| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Yiyang Zhu, Wade K Self, David M Holtzma. An emerging role for the gut microbiome in tauopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-04. PMID:38964948. |
tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. |
2024-07-04 |
2024-07-11 |
human |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including alzheimer's disease (ad). |
2024-07-02 |
2024-07-06 |
mouse |
| Sebastian N Roemer, Matthias Brendel, Johannes Gnoerich, Maura Malpetti, Mirlind Zaganjori, Andrea Quattrone, Mattes Gross, Anna Steward, Anna Dewenter, Fabian Wagner, Amir Dehsarvi, Christian Ferschmann, Stephan Wall, Carla Palleis, Boris S Rauchmann, Sabrina Katzdobler, Alexander Jaeck, Anna Stockbauer, Urban M Fietzek, Alexander M Bernhardt, Endy Weidinger, Andreas Zwergal, Sophia Stoecklein, Robert Perneczky, Henryk Barthel, Osama Sabri, Johannes Levin, Guenter U Hoeglinger, Nicolai Franzmeie. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain : a journal of neurology. 2024-06-06. PMID:38842726. |
4-repeat (4r) tauopathies are neurodegenerative diseases characterized by cerebral accumulation of 4r tau pathology. |
2024-06-06 |
2024-06-08 |
Not clear |
| Itzhak Fischer, Theresa Connors, Julien Bouyer, Ying Ji. The unique properties of Big tau in the visual system. Cytoskeleton (Hoboken, N.J.). 2024-05-18. PMID:38761116. |
tau is a microtubule associated protein that plays important roles in regulating the properties of microtubules and axonal transport, as well as tauopathies associated with toxic aggregates leading to neurodegenerative diseases. |
2024-05-18 |
2024-05-27 |
rat |
| Chenxi Qiu, Zhixiong Li, David A Leigh, Bingbing Duan, Joseph E Stucky, Nami Kim, George Xie, Kun Ping Lu, Xiao Zhen Zho. The role of the Pin1- Frontiers in cell and developmental biology. vol 12. 2024-04-17. PMID:38628595. |
the role of the pin1- tauopathies are neurodegenerative diseases characterized by deposits of abnormal tau protein in the brain. |
2024-04-17 |
2024-04-19 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512672. |
under its aggregated form, tau is a hallmark of alzheimer's disease and other neurodegenerative diseases named tauopathies involving tau dysfunction and/or mutations. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Sarah Buchholz, Michael Bell-Simons, Cagla Cakmak, Jennifer Klimek, Li Gan, Hans Zempe. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512688. |
tau pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Felix Langerscheidt, Michael Bell-Simons, Hans Zempe. Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512687. |
pathological alterations of the neuronal tau protein are characteristic for many neurodegenerative diseases, called tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
background tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically phosphorylated tau protein in the brain, leading to prion-like propagation and aggregation. |
2024-03-18 |
2024-03-20 |
Not clear |
| Goonho Park, Angela Galdamez, Keon-Hyoung Song, Masako Le, Kyle Kim, Jonathan H Li. Ethnic variation and structure-function analysis of tauopathy-associated medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496636. |
in addition to its central position in intracellular stress regulation, human gwas identify eif2ak3 as a risk factor in tauopathies, neurodegenerative diseases caused by aberrant tau protein accumulation. |
2024-03-18 |
2024-03-20 |
human |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Marina Han, Aleen Saxton, Heather Currey, Sarah M Waldherr, Nicole F Liachko, Brian C Kraeme. Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in C. elegans. Disease models & mechanisms. 2024-03-12. PMID:38469687. |
protein homeostasis is perturbed in aging-related neurodegenerative diseases called tauopathies, which are pathologically characterized by aggregation of the microtubule-associated protein tau. |
2024-03-12 |
2024-03-14 |
caenorhabditis_elegans |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. |
2024-02-04 |
2024-02-06 |
mouse |
| Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R S Barbosa, Luciana Magalhães Rebelo Alenca. Atomic Force Microscopy Applied to the Study of Tauopathies. ACS chemical neuroscience. 2024-02-02. PMID:38305187. |
tauopathies are neurodegenerative diseases featured by aggregation of phosphorylated tau protein inside neurons, leading to functional loss and progressive neurotoxicity. |
2024-02-02 |
2024-02-04 |
Not clear |
| Courtney Lane-Donovan, Adam L Boxe. Disentangling tau: One protein, many therapeutic approaches. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-01-26. PMID:38278659. |
the tauopathies encompass over 20 adult neurodegenerative diseases and are characterized by the dysfunction and accumulation of insoluble tau protein. |
2024-01-26 |
2024-01-29 |
Not clear |