| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Tramutola, Hannah S Bakels, Federica Perrone, Michela Di Nottia, Tommaso Mazza, Maria Pia Abruzzese, Martina Zoccola, Sara Pagnotta, Rosalba Carrozzo, Susanne T de Bot, Marzia Perluigi, Willeke M C van Roon-Mom, Ferdinando Squitier. GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study. EBioMedicine. vol 97. 2023-10-28. PMID:37898095. |
glut-1 changes in paediatric huntington disease brain cortex and fibroblasts: an observational case-control study. |
2023-10-28 |
2023-11-08 |
Not clear |
| Andrea M Reyes-Ortiz, Edsel M Abud, Mara S Burns, Jie Wu, Sarah J Hernandez, Nicolette McClure, Keona Q Wang, Corey J Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W Poon, Ryan G Lim, Leslie M Thompso. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. iScience. vol 26. issue 1. 2023-01-02. PMID:36590162. |
huntington disease (hd) is a neurodegenerative disorder caused by expanded cag repeats in the huntingtin gene that alters cellular homeostasis, particularly in the striatum and cortex. |
2023-01-02 |
2023-08-14 |
mouse |
| Uri Nimrod Ram\\xc3\\xadrez-Jarqu\\xc3\\xadn, Manish Sharma, Wuyue Zhou, Neelam Shahani, Srinivasa Subramania. Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 5. 2022-01-28. PMID:35086928. |
the cag expansion of huntingtin (mhtt) associated with huntington disease (hd) is a ubiquitously expressed gene, yet it prominently damages the striatum and cortex, followed by widespread peripheral defects as the disease progresses. |
2022-01-28 |
2023-08-13 |
mouse |
| Wei-Ti Hsu, Yi-Hung Chen, Han-Bin Yang, Jaung-Geng Lin, Shih-Ya Hun. Electroacupuncture Improves Motor Symptoms of Parkinson's Disease and Promotes Neuronal Autophagy Activity in Mouse Brain. The American journal of Chinese medicine. vol 48. issue 7. 2021-02-09. PMID:33202151. |
we report that ea improves pd motor symptoms in mice and enhances (1) autophagy initiation (increased beclin 1), (2) autophagosome biogenesis (increased atg5, atg7, atg9a, atg12, atg16l, atg3, and lc3-ii), (3) autophagy flux/substrate degradation (decreased p62), and (4) mitophagy (increased pink1 and dj-1) in neurons of the substantia nigra, striatum, hippocampus, and cortex (affected brain areas of pd, huntington disease, and alzheimer's disease). |
2021-02-09 |
2023-08-13 |
mouse |
| Malvindar K Singh-Bains, Nasim F Mehrabi, Tvesa Sehji, Micah D R Austria, Adelie Y S Tan, Lynette J Tippett, Mike Dragunow, Henry J Waldvogel, Richard L M Faul. Cerebellar degeneration correlates with motor symptoms in Huntington disease. Annals of neurology. vol 85. issue 3. 2020-01-13. PMID:30635944. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder characterized by variable motor and behavioral symptoms attributed to major neuropathology of mainly the basal ganglia and cerebral cortex. |
2020-01-13 |
2023-08-13 |
human |
| Jordan L Schultz, Peg C Nopoulos, Pedro Gonzalez-Alegr. Human Immunodeficiency Virus Infection in Huntington's Disease is Associated with an Earlier Age of Symptom Onset. Journal of Huntington's disease. vol 7. issue 2. 2019-10-21. PMID:29843248. |
huntington disease (hd) and human immunodeficiency virus (hiv) are both associated with neurodegeneration in the cerebral cortex and striatum. |
2019-10-21 |
2023-08-13 |
human |
| Arianna Novati, Thomas Hentrich, Zinah Wassouf, Jonasz J Weber, Libo Yu-Taeger, Nicole D\\xc3\\xa9glon, Huu Phuc Nguyen, Julia M Schulze-Hentric. Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease. Scientific reports. vol 8. issue 1. 2019-10-07. PMID:29643462. |
huntington disease (hd) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (htt) gene which results in progressive neurodegeneration in the striatum, cortex, and eventually most brain areas. |
2019-10-07 |
2023-08-13 |
mouse |
| Anastasia No\\xc3\\xabl, Libin Zhou, B\\xc3\\xa9n\\xc3\\xa9dicte Foveau, P Jesper Sj\\xc3\\xb6str\\xc3\\xb6m, Andr\\xc3\\xa9a C LeBlan. Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6. Cell death and differentiation. vol 25. issue 7. 2019-09-16. PMID:29352267. |
to assess whether caspase-6 causes damage to another neuronal system, a transgenic knock-in mouse overexpressing a self-activated form of caspase-6 five-fold in the striatum, the area affected in huntington disease, and 2.5-fold in the hippocampus and cortex, was generated. |
2019-09-16 |
2023-08-13 |
mouse |
| William Andr\\xc3\\xa9, Christophe Sandt, Isabelle Nondier, Philippe Djian, Guylaine Hoffne. Inclusions of R6/2 Mice Are Not Amyloid and Differ Structurally from Those of Huntington Disease Brain. Analytical chemistry. vol 89. issue 10. 2019-02-19. PMID:28398721. |
in that respect, r6/2 mice differ from patients with huntington disease whose striatum and cerebral cortex develop inclusions associated with extensive neuronal loss. |
2019-02-19 |
2023-08-13 |
mouse |
| William Andr\\xc3\\xa9, Christophe Sandt, Isabelle Nondier, Philippe Djian, Guylaine Hoffne. Inclusions of R6/2 Mice Are Not Amyloid and Differ Structurally from Those of Huntington Disease Brain. Analytical chemistry. vol 89. issue 10. 2019-02-19. PMID:28398721. |
we have previously demonstrated using synchrotron-based infrared microspectroscopy that the striatum and the cortex of patients with huntington disease contained inclusions specifically enriched in amyloid \xce\xb2-sheets. |
2019-02-19 |
2023-08-13 |
mouse |
| Menno H Schut, Stefano Patassini, Eric H Kim, Jocelyn Bullock, Henry J Waldvogel, Richard L M Faull, Barry A Pepers, Johan T den Dunnen, Gert-Jan B van Ommen, Willeke M C van Roon-Mo. Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates. PloS one. vol 12. issue 6. 2017-09-26. PMID:28570578. |
the influence of subject-to-subject variation on n-terminal huntingtin fragments was assessed in human cortex and human striatum using two cohorts of control and huntington disease subjects. |
2017-09-26 |
2023-08-13 |
human |
| Rodrigo A Quintanilla, Cheril Tapia, Mar\\xc3\\xada Jos\\xc3\\xa9 P\\xc3\\xa9re. Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease. Biochemical and biophysical research communications. vol 483. issue 4. 2017-06-06. PMID:27638306. |
huntington disease (hd) is a devastating neurological disorder that affects the striatum and cortex of patients. |
2017-06-06 |
2023-08-13 |
Not clear |
| Jenny H\\xc3\\xa4ggkvist, Mikl\\xc3\\xb3s T\\xc3\\xb3th, Lenke Tari, Katarina Varn\\xc3\\xa4s, Marie Svedberg, Anton Forsberg, Sangram Nag, Celia Dominguez, Ignacio Munoz-Sanjuan, Jonathan Bard, John Wityak, Andrea Varrone, Christer Halldin, Ladislav Mrzlja. Longitudinal Small-Animal PET Imaging of the zQ175 Mouse Model of Huntington Disease Shows In Vivo Changes of Molecular Targets in the Striatum and Cerebral Cortex. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 58. issue 4. 2017-05-23. PMID:27856625. |
longitudinal small-animal pet imaging of the zq175 mouse model of huntington disease shows in vivo changes of molecular targets in the striatum and cerebral cortex. |
2017-05-23 |
2023-08-13 |
mouse |
| Valerio Leoni, Claudio Cacci. The impairment of cholesterol metabolism in Huntington disease. Biochimica et biophysica acta. vol 1851. issue 8. 2015-08-25. PMID:25596342. |
huntington disease (hd), an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of cag trinucleotide repeat in the huntingtin (htt) gene, is characterized by extensive neurodegeneration of striatum and cortex and severe diffuse atrophy at mri. |
2015-08-25 |
2023-08-13 |
Not clear |
| Hyun Ah Kim, Luning Jiang, Heather Madsen, Clare L Parish, Jim Massalas, Arthur Smardencas, Claire O'Leary, Ilse Gantois, Colm O'Tuathaigh, John L Waddington, Michelle E Ehrlich, Andrew J Lawrence, John Drag. Resolving pathobiological mechanisms relating to Huntington disease: gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells. Neurobiology of disease. vol 62. 2014-09-03. PMID:24135007. |
progressive cell loss is observed in the striatum, cerebral cortex, thalamus, hypothalamus, subthalamic nucleus and hippocampus in huntington disease. |
2014-09-03 |
2023-08-12 |
mouse |
| Christine Delmaire, Eve M Dumas, Michael A Sharman, Simon J A van den Bogaard, Romain Valabregue, C\\xc3\\xa9line Jauffret, Damian Justo, Ralf Reilmann, Julie C Stout, David Craufurd, Sarah J Tabrizi, Raymund A C Roos, Alexandra Durr, St\\xc3\\xa9phane Leh\\xc3\\xa9ric. The structural correlates of functional deficits in early huntington's disease. Human brain mapping. vol 34. issue 9. 2014-03-20. PMID:22438242. |
neuropathological studies in huntington disease (hd) have demonstrated neuronal loss in the striatum, as well as in other brain regions including the cortex. |
2014-03-20 |
2023-08-12 |
Not clear |
| Libo Yu-Taeger, Elisabeth Petrasch-Parwez, Alexander P Osmand, Adriana Redensek, Silke Metzger, Laura E Clemens, Larry Park, David Howland, Carsten Calaminus, Xiaofeng Gu, Bernd Pichler, X William Yang, Olaf Riess, Huu Phuc Nguye. A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 44. 2013-01-04. PMID:23115180. |
huntington disease (hd) is an inherited progressive neurodegenerative disorder, characterized by motor, cognitive, and psychiatric deficits as well as neurodegeneration and brain atrophy beginning in the striatum and the cortex and extending to other subcortical brain regions. |
2013-01-04 |
2023-08-12 |
mouse |
| M Alba Sorolla, Mar\\xc3\\xada Jos\\xc3\\xa9 Rodr\\xc3\\xadguez-Colman, N\\xc3\\xbaria Vall-llaura, Jordi Tamarit, Joaquim Ros, Elisa Cabisco. Protein oxidation in Huntington disease. BioFactors (Oxford, England). vol 38. issue 3. 2012-10-11. PMID:22473822. |
huntington disease (hd) is an inherited neurodegenerative disorder caused by expansion of cag repeats in the huntingtin gene, affecting initially the striatum and progressively the cortex. |
2012-10-11 |
2023-08-12 |
Not clear |
| Sebastien Cayzac, Sebastien Delcasso, Vietminh Paz, Yannick Jeantet, Yoon H Ch. Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576479. |
in hereditary neurodegenerative huntington disease (hd), early cognitive impairments before motor deficits have been hypothesized to result from dysfunction in the striatum and cortex before degeneration. |
2011-08-23 |
2023-08-12 |
mouse |
| Peggy C Nopoulos, Elizabeth H Aylward, Christopher A Ross, Hans J Johnson, Vincent A Magnotta, Andrew R Juhl, Ronald K Pierson, James Mills, Douglas R Langbehn, Jane S Paulse. Cerebral cortex structure in prodromal Huntington disease. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20688164. |
cerebral cortex structure in prodromal huntington disease. |
2011-01-25 |
2023-08-12 |
human |