Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Weronika Bagrowska, Angelika Karasewicz, Artur Gór. Comprehensive analysis of acetylcholinesterase inhibitor and reactivator complexes: implications for drug design and antidote development. Drug discovery today. 2024-10-30. PMID:39476946. |
this makes ache an ideal molecular target for the treatment of neurodegenerative diseases and dementia (such as alzheimer's disease), as well as for the neutralisation of natural toxins (e.g., venom peptides) and chemical warfare agents. |
2024-10-30 |
2024-11-02 |
Not clear |
Anna Planas-Ballvé, Jose Rios, Mireia Gea, Neus Rabaneda-Lombarte, Lourdes Ispierto, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vila. Substantia nigra hyperechogenicity and brain ventricular size as biomarkers of early dementia with Lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-16. PMID:39407323. |
diagnosis of dementia with lewy bodies (dlb) is challenging, especially in the earlier stages of the disease, owing to the clinical overlap with other neurodegenerative diseases such as alzheimer's (ad) and parkinson's disease (pd). |
2024-10-16 |
2024-10-18 |
Not clear |
Junyun Wu, Jia Nan Wu, Tao Chen, Jing Cai, Reng Re. Protein Aggregation and its Affecting Mechanisms in Neurodegenerative Diseases. Neurochemistry international. 2024-10-13. PMID:39396709. |
protein aggregation serves as a critical pathological marker in a spectrum of neurodegenerative diseases (nds), including the formation of amyloid β (aβ) and tau neurofibrillary tangles in alzheimer's disease, as well as α-synuclein (α-syn) aggregates in parkinson's disease, parkinson's disease-related dementia (pdd), dementia with lewy bodies (dlb), and multiple system atrophy (msa). |
2024-10-13 |
2024-10-16 |
Not clear |
Zoë Bell, Maureen K O'Connor, Lauren R Mo. Neuropsychiatric presentations of common dementia syndromes: A concise review for primary care team members. Journal of the American Geriatrics Society. 2024-10-10. PMID:39387518. |
we provide a concise narrative review of four dementia syndromes (alzheimer's disease, vascular dementia, dementia with lewy bodies, and behavioral variant frontotemporal dementia) and their associated neuropsychiatric presentations, as well as at-a-glance clinical guides, to help primary care team members recognize possible prodromal neurodegenerative disease and to prompt further workup. |
2024-10-10 |
2024-10-16 |
Not clear |
Hoi-Khoanh Giong, Seung Jae Hyeon, Jae-Geun Lee, Hyun-Ju Cho, Uiyeol Park, Thor D Stein, Junghee Lee, Kweon Yu, Hoon Ryu, Jeong-Soo Le. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta neuropathologica. vol 148. issue 1. 2024-09-24. PMID:39316141. |
tauopathy, including frontotemporal lobar dementia and alzheimer's disease, describes a class of neurodegenerative diseases characterized by the aberrant accumulation of tau protein due to defects in proteostasis. |
2024-09-24 |
2024-09-26 |
human |
Francesca Gorini, Alessandro Tonacc. Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge. Antioxidants (Basel, Switzerland). vol 13. issue 8. 2024-08-29. PMID:39199184. |
frontotemporal dementia (ftd) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are often difficult to diagnose due to their similar phenotypic characteristics to other dementias and psychiatric disorders. |
2024-08-29 |
2024-09-01 |
Not clear |
Jana Schepers, Timo Löser, Christian Beh. Lipids and α-Synuclein: adding further variables to the equation. Frontiers in molecular biosciences. vol 11. 2024-08-28. PMID:39188788. |
aggregation of alpha-synuclein (αsyn) has been connected to several neurodegenerative diseases, such as parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy (msa), that are collected under the umbrella term |
2024-08-28 |
2024-08-30 |
Not clear |
Julian Jeyasingh-Jacob, Mark Crook-Rumsey, Harshvi Shah, Theresita Joseph, Subati Abulikemu, Sarah Daniels, David J Sharp, Shlomi Haa. Markerless Motion Capture to Quantify Functional Performance in Neurodegeneration: Systematic Review. JMIR aging. vol 7. 2024-08-06. PMID:39106477. |
markerless motion capture (mmc) uses video cameras or depth sensors for full body tracking and presents a promising approach for objectively and unobtrusively monitoring functional performance within community settings, to aid clinical decision-making in neurodegenerative diseases such as dementia. |
2024-08-06 |
2024-08-09 |
Not clear |
Ankit Kolay, Neelam Singh, Puneet Gupta, Ayaz Mukarram Shaikh, Radha Goel, Dheeraj Nagpal, Havagiray Chitm. Immunotherapies: A Treasure Trove of Alzheimer's Disease. Current pharmaceutical biotechnology. 2024-07-23. PMID:39039684. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein inside the brain. |
2024-07-23 |
2024-07-25 |
Not clear |
Cui Yang, Guangdong Liu, Xi Chen, Weidong L. Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier. MedComm. vol 5. issue 7. 2024-07-16. PMID:39006764. |
alzheimer's disease (ad), alongside other dementias such as vascular dementia (vad), lewy body dementia (dlb), and frontotemporal dementia (ftd), as well as other neurodegenerative diseases (nds) like parkinson's disease (pd), amyotrophic lateral sclerosis (als), huntington's disease (hd), and spinocerebellar ataxias (sca), are characterized by specific and non-specific neurodegenerations in central nervous system. |
2024-07-16 |
2024-07-18 |
Not clear |
Ke Yu, Katherine R Yao, Miguel A Aguinaga, Jessica M Choquette, Chengliang Liu, Yuxin Wang, Dezhi Lia. G272V and P301L mutations induce isoform specific tau mislocalization to dendritic spines and synaptic dysfunctions in cellular models of 3R and 4R tau frontotemporal dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-10. PMID:38858079. |
tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including alzheimer's disease (ad), lewy body dementia (lbd), chronic traumatic encephalopathy (cte), and frontotemporal dementia (ftd). |
2024-06-10 |
2024-06-14 |
rat |
Erica Costantini, Claudia Carrarini, Dario Calisi, Matteo De Rosa, Marianna Simone, Adolfo Di Crosta, Rocco Palumbo, Alessia Cipollone, Lisa Aielli, Maria De Laurentis, Lucilla Colarusso, Andrea Pilotto, Alessandro Padovani, Fani Konstantinidou, Valentina Gatta, Liborio Stuppia, Francesco Cipollone, Marta Di Nicola, Marcella Reale, Laura Bonann. Search in the Periphery for Potential Inflammatory Biomarkers of Dementia with Lewy Bodies and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-05-17. PMID:38759010. |
neuroinflammation, with altered peripheral proinflammatory cytokine production, plays a major role in the pathogenesis of neurodegenerative diseases, such as alzheimer's disease (ad), while the role of inflammation in dementia with lewy bodies (dlb) is less known and the results of different studies are often in disagreement. |
2024-05-17 |
2024-05-27 |
Not clear |
Mohit Kumar, Sharma Anita Ashok, Ashok Kumar Datusalia, Gopal L Khati. PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). 2024-05-10. PMID:38726789. |
alzheimer's disease (ad) is a neurodegenerative disease leading to dementia because of complex phathomechanisms like amyloid β (aβ) aggregation, tau aggregates, and neurofibrillary tangles. |
2024-05-10 |
2024-05-27 |
human |
Li-Chai Chen, Mei-Chou Lai, Tang-Yao Hong, I-Min Li. γ-Oryzanol from Rice Bran Antagonizes Glutamate-Induced Excitotoxicity in an In Vitro Model of Differentiated HT-22 Cells. Nutrients. vol 16. issue 8. 2024-04-27. PMID:38674927. |
therefore, γ-oryzanol could be a promising candidate for the development of therapies for glutamate excitotoxicity-associated neurodegenerative diseases, including vascular dementia. |
2024-04-27 |
2024-04-29 |
Not clear |
Zubaida Shebani, Karalyn Patterso. (What) can patients with semantic dementia learn? Neuropsychologia. 2024-03-01. PMID:38428519. |
semantic dementia (sd) is a neurodegenerative disease characterised by progressive deterioration of semantic knowledge, resulting in diminished understanding of concepts, whether encountered in verbal or non-verbal form. |
2024-03-01 |
2024-03-04 |
Not clear |
Tugba Keskin, Orcun Avsar, Sinan Eliacik, Funda Uysal Ta. Investigation of the relationship between Nucleosides, nucleotides & nucleic acids. 2024-02-10. PMID:38340307. |
investigation of the relationship between alzheimer's disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. |
2024-02-10 |
2024-02-14 |
Not clear |
El Jeong, Yong Woo Shin, Jung-Ick Byun, Jun-Sang Sunwoo, Monica Roascio, Pietro Mattioli, Laura Giorgetti, Francesco Famà, Gabriele Arnulfo, Dario Arnaldi, Han-Joon Kim, Ki-Young Jun. EEG-based Machine Learning Models for the Prediction of Phenoconversion Time and Subtype in iRBD. Sleep. 2024-02-08. PMID:38330231. |
idiopathic/isolated rapid eye movement sleep behavior disorder (irbd) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including parkinson's disease (pd), dementia with lewy bodies (dlb) and multiple system atrophy (msa). |
2024-02-08 |
2024-02-11 |
Not clear |
Xiaoxiao Zheng, Jingyao Yang, Yiwei Hou, Xinye Shi, Kangding Li. Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP). European journal of medical research. vol 29. issue 1. 2024-01-12. PMID:38216970. |
the reason plasma gfap could serve as a promising biomarker for diagnosis and prediction of alzheimer's disease (ad) is that it effectively distinguished ad dementia from multiple neurodegenerative diseases and predicted the individual risk of ad progression. |
2024-01-12 |
2024-01-15 |
Not clear |
Jun Ma, Bingqian Wang, Xiaoxi Wei, Meng Tian, Xingfu Bao, Yifan Zhang, Huichuan Qi, Yi Zhang, Min H. Accumulation of extracellular elastin-derived peptides disturbed neuronal morphology and neuron-microglia crosstalk in aged brain. Journal of neurochemistry. 2024-01-03. PMID:38168728. |
these findings in extracellular edps provided more evidence for the relationship between aging and neuron dysfunction, increasing the insight of neuroinflammatory responses and the development of new specialized extracellular matrix remolding-targeted therapy options for dementia or other neurodegenerative disease. |
2024-01-03 |
2024-01-06 |
Not clear |
Mahdi Khorsand Ghaffari, Ali Rafati, Narges Karbalaei, Masoud Haghani, Marzieh Nemati, Niloofar Sefati, Mohammad Reza Namava. The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampal oxidative-nitrosative stress, and histological changes induced by icv-STZ in a rat model. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-29. PMID:38157024. |
impaired insulin and growth factor functions are thought to drive many alterations in neurodegenerative diseases like dementia and seem to contribute to oxidative stress and inflammatory responses. |
2023-12-29 |
2024-01-05 |
rat |