| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Zhao, Yinchao Li, Huanling Lai, Ruili Niu, Huifeng Li, Shipei He, Zhengwei Su, Yue Gui, Lijie Ren, Xiaofeng Yang, Liemin Zho. Alterations in HCN1 expression and distribution during epileptogenesis in rats. Epilepsy research. vol 202. 2024-03-31. PMID:38555654. |
in temporal lobe epilepsy, the expression of hcn1 is decreased in the hippocampi of both animal models and patients. |
2024-03-31 |
2024-04-03 |
rat |
| Shawn McClelland, Corey Flynn, Celine Dubé, Cristina Richichi, Qinqin Zha, Antoine Ghestem, Monique Esclapez, Christophe Bernard, Tallie Z Bara. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Annals of neurology. vol 70. issue 3. 2011-10-31. PMID:21905079. |
enduring, abnormal expression and function of the ion channel hyperpolarization-activated cyclic adenosine monophosphate gated channel type 1 (hcn1) occurs in temporal lobe epilepsy (tle). |
2011-10-31 |
2023-08-12 |
Not clear |
| Bina Santoro, Janet Y Lee, Dario J Englot, Sandra Gildersleeve, Rebecca A Piskorowski, Steven A Siegelbaum, Melodie R Winawer, Hal Blumenfel. Increased seizure severity and seizure-related death in mice lacking HCN1 channels. Epilepsia. vol 51. issue 8. 2010-10-22. PMID:20384728. |
persistent down-regulation in the expression of the hyperpolarization-activated hcn1 cation channel, a key determinant of intrinsic neuronal excitability, has been observed in febrile seizure, temporal lobe epilepsy, and generalized epilepsy animal models, as well as in patients with epilepsy. |
2010-10-22 |
2023-08-12 |
mouse |
| Zhuo Huang, Matthew C Walker, Mala M Sha. Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 35. 2009-09-21. PMID:19726656. |
hyperpolarization-activated cation nonselective 1 (hcn1) plasticity in entorhinal cortical (ec) and hippocampal pyramidal cell dendrites is a salient feature of temporal lobe epilepsy. |
2009-09-21 |
2023-08-12 |
mouse |
| Bina Santoro, Rebecca A Piskorowski, Phillip Pian, Lei Hu, Haiying Liu, Steven A Siegelbau. TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain. Neuron. vol 62. issue 6. 2009-07-09. PMID:19555649. |
altered expression of hcn1 following seizures may contribute to the development of temporal lobe epilepsy. |
2009-07-09 |
2023-08-12 |
Not clear |