| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Michael G Ricos, Leanne M Dibbens, Stephen L Gregor. Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress. Journal of molecular neuroscience : MN. vol 74. issue 2. 2024-05-01. PMID:38693434. |
a growing body of research from numerous laboratories suggests that many neurodegenerative disorders, especially alzheimer's disease and frontotemporal dementia, are characterised by neuronal aneuploidy and the ensuing apoptosis, which may contribute to neuronal loss. |
2024-05-01 |
2024-05-04 |
drosophila_melanogaster |
| Huntington Potter, Heidi J Chial, Julbert Caneus, Mihret Elos, Nina Elder, Sergiy Borysov, Antoneta Grani. Chromosome Instability and Mosaic Aneuploidy in Neurodegenerative and Neurodevelopmental Disorders. Frontiers in genetics. vol 10. 2020-09-28. PMID:31788001. |
evidence from multiple laboratories has accumulated to show that mosaic neuronal aneuploidy and consequent apoptosis characterizes and may underlie neuronal loss in many neurodegenerative diseases, particularly alzheimer's disease and frontotemporal dementia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Andrea Tedde, Irene Piaceri, Silvia Bagnoli, Ersilia Lucenteforte, Silvia Piacentini, Sandro Sorbi, Benedetta Nacmia. DAPK1 is associated with FTD and not with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 32. issue 1. 2013-02-20. PMID:22785394. |
death-associated protein kinase 1 (dapk1) plays an important role in neuronal apoptosis and could influence the pathology of late-onset alzheimer's disease (load) and frontotemporal dementia (ftd). |
2013-02-20 |
2023-08-12 |
human |
| Alix de Calignon, Leora M Fox, Rose Pitstick, George A Carlson, Brian J Bacskai, Tara L Spires-Jones, Bradley T Hyma. Caspase activation precedes and leads to tangles. Nature. vol 464. issue 7292. 2010-06-07. PMID:20357768. |
studies of post-mortem tissue have shown that the location of fibrillar tau deposits, called neurofibrillary tangles (nft), matches closely with regions of massive neuronal death, severe cytological abnormalities, and markers of caspase activation and apoptosis, leading to the idea that tangles cause neurodegeneration in alzheimer's disease and tau-related frontotemporal dementia. |
2010-06-07 |
2023-08-12 |
mouse |
| J H Su, K E Nichol, T Sitch, P Sheu, C Chubb, B L Miller, K J Tomaselli, R C Kim, C W Cotma. DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785439. |
dna damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. |
2000-06-13 |
2023-08-12 |
Not clear |