| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Hayashi, Joseph B Lesnak, Ashley N Plumb, Adam J Janowski, Angela F Smith, Joslyn K Hill, Kathleen A Sluk. Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice. Brain, behavior, and immunity. 2024-06-26. PMID:38925417. |
thus, we hypothesize that in activity-induced pain, fatigue metabolites combined with il-1β activate sensory neurons to increase bdnf release, peripherally in muscle and centrally in the spinal dorsal horn, to produce hyperalgesia. |
2024-06-26 |
2024-06-29 |
mouse |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
bone-cancer-related chronic pain and hyperalgesia are likely to be mediated by central sensitization involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the capsaicin-sensitive sensory neuronal system. |
2024-05-25 |
2024-05-27 |
mouse |
| Chen-Xi Xu, Xin-Yi Qiu, Yi Guo, Tian-Ming Xu, Richard J Traub, Hai-Nan Feng, Dong-Yuan Ca. Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation. Brain research bulletin. 2024-01-30. PMID:38290590. |
the results showed that vpa inhibited somatic hyperalgesia induced by orofacial inflammation combined with stress, and down-regulated the interleukin-6 (il-6) expression in the l4-l5 spinal dorsal horn of female rats. |
2024-01-30 |
2024-02-02 |
rat |
| Vikram Thakur, Mayra A Gonzalez, Maria Parada, Robert D Martinez, Munmun Chattopadhya. Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy. Molecular neurobiology. 2023-10-24. PMID:37875708. |
the results demonstrate that fk228 treatment can alleviate thermal hyperalgesia and mechanical allodynia significantly along with changes in the expression of hdacs in the dorsal root ganglia (drg) and spinal cord dorsal horn neurons of diabetic animals. |
2023-10-24 |
2023-11-08 |
mouse |
| John E Gilbert, Tianhe Zhang, Rosana Esteller, Warren M Gril. Network Model of Nociceptive Processing in the Superficial Spinal Dorsal Horn Reveals Mechanisms of Hyperalgesia, Allodynia, and Spinal Cord Stimulation. Journal of neurophysiology. 2023-09-20. PMID:37727912. |
network model of nociceptive processing in the superficial spinal dorsal horn reveals mechanisms of hyperalgesia, allodynia, and spinal cord stimulation. |
2023-09-20 |
2023-10-07 |
Not clear |
| John E Gilbert, Tianhe Zhang, Rosana Esteller, Warren M Gril. Network Model of Nociceptive Processing in the Superficial Spinal Dorsal Horn Reveals Mechanisms of Hyperalgesia, Allodynia, and Spinal Cord Stimulation. Journal of neurophysiology. 2023-09-20. PMID:37727912. |
loss of dh inhibition during neuropathic pain unmasks a pathway from non-nociceptive aβ-afferent inputs to superficial dorsal horn (sdh) nociceptive-specific (ns) projection neurons, and this change may contribute to hyperalgesia and allodynia. |
2023-09-20 |
2023-10-07 |
Not clear |
| Yan-Hui Gu, Jing Wang, Wei-Cheng Lu, Yong Cheng, Rong Tao, Shi-Jia Zhang, Ting Xu, Ke-Wei Zhai, Su-Xia Luo, Wen-Jun Xi. POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment. Neurochemical research. 2023-08-17. PMID:37592110. |
the assays with gain and loss of lrfn4 function demonstrated that lrfn4 downregulation in spinal dorsal horn contributed to the oxaliplatin-induced mechanical allodynia and cold hyperalgesia. |
2023-08-17 |
2023-09-07 |
Not clear |
| Li-Guo Dong, Meng-Qi An, Han-Ying Gu, Li-Ge Zhang, Jin-Bao Zhang, Cheng-Jie Li, Cheng-Jie Mao, Fen Wang, Chun-Feng Li. PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons. Acta pharmacologica Sinica. 2023-08-10. PMID:37563446. |
pacap/pac1-r activation contributes to hyperalgesia in 6-ohda-induced parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons. |
2023-08-10 |
2023-08-16 |
rat |
| b' Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Meng-Hua Zhou \\xe5\\x91\\xa8\\xe5\\xad\\x9f\\xe5\\x8d\\x8e, Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. mGluR5 from primary sensory neurons promotes opioid-induced hyperalgesia and tolerance by interacting with and potentiating synaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-14. PMID:37451981.' |
aberrant activation of presynaptic nmda receptors (nmdars) in the spinal dorsal horn is integral to opioid-induced hyperalgesia and analgesic tolerance. |
2023-07-14 |
2023-08-14 |
mouse |
| Victoria M Rogness, Joseph Juliette, Iryna A Khasabova, Kalpna Gupta, Sergey G Khasabov, Donald A Simon. Descending facilitation of nociceptive transmission from the rostral ventromedial medulla contributes to hyperalgesia in mice with sickle cell disease. Neuroscience. 2023-06-17. PMID:37330194. |
mice with scd have robust hyperalgesia mediated, in part, by sensitization of spinal dorsal horn neurons. |
2023-06-17 |
2023-08-14 |
mouse |
| Jie Li, Qian Wang, Yangzheng Gao, Wanjie Ma, Zexian Sun, Yonghao Yu, Yize Li, Qing Li, Chunyan Wan. Blocking SphK/S1P/S1PR1 axis Signaling Pathway Alleviates Remifentanil- induced Hyperalgesia in Rats. Neuroscience letters. 2023-02-21. PMID:36801239. |
our findings indicate that the sphk/sip/s1pr1 axis regulates the expression of nlrp3, caspase-1, il-1β, il-18 and ros in the spinal dorsal horn to mediate remifentanil-induced hyperalgesia. |
2023-02-21 |
2023-08-14 |
rat |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
inhibition of spinal 5-ht3 receptor and spinal dorsal horn neuronal excitability alleviates hyperalgesia in a rat model of parkinson's disease. |
2022-09-28 |
2023-08-14 |
rat |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology. 2022-09-28. PMID:36168076. |
our previous study demonstrated that 6-ohda induced pd model manifested hyperalgesia to thermal and mechanical stimuli and decreased serotonin (5-hydroxytryptamine; 5-ht) in the spinal dorsal horn (sdh). |
2022-09-28 |
2023-08-14 |
rat |
| Jiang Bian, Bangjian Zhang, Ying Zhang, Yunyun Tian, LiYin, WanyunZo. FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling. Neuroscience. 2022-08-07. PMID:35934252. |
behavioral tests and immunostaining results showed that fgf 10 relieved hyperalgesia in sni rats and inhibited microglial activity in the ipsilateral spinal dorsal horn in a dose-dependent manner. |
2022-08-07 |
2023-08-14 |
rat |
| Franz Nürnberger, Christoph Rummel, Daniela Ott, Rüdiger Gerstberger, Martin J Schmidt, Joachim Roth, Stephan Leisengan. Gabapentinoids Suppress Lipopolysaccharide-Induced Interleukin-6 Production in Primary Cell Cultures of the Rat Spinal Dorsal Horn. Neuroimmunomodulation. 2022-07-17. PMID:35843206. |
treatment with gabapentin or pregabalin in animal models of neuropathic pain resulted not only in reduced symptoms of hyperalgesia but also in an attenuated activation of glial cells and decreased production of pro-inflammatory mediators in the spinal dorsal horn. |
2022-07-17 |
2023-08-14 |
rat |
| Lingyu Zhou, Shanchun Su, Jiaqi Yu, Shengjun Wan, Xueqin Xu, Xiaohui Li, Mengyuan Xiong, Wei Tian, Linhan Wang, Yanqiong Wu, Changbin K. Schnurri-2 promotes the expression of excitatory glutamate receptors and contributes to neuropathic pain. Neuroscience. 2022-02-26. PMID:35218885. |
accumulating evidence has shown that the pathogenesis of neuropathic pain is mediated by the plasticity of excitatory neurons in the dorsal horn of the spinal cord, which provides insights into the treatment of hyperalgesia. |
2022-02-26 |
2023-08-13 |
mouse |
| Xue Bai, Min Gao, Yinxia Li, Haikun Chen, Xiaoyao Ma, Huhu Bai, Yanni Liu, Xiaodong Hu, Zhanwei Su. Upregulation of RCAN1.4 in spinal dorsal horn is involved in inflammatory pain hypersensitivity. Neuroscience letters. 2022-02-21. PMID:35189316. |
overexpression of rcan1.4 in spinal dorsal horn of intact mice produced both mechanical allodynia and thermal hyperalgesia, which were accompanied by increased synaptic expression and phosphorylation of glua1 subunit. |
2022-02-21 |
2023-08-13 |
mouse |
| Xin Liu, Chilman Bae, Benjamin B Gelman, Jin Mo Chung, Shao-Jun Tan. A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis. Brain : a journal of neurology. 2022-01-18. PMID:35040478. |
ablation of astrogliosis blocked the development of gp120-induced mechanical hyperalgesia, and concomitantly the expression of neural circuit polarization (ncp) in the spinal dorsal horn (sdh). |
2022-01-18 |
2023-08-13 |
Not clear |
| Xiaona Feng, Donglin Xiong, Jie Li, Lizu Xiao, Weijiao Xie, Yunhai Qi. Direct Inhibition of Microglia Activation by Pretreatment With Botulinum Neurotoxin A for the Prevention of Neuropathic Pain. Frontiers in neuroscience. vol 15. 2021-12-24. PMID:34949981. |
moreover, a single intrathecal pre-administration of a low dose of bont/a (1 u/kg) significantly prohibited the partial sciatic nerve ligation (psnl)- induced upregulation of pro-inflammatory cytokines in both the spinal cord dorsal horn and dorsal root ganglions (drgs), which in turn prevented the psnl-induced mechanical allodynia and thermal hyperalgesia. |
2021-12-24 |
2023-08-13 |
Not clear |
| Austin Kearns, Jazmine Jayasi, Xin Liu, Jigong Wang, Yuqiang Shi, Jin Mo Chung, Jun-Ho La, Shao-Jun Tang, Chilman Ba. Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model. Frontiers in synaptic neuroscience. vol 13. 2021-12-07. PMID:34867259. |
neuron type-dependent synaptic activity in the spinal dorsal horn of opioid-induced hyperalgesia mouse model. |
2021-12-07 |
2023-08-13 |
mouse |