| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Quentin Calonge, Aurore Besnard, Laurent Bailly, Maria Damiano, Phintip Pichit, Sophie Dupont, Isabelle Gourfinkel-An, Vincent Navarr. Cannabidiol Treatment for Adult Patients with Drug-Resistant Epilepsies: A Real-World Study in a Tertiary Center. Brain and behavior. vol 14. issue 11. 2024-11-06. PMID:39501537. |
while cannabidiol has demonstrated efficacy as an adjunctive treatment in dravet syndrome (ds), lennox-gastaut syndrome (lgs), and epilepsy related to tuberous sclerosis complex (tsc), its more global effectiveness in adult patients with dre apart from these three specific contexts needs to be clarified. |
2024-11-06 |
2024-11-08 |
Not clear |
| Pavel Klein, Daniel Friedman, Patrick Kwa. Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight. CNS drugs. 2024-10-21. PMID:39433725. |
fenfluramine, a serotonin-acting drug, dramatically reduces the frequency of convulsive seizures in dravet syndrome, a devastating developmental epileptic encephalopathy with severe dre. both drugs reduce mortality. in addition, the possibility of dre prevention was recently raised in patients with tuberous sclerosis complex, a relatively common genetic form of epilepsy. |
2024-10-21 |
2024-10-24 |
Not clear |
| Sean Massey, Anita Quigley, Simone Rochfort, John Christodoulou, Nicole J Van Berge. Cannabinoids and Genetic Epilepsy Models: A Review with Focus on CDKL5 Deficiency Disorder. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39409097. |
cbd's antiseizure properties have shown promise, particularly in treating drug-resistant genetic epilepsies associated with lennox-gastaut syndrome (lgs), dravet syndrome (ds), and tuberous sclerosis complex (tsc). |
2024-10-16 |
2024-10-18 |
Not clear |
| Paige J Brabant, Cameron P Beaudreault, Steven M Wolf, Patricia E McGoldrick, Saadi Ghatan, Carrie R Mu. Responsive neurostimulation of the frontal lobe for the detection and treatment of seizures in intractable epilepsy due to tuberous sclerosis complex: illustrative case. Journal of neurosurgery. Case lessons. vol 8. issue 15. 2024-10-08. PMID:39378523. |
responsive neurostimulation of the frontal lobe for the detection and treatment of seizures in intractable epilepsy due to tuberous sclerosis complex: illustrative case. |
2024-10-08 |
2024-10-11 |
Not clear |
| Laura S Farach, Melissa A Richard, Aynara C Wulsin, Elizabeth M Bebin, Darcy A Krueger, Mustafa Sahin, Brenda E Porter, Tarrant O McPherson, Jurriaan M Peters, Sarah O'Kelley, Katherine S Taub, Rajsekar Rajaraman, Stephanie C Randle, William M McClintock, Mary Kay Koenig, Michael D Frost, Klaus Werner, Danielle A Nolan, Michael Wong, Gary Cutter, Hope Northrup, Kit Sing A. Drug-Resistant Epilepsy in Tuberous Sclerosis Complex Is Associated With TSC2 Genotype: More Findings From the Preventing Epilepsy Using Vigatrin (PREVeNT) Trial. Pediatric neurology. vol 159. 2024-08-14. PMID:39142021. |
drug-resistant epilepsy in tuberous sclerosis complex is associated with tsc2 genotype: more findings from the preventing epilepsy using vigatrin (prevent) trial. |
2024-08-14 |
2024-08-17 |
Not clear |
| Arie Weinstock, E Martina Bebin, Daniel Checketts, Gary D Clark, Jerzy P Szaflarski, Laurie E Seltzer, Elizabeth A Thiele, Farhad Sahebka. Long-term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3-year results from the cannabidiol expanded access program. Epilepsia open. 2024-08-01. PMID:39088193. |
the cannabidiol (cbd) expanded access program provided compassionate access to cbd for patients with treatment-resistant epilepsy, including tuberous sclerosis complex (tsc), at 35 us epilepsy centers. |
2024-08-01 |
2024-08-03 |
Not clear |
| Michael LoPresti, Ataru Igarashi, Yaoki Sonohara, Sally Bowditc. The emotional burden of caring for patients with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex-associated epilepsy: A qualitative study in Japan. Epilepsy & behavior : E&B. vol 158. 2024-07-19. PMID:39029305. |
the emotional burden of caring for patients with lennox-gastaut syndrome, dravet syndrome, and tuberous sclerosis complex-associated epilepsy: a qualitative study in japan. |
2024-07-19 |
2024-07-22 |
Not clear |
| Mariana L Pais, João Martins, Miguel Castelo-Branco, Joana Gonçalve. Increased susceptibility to kainate-induced seizures in a mouse model of tuberous sclerosis complex: Importance of sex and circadian cycle. Epilepsia open. 2024-07-16. PMID:39010669. |
comorbidity of epilepsy and autism in tuberous sclerosis complex 2 (tsc2) is very frequent, but the link between these conditions is still poorly understood. |
2024-07-16 |
2024-07-18 |
mouse |
| Michael LoPresti, Ataru Igarashi, Yaoki Sonohara, Sally Bowditc. A quantitative cross-sectional study of the burden of caring for patients with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex-associated epilepsy in Japan. Epilepsy & behavior : E&B. vol 154. 2024-03-31. PMID:38555725. |
lennox-gastaut syndrome (lgs), dravet syndrome (ds), and tuberous sclerosis complex (tsc)-associated epilepsy are rare conditions associated with severe childhood-onset epilepsy. |
2024-03-31 |
2024-04-03 |
Not clear |
| Jingyi Tong, Tingting Ji, Ting Liu, Jiaqi Liu, Yibin Chen, Zongjun Li, Na Lu, Qifu L. Efficacy and safety of six new antiseizure medications for adjunctive treatment of focal epilepsy and epileptic syndrome: A systematic review and network meta-analysis. Epilepsy & behavior : E&B. vol 152. 2024-01-26. PMID:38277848. |
this study aimed to evaluate the efficacy and safety of six new antiseizure medications (asms) for adjunctive treatment in adult patients with focal epilepsy and adolescents with dravet syndrome (ds), lennox-gastaut syndrome (lgs), or tuberous sclerosis complex (tsc). |
2024-01-26 |
2024-01-29 |
Not clear |
| Zhirong Wei, Aria Fallah, Yangshuo Wang, Suhui Kuang, Alexader G Weil, Jiaqi Wang, Shuli Lian. Influence of resective extent of epileptogenic tuber on seizure outcome in patients with tuberous sclerosis complex-related epilepsy: A systematic review and meta-analysis. Seizure. vol 108. 2023-04-28. PMID:37116294. |
influence of resective extent of epileptogenic tuber on seizure outcome in patients with tuberous sclerosis complex-related epilepsy: a systematic review and meta-analysis. |
2023-04-28 |
2023-08-14 |
Not clear |
| Dominika Śmiałek, Katarzyna Kotulska, Aleksandra Duda, Sergiusz Jóźwia. Effect of mTOR Inhibitors in Epilepsy Treatment in Children with Tuberous Sclerosis Complex Under 2 Years of Age. Neurology and therapy. 2023-04-21. PMID:37085686. |
effect of mtor inhibitors in epilepsy treatment in children with tuberous sclerosis complex under 2 years of age. |
2023-04-21 |
2023-08-14 |
Not clear |
| Antônio Silvinato, Idevaldo Floriano, Wanderley Marques Bernard. Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex. Revista da Associacao Medica Brasileira (1992). vol 68. issue 10. 2022-11-23. PMID:36417631. |
use of cannabidiol in the treatment of epilepsy: lennox-gastaut syndrome, dravet syndrome, and tuberous sclerosis complex. |
2022-11-23 |
2023-08-14 |
Not clear |
| Ashna Talwar, Emily Estes, Rajender Aparasu, Doodipala Samba Redd. Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis. Experimental neurology. 2022-10-07. PMID:36206805. |
in this study, we evaluated the overall clinical potential of oral cbd to treat refractory epilepsy in patients with dravet syndrome (ds), lennox-gastaut syndrome (lgs), and tuberous sclerosis complex (tsc) through a systematic review and meta-analysis. |
2022-10-07 |
2023-08-14 |
Not clear |
| Małgorzata Foryś-Basiejko, Katarzyna Kotulska, Agnieszka Maryniak, Agata Siłuszyk, Monika Szkop, Julita Borkowska, Monika Sugalska, Jagoda Głowacka-Walas, Sergiusz Jóźwia. Epilepsy and Language Development in 8-36-Month-Old Toddlers with Tuberous Sclerosis Complex. Journal of clinical medicine. vol 11. issue 15. 2022-08-12. PMID:35956179. |
epilepsy and language development in 8-36-month-old toddlers with tuberous sclerosis complex. |
2022-08-12 |
2023-08-14 |
Not clear |
| Fuyi Zhang, Lingling Xie, Xiaoya He, Xiaojie Song, Helin Zheng, Longlun Wang, Li Jian. Tuber Brain Proportion Determines Epilepsy Onset in Children With Tuberous Sclerosis Complex. Pediatric neurology. vol 129. 2022-02-26. PMID:35217276. |
tuber brain proportion determines epilepsy onset in children with tuberous sclerosis complex. |
2022-02-26 |
2023-08-13 |
Not clear |
| Lena H Nguyen, Steven C Leiser, Dekun Song, Daniela Brunner, Steven L Roberds, Michael Wong, Angelique Borde. Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Epilepsy research. vol 181. 2022-02-26. PMID:35219048. |
tuberous sclerosis complex (tsc) is a monogenic disorder characterized by hyperactivation of the mtor signaling pathway and developmental brain malformations leading to intractable epilepsy. |
2022-02-26 |
2023-08-13 |
mouse |
| Joyce Y Wu, Hannah R Cock, Orrin Devinsky, Charuta Joshi, Ian Miller, Colin M Roberts, Rocio Sanchez-Carpintero, Daniel Checketts, Farhad Sahebka. Time to Onset of Cannabidiol (CBD) Treatment Effect and Resolution of Adverse Events in Tuberous Sclerosis Complex: Post Hoc Analysis of Randomized Controlled Phase 3 Trial GWPCARE6. Epilepsia. 2022-02-17. PMID:35175622. |
to estimate the timing of cannabidiol (cbd) treatment effect (seizure reduction and adverse events [aes]) onset, we conducted a post hoc analysis of gwpcare6 (nct02544763), a randomized, placebo-controlled, phase 3 trial in patients with drug-resistant epilepsy associated with tuberous sclerosis complex (tsc). |
2022-02-17 |
2023-08-13 |
Not clear |
| Linda Mc Koene, Eva Niggl, Ilse Wallaard, Martina Proietti-Onori, Diana C Rotaru, Ype Elgersm. Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis. JCI insight. vol 6. issue 23. 2021-12-08. PMID:34877936. |
tuberous sclerosis complex (tsc), caused by heterozygous mutations in tsc1 or tsc2, frequently results in intractable epilepsy. |
2021-12-08 |
2023-08-13 |
mouse |
| George H Korkar, Jean Isnard, Alexandra Montavont, Hélène Catenoix, Sylvain Rheims, Marc Guéno. Awake craniotomy for epilepsy surgery on eloquent speech areas: a single-centre experience. Epileptic disorders : international epilepsy journal with videotape. vol 23. issue 2. 2021-11-29. PMID:33926856. |
we conducted a retrospective cohort study of 17 consecutive patients with intractable partial seizures of different aetiologies (non-lesional epilepsy [n=3], tuberous sclerosis [n=1], hypoxic ischaemic insult [n=1], dysembryoplastic neuroepithelial tumours [dnet] [n=2], focal cortical dysplasia type 2 [fcd] [n=4], and other malformations of cortical development [n=6]), located in eloquent language cortex (frontal [n=7], insular [n=5], and latero-temporal [n=5] regions). |
2021-11-29 |
2023-08-13 |
Not clear |