| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hayriye Soytürk, Cansu Önal, Ümit Kılıç, Şule Aydın Türkoğlu, Erol Aya. The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis. Journal of cellular and molecular medicine. vol 28. issue 14. 2024-07-24. PMID:39046369. |
the signalling pathway in epilepsy may be activated by hmgb1, tlr4, and tlr2, which are considered to increase the level of proinflammatory cytokines. |
2024-07-24 |
2024-07-26 |
Not clear |
| Hayriye Soytürk, Cansu Önal, Ümit Kılıç, Şule Aydın Türkoğlu, Erol Aya. The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis. Journal of cellular and molecular medicine. vol 28. issue 14. 2024-07-24. PMID:39046369. |
hmgb1, tlr4, irak2, ikbkb, il10, il1b, il1b, and il8 in this signalling pathway are highly expressed in epilepsy patients in g1 and seizures occur with the stimulation of excitatory mechanisms by acting through this pathway. |
2024-07-24 |
2024-07-26 |
Not clear |
| Zongwei Yue, Jingyi Tang, Sudan Peng, Xuehua Cai, Xiaoming Rong, Lianhong Yan. Serum concentration of high-mobility group box 1, Toll-like receptor 4 as biomarker in epileptic patients. Epilepsy research. vol 192. 2023-04-19. PMID:37075527. |
to explore whether hmgb1 and tlr4 could serve as clinical biomarkers in epileptic patients, we recruited a total of 72 epilepsy patients and measured the serum level of hmgb1 and tlr4 by flow fluorescence technology and elisa respectively. |
2023-04-19 |
2023-08-14 |
Not clear |
| Yao Lin, Man Ding, Qiaoyu Gong, Zheman Xia. Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358363. |
downregulation of gabaarα1 aggravates comorbidity of epilepsy and migraine via the tlr4 signaling pathway. |
2022-11-11 |
2023-08-14 |
rat |
| Bryan Gervais de Liyis, Sevinna Geshie Tandy, Joana Fourta Endira, Komang Andjani Putri, Desak Ketut Indrasari Utam. Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics. The Egyptian journal of neurology, psychiatry and neurosurgery. vol 58. issue 1. 2022-10-31. PMID:36310854. |
through the process, anti-hmgb1 mab reduces the tlr4 activity and other receptors that may involve in promote signal of epilepsy such as rage. |
2022-10-31 |
2023-08-14 |
Not clear |
| Jibo Dong, Yong Liao, Bihua W. TAK-242 ameliorates epileptic symptoms in mice by inhibiting the TLR4/NF-κB signaling pathway. Annals of translational medicine. vol 10. issue 14. 2022-08-15. PMID:35965792. |
the toll-like receptor 4 (tlr4)/nuclear factor kappa beta (nf-κb) signaling pathway is a target for the treatment of epilepsy. |
2022-08-15 |
2023-08-14 |
mouse |
| Lennart Seizer, Sadegh Rahimi, Sandra Santos-Sierra, Meinrad Drexe. Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons. PloS one. vol 17. issue 5. 2022-05-04. PMID:35507634. |
tlr2, 3, and 4 have been described in cortical neurons and, for tlr4, a seizure-promoting role in epilepsies associated with inflammation has been shown. |
2022-05-04 |
2023-08-13 |
mouse |
| Xinghua Tang, Xiaoxia Chen, Xinjuan Li, Huan Cheng, Jing Gan, Zhenguo Li. The TLR4 mediated inflammatory signal pathway might be involved in drug resistance in drug-resistant epileptic rats. Journal of neuroimmunology. vol 365. 2022-02-26. PMID:35217365. |
we speculate tlr4 related inflammatory signal pathway might take part in the emergence of epilepsy resistance, which is important in drug resistance. |
2022-02-26 |
2023-08-13 |
rat |
| Tülay Kamaşak, Beril Dilber, Serap Özer Yaman, Betül Diler Durgut, Tuba Kurt, Elif Çoban, Elif Acar Arslan, Sevim Şahin, Süleyman Caner Karahan, Ali Cans. HMGB-1, TLR4, IL-1R1, TNF-α, and IL-1β: novel epilepsy markers? Epileptic disorders : international epilepsy journal with videotape. vol 22. issue 2. 2020-12-07. PMID:32301731. |
hmgb-1, tlr4, tnf-α, and il-1β levels in the severe epilepsy group were higher than in the control group and the mild epilepsy group (p<0.05), and were higher in the mild epilepsy group than in the control group (p<0.05). |
2020-12-07 |
2023-08-13 |
Not clear |
| Tülay Kamaşak, Beril Dilber, Serap Özer Yaman, Betül Diler Durgut, Tuba Kurt, Elif Çoban, Elif Acar Arslan, Sevim Şahin, Süleyman Caner Karahan, Ali Cans. HMGB-1, TLR4, IL-1R1, TNF-α, and IL-1β: novel epilepsy markers? Epileptic disorders : international epilepsy journal with videotape. vol 22. issue 2. 2020-12-07. PMID:32301731. |
hmgb-1, tlr4, il-1r1, tnf-α, and il-1β: novel epilepsy markers? |
2020-12-07 |
2023-08-13 |
Not clear |
| Tülay Kamaşak, Beril Dilber, Serap Özer Yaman, Betül Diler Durgut, Tuba Kurt, Elif Çoban, Elif Acar Arslan, Sevim Şahin, Süleyman Caner Karahan, Ali Cans. HMGB-1, TLR4, IL-1R1, TNF-α, and IL-1β: novel epilepsy markers? Epileptic disorders : international epilepsy journal with videotape. vol 22. issue 2. 2020-12-07. PMID:32301731. |
the purpose of this study was to compare hmgb-1, tlr4, il-1β, il-1r1, and tnf-α levels in patients with mild and severe epilepsy with those in a healthy control group. |
2020-12-07 |
2023-08-13 |
Not clear |
| Tülay Kamaşak, Beril Dilber, Serap Özer Yaman, Betül Diler Durgut, Tuba Kurt, Elif Çoban, Elif Acar Arslan, Sevim Şahin, Süleyman Caner Karahan, Ali Cans. HMGB-1, TLR4, IL-1R1, TNF-α, and IL-1β: novel epilepsy markers? Epileptic disorders : international epilepsy journal with videotape. vol 22. issue 2. 2020-12-07. PMID:32301731. |
in this first report to identity a possible correlation between hmgb-1, tlr4, il-1β, il-1r1, and tnf-α levels and severity of epilepsy, our data demonstrates that the serum level of these cytokines is higher in cases of drug-refractory epilepsy. |
2020-12-07 |
2023-08-13 |
Not clear |
| Li Wang, Li-Fang Song, Xiao-Yi Chen, Yan-Li Ma, Jun-Fang Suo, Jing-He Shi, Guo-Hong Che. MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4. CNS neuroscience & therapeutics. vol 25. issue 1. 2020-04-06. PMID:29808547. |
mir-181b inhibits p38/jnk signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting tlr4. |
2020-04-06 |
2023-08-13 |
rat |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
both serum hmgb1 (p<0.001) and tlr4 (p<0.001) expressions were higher in epilepsy patients than in hcs, and they displayed good predictive values for risk of epilepsy. |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
this study aimed to investigate the association of serum high-mobility group box-1 (hmgb1) and toll-like receptor 4 (tlr4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
in conclusion, both hmgb1 and tlr4 expressions were correlated with increased risk and severity of epilepsy and their level was higher in patients resistant to anti-epilepsy drugs. |
2019-09-06 |
2023-08-13 |
human |
| Minchen Kan, Lihong Song, Xueqiang Zhang, Jing Zhang, Pingping Fan. Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 7. 2019-09-06. PMID:31241711. |
one hundred and five epilepsy patients and 100 healthy controls (hcs) were enrolled in this case-control study, and serum samples were collected from all participants to assess the hmgb1 and tlr4 expressions by enzyme-linked immunosorbent assay (elisa). |
2019-09-06 |
2023-08-13 |
human |
| Zhenzhen Qu, Lijing Jia, Tao Xie, Junli Zhen, Peipei Si, Zhiqiang Cui, Yan Xue, Can Sun, Weiping Wan. (-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-05-22. PMID:30843525. |
(-)-epigallocatechin-3-gallate protects against lithium-pilocarpine-induced epilepsy by inhibiting the toll-like receptor 4 (tlr4)/nuclear factor-κb (nf-κb) signaling pathway. |
2019-05-22 |
2023-08-13 |
rat |
| Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Mia. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393419. |
hmgb1, tlr4, receptor for advanced glycation end products (rage), nf‑κb p65 and inducible nitric oxide synthase (inos) expression levels were detected by western blotting, and serum cytokine levels of interleukin (il)‑1, il‑6, tumor necrosis factor (tnf)‑α, transforming growth factor (tgf)‑β and il‑10 in patients with epilepsy and craniocerebral trauma were detected by elisa. |
2018-08-27 |
2023-08-13 |
Not clear |
| Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Mia. HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393419. |
the results demonstrated that compared with the control group, levels of hmgb1, tlr4, rage, nf‑κb p65 and inos in the brain of the epilepsy group were significantly increased, and increased cytokine levels of il‑1, il‑6, tnf‑α, tgf‑β and il‑10 in patients with epilepsy were also observed. |
2018-08-27 |
2023-08-13 |
Not clear |