| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karrar Mahmood Shaker Al-Khfaji, Nika Kooshki Zamani, Ehsan Arefia. HSV-1 latency-associated transcript miR-H3 and miR-H4 target STXBP1 and GABBR2 genes. Journal of neurovirology. 2023-09-05. PMID:37668872. |
the gabaergic pathway signaling system is an essential cell signaling pathway influenced by various therapeutic targets and some brain disorders, such as epilepsy. |
2023-09-05 |
2023-09-07 |
Not clear |
| Smruti Ranjan Nayak, Deepthi Joseph, Georg H\\xc3\\xb6fner, Archishman Dakua, Arunabh Athreya, Klaus T Wanner, Baruch I Kanner, Aravind Penmats. Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism. Nature structural & molecular biology. 2023-07-03. PMID:37400654. |
inhibition of gat1 prolongs the gabaergic signaling at the synapse and is a strategy to treat certain forms of epilepsy. |
2023-07-03 |
2023-08-14 |
rat |
| Balbine Kamleu Nkwingwa, Eglantine Keugong Wado, Harquin Simplice Foyet, Parfait Bouvourne, Vanessa Tita Jugha, Alain Hart Mann Youbi Mambou, Raymond Bess Bila, Germain Sotoing Taiw. Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392651. |
ameliorative effects of albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: role of gabaergic, antioxidant defense and anti-inflammatory systems. |
2023-07-01 |
2023-08-14 |
mouse |
| Jiachao Yang, Mi Wang, Yang Lv, Jiadong Che. Cortical Layer Markers Expression and Increased Synaptic Density in Interstitial Neurons of the White Matter from Drug-Resistant Epilepsy Patients. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190591. |
the density of glutamatergic and gabaergic synaptic puncta was increased in interstitial neurons in the white matter of drug-resistant epilepsy patients compared with control brain tissues with no history of epilepsy. |
2023-05-16 |
2023-08-14 |
human |
| Elena Dossi, Gilles Huberfel. GABAergic circuits drive focal seizures. Neurobiology of disease. 2023-03-28. PMID:36977455. |
epilepsy is based on abnormal neuronal activities that have historically been suggested to arise from an excess of excitation and a defect of inhibition, or in other words from an excessive glutamatergic drive not balanced by gabaergic activity. |
2023-03-28 |
2023-08-14 |
Not clear |
| Yosuke Niibori, Robert Duba-Kiss, Joseph T Bruder, Jared B Smith, David R Hampso. Molecular therapy. Methods & clinical development. vol 28. 2023-03-06. PMID:36874244. |
impairment of gabaergic inhibitory neuronal function is linked to epilepsy and other neurological and psychiatric disorders. |
2023-03-06 |
2023-08-14 |
Not clear |
| Sana Javaid, Faleh Alqahtani, Waseem Ashraf, Syed Muhammad Muneeb Anjum, Muhammad Fawad Rasool, Tanveer Ahmad, Fawaz Alasmari, Abdullah F Alasmari, Saleh Abdullah Alqarni, Imran Imra. Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-15. PMID:36791567. |
tiagabine (tia), a new-generation antiseizure drug that mimics the gabaergic signaling by inhibiting gaba transporter type-1, is the least studied molecule in chronic epilepsy models with comorbid neurobehavioral and neuroinflammatory parameters. |
2023-02-15 |
2023-08-14 |
mouse |
| Roberto Colangeli, Maria Morena, Allison Werner, Roger J Thompson, Mario van der Stelt, Quentin J Pittman, Matthew N Hill, G Campbell Teske. 2-AG-mediated Control of GABAergic Signaling is Impaired in a Model of Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-12-02. PMID:36460464. |
2-ag-mediated control of gabaergic signaling is impaired in a model of epilepsy. |
2022-12-02 |
2023-08-14 |
Not clear |
| Jiahao Meng, Zeya Yan, Xinyu Tao, Wei Wang, Fei Wang, Tao Xue, Yanfei Liu, Zhong Wan. The efficacy and safety of ganaxolone for the treatment of refractory epilepsy: A meta-analysis from randomized controlled trials. Epilepsia open. 2022-11-05. PMID:36333279. |
ganaxolone, a neuroactive steroid that enhances gabaergic inhibition, has been tested in many trials for the resolution of refractory epilepsy. |
2022-11-05 |
2023-08-14 |
Not clear |
| V\\xc3\\xadctor Ruggier. [Autism. Neurobiological aspects]. Medicina. vol 82 Suppl 3. 2022-09-02. PMID:36054859. |
among the neurobiological bases we can include: deficit in the social reward system, which generates poor social initiative; dysfunctions and disorders of the amygdala and the mirror neuron system, related to compromised empathy and social cognition; abnormalities in the minicolumns related to hyper-systematization; persistent inflammatory phenomena of the central nervous system related to microglia; alterations of neuropeptides such as oxytocin, vasopressin and cortisol, which compromise socialization, and neuronal inhibition disorders, expressed in gabaergic dysfunctions in interneurons, linked to autistic behaviors, epilepsy and sensory phenomena. |
2022-09-02 |
2023-08-14 |
Not clear |
| Drashti Desai, Pravin Shend. \\xce\\xb2-Cyclodextrin-crosslinked synthetic neuropeptide Y-based nanosponges in epilepsy by contributing GABAergic signal. Nanomedicine : nanotechnology, biology, and medicine. 2022-08-07. PMID:35934306. |
\xce\xb2-cyclodextrin-crosslinked synthetic neuropeptide y-based nanosponges in epilepsy by contributing gabaergic signal. |
2022-08-07 |
2023-08-14 |
Not clear |
| Dipan C Patel, Emily G Thompson, Harald Sontheime. Brain-Derived Neurotrophic Factor Inhibits the Function of Cation-Chloride Cotransporter in a Mouse Model of Viral Infection-Induced Epilepsy. Frontiers in cell and developmental biology. vol 10. 2022-07-25. PMID:35874836. |
epilepsy generally results from an imbalance in excitatory glutamatergic and inhibitory gabaergic neurotransmission. |
2022-07-25 |
2023-08-14 |
mouse |
| Allison E Tipton, Shelley J Russe. Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy. Frontiers in synaptic neuroscience. vol 14. 2022-07-25. PMID:35874848. |
regulation of inhibitory signaling at the receptor and cellular level; advances in our understanding of gabaergic neurotransmission and the mechanisms by which it is disrupted in epilepsy. |
2022-07-25 |
2023-08-14 |
Not clear |
| F\\xc3\\xa1bio Rodrigues de Oliveira, N\\xc3\\xa1gila Monteiro da Silva, Mois\\xc3\\xa9s Hamoy, Maria Elena Crespo-L\\xc3\\xb3pez, Irlon Maciel Ferreira, Edilene Oliveira da Silva, Barbarella de Matos Macchi, Jos\\xc3\\xa9 Luiz Martins do Nasciment. The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684543. |
the gabaergic system and endocannabinoids in epilepsy and seizures: what can we expect from plant oils? |
2022-06-10 |
2023-08-14 |
Not clear |
| Yi Cao, Chongyang Sun, Jianyu Huang, Peng Sun, Lulu Wang, Shuyu He, Jianxiang Liao, Zhonghua Lu, Yi Lu, Cheng Zhon. Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice. Frontiers in molecular neuroscience. vol 15. 2022-05-16. PMID:35571372. |
in particular, excitation/inhibition imbalance caused by hyperexcitability of glutamatergic neurons and/or dysfunction of gabaergic neurons, have been implicated in epilepsy. |
2022-05-16 |
2023-08-13 |
mouse |
| Miren Altuna, Gonzalo Olmedo-Saura, Mar\\xc3\\xada Carmona-Iragui, Juan Forte. Mechanisms Involved in Epileptogenesis in Alzheimer's Disease and Their Therapeutic Implications. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457126. |
accordingly, epilepsy and ad share pathophysiological processes, including neuronal hyperexcitability and an early excitatory-inhibitory dysregulation, leading to dysfunction in the inhibitory gabaergic and excitatory glutamatergic systems. |
2022-04-23 |
2023-08-13 |
Not clear |
| Lin Yang, Yi Wang, Zhong Che. Central histaminergic signalling, neural excitability and epilepsy. British journal of pharmacology. 2021-11-10. PMID:34599508. |
traditional theory suggests that epilepsy results from an imbalance of excitatory glutamate neurons and inhibitory gabaergic neurons. |
2021-11-10 |
2023-08-13 |
Not clear |
| Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani, Massimo Mantegazz. Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine. PLoS computational biology. vol 17. issue 7. 2021-10-25. PMID:34314446. |
modeling nav1.1/scn1a sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential gabaergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine. |
2021-10-25 |
2023-08-13 |
Not clear |
| Maja Milovanovic, Roberto Grujici. Electroencephalography in Assessment of Autism Spectrum Disorders: A Review. Frontiers in psychiatry. vol 12. 2021-10-22. PMID:34658944. |
recent advances in quantitative eeg data analysis and well-known epilepsy asd co-morbidity consistently indicate a role of aberrant gabaergic transmission that has consequences on neuronal organization and connectivity especially in the frontal cortex. |
2021-10-22 |
2023-08-13 |
Not clear |
| Moran Guo, Can Cui, Xueqin Song, Lijing Jia, Duan Li, Xiuli Wang, Hui Dong, Yanqin Ma, Yaling Liu, Zhiqiang Cui, Le Yi, Zhongyao Li, Yue Bi, Yuanyuan Li, Yakun Liu, Weisong Duan, Chunyan L. Deletion of FGF9 in GABAergic neurons causes epilepsy. Cell death & disease. vol 12. issue 2. 2021-09-14. PMID:33608505. |
deletion of fgf9 in gabaergic neurons causes epilepsy. |
2021-09-14 |
2023-08-13 |
mouse |