| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yejin Yun, Sang-Yeon Le. Updates on Genetic Hearing Loss: From Diagnosis to Targeted Therapies. Journal of audiology & otology. vol 28. issue 2. 2024-05-02. PMID:38695053. |
for example, targeted small molecules have been used to ameliorate autoinflammatory hearing loss caused by gain-of-function variants of nlrp3 and inner ear proteinopathy with osbpl2 variants underlying dysfunctional autophagy. |
2024-05-02 |
2024-05-04 |
human |
| Merav Birk-Bachar, Hadar Cohen, Efrat Sofrin-Drucker, Nesia Kropach-Gilad, Naama Orenstein, Gabriel Lidzbarsky, Liora Kornreich, Rotem Tal, Gil Amarilyo, Yoel Levinsky, Meirav Sokolov, Eyal Raveh, Motti Gerlic, Liora Hare. Discovery of a novel missense variant in NLRP3 causing atypical CAPS with hearing loss as the primary presentation, responsive to anti-IL-1 therapy. Arthritis & rheumatology (Hoboken, N.J.). 2023-09-22. PMID:37738164. |
discovery of a novel missense variant in nlrp3 causing atypical caps with hearing loss as the primary presentation, responsive to anti-il-1 therapy. |
2023-09-22 |
2023-10-07 |
Not clear |
| Grace E Gregory, Kevin J Munro, Kevin N Couper, Omar N Pathmanaban, David Broug. The NLRP3 inflammasome as a target for sensorineural hearing loss. Clinical immunology (Orlando, Fla.). 2023-03-12. PMID:36907540. |
the nlrp3 inflammasome is a multi-molecular pro-inflammatory protein complex that forms in activated macrophages and may contribute to hearing loss. |
2023-03-12 |
2023-08-14 |
Not clear |
| Grace E Gregory, Kevin J Munro, Kevin N Couper, Omar N Pathmanaban, David Broug. The NLRP3 inflammasome as a target for sensorineural hearing loss. Clinical immunology (Orlando, Fla.). 2023-03-12. PMID:36907540. |
the aim of this article is to discuss the evidence for the nlrp3 inflammasome and associated cytokines as potential therapeutic targets for sensorineural hearing loss in conditions ranging from auto-inflammatory disease to tumour-induced hearing loss in vestibular schwannoma. |
2023-03-12 |
2023-08-14 |
Not clear |
| Grace E Gregory, Kevin J Munro, Kevin N Couper, Omar N Pathmanaban, David Broug. The NLRP3 inflammasome as a target for sensorineural hearing loss. Clinical immunology (Orlando, Fla.). 2023-03-12. PMID:36907540. |
the nlrp3 inflammasome as a target for sensorineural hearing loss. |
2023-03-12 |
2023-08-14 |
Not clear |
| Peipei Li, Shen Li, Le Wang, Hongmin Li, Yang Wang, Hongbing Liu, Xin Wang, Xiaodan Zhu, Zhangsuo Liu, Fanglei Ye, Yuan Zhan. Mitochondrial dysfunction in hearing loss: Oxidative stress, autophagy and NLRP3 inflammasome. Frontiers in cell and developmental biology. vol 11. 2023-03-09. PMID:36891515. |
in addition, we further discuss the interplays linking ros generation, nlrp3 inflammasome activation, and autophagy underlying the pathogenesis of deafness, including ototoxic drugs-, noise- and aging-related hearing loss. |
2023-03-09 |
2023-08-14 |
Not clear |
| Peipei Li, Shen Li, Le Wang, Hongmin Li, Yang Wang, Hongbing Liu, Xin Wang, Xiaodan Zhu, Zhangsuo Liu, Fanglei Ye, Yuan Zhan. Mitochondrial dysfunction in hearing loss: Oxidative stress, autophagy and NLRP3 inflammasome. Frontiers in cell and developmental biology. vol 11. 2023-03-09. PMID:36891515. |
mitochondrial dysfunction in hearing loss: oxidative stress, autophagy and nlrp3 inflammasome. |
2023-03-09 |
2023-08-14 |
Not clear |
| Ji-Hyun Ma, Eunju Lee, Sung-Hyun Yoon, Hyehyun Min, Jae Hwan Oh, Inhwa Hwang, Yejin Sung, Ju Hee Ryu, Jinwoong Bok, Je-Wook Y. Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine. vol 82. 2022-07-23. PMID:35870427. |
although caps patients frequently suffer from sensorineural hearing loss, it remains unclear whether caps-associated mutation in nlrp3 is associated with the progression of hearing loss. |
2022-07-23 |
2023-08-14 |
mouse |
| Ji-Hyun Ma, Eunju Lee, Sung-Hyun Yoon, Hyehyun Min, Jae Hwan Oh, Inhwa Hwang, Yejin Sung, Ju Hee Ryu, Jinwoong Bok, Je-Wook Y. Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine. vol 82. 2022-07-23. PMID:35870427. |
therapeutic effect of nlrp3 inhibition on hearing loss induced by systemic inflammation in a caps-associated mouse model. |
2022-07-23 |
2023-08-14 |
mouse |
| Liyuan Wu, Mengbing Chen, Menghua Li, Yifeng Wang, Yalan Li, Liting Zheng, Zhaoyang Ke, Ke Liu, Yuehua Qiao, Xi Sh. Oridonin alleviates kanamycin-related hearing loss by inhibiting NLRP3/caspase-1/gasdermin D-induced inflammasome activation and hair cell pyroptosis. Molecular immunology. vol 149. 2022-06-24. PMID:35749835. |
moreover, we also found that the nlrp3 inhibitor oridonin (ori) could significantly rescue km-related hearing loss by inhibiting nlrp3-inflammasome activation and caspase-1/gsdmd-related hair cell pyroptosis. |
2022-06-24 |
2023-08-14 |
mouse |
| Liyuan Wu, Mengbing Chen, Menghua Li, Yifeng Wang, Yalan Li, Liting Zheng, Zhaoyang Ke, Ke Liu, Yuehua Qiao, Xi Sh. Oridonin alleviates kanamycin-related hearing loss by inhibiting NLRP3/caspase-1/gasdermin D-induced inflammasome activation and hair cell pyroptosis. Molecular immunology. vol 149. 2022-06-24. PMID:35749835. |
therefore, this study aimed to determine whether nlrp3 inflammasomes are involved in km-related hearing loss in mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Hiroshi Nakanishi, Satoshi Yamada, Junya Kita, Daichi Shinmura, Kumiko Hosokawa, Sosuke Sahara, Kiyoshi Misaw. Auditory and Vestibular Characteristics of NLRP3 Inflammasome Related Autoinflammatory Disorders: Monogenic Hearing Loss Can Be Improved by Anti-interleukin-1 Therapy. Frontiers in neurology. vol 13. 2022-05-16. PMID:35572943. |
auditory and vestibular characteristics of nlrp3 inflammasome related autoinflammatory disorders: monogenic hearing loss can be improved by anti-interleukin-1 therapy. |
2022-05-16 |
2023-08-13 |
Not clear |
| Bong Jik Kim, Young Ho Kim, Jin Hee Han, Sang-Yeon Lee, Marge Carandang, Dong-Han Lee, Soyoung Lee, Byung Yoon Cho. Outcome of Cochlear Implantation in NLRP3-related Autoinflammatory Inner Ear Disorders. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. vol 42. issue 2. 2021-04-21. PMID:33156237. |
hearing loss is a highly penetrant phenotype in nlrp3 (nod-like-receptor-pyrin containing 3) gene-related autoinflammatory disorders. |
2021-04-21 |
2023-08-13 |
Not clear |
| Jessica E Sagers, Mehmet I Sahin, InSeok Moon, Sherif G Ahmed, Anat Stemmer-Rachamimov, Gary J Brenner, Konstantina M Stankovi. NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss. Hearing research. vol 381. 2020-11-16. PMID:31430634. |
notably, after analysis of 30 vss, we observe that overexpression of key components of the nlrp3 inflammasome is preferentially associated with tumors that produce increased hearing loss in vs patients. |
2020-11-16 |
2023-08-13 |
human |
| Jessica E Sagers, Mehmet I Sahin, InSeok Moon, Sherif G Ahmed, Anat Stemmer-Rachamimov, Gary J Brenner, Konstantina M Stankovi. NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss. Hearing research. vol 381. 2020-11-16. PMID:31430634. |
nlrp3 inflammasome activation in human vestibular schwannoma: implications for tumor-induced hearing loss. |
2020-11-16 |
2023-08-13 |
human |
| Hiroshi Nakanishi, Yoshiyuki Kawashima, Kiyoto Kurima, Julie A Muskett, H Jeffrey Kim, Carmen C Brewer, Andrew J Griffit. Gradual Symmetric Progression of DFNA34 Hearing Loss Caused by an NLRP3 Mutation and Cochlear Autoinflammation. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. vol 39. issue 3. 2019-09-23. PMID:29342053. |
to characterize the audiometric phenotype of autosomal-dominant dfna34 hearing loss (hl) caused by a missense substitution in the nlrp3 gene. |
2019-09-23 |
2023-08-13 |
Not clear |
| Hiroshi Nakanishi, Yoshiyuki Kawashima, Kiyoto Kurima, Julie A Muskett, H Jeffrey Kim, Carmen C Brewer, Andrew J Griffit. Gradual Symmetric Progression of DFNA34 Hearing Loss Caused by an NLRP3 Mutation and Cochlear Autoinflammation. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. vol 39. issue 3. 2019-09-23. PMID:29342053. |
gradual symmetric progression of dfna34 hearing loss caused by an nlrp3 mutation and cochlear autoinflammation. |
2019-09-23 |
2023-08-13 |
Not clear |