| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shreya N Kashyap, Stephanie N Fox, Katherine I Wilson, Charles F Murchison, Yohannes A Ambaw, Tobias C Walther, Robert V Farese, Andrew E Arrant, Erik D Roberso. Carboxy-terminal blockade of sortilin binding enhances progranulin gene therapy, a potential treatment for frontotemporal dementia. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345608. |
carboxy-terminal blockade of sortilin binding enhances progranulin gene therapy, a potential treatment for frontotemporal dementia. |
2024-09-30 |
2024-10-02 |
mouse |
| Malene Overby, Antonio Serrano-Rodriguez, Somayeh Dadras, Ann Kathrine Christiansen, Gözde Ozcelik, Stefan F Lichtenthaler, Jason Porter Weick, Heidi Kaastrup Mülle. Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism. The Journal of biological chemistry. 2023-11-10. PMID:37949230. |
however, using cell surface biotinylation we found only nsg1 reduced sortilin cell surface expression, which caused significant reductions in uptake of progranulin (pgrn), a molecular determinant for frontotemporal dementia. |
2023-11-10 |
2023-11-20 |
Not clear |
| Malene Overby, Antonio Serrano-Rodriguez, Somayeh Dadras, Ann Kathrine Christiansen, Gözde Ozcelik, Stefan F Lichtenthaler, Jason Porter Weick, Heidi Kaastrup Mülle. Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism. The Journal of biological chemistry. 2023-11-10. PMID:37949230. |
increasing evidence suggests that aberrant regulation of sortilin ectodomain shedding can contribute to amyloid-β pathology and frontotemporal dementia, although the mechanism by which this occurs has not been elucidated. |
2023-11-10 |
2023-11-20 |
Not clear |
| Stéphanie Philtjens, Sara Van Mossevelde, Julie van der Zee, Eline Wauters, Lubina Dillen, Mathieu Vandenbulcke, Rik Vandenberghe, Adrian Ivanoiu, Anne Sieben, Christiana Willems, Luisa Benussi, Roberta Ghidoni, Giuliano Binetti, Barbara Borroni, Alessandro Padovani, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Alexandre de Mendonça, Gabriel Miltenberger-Miltényi, Isabel Hernández, Merce Boada, Agustín Ruiz, Benedetta Nacmias, Sandro Sorbi, Maria Rosário Almeida, Isabel Santana, Jordi Clarimón, Alberto Lleó, Giovanni B Frisoni, Raquel Sanchez-Valle, Albert Lladó, Estrella Gómez-Tortosa, Ellen Gelpi, Marleen Van den Broeck, Karin Peeters, Patrick Cras, Peter P De Deyn, Sebastiaan Engelborghs, Marc Cruts, Christine Van Broeckhove. Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia. Neurobiology of aging. vol 66. 2018-10-05. PMID:29555433. |
we investigated the genetic role of sortilin (sort1) in frontotemporal dementia (ftd). |
2018-10-05 |
2023-08-13 |
Not clear |
| Lone Tjener Pallesen, Christian Bjerggaard Vaegte. Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins. Molecular neurobiology. vol 45. issue 2. 2012-12-04. PMID:22297619. |
the current understanding of these issues as well as the recent recognition of a molecular link between sortilin and frontotemporal dementia is addressed in this present review. |
2012-12-04 |
2023-08-12 |
Not clear |