| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Yao, Jingyi Du, Dongshuang Wang, Naigang Li, Zhouhang Tao, Dong Wu, Fan Peng, Jiaming Shi, Wenjuan Zhou, Tiantian Zhao, Yuchun Tan. High-intensity interval training ameliorates postnatal immune activation-induced mood disorders through KDM6B-regulated glial activation. Brain, behavior, and immunity. 2024-06-08. PMID:38851307. |
both hiit and mict in adolescent mice inhibited neuroinflammation, remodeled synaptic plasticity, and improved pia-induced mood disorders in adulthood. |
2024-06-08 |
2024-06-11 |
mouse |
| Yitong Zhou, Ting Cong, Jun Chen, Zhenchen Chu, Ye Sun, Danmei Zhao, Xue Chen, Liya Li, Yingxin Liu, Jiani Cheng, Qiwei Li, Shengming Yin, Zhaoyang Xia. Protective role of TRPV2 in synaptic plasticity through the ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress rats. Biochemical and biophysical research communications. vol 721. 2024-05-22. PMID:38776831. |
chronic stress is a significant risk factor for mood disorders such as depression, where synaptic plasticity plays a central role in pathogenesis. |
2024-05-22 |
2024-05-27 |
rat |
| Yuhui Deng, Xin Liang, Yue Li, Lin Jiang, Jin Wang, Jing Tang, Jing Li, Yuhan Xie, Kai Xiao, Peilin Zhu, Yijing Guo, Yanmin Luo, Yong Tan. PGC-1α in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice. Neuropharmacology. 2024-03-16. PMID:38492883. |
decreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. |
2024-03-16 |
2024-03-19 |
mouse |
| José Francis-Oliveira, Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, Emily Cruvinel, Estevão Carlos Lima, Fernando da Silva Borges, Thais Zampieri, Fernanda Pereira Rebello, Henning Ulrich, Roberto De Pasqual. TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex. Experimental neurology. 2023-12-16. PMID:38103709. |
early life stress (els) affects the shaping of cortical circuitries through impairment of synaptic plasticity supporting the onset of mood disorders. |
2023-12-16 |
2023-12-21 |
rat |
| Mingyi Xia, Busra Nur Agca, Tomoko Yoshida, Jiwon Choi, Usamma Amjad, Kade Bose, Nikol Keren, Shahar Zukerman, Michael J Cima, Ann M Graybiel, Helen N Schwerd. Scalable, flexible carbon fiber electrode thread arrays for three-dimensional probing of neurochemical activity in deep brain structures of rodents. Biosensors & bioelectronics. vol 241. 2023-09-14. PMID:37708685. |
our cfet array has the potential to unlock a wide range of applications, from uncovering the role of neuromodulators in synaptic plasticity, to addressing critical safety barriers in clinical translation towards diagnostic and adaptive treatment in parkinson's disease and major mood disorders. |
2023-09-14 |
2023-10-07 |
rat |
| Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Y. N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype. European journal of pharmacology. 2023-09-06. PMID:37673363. |
in conclusion, the therapeutic potential of pea for depressive mood disorders may be through targeting the hippocampal neuroplasticity, including increasing adult neurogenesis and synaptic plasticity, as well as down-regulated neuronal apoptosis, to remodel hippocampal circuitries upon functional integration and pparα pathway may be involved in this process. |
2023-09-06 |
2023-10-07 |
rat |
| John H Krystal, Ege T Kavalali, Lisa M Monteggi. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-07-24. PMID:37488280. |
this discovery not only provided new insight into the neurobiology of mood disorders but also uncovered fundamental synaptic plasticity mechanisms that underlie its treatment. |
2023-07-24 |
2023-08-14 |
Not clear |
| Laifa Wang, Xueqin Wang, Ling Deng, Hui Zhang, Binsheng He, Wenyu Cao, Yanhui Cu. Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders. International immunopharmacology. vol 113. issue Pt B. 2022-11-17. PMID:36395673. |
pexidartinib (plx3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders. |
2022-11-17 |
2023-08-14 |
mouse |
| Li-Juan Zhu, Chengcheng Zhang, Ce Che. Research progress on vesicle cycle and neurological disorders. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 24. 2021-12-05. PMID:34343470. |
this review of the relationships between the structure and function of synaptic vesicles in physiological and pathological conditions provides a theoretical basis for synaptic transmission and a novel avenue for the study of synaptic plasticity associated with mood disorders, highlighting potential targets for treating diseases. |
2021-12-05 |
2023-08-13 |
Not clear |
| Maksim Storozhuk, Andrii Cherninskyi, Oleksandr Maximyuk, Dmytro Isaev, Oleg Krishta. Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. Current neuropharmacology. vol 19. issue 9. 2021-11-25. PMID:33550975. |
here we review and discuss evidence regarding the roles of asics: (i) as postsynaptic receptors activated by protons coreleased with glutamate at glutamatergic synapses; (ii) as modulators of synaptic transmission at glutamatergic synapses and gabaergic synapses; (iii) in synaptic plasticity, memory and learning; (iv) in some pathologies such as epilepsy, mood disorders and alzheimer's disease. |
2021-11-25 |
2023-08-13 |
Not clear |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
deficits in hippocampal cellular and synaptic plasticity are frequently associated with cognitive and mood disorders, and indeed common mechanisms of antidepressants are thought to involve neuroplastic processes. |
2021-06-15 |
2023-08-13 |
mouse |
| Feifei Ren, Rongjuan Gu. Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity. Neuropsychiatric disease and treatment. vol 17. 2021-02-02. PMID:33519203. |
accumulating evidence implies that synaptic plasticity is integrally involved in the pathological changes of mood disorders, especially in depressive disorder. |
2021-02-02 |
2023-08-13 |
Not clear |
| Ege T Kavalali, Lisa M Monteggi. Targeting Homeostatic Synaptic Plasticity for Treatment of Mood Disorders. Neuron. vol 106. issue 5. 2020-09-08. PMID:32497508. |
targeting homeostatic synaptic plasticity for treatment of mood disorders. |
2020-09-08 |
2023-08-13 |
Not clear |
| Aisha S Shariq, Elisa Brietzke, Joshua D Rosenblat, Zihang Pan, Carola Rong, Renee-Marie Ragguett, Caroline Park, Roger S McIntyr. Therapeutic potential of JAK/STAT pathway modulation in mood disorders. Reviews in the neurosciences. vol 30. issue 1. 2019-08-29. PMID:29902157. |
the jak/stat signaling pathway is involved in mediating several functions of the central nervous system, including neurogenesis, synaptic plasticity, gliogenesis, and microglial activation, all of which have been implicated in the pathophysiology of mood disorders. |
2019-08-29 |
2023-08-13 |
Not clear |
| J Ma, X Qi, C Yang, R Pan, S Wang, J Wu, L Huang, H Chen, J Cheng, R Wu, Y Liao, L Mao, F C Wang, Z Wu, J X An, Y Wang, X Zhang, C Zhang, Z Yua. Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors. Molecular psychiatry. vol 23. issue 4. 2019-04-04. PMID:29180673. |
although atp exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of atp release remain to be elaborated. |
2019-04-04 |
2023-08-13 |
mouse |
| Rafael N Ruggiero, Matheus T Rossignoli, Cleiton Lopes-Aguiar, João P Leite, Lezio S Bueno-Junior, Rodrigo N Romcy-Pereir. Lithium modulates the muscarinic facilitation of synaptic plasticity and theta-gamma coupling in the hippocampal-prefrontal pathway. Experimental neurology. vol 304. 2019-01-07. PMID:29458058. |
because these alterations varied with time, oscillatory parameters, and type of synaptic plasticity, our study suggests that lithium influences prefrontal-related circuits through intricate dynamics, informing future experiments on mood disorders. |
2019-01-07 |
2023-08-13 |
rat |
| Anu Aonurm-Helm, Kaili Anier, Tamara Zharkovsky, Eero Castrén, Tomi Rantamäki, Vladimir Stepanov, Jaak Järv, Alexander Zharkovsk. NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26499173. |
mood disorders are associated with alterations in serotonergic system, deficient bdnf (brain-derived neurotrophic factor) signaling and abnormal synaptic plasticity. |
2016-10-05 |
2023-08-13 |
mouse |
| Igor Delvendahl, Hannes Lindemann, Tonio Heidegger, Claus Normann, Ulf Ziemann, Volker Mal. Effects of lamotrigine on human motor cortex plasticity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 124. issue 1. 2013-02-12. PMID:22750085. |
the pathophysiology of mood disorders may incorporate a dysfunction of neuronal plasticity and animal experiments suggest that mood stabilizers influence induction of long-term potentiation (ltp) and -depression (ltd), two major forms of synaptic plasticity. |
2013-02-12 |
2023-08-12 |
human |
| Yoshifumi Watanabe, Shusaku Uchida, Kouji Otsuki, Hirotaka Yamagata, Teruyuki Hobara, Naoko Abe, Fumihiro Higuchi, Toshio Watanuki, Toshio Matsubar. [Functional biomarkers of mood disorders: differential diagnosis and clinical classification with gene expression in peripheral leukocytes]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 114. issue 7. 2012-11-09. PMID:22897028. |
we selected and measured the levels of genes of interest, which are listed as follows: glucocorticoid receptor, neurotrophic factors, cell adhesion molecules, sr protein splicing factors, transcription factors, epigenetic factors (histone deacetylase, sirtuin, dna methyltransferase), since these molecules are suggested to be associated with the neural function, synaptic plasticity, and behaviors in animal models, as well as with the pathophysiology and pathogenesis of mood disorders. |
2012-11-09 |
2023-08-12 |
Not clear |
| Jing Du, Jorge Quiroz, Peixiong Yuan, Carlos Zarate, Husseini K Manj. Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses. Neuron glia biology. vol 1. issue 3. 2012-10-02. PMID:18634600. |
these studies indicate that regulation of glutamate-mediated synaptic plasticity might play a role in the treatment of mood disorders, and raise new avenues for novel therapies for this devastating illness. |
2012-10-02 |
2023-08-12 |
rat |