| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vikram Thakur, Mayra A Gonzalez, Maria Parada, Robert D Martinez, Munmun Chattopadhya. Role of Histone Deacetylase Inhibitor in Diabetic Painful Neuropathy. Molecular neurobiology. 2023-10-24. PMID:37875708. |
the results demonstrate that fk228 treatment can alleviate thermal hyperalgesia and mechanical allodynia significantly along with changes in the expression of hdacs in the dorsal root ganglia (drg) and spinal cord dorsal horn neurons of diabetic animals. |
2023-10-24 |
2023-11-08 |
mouse |
| Yizhong Peng, Xuanzuo Chen, Zilong Rao, Wei Wu, Huiyin Zuo, Kaibin Chen, Kanglu Li, Hui Lin, Sheng Liu, Yan Xiao, BaiChuan Wang, Daping Quan, Xiangcheng Qing, Ying Bai, Zengwu Sha. Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization. Acta biomaterialia. 2023-08-20. PMID:37598791. |
besides, ti-cnp-daf relieved mechanical hyperalgesia, reduced cgrp and substance p expression in the dorsal root ganglion, and downregulated gfap and c-fos signaling in the spinal cord in the rat disc herniation model. |
2023-08-20 |
2023-09-07 |
rat |
| Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Meng-Hua Zhou \\xe5\\x91\\xa8\\xe5\\xad\\x9f\\xe5\\x8d\\x8e, Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. mGluR5 from primary sensory neurons promotes opioid-induced hyperalgesia and tolerance by interacting with and potentiating synaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-14. PMID:37451981. |
correspondingly, intrathecal injection of mpep or conditional mglur5 knockdown in drg neurons not only potentiated the acute analgesic effect of morphine but also attenuated morphine treatment-induced hyperalgesia and tolerance. |
2023-07-14 |
2023-08-14 |
mouse |
| Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun Jian. Nerve Injury-Induced \\xce\\xb3H2AX Reduction in Primary Sensory Neurons Is Involved in Neuropathic Pain Processing. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373296. |
the intrathecal injection of ku55933 down-regulated drg \xce\xb3h2ax expression and significantly induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. |
2023-06-28 |
2023-08-14 |
mouse |
| Shunsuke Yamakita, Daisuke Fujita, Kazuki Sudo, Daiki Ishikawa, Kohsuke Kushimoto, Yasuhiko Horii, Fumimasa Amay. Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia. Molecular pain. 2023-05-31. PMID:37254240. |
activation of neurons and satellite glial cells in the drg produces morphine-induced hyperalgesia. |
2023-05-31 |
2023-08-14 |
rat |
| Shunsuke Yamakita, Daisuke Fujita, Kazuki Sudo, Daiki Ishikawa, Kohsuke Kushimoto, Yasuhiko Horii, Fumimasa Amay. Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia. Molecular pain. 2023-05-31. PMID:37254240. |
activation of neurons and glial cells in the dorsal root ganglion is one of the key mechanisms for the development of hyperalgesia. |
2023-05-31 |
2023-08-14 |
rat |
| Songbin Wu, Shaomin Yang, Rongzhen Li, Xiyuan Ba, Changyu Jiang, Donglin Xiong, Lizu Xiao, Wuping Su. HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism. Journal of medical virology. vol 95. issue 4. 2023-05-16. PMID:37185840. |
hsv-1 inoculation in mice resulted in mechanical allodynia, thermal hyperalgesia, and cold allodynia, following the infection of hsv-1 in both drg and spinal cord. |
2023-05-16 |
2023-08-14 |
mouse |
| Lai Wang, Shingo Ishihara, Jun Li, Rachel E Miller, Anne-Marie Malfai. Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain. Arthritis research & therapy. vol 25. issue 1. 2023-04-15. PMID:37061736. |
we aimed to explore activation of the notch signaling pathway in knee-innervating lumbar dorsal root ganglia (drg) in the course of experimental osteoarthritis (oa) in mice, and its role in knee hyperalgesia. |
2023-04-15 |
2023-08-14 |
mouse |
| Junying Du, Min Yi, Danning Xi, Sisi Wang, Boyi Liu, Xiaomei Shao, Yi Liang, Xiaofen He, Jianqiao Fang, Junfan Fan. Satellite glial cells drive the transition from acute to chronic pain in a rat model of hyperalgesic priming. Frontiers in molecular neuroscience. vol 16. 2023-02-23. PMID:36818653. |
in this study, hp model rats developed prolonged hyperalgesia in the hind paw after carrageenan (car) and pge2 injection, accompanied by obvious satellite glial cell (sgc) activation in the dorsal root ganglion (drg), as indicated by upregulation of gfap. |
2023-02-23 |
2023-08-14 |
rat |
| Junying Du, Min Yi, Danning Xi, Sisi Wang, Boyi Liu, Xiaomei Shao, Yi Liang, Xiaofen He, Jianqiao Fang, Junfan Fan. Satellite glial cells drive the transition from acute to chronic pain in a rat model of hyperalgesic priming. Frontiers in molecular neuroscience. vol 16. 2023-02-23. PMID:36818653. |
pharmacological blockade of cxcl1 reduced protein kinase c epsilon overproduction as well as hyperalgesia in hp rats but did not prevent the upregulation of gfap in the drg. |
2023-02-23 |
2023-08-14 |
rat |
| Yi-Qi Ma, Qun-Qi Hu, Yu Rong Kang, Li-Qian Ma, Si-Ying Qu, Han-Zhi Wang, Yin-Mu Zheng, Si-Yi Li, Xiao-Mei Shao, Xiao-Yu Li, Han-Tong Hu, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture Alleviates Diabetic Neuropathic Pain and Downregulates p-PKC and TRPV1 in Dorsal Root Ganglions and Spinal Cord Dorsal Horn. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-02-13. PMID:36777630. |
ea reversed thermal hyperalgesia in dnp rats and downregulated the expression of p-pkc, trpv1, sp, and cgrp in drg and scdh. |
2023-02-13 |
2023-08-14 |
rat |
| InSug O-Sullivan, Ranjan Kc, Gurjit Singh, Vaskar Das, Kaige Ma, Xin Li, Fackson Mwale, Gina Votta-Velis, Benjamin Bruce, Arivarasu Natarajan Anbazhagan, Andre J van Wijnen, Hee-Jeong I. Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A ( International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36292950. |
we investigated the mechanisms of pain transmission as to whether peripheral sensory neurons are linked to the cellular plasticity in the dorsal root ganglia (drg) and are critical for oa hyperalgesia. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ying-Yi Lu, Chun-Ching Lu, Chao-Lan Huang, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin W. Article Type: Original Article Title: Linalyl Acetate Ameliorates Mechanical Hyperalgesia Through Suppressing Inflammation by TSLP/IL-33 Signaling. Neurochemical research. 2022-10-26. PMID:36287299. |
sni rats were more sensitive to hyperalgesia response to mechanical stimulus since operation, which was accompanied by spinal cord glial cells reactions and drg neuro-glial interaction. |
2022-10-26 |
2023-08-14 |
rat |
| Ziping Li, Haoyue Zhang, Yigang Wang, Yize Li, Qing Li, Linlin Zhan. The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances. Frontiers in molecular neuroscience. vol 15. 2022-10-24. PMID:36277488. |
under physiological condition, low to moderate concentrations of menthol activate transient receptor potential cation channel subfamily m member 8 (trpm8) in the primary nociceptors, such as dorsal root ganglion (drg) and trigeminal ganglion, generating a cooling sensation, whereas menthol at higher concentration could induce cold allodynia, and cold hyperalgesia mediated by trpm8 sensitization. |
2022-10-24 |
2023-08-14 |
Not clear |
| Hourong Wang, Zhifeng Liu, Tianyuan Yu, Yingqi Zhang, Yajing Xu, Yi Jiao, Qian Guan, Di Li. Exploring the mechanism of immediate analgesic effect of 1-time tuina intervention in minor chronic constriction injury rats using RNA-seq. Frontiers in neuroscience. vol 16. 2022-10-21. PMID:36267229. |
1-time tuina was more effective in the amelioration of thermal hyperalgesia, but no changes were found in the ultrastructure of drg and sdh. |
2022-10-21 |
2023-08-14 |
rat |
| Yong Fang Zhu, Peter Kan, Gurmit Sing. Differences and Similarities in Spontaneous Activity Between Animal Models of Cancer-Induced Pain and Neuropathic Pain. Journal of pain research. vol 15. 2022-10-19. PMID:36258759. |
in our previous studies in an animal model of cip, we observed changes in intrinsic membrane properties and excitability of dorsal root ganglion (drg) sensory neurons corresponding to mechanical allodynia and hyperalgesia, of which abnormal activities of a\xce\xb2-fiber sensory neurons are consistent in a rat model of peripheral neuropathic pain (nep). |
2022-10-19 |
2023-08-14 |
rat |
| Mei Yu, Fan Ye, Chao Ma, Xiang Jin, Haiwang Ji, Dijun Wang, Yan Yang, Chan Zhu, Zongxiang Tan. Ligustrazine mitigates chronic venous disease-induced pain hyperalgesia through desensitization of inflammation-associated TRPA1 activity in DRG. Journal of ethnopharmacology. 2022-08-27. PMID:36030028. |
ligustrazine mitigates chronic venous disease-induced pain hyperalgesia through desensitization of inflammation-associated trpa1 activity in drg. |
2022-08-27 |
2023-08-14 |
Not clear |
| Tae-Hwan Gil, Haiyan Zheng, Hyo Gyeong Lee, Ji-Won Shin, Sun Wook Hwang, Ki-Mo Jang, Ok Hee Jeo. Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis. Aging. vol 14. issue undefined. 2022-08-11. PMID:35951358. |
treatment reduced thermal and mechanical hyperalgesia associated with oa and peripheral sensitization through decreased expression of axon guidance proteins (nerve growth factor ngf/trka) and nociceptive neuron (calcitonin gene-related peptide, cgrp) projection to the synovium, subchondral bone marrow, and dorsal root ganglion, and knee joint angiogenesis. |
2022-08-11 |
2023-08-14 |
mouse |
| Giacomo Carta, Benedetta Elena Fornasari, Federica Fregnan, Giulia Ronchi, Stefano De Zanet, Luisa Muratori, Giulia Nato, Marco Fogli, Giovanna Gambarotta, Stefano Geuna, Stefania Raimond. Neurodynamic Treatment Promotes Mechanical Pain Modulation in Sensory Neurons and Nerve Regeneration in Rats. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740318. |
we aimed to define, both in vivo and ex vivo, how ndt could promote nerve regeneration and modulate some processes in the drg linked to ma and hyperalgesia. |
2022-06-24 |
2023-08-14 |
rat |
| Yize Li, Jiamin Kang, Ying Xu, Nan Li, Yang Jiao, Chenxu Wang, Chunyan Wang, Guolin Wang, Yonghao Yu, Jingjing Yuan, Linlin Zhan. Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons. Frontiers in molecular neuroscience. vol 15. 2022-06-13. PMID:35694442. |
in conclusion, this study revealed that artesunate alleviates paclitaxel-induced hyperalgesia and spontaneous pain by decreasing drg mglur5 expression and neuroinflammation in the mouse model of pinp. |
2022-06-13 |
2023-08-14 |
mouse |