| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dale D O Martin, Shaun S Sander. Let's get fat: emergence of S-acylation as a therapeutic target in Huntington disease. Biochemical Society transactions. 2024-05-02. PMID:38695682. |
huntington disease (hd) is a devastating, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric deficits caused by a cag repeat expansion in the htt gene. |
2024-05-02 |
2024-05-04 |
Not clear |
| Xuanzhuo Liu, Fang Wang, Xinman Fan, Mingyi Chen, Xiaoxin Xu, Qiuhong Xu, Huili Zhu, Anding Xu, Mahmoud A Pouladi, Xiaohong X. CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress. Cell death & disease. vol 15. issue 2. 2024-02-10. PMID:38341417. |
huntington disease (hd) is a neurodegenerative disease caused by the abnormal expansion of a polyglutamine tract resulting from a mutation in the htt gene. |
2024-02-10 |
2024-02-14 |
mouse |
| Leonard L Sokol, Jonathan P Troost, Danny Bega, Benzi M Kluger, Holly G Prigerson, Martha Nance, Samuel Frank, Joel S Perlmutter, Praveen Dayalu, David Cella, Noelle E Carlozz. Advance Care Planning and Health-Related Quality of Life in Huntington Disease: Results from a Multicenter National Study. Palliative medicine reports. vol 4. issue 1. 2023-03-27. PMID:36969738. |
with huntington disease (hd), a fatal neurodegenerative disease where the prevalence of suicidal thoughts and behavior (stb) remains elevated as compared to other neurological disorders, it is unknown whether stb and health-related quality of life (hrqol) affect plans for the end of life or more broadly, advance care planning (acp). |
2023-03-27 |
2023-08-14 |
Not clear |
| Xiaolin Dong, Yanping Li, Qingyun Li, Wenhao Li, Gang W. Identification of immune signatures in Parkinson's disease based on co-expression networks. Frontiers in genetics. vol 14. 2023-02-03. PMID:36733342. |
in addition, functional analysis indicated that module genes were involved in various neurodegenerative diseases, such as alzheimer disease, huntington disease, parkinson disease, and long-term depression. |
2023-02-03 |
2023-08-14 |
human |
| Hannah S Hart, Madeline A Valentin, Stephanie Toering Peters, Susan W Holler, Hongmin Wang, Aaron F Harmon, Larry D Holle. The cytoprotective role of GM1 ganglioside in Huntington disease cells. Molecular biology reports. 2022-09-30. PMID:36180805. |
huntington disease (hd) is a neurodegenerative disease where a genetic mutation leads to excessive polyglutamine (q) repeats in the huntingtin protein. |
2022-09-30 |
2023-08-14 |
Not clear |
| E Srinivasan, Vavish Ram, R Rajasekara. A review on Huntington protein Insight into protein aggregation and therapeutic interventions. Current drug metabolism. 2022-03-23. PMID:35319359. |
huntington disease (hd) is a distressing, innate neurodegenerative disease that descends from cag repeat expansion in the huntingtin gene causing behavioral changes, motor dysfunction, and dementia in children and adults. |
2022-03-23 |
2023-08-13 |
Not clear |
| Alice Drobny, Susy Prieto Huarcaya, Jan Dobert, Annika Kluge, Josina Bunk, Theresia Schlothauer, Friederike Zunk. The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches. Biochimica et biophysica acta. Molecular cell research. 2022-02-26. PMID:35217144. |
particularly, alterations in lysosomal cathepsins ctsd, ctsb and ctsl can contribute to the pathogenesis of neurodegenerative diseases as seen for neuronal ceroid lipofuscinosis, synucleinopathies (parkinson's disease, dementia with lewy body and multiple system atrophy) as well as alzheimer's and huntington disease. |
2022-02-26 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
huntington disease (hd) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene encoding an elongated polyglutamine tract in the huntingtin (htt) protein. |
2022-02-10 |
2023-08-13 |
mouse |
| Nour S Ereka. Apoptosis and its therapeutic implications in neurodegenerative diseases. Clinical anatomy (New York, N.Y.). vol 35. issue 1. 2021-12-08. PMID:34558138. |
apoptosis has been implicated in the pathogenesis of neurodegenerative diseases, including parkinson disease, alzheimer disease, huntington disease, and amyotrophic lateral sclerosis. |
2021-12-08 |
2023-08-13 |
Not clear |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
huntington disease (hd) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the cag expansion mutation in the huntingtin gene (htt) is in the range of full penetrance. |
2021-11-11 |
2023-08-13 |
Not clear |
| Francesca Fagiani, Stefano Govoni, Marco Racchi, Cristina Lann. The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33083964. |
besides its implication in physiological processes, a growing body of evidence suggests the crucial involvement of pin1 in aging and age-related and neurodegenerative diseases, including alzheimer's disease, parkinson disease, frontotemporal dementias, huntington disease, and amyotrophic lateral sclerosis, where it mediates profoundly different effects, ranging from neuroprotective to neurotoxic. |
2021-10-13 |
2023-08-13 |
Not clear |
| X Zhao, A Chen, Z Wang, Xiao-Han Xu, Y Ta. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021-09-26. PMID:34564830. |
huntington disease (hd) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (htt). |
2021-09-26 |
2023-08-13 |
Not clear |
| Saurabh Gupta, Arzoo Khan, Sukriti Vishwas, Monica Gulati, Thakur Gurjeet Singh, Kamal Dua, Sachin Kumar Singh, Agnieszka Najda, Amany A Sayed, Rafa Almeer, Mohamed M Abdel-Dai. Demethyleneberberine: A possible treatment for Huntington's disease. Medical hypotheses. vol 153. 2021-08-09. PMID:34229236. |
huntington disease (hd) is a type of neurodegenerative disease that is characterized by presence of multiple repeats (more than 36) of cytosine-adenine-guanine (cag) trinucleotides and mutated huntingtin (mhtt). |
2021-08-09 |
2023-08-13 |
Not clear |
| Sarah J Tabrizi, Michael D Flower, Christopher A Ross, Edward J Wil. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32796930. |
huntington disease (hd) is a neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt) and involves a complex web of pathogenic mechanisms. |
2021-06-24 |
2023-08-13 |
human |
| Chia-Lung Chuang, Fabio Demonti. Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis. Ageing research reviews. vol 69. 2021-06-24. PMID:33979693. |
huntington disease (hd) is an autosomal dominant neurodegenerative disease that is caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (htt) gene, which leads to a toxic, aggregation-prone, mutant htt-polyq protein. |
2021-06-24 |
2023-08-13 |
Not clear |
| Baojin Ding, Masood Sepehrimanes. Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration. International journal of molecular sciences. vol 22. issue 8. 2021-05-12. PMID:33920577. |
accumulating evidence has demonstrated that dysregulations of nct are implicated in aging and age-related neurodegenerative diseases, including amyotrophic lateral sclerosis (als), frontotemporal dementia (ftd), alzheimer's disease (ad), and huntington disease (hd). |
2021-05-12 |
2023-08-13 |
Not clear |
| Thays A Apolinário, Iane Dos Santos da Silva, Luciana de Andrade Agostinho, Carmen L A Paiv. Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease-affected families. Molecular genetics & genomic medicine. vol 8. issue 4. 2021-04-02. PMID:32067426. |
huntington disease (hd) (mim: 143100) is a severe autosomal dominant neurodegenerative disease caused by the expansion of cag trinucleotides (>35) in the htt. |
2021-04-02 |
2023-08-13 |
Not clear |
| Nicholas S Caron, Raul Banos, Christopher Yanick, Amirah E Aly, Lauren M Byrne, Ethan D Smith, Yuanyun Xie, Stephen E P Smith, Nalini Potluri, Hailey Findlay Black, Lorenzo Casal, Seunghyun Ko, Daphne Cheung, Hyeongju Kim, Ihn Sik Seong, Edward J Wild, Ji-Joon Song, Michael R Hayden, Amber L Southwel. Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 4. 2021-03-26. PMID:33310753. |
huntington disease (hd) is a neurodegenerative disease caused by a cag trinucleotide repeat expansion in the huntingtin ( |
2021-03-26 |
2023-08-13 |
Not clear |
| Havva Yalinca, Charlotte Julie Caroline Gehin, Vladimiras Oleinikovas, Hilal A Lashuel, Francesco Luigi Gervasio, Annalisa Pastor. The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus. Frontiers in molecular biosciences. vol 6. 2021-01-10. PMID:31632982. |
huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. |
2021-01-10 |
2023-08-13 |
human |
| Diogo Ferreira, Berta Carvalho, Ana P Neto, Joaquina Silva, Ana M Póvoa, Alberto Barros, Filipa Carvalh. Preimplantation genetic testing for Huntington disease: the perspective of one Portuguese center. Porto biomedical journal. vol 4. issue 5. 2020-10-01. PMID:31893246. |
huntington disease (hd) is an autosomal dominant late-onset neurodegenerative disease caused by an unstable cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin ( |
2020-10-01 |
2023-08-13 |
Not clear |