| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeie. ApoE4 expression disrupts tau uptake, trafficking, and clearance in astrocytes. Glia. 2023-09-05. PMID:37668005. |
tauopathies are a collection of neurodegenerative diseases characterized by the accumulation of pathogenic aggregates of the microtubule-associated protein tau. |
2023-09-05 |
2023-09-07 |
mouse |
| Sanghyun Ahn, Jung-Soo Suh, Yoon-Kwan Jang, Heonsu Kim, Kiseok Han, Yerim Lee, Gyuho Choi, Tae-Jin Ki. TAUCON and TAUCOM: A novel biosensor based on fluorescence resonance energy transfer for detecting tau hyperphosphorylation-associated cellular pathologies. Biosensors & bioelectronics. vol 237. 2023-07-30. PMID:37517333. |
tauopathies are neurodegenerative diseases characterized by abnormal conformational changes in tau protein. |
2023-07-30 |
2023-08-14 |
Not clear |
| Zhikai Zeng, Vishnu Vijayan, Karen Tsay, Matthew P Frost, Athena Quddus, Alexa Albert, Michael Vigers, Amanda L Woerman, Songi Ha. CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502998. |
the recent discovery by cryo-electron microscopy that the neuropatho-logical hallmarks of different tauopathies, including alzheimer's disease, corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), are caused by unique misfolded conformations of the protein tau is among the most profound developments in neurodegenerative disease research. |
2023-07-28 |
2023-08-14 |
Not clear |
| Alisa Cario, Christopher L Berge. Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 45. issue 8. 2023-07-25. PMID:37489532. |
the etiology of tauopathies, a diverse class of neurodegenerative diseases associated with the microtubule associated protein (map) tau, is usually described by a common mechanism in which tau dysfunction results in the loss of axonal microtubule stability. |
2023-07-25 |
2023-08-14 |
Not clear |
| Marta Jorge-Oliva, Jan R T van Weering, Wiep Schepe. Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446051. |
tau aggregation is central to the pathogenesis of a large group of neurodegenerative diseases termed tauopathies, but it is still unclear in which way neurons respond to tau pathology and how tau accumulation leads to neurodegeneration. |
2023-07-14 |
2023-08-14 |
Not clear |
| Marta Le\\xc5\\x84ska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Kr\\xc3\\xb3licki, Urszula Fiszer, Dariusz Koziorowsk. Inflammation in multiple system atrophy. Frontiers in immunology. vol 14. 2023-07-10. PMID:37426656. |
among proteinopathies are neurodegenerative diseases with atypical parkinsonism and an accumulation of insoluble fibrillary alpha-synuclein (synucleinopathies) or hyperphosphorylated tau protein fragments (tauopathies). |
2023-07-10 |
2023-08-14 |
Not clear |
| Leonora Szabo, Amandine Grimm, Juan Antonio Garc\\xc3\\xada-Le\\xc3\\xb3n, Catherine M Verfaillie, Anne Ecker. Genetically Engineered Triple Cells. vol 12. issue 10. 2023-07-06. PMID:37408218. |
genetically engineered triple pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. |
2023-07-06 |
2023-08-14 |
Not clear |
| Galina Limorenko, Meltem Tatli, Rajasekhar Kolla, Sergey Nazarov, Marie-Theres Weil, David C Sch\\xc3\\xb6ndorf, Daniela Geist, Peter Reinhardt, Dagmar E Ehrnhoefer, Henning Stahlberg, Laura Gasparini, Hilal A Lashue. Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature communications. vol 14. issue 1. 2023-07-04. PMID:37402718. |
tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative diseases collectively known as tauopathies. |
2023-07-04 |
2023-08-14 |
Not clear |
| P Hemachandra Reddy, Sudhir Kshirsagar, Chhanda Bose, Jangampalli Adi Pradeepkiran, Ashly Hindle, Sharda P Singh, Arubala P Reddy, Javaria Bai. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells. vol 12. issue 12. 2023-06-28. PMID:37371116. |
ralbp1 (rlip) is a stress-activated protein that is believed to play a large role in aging and neurodegenerative diseases such as alzheimer's disease (ad) and other tauopathies. |
2023-06-28 |
2023-08-14 |
Not clear |
| Yi Yao, Yanmin Chang, Shaomin Li, Jiahui Zhu, Yanqing Wu, Xingjun Jiang, Lulu Li, Ruitian Liu, Rong Ma, Gang L. Complement C3a Receptor Antagonist Alleviates Tau Pathology and Ameliorates Cognitive Deficits in P301S Mice. Brain research bulletin. 2023-06-17. PMID:37330021. |
human tauopathies, including alzheimer's disease (ad), are a major class of neurodegenerative diseases characterized by intracellular deposition of pathological hyperphosphorylated forms of tau protein. |
2023-06-17 |
2023-08-14 |
mouse |
| Niyatee Samudra, Courtney Lane-Donovan, Lawren VandeVrede, Adam L Boxe. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. The Journal of clinical investigation. vol 133. issue 12. 2023-06-15. PMID:37317972. |
despite limited clinical success to date, as we continue to refine our understanding of tau's pathogenic mechanism(s) in different neurodegenerative diseases, we remain optimistic that tau-targeting therapies will eventually play a central role in the treatment of tauopathies. |
2023-06-15 |
2023-08-14 |
human |
| Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. |
tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. |
2023-06-12 |
2023-08-14 |
Not clear |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175990. |
alzheimer's disease (ad) and frontotemporal dementia (ftd) can be classified as tauopathies, which are a group of neurodegenerative diseases that develop toxic tau aggregates in specific brain regions. |
2023-05-14 |
2023-08-14 |
Not clear |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090552. |
tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the |
2023-04-24 |
2023-08-14 |
Not clear |
| Tony S Etel\\xc3\\xa4inen, M Catarina Silva, Johanna K Uhari-V\\xc3\\xa4\\xc3\\xa4n\\xc3\\xa4nen, Francesca De Lorenzo, Maria H J\\xc3\\xa4ntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpel\\xc3\\xa4inen, Christina Mechtler, Reinis Svarcbahs, Erin Sepp\\xc3\\xa4l\\xc3\\xa4, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T My\\xc3\\xb6h\\xc3\\xa4ne. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine. vol 15. issue 691. 2023-04-12. PMID:37043557. |
tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. |
2023-04-12 |
2023-08-14 |
mouse |
| Haiyang Zhong, Hongli Liu, Huanxiang Li. Molecular Mechanism of Tau Misfolding and Aggregation: Insights from Molecular Dynamics Simulation. Current medicinal chemistry. 2023-04-09. PMID:37031392. |
tau dysfunction has a close association with many neurodegenerative diseases, which are collectively referred to as tauopathies. |
2023-04-09 |
2023-08-14 |
Not clear |
| Prechiel A Barredo, Mannix P Balana. Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers. Membranes. vol 13. issue 3. 2023-03-29. PMID:36984665. |
the study of tau protein aggregation and interactions with other molecules or solvents using molecular dynamics simulations (mds) is of interest to many researchers to propose new mechanism-based therapeutics for neurodegenerative diseases such as alzheimer's disease, pick's disease, chronic traumatic encephalopathy, and other tauopathies. |
2023-03-29 |
2023-08-14 |
Not clear |
| Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud Fran\\xc3\\xa7ois, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jocker. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. eLife. vol 12. 2023-03-14. PMID:36917493. |
aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and alzheimer's disease (ad). |
2023-03-14 |
2023-08-14 |
Not clear |
| Narendran Annadurai, Ji\\xc5\\x99\\xc3\\xad Hrub\\xc3\\xbd, Ag\\xc3\\xa1ta Kub\\xc3\\xad\\xc4\\x8dkov\\xc3\\xa1, Luk\\xc3\\xa1\\xc5\\xa1 Malina, Mari\\xc3\\xa1n Hajd\\xc3\\xbach, Viswanath Da. Time- and dose-dependent seeding tendency of exogenous tau R2 and R3 aggregates in cells. Biochemical and biophysical research communications. vol 653. 2023-03-02. PMID:36863211. |
tauopathies are a group of neurodegenerative diseases categorised into three types, 3r, 4r, or 3r+4r (mixed) tauopathies, based on the tau isoforms that make up the aberrant filaments. |
2023-03-02 |
2023-08-14 |
Not clear |