| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilenia Paparella, Paolo Cardone, Benedetta Zanichelli, Laurent Lamalle, Fabienne Collette, Siya Sherif, Mikhail Zubkov, William T Clarke, Charlotte J Stagg, Pierre Maquet, Gilles Vandewall. 7 Tesla magnetic resonance spectroscopy estimates of GABA concentration relate to physiological measures of tonic inhibition in the human motor cortex. The Journal of physiology. 2025-04-02. PMID:40173216. |
key points: gaba neurotransmission is essential for synaptic plasticity and learning (especially motor learning) and is altered in several brain disorders, such as epilepsy and stroke. |
2025-04-02 |
2025-04-04 |
human |
| Nicola Specchio, Valentina Di Micco, Eleonora Aronica, Stéphane Auvin, Simona Balestrini, Andreas Brunklaus, Elena Gardella, Mirte Scheper, Maurizio Taglialatela, Marina Trivisano, Paolo Curatol. The epilepsy-autism phenotype associated with developmental and epileptic encephalopathies: New mechanism-based therapeutic options. Epilepsia. 2025-02-22. PMID:39985505. |
mechanisms linking epilepsy and autism include γ-aminobutyric acidergic (gabaergic) signaling dysregulation, synaptic plasticity, disrupted functional connectivity, and neuroinflammatory responses. |
2025-02-22 |
2025-02-25 |
human |
| Luis A Marin-Castañeda, Gerónimo Pacheco Aispuro, Guillermo Gonzalez-Garibay, Carlos Alejandro Martínez Zamora, Hector Romo-Parra, Moisés Rubio-Osornio, Carmen Rubi. Interplay of epilepsy and long-term potentiation: implications for memory. Frontiers in neuroscience. vol 18. 2025-01-27. PMID:39867454. |
the interplay between long-term potentiation (ltp) and epilepsy represents a crucial facet in understanding synaptic plasticity and memory within neuroscience. |
2025-01-27 |
2025-01-29 |
Not clear |
| Luis A Marin-Castañeda, Gerónimo Pacheco Aispuro, Guillermo Gonzalez-Garibay, Carlos Alejandro Martínez Zamora, Hector Romo-Parra, Moisés Rubio-Osornio, Carmen Rubi. Interplay of epilepsy and long-term potentiation: implications for memory. Frontiers in neuroscience. vol 18. 2025-01-27. PMID:39867454. |
this review delves into the intricate relationship between ltp and epilepsy, exploring how alterations in synaptic plasticity mechanisms akin to those seen in ltp contribute to the hyperexcitable state of epilepsy. |
2025-01-27 |
2025-01-29 |
Not clear |
| Luis A Marin-Castañeda, Gerónimo Pacheco Aispuro, Guillermo Gonzalez-Garibay, Carlos Alejandro Martínez Zamora, Hector Romo-Parra, Moisés Rubio-Osornio, Carmen Rubi. Interplay of epilepsy and long-term potentiation: implications for memory. Frontiers in neuroscience. vol 18. 2025-01-27. PMID:39867454. |
additionally, the role of neuroinflammation in both ltp and epilepsy is examined, highlighting how inflammatory mediators can influence synaptic plasticity. |
2025-01-27 |
2025-01-29 |
Not clear |
| Luis A Marin-Castañeda, Gerónimo Pacheco Aispuro, Guillermo Gonzalez-Garibay, Carlos Alejandro Martínez Zamora, Hector Romo-Parra, Moisés Rubio-Osornio, Carmen Rubi. Interplay of epilepsy and long-term potentiation: implications for memory. Frontiers in neuroscience. vol 18. 2025-01-27. PMID:39867454. |
the significance of various signaling pathways, including the mapk, mtor, and wnt/β-catenin pathways, in the modulation of synaptic plasticity and their relevance in both ltp and epilepsy. |
2025-01-27 |
2025-01-29 |
Not clear |
| Yunfei Tan, Kenji Hashimot. Therapeutic potential of ketamine in management of epilepsy: Clinical implications and mechanistic insights. Asian journal of psychiatry. vol 101. 2024-10-04. PMID:39366036. |
it will focus its impact on neuronal excitability and synaptic plasticity, its neuroprotective qualities, and elucidate the drug's potential mechanisms of action in treating epilepsy. |
2024-10-04 |
2024-10-07 |
Not clear |
| Zheng Liu, Chunhua Pan, Hao Huan. The role of axon guidance molecules in the pathogenesis of epilepsy. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075893. |
in this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. |
2024-07-30 |
2024-08-02 |
Not clear |
| Anna Maria Carrese, Rossella Vitale, Manuela Turco, Valeria Masola, Francesco Aniello, Emilia Vitale, Aldo Donizett. Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model. Molecular neurobiology. 2024-06-28. PMID:38941065. |
the interplay among synaptic activity, gene expression, and synaptic plasticity has crucial implications for understanding the pathophysiology of diseases such as alzheimer's disease and epilepsy. |
2024-06-28 |
2024-06-30 |
human |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
we believe this may be caused by a problem in the mechanisms regulating the interaction of neuroplastin and glua1 and may cause problems in synaptic plasticity in the experimental epilepsy model. |
2024-03-04 |
2024-03-06 |
rat |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
neuroplastin, and its related molecules which are known to play a role in synaptic plasticity, neurotransmitter activities that provide balance of excitability and, different neurological diseases, have not been studied before in epilepsy. |
2024-03-04 |
2024-03-06 |
rat |
| Shuang Chen, Ming Huang, Da Xu, Man L. Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy. Neurochemistry international. 2023-12-25. PMID:38145842. |
epileptogenesis is usually involved in neuropathological processes such as ion channel dysfunction, neuronal injury, inflammatory response, synaptic plasticity, gliocyte proliferation and mossy fiber sprouting, currently the pathogenesis of epilepsy is not yet completely understood. |
2023-12-25 |
2023-12-28 |
human |
| Qi Qiao, Shuang Tian, Yuan Zhang, Liqin Che, Qing Li, Zhenzhen Qu, Weiping Wan. A Ketogenic Diet may Improve Cognitive Function in Rats with Temporal Lobe Epilepsy by Regulating Endoplasmic Reticulum Stress and Synaptic Plasticity. Molecular neurobiology. 2023-10-23. PMID:37870676. |
recently, studies have found that a kd has a certain regulatory effect on both ers and synaptic plasticity, but this result has not been confirmed in epilepsy. |
2023-10-23 |
2023-11-08 |
rat |
| Stephen Beesley, Sanjay S Kuma. The t-N-methyl-d-aspartate receptor: Making the case for d-Serine to be considered its inverse co-agonist. Neuropharmacology. 2023-07-12. PMID:37437688. |
the motivation for this review stems from the need for synthesizing new information gathered about these receptors that sheds light on their role in synaptic plasticity and their dichotomous relationship with the amino acid d-serine through which they influence the pathogenesis of neurodegenerative diseases like temporal lobe epilepsy (tle), the most common type of adult epilepsies (beesley et al., 2020a). |
2023-07-12 |
2023-08-14 |
Not clear |
| Suhui Kuang, Jiaqi Wang, Zhirong Wei, Feng Zhai, Shuli Lian. The regulatory function of lncRNA and constructed network in epilepsy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-02-13. PMID:36781564. |
epilepsy is a neurological disease characterized by neural network dysfunction. although most reports indicate that the pathological process of epilepsy is related to inflammation, synaptic plasticity, cell apoptosis, and ion channel dysfunction, the underlying molecular mechanisms of epilepsy are not fully understood. |
2023-02-13 |
2023-08-14 |
Not clear |
| Raghava Jagadeesh Salaka, Kala P Nair, Reddy Bedadala Sasibhushana, Deepashree Udayakumar, Bindu M Kutty, Bettadapura N Srikumar, Byrathnahalli S Shankaranarayana Ra. Differential effects of levetiracetam on hippocampal CA1 synaptic plasticity and molecular changes in the dentate gyrus in epileptic rats. Neurochemistry international. 2022-06-26. PMID:35753511. |
particularly, its effects on neuronal excitability, synaptic plasticity, adult hippocampal neurogenesis, and histological changes in chronic epilepsy have not been evaluated thus far, which formed the basis of the present study. |
2022-06-26 |
2023-08-14 |
rat |
| Ying Chen, Juan Chen, Yu Chen, Yuan L. miR-146a/KLF4 axis in epileptic mice: a novel regulator of synaptic plasticity involving STAT3 signaling. Brain research. 2022-06-21. PMID:35728661. |
this study is aimed to investigate the mechanism of mir-146a/klf4 axis regarding epilepsy seizure and synaptic plasticity. |
2022-06-21 |
2023-08-14 |
mouse |
| Ding Wan, Lu Yang, Jia Ren, Haiyue Huang, Chen Zhang, Le Chen, Xueyao Su, Qi Huang, Jianguo Niu, Tao Sun, Peng Wan. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the hippocampus of lithium-pilocarpine-induced acute epileptic rats. Molecular biology reports. 2022-06-17. PMID:35715602. |
epilepsy is characterised by abnormal neuronal discharges, including aberrant expression of extracellular matrix (ecm) components and synaptic plasticity stabilisation. |
2022-06-17 |
2023-08-14 |
rat |
| Andrés Martorell, Mario Wellmann, Felipe Guiffa, Marco Fuenzalida, Christian Bonansc. P2Y1 receptor inhibition rescues impaired synaptic plasticity and astroglial Ca Neurobiology of disease. vol 146. 2021-10-25. PMID:33049315. |
p2y1 receptor inhibition rescues impaired synaptic plasticity and astroglial ca epilepsy is characterized by a progressive predisposition to suffer seizures due to neuronal hyperexcitability, and one of its most common co-morbidities is cognitive decline. |
2021-10-25 |
2023-08-13 |
Not clear |
| Sebastian Brandner, Sarah Schroeter, Gürsel Çalışkan, Seda Salar, Katja Kobow, Roland Coras, Ingmar Blümcke, Hajo Hamer, Michael Schwarz, Michael Buchfelder, Anna Maslarov. Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment? Epilepsia. 2021-10-23. PMID:34687218. |
the aim of this study was, therefore, to investigate the effect of glucocorticoid receptor (gr) modulation on synaptic plasticity in the human cortex of epilepsy patients. |
2021-10-23 |
2023-08-13 |
human |