones, Radosveta Koldamova, Cynthia A Lemere, Shane A Liddelow, Edoardo Marcora, Samuel E Marsh, Henrietta M Nielsen, Kellen K Petersen, Melissa Petersen, Stefanie D Piña-Escudero, Wei Qiao Qiu, Yakeel T Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia Tcw, Charlotte E Teunissen, Betty M Tijms, Rik van der Kant, Rebecca Wallings, Stacie C Weninger, Whitney Wharton, Donna M Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C Carrill. APOE and immunity: Research highlights. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-03-28. PMID:36975090. |
at the alzheimer's association's apoe and immunity virtual conference, held in october 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein e gene (apoe) and facets of immunity play in neurodegenerative diseases, including alzheimer's disease and other dementias. |
2023-03-28 |
2023-08-14 |
Not clear |
| Rolf Antonie Loch, Hongzhi Wang, Alex Perálvarez-Marín, Philipp Berger, Henrietta Nielsen, Angeliki Chroni, Jinghui Lu. Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases. Computational and structural biotechnology journal. vol 21. 2023-02-23. PMID:36817952. |
the molecular and genetic interactions of apoe with amyloid proteins have been extensively studied in neurodegenerative diseases, but have not yet been well connected and clarified. |
2023-02-23 |
2023-08-14 |
Not clear |
| Rolf Antonie Loch, Hongzhi Wang, Alex Perálvarez-Marín, Philipp Berger, Henrietta Nielsen, Angeliki Chroni, Jinghui Lu. Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases. Computational and structural biotechnology journal. vol 21. 2023-02-23. PMID:36817952. |
perhaps more importantly, this review outlines what we can learn from the interactome of apoe and amyloid proteins; that is the need to see both apoe and amyloid proteins as a basis to understand neurodegenerative diseases. |
2023-02-23 |
2023-08-14 |
Not clear |
| Ganggang Miao, Danping Zhuo, Xue Han, Wentao Yao, Chuan Liu, Hanyuan Liu, Hongyong Cao, Yangbai Sun, Zhiqiang Chen, Tingting Fen. From degenerative disease to malignant tumors: Insight to the function of ApoE. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-14. PMID:36516696. |
due to genetic polymorphisms of apoe (ε2, ε3, and ε4), its three common structural isoforms (apoe2, apoe3, apoe4) are also associated with the risk of many diseases, especially degenerative diseases, such as vascular degenerative diseases including atherosclerosis (as), coronary heart disease (chd), and neurodegenerative disease like alzheimer's disease (ad). |
2022-12-14 |
2023-08-14 |
Not clear |
| Kristen M Pitts, Cameron E Neeson, Nathan E Hall, Jonathan B Lin, Henisk K Falah, Silas L Wang, Kristine T Lo, Christian E Song, Milica A Margeta, David A Solá-Del Vall. Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma. Translational vision science & technology. vol 11. issue 11. 2022-11-01. PMID:36318198. |
galectin-3 (gal-3) and apolipoprotein e (apoe) are markers of activated microglia in neurodegenerative diseases of the central nervous system, whose targeting is protective in mouse models of glaucoma. |
2022-11-01 |
2023-08-14 |
mouse |
| Rosalía Fernández-Calle, Sabine C Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M Nielsen, Gunnar K Gouras, Tomas Deierbor. APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-09-24. PMID:36153580. |
apoe in the bullseye of neurodegenerative diseases: impact of the apoe genotype in alzheimer's disease pathology and brain diseases. |
2022-09-24 |
2023-08-14 |
human |
| Rosalía Fernández-Calle, Sabine C Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M Nielsen, Gunnar K Gouras, Tomas Deierbor. APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. Molecular neurodegeneration. vol 17. issue 1. 2022-09-24. PMID:36153580. |
the impact of the apoe genotype in other neurodegenerative diseases characterized by overt inflammation, e.g., alpha- synucleinopathies and parkinson's disease, traumatic brain injury, stroke, amyotrophic lateral sclerosis, and multiple sclerosis, is also addressed. |
2022-09-24 |
2023-08-14 |
human |