| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giota Tsotsokou, Athina Miliou, George Trompoukis, Leonidas J Leontiadis, Costas Papatheodoropoulo. Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000085. |
region-related differences in short-term synaptic plasticity and synaptotagmin-7 in the male and female hippocampus of a rat model of fragile x syndrome. |
2024-07-13 |
2024-07-15 |
rat |
| M Angeles Luque, Sara Morcuende, Blas Torres, Luis Herrer. Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. The Journal of physiology. 2024-07-08. PMID:38976504. |
kv7/m channels may represent a therapeutic target for treating symptoms associated with hippocampal alterations in fragile x syndrome. |
2024-07-08 |
2024-07-12 |
mouse |
| Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. |
role of fmrp in akt/mtor pathway-mediated hippocampal autophagy in fragile x syndrome. |
2024-06-08 |
2024-06-11 |
mouse |
| Antonia Manduca, Valeria Buzzelli, Alessandro Rava, Alessandro Feo, Emilia Carbone, Sara Schiavi, Barbara Peruzzi, Valentina D'Oria, Marco Pezzullo, Andrea Pasquadibisceglie, Fabio Polticelli, Vincenzo Micale, Martin Kuchar, Viviana Trezz. Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: obligatory role of hippocampal GPR55 receptors. Pharmacological research. 2024-04-07. PMID:38583687. |
cannabidiol and positive effects on object recognition memory in an in vivo model of fragile x syndrome: obligatory role of hippocampal gpr55 receptors. |
2024-04-07 |
2024-04-10 |
Not clear |
| Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, Barbara Bardon. Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a. Neurobiology of disease. 2023-12-28. PMID:38154608. |
in cerebral cortex and hippocampus, pde2a expression level is upregulated in fmr1-ko mice, a model of the fragile x syndrome (fxs), the most common form of inherited intellectual disability (id) and autism spectrum disorder (asd). |
2023-12-28 |
2023-12-31 |
mouse |
| Leonidas J Leontiadis, George Trompoukis, Giota Tsotsokou, Athina Miliou, Panagiotis Felemegkas, Costas Papatheodoropoulo. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Frontiers in cellular neuroscience. vol 17. 2023-12-19. PMID:38107412. |
rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile x syndrome. |
2023-12-19 |
2023-12-21 |
rat |
| Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. |
increased inhibition may contribute to maintaining normal network function in the ventral hippocampus of a fmr1-targeted transgenic rat model of fragile x syndrome. |
2023-11-25 |
2023-11-28 |
rat |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile x syndrome. |
2023-07-29 |
2023-08-14 |
mouse |
| Antonis Asiminas, Sam A Booker, Owen R Dando, Zrinko Kozic, Daisy Arkell, Felicity H Inkpen, Anna Sumera, Irem Akyel, Peter C Kind, Emma R Woo. Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome. Molecular autism. vol 13. issue 1. 2022-12-19. PMID:36536454. |
experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of fragile x syndrome. |
2022-12-19 |
2023-08-14 |
rat |
| Luisa Speranza, Kardelen Dalım Filiz, Sarah Goebel, Carla Perrone-Capano, Salvatore Pulcrano, Floriana Volpicelli, Anna Francescon. Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome. Biomedicines. vol 10. issue 11. 2022-11-11. PMID:36359212. |
combined dii and antibody labeling reveals complex dysgenesis of hippocampal dendritic spines in a mouse model of fragile x syndrome. |
2022-11-11 |
2023-08-14 |
mouse |
| Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang, Xinyu Zha. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome. BMC medicine. vol 20. issue 1. 2022-05-13. PMID:35549943. |
sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by nutlin-3 in a mouse model of fragile x syndrome. |
2022-05-13 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
serotonin 5-ht7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of fragile x syndrome. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |
| Michael J Hurley, Robert M J Deacon, A W Edith Chan, David Baker, David L Selwood, Patricia Cogra. Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice. Brain : a journal of neurology. 2021-07-01. PMID:34196695. |
using the cannabinoid-like large-conductance calcium-activated potassium channel activator vsn16r we rescued behavioural deficits such as repetitive behaviour, hippocampal dependent tests of daily living, hyperactivity and memory in a mouse model of fragile x syndrome. |
2021-07-01 |
2023-08-13 |
mouse |
| Sheng-Tao Yang, Min Wang, Veronica Galvin, Yang Yang, Amy F T Arnste. Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance. Psychopharmacology. vol 238. issue 1. 2021-02-26. PMID:32939596. |
metabotropic glutamate type 5 receptor (mglur5) antagonists are under development for treating cognitive disorders such as fragile x syndrome and alzheimer's disease, largely based on success in mouse models, where post-synaptic mglur5 stimulation weakens synaptic functions in hippocampus. |
2021-02-26 |
2023-08-13 |
mouse |
| Ronald R Seese, Aliza A Le, Kathleen Wang, Conor D Cox, Gary Lynch, Christine M Gal. A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Neurobiology of disease. vol 134. 2021-01-13. PMID:31494285. |
fragile x syndrome (fxs) is associated with deficits in various types of learning, including those that require the hippocampus. |
2021-01-13 |
2023-08-13 |
mouse |
| Tue G Banke, Andres Barri. Transient Enhanced GluA2 Expression in Young Hippocampal Neurons of a Fragile X Mouse Model. Frontiers in synaptic neuroscience. vol 12. 2020-12-22. PMID:33343326. |
here, we have investigated the development of ampar-mediated synaptic transmission in the hippocampus of the fmr1 knock-out (ko) mouse, a widely used model of fragile x syndrome (fxs). |
2020-12-22 |
2023-08-13 |
mouse |
| Jessica L Huebschman, Kitzia S Corona, Yuhong Guo, Laura N Smit. The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology. Frontiers in molecular neuroscience. vol 13. 2020-10-06. PMID:33013316. |
loss of fmrp, as in fragile x syndrome (fxs), is a leading monogenic cause of autism and results in altered structural and functional synaptic plasticity, widely described in the hippocampus and cortex. |
2020-10-06 |
2023-08-13 |
Not clear |
| Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31827422. |
pituitary adenylate cyclase-activating polypeptide modulates hippocampal synaptic transmission and plasticity: new therapeutic suggestions for fragile x syndrome. |
2020-10-01 |
2023-08-13 |
mouse |
| Lucia Ciranna, Lara Cost. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31827422. |
in this context, results from our laboratory demonstrate that pacap rescued metabotropic glutamate receptor-mediated synaptic plasticity in the hippocampus of a mouse model of fragile x syndrome (fxs), a genetic form of intellectual disability. |
2020-10-01 |
2023-08-13 |
mouse |