| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Almundher Al-Maawali, Fathiya Al-Murshedi, Amna Al-Futaisi, Ahmed Mansy, Asila Al-Habsi, Katta M Girish. Biallelic variants in the synaptic vesicle glycoprotein 2\\xe2\\x80\\x89A are associated with epileptic encephalopathy. European journal of human genetics : EJHG. 2023-11-21. PMID:37985816. |
these findings support that biallelic loss of function variants in sv2a result in early onset intractable epilepsy in humans. |
2023-11-21 |
2023-11-29 |
mouse |
| Peng-Peng Wu, Bi-Rong Cao, Fu-Yun Tian, Zhao-Bing Ga. Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil. Neuroscience bulletin. 2023-10-28. PMID:37897555. |
development of sv2a ligands for epilepsy treatment: a review of levetiracetam, brivaracetam, and padsevonil. |
2023-10-28 |
2023-11-08 |
Not clear |
| Peng-Peng Wu, Bi-Rong Cao, Fu-Yun Tian, Zhao-Bing Ga. Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil. Neuroscience bulletin. 2023-10-28. PMID:37897555. |
even so, the next-generation sv2a ligands against epilepsy based on the structure of lev have achieved clinical success. |
2023-10-28 |
2023-11-08 |
Not clear |
| Magdalena Badura-Stronka, \\xc5\\x81ukasz Kuszel, Agnieszka Wencel-Warot, Kamila Cudnoch, Katarzyna Wo\\xc5\\x82y\\xc5\\x84ska, Karolina Rutkowska, Barbara Steinborn, Rafa\\xc5\\x82 P\\xc5\\x82osk. Broadening the phenotypic spectrum of the presumably epilepsy-related SV2A gene variants. Epilepsy research. vol 190. 2023-02-09. PMID:36758444. |
missense variants in the synaptic vesicle glycoprotein sv2a gene have been previously found in a few individuals with epilepsy. |
2023-02-09 |
2023-08-14 |
Not clear |
| Magdalena Badura-Stronka, \\xc5\\x81ukasz Kuszel, Agnieszka Wencel-Warot, Kamila Cudnoch, Katarzyna Wo\\xc5\\x82y\\xc5\\x84ska, Karolina Rutkowska, Barbara Steinborn, Rafa\\xc5\\x82 P\\xc5\\x82osk. Broadening the phenotypic spectrum of the presumably epilepsy-related SV2A gene variants. Epilepsy research. vol 190. 2023-02-09. PMID:36758444. |
this family case further supports the role of the sv2a gene in autosomal dominant epilepsy. |
2023-02-09 |
2023-08-14 |
Not clear |
| Magdalena Badura-Stronka, \\xc5\\x81ukasz Kuszel, Agnieszka Wencel-Warot, Kamila Cudnoch, Katarzyna Wo\\xc5\\x82y\\xc5\\x84ska, Karolina Rutkowska, Barbara Steinborn, Rafa\\xc5\\x82 P\\xc5\\x82osk. Broadening the phenotypic spectrum of the presumably epilepsy-related SV2A gene variants. Epilepsy research. vol 190. 2023-02-09. PMID:36758444. |
it provides new information on the course of epilepsy in people with variants in the sv2a gene who have never been treated with sv2a agonists and specific neurodevelopmental features of this syndrome. |
2023-02-09 |
2023-08-14 |
Not clear |
| Raghava Jagadeesh Salaka, Kala P Nair, Reddy Bedadala Sasibhushana, Deepashree Udayakumar, Bindu M Kutty, Bettadapura N Srikumar, Byrathnahalli S Shankaranarayana Ra. Differential effects of levetiracetam on hippocampal CA1 synaptic plasticity and molecular changes in the dentate gyrus in epileptic rats. Neurochemistry international. 2022-06-26. PMID:35753511. |
levetiracetam (lev) is a second-generation asd with a novel sv2a protein target and is indicated for treating focal epilepsies. |
2022-06-26 |
2023-08-14 |
rat |
| Yifan Zhang, Lise Heylen, Mich\\xc3\\xa8le Partoens, James D Mills, Rafal M Kaminski, Patrice Godard, Michel Gillard, Peter A M de Witte, Aleksandra Siekiersk. Connectivity Mapping Using a Novel Frontiers in molecular neuroscience. vol 15. 2022-06-10. PMID:35686059. |
although several rodent knockout models have demonstrated the importance of sv2a for functional neurotransmission, its precise physiological function and role in epilepsy pathophysiology remains to be elucidated. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yanyan Kong, Shibo Zhang, Lin Huang, Chencheng Zhang, Fang Xie, Zhengwei Zhang, Qi Huang, Donglang Jiang, Junpeng Li, Weiyan Zhou, Tao Hua, Bomin Sun, Jiao Wang, Yihui Gua. Positron Emission Computed Tomography Imaging of Synaptic Vesicle Glycoprotein 2A in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-11-20. PMID:34795573. |
in view of the fact that synaptic loss is the pathology of both epilepsy and ad, this review summarizes the potential role of sv2a in the pathogenesis of ad, and suggests that sv2a should be used as an important target molecule of pet imaging agent for the early diagnosis of ad. |
2021-11-20 |
2023-08-13 |
Not clear |
| Itzel Jatziri Contreras-Garc\\xc3\\xada, Gisela G\\xc3\\xb3mez-Lira, Bryan V\\xc3\\xadctor Phillips-Farf\\xc3\\xa1n, Luz Adriana Pichardo-Mac\\xc3\\xadas, Mercedes Edna Garc\\xc3\\xada-Cruz, Juan Luis Ch\\xc3\\xa1vez-Pacheco, Julieta G Mendoza-Torreblanc. Synaptic Vesicle Protein 2A Expression in Glutamatergic Terminals Is Associated with the Response to Levetiracetam Treatment. Brain sciences. vol 11. issue 5. 2021-05-27. PMID:33922424. |
epilepsy is characterized by an imbalance between excitation and inhibition, hence sv2a levels in particular terminals could also influence the lev response. |
2021-05-27 |
2023-08-13 |
rat |
| Itzel Jatziri Contreras-Garc\\xc3\\xada, Gisela G\\xc3\\xb3mez-Lira, Bryan V\\xc3\\xadctor Phillips-Farf\\xc3\\xa1n, Luz Adriana Pichardo-Mac\\xc3\\xadas, Mercedes Edna Garc\\xc3\\xada-Cruz, Juan Luis Ch\\xc3\\xa1vez-Pacheco, Julieta G Mendoza-Torreblanc. Synaptic Vesicle Protein 2A Expression in Glutamatergic Terminals Is Associated with the Response to Levetiracetam Treatment. Brain sciences. vol 11. issue 5. 2021-05-27. PMID:33922424. |
sv2a expression was not modified during epilepsy. |
2021-05-27 |
2023-08-13 |
rat |
| Di Wang, Qilin Zhou, Liankun Ren, Yicong Lin, Lehong Gao, Jialin Du, Yuping Wan. Levetiracetam-induced a new seizure type in a girl with a novel SV2A gene mutation. Clinical neurology and neurosurgery. vol 181. 2020-09-29. PMID:31005049. |
we now report a novel heterozygous pathogenic sv2a gene mutation both in a girl and her mother result in epilepsy and poor response to lev. |
2020-09-29 |
2023-08-13 |
human |
| Mauro Rassu, Alice Biosa, Manuela Galioto, Milena Fais, Paola Sini, Elisa Greggio, Giovanni Piccoli, Claudia Crosio, Ciro Iaccarin. Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31560168. |
importantly, sv2a is the binding site of the levetiracetam (lev), a compound largely used in human therapy for epilepsy treatment. |
2020-09-22 |
2023-08-13 |
human |
| Am\\xc3\\xa9rica Vanoye-Carlo, Gisela G\\xc3\\xb3mez-Lir. Differential expression of SV2A in hippocampal glutamatergic and GABAergic terminals during postnatal development. Brain research. vol 1715. 2020-09-18. PMID:30905653. |
changes in sv2a expression have been linked to several diseases that could implicate an imbalance between excitation and inhibition, such as epilepsy. |
2020-09-18 |
2023-08-13 |
rat |
| Maria Elisa Serrano, Odile Bartholom\\xc3\\xa9, Priscilla Van den Ackerveken, Andr\\xc3\\xa9 Ferrara, Bernard Rogister, Alain Plenevaux, Ezio Tirell. Anxiety-like features and spatial memory problems as a consequence of hippocampal SV2A expression. PloS one. vol 14. issue 6. 2020-02-11. PMID:31166988. |
the synaptic vesicle protein 2a (sv2a) is a transmembrane protein whose presence is reduced both in animal models and in patients with chronic epilepsy. |
2020-02-11 |
2023-08-13 |
mouse |
| Michele Romoli, Martina Mandarano, Marina Romozzi, Paolo Eusebi, Chiara Bedetti, Elena Nardi Cesarini, Angela Verzina, Carmen Calvello, Elisabetta Loreti, Angelo Sidoni, Paolo Giovenali, Paolo Calabresi, Cinzia Cost. Synaptic vesicle protein 2A tumoral expression predicts levetiracetam adverse events. Journal of neurology. vol 266. issue 9. 2020-01-28. PMID:31168673. |
the efficacy of levetiracetam (lev) in controlling seizures in patients with brain tumor-related epilepsy (btre) depends on tumoral expression of synaptic vesicle protein 2a (sv2a). |
2020-01-28 |
2023-08-13 |
Not clear |
| Maria Elisa Serrano, Guillaume Becker, Mohamed Ali Bahri, Alain Seret, Nathalie Mestdagh, Jo\\xc3\\xabl Mercier, Fr\\xc3\\xa9d\\xc3\\xa9ric Mievis, Fabrice Giacomelli, Christian Lemaire, Eric Salmon, Andr\\xc3\\xa9 Luxen, Alain Plenevau. Evaluating the In Vivo Specificity of [ Molecules (Basel, Switzerland). vol 24. issue 9. 2019-08-22. PMID:31052478. |
the sv2a isoform is the most studied and its implication in epilepsy therapy led to the development of the first sv2a pet radiotracer [ |
2019-08-22 |
2023-08-13 |
Not clear |
| Kentaro Tokudome, Saki Shimizu, Tadao Serikawa, Yukihiro Ohn. [Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 6. 2019-05-06. PMID:30531097. |
[function of synaptic vesicle protein 2a (sv2a) as a novel therapeutic target for epilepsy]. |
2019-05-06 |
2023-08-13 |
mouse |
| Kentaro Tokudome, Saki Shimizu, Tadao Serikawa, Yukihiro Ohn. [Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 6. 2019-05-06. PMID:30531097. |
furthermore, it has been shown that a missense mutation in the sv2a gene caused intractable epilepsy, involuntary movements and developmental retardation, indicating a causative role of sv2a dysfunction in epilepsy. |
2019-05-06 |
2023-08-13 |
mouse |
| Itzel Jatziri Contreras-Garc\\xc3\\xada, Luz Adriana Pichardo-Mac\\xc3\\xadas, C\\xc3\\xa9sar Emmanuel Santana-G\\xc3\\xb3mez, Karla S\\xc3\\xa1nchez-Huerta, Rogelio Ram\\xc3\\xadrez-Hern\\xc3\\xa1ndez, Beatriz G\\xc3\\xb3mez-Gonz\\xc3\\xa1lez, Luisa Rocha, Julieta G Mendoza Torreblanc. Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model. Epilepsy & behavior : E&B. vol 88. 2019-04-25. PMID:30336420. |
synaptic vesicle protein 2a (sv2a) has become an attractive target of investigation because of its role in the pathophysiology of epilepsy; sv2a is expressed ubiquitously throughout the brain in all nerve terminals independently of their neurotransmitter content and plays an important but poorly defined role in neurotransmission. |
2019-04-25 |
2023-08-13 |
rat |