| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph Kuchling, Betty Jurek, Mariya Kents, Jakob Kreye, Christian Geis, Jonathan Wickel, Susanne Mueller, Stefan Paul Koch, Philipp Boehm-Sturm, Harald Pr\\xc3\\xbcss, Carsten Fink. Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology. Molecular psychiatry. 2023-10-24. PMID:37875549. |
decreased hippocampal connectivity and disruption of functional networks are established resting-state functional mri (rs-fmri) features that are associated with neuropsychiatric symptom severity in human anti-n-methyl-d-aspartate receptor (nmdar) encephalitis. |
2023-10-24 |
2023-11-08 |
mouse |
| Joseph Kuchling, Betty Jurek, Mariya Kents, Jakob Kreye, Christian Geis, Jonathan Wickel, Susanne Mueller, Stefan Paul Koch, Philipp Boehm-Sturm, Harald Pr\\xc3\\xbcss, Carsten Fink. Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology. Molecular psychiatry. 2023-10-24. PMID:37875549. |
adult nr1-antibody injected mice showed impaired functional connectivity within the left hippocampus compared to controls, resembling impaired connectivity patterns observed in human nmdar encephalitis patients. |
2023-10-24 |
2023-11-08 |
mouse |
| Joseph Kuchling, Betty Jurek, Mariya Kents, Jakob Kreye, Christian Geis, Jonathan Wickel, Susanne Mueller, Stefan Paul Koch, Philipp Boehm-Sturm, Harald Pr\\xc3\\xbcss, Carsten Fink. Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology. Molecular psychiatry. 2023-10-24. PMID:37875549. |
we successfully reproduced functional connectivity changes within the hippocampus in different experimental murine systems that were previously observed in human nmdar encephalitis patients. |
2023-10-24 |
2023-11-08 |
mouse |
| Yu Liu, Yu Gong, Xiao-Li Wu, Xiao-Min Hao, Ji-Peng Liu, Yin-Yin Li, Ke-Zhen Yang, Xin-Yu Gao, Jing Zhang, Lin Zhang, Xu-Dong Zhang, Jun Wang, Qing-Guo Li. Fire acupuncture for anti-LGI1 antibody autoimmune encephalitis: a case report. Frontiers in neuroscience. vol 17. 2023-08-04. PMID:37539383. |
in this article, we describe a female patient with autoimmune encephalitis who tested positive for leucine-rich glioma inactivated 1 (lgi1) antibodies and had hippocampal inflammatory edema in the lesion area. |
2023-08-04 |
2023-08-14 |
Not clear |
| Konstantina Yiannopoulou, Aigli G Vakrakou, Aikaterini Anastasiou, Georgia Nikolopoulou, Athina Sourdi, John S Tzartos, Constantinos Kilidireas, Antonios Dimitrakopoulo. Cerebrospinal Fluid Anti-Neuronal Autoantibodies in COVID-19-Associated Limbic Encephalitis with Acute Cerebellar Ataxia and Myoclonus Syndrome: Case Report and Literature Review. Diagnostics (Basel, Switzerland). vol 13. issue 12. 2023-06-28. PMID:37370950. |
a diagnosis of covid-19-associated autoimmune encephalitis with characteristics of limbic encephalitis and immune-mediated acute cerebellar ataxia and myoclonus syndrome was supported by alterations in the limbic system shown in magnetic resonance imaging, lateralized discharges shown in electroencephalography, a slightly elevated protein level in the cerebrospinal fluid (csf), and indirect immunofluorescence in the csf with autoantibody binding to anatomical structures of the cerebellum and hippocampus. |
2023-06-28 |
2023-08-14 |
Not clear |
| Katerina Segklia, Rebecca Matsas, Florentia Papastefanak. Brain Infection by Group B Streptococcus Induces Inflammation and Affects Neurogenesis in the Adult Mouse Hippocampus. Cells. vol 12. issue 12. 2023-06-28. PMID:37371040. |
experimental encephalitis elicited neurological deficits and death, induced inflammation, and affected neurogenesis in the dentate gyrus of the adult hippocampus by suppressing the proliferation of progenitor cells and the generation of newborn neurons. |
2023-06-28 |
2023-08-14 |
mouse |
| Yunmeng Bai, Zhuhe Liu, Tinglin Qian, Yu Peng, Huan Ma, Hong Hu, Guangqing Cheng, Haixia Wen, Lulin Xie, Dong Zheng, Qingshan Geng, Jigang Wang, Honghao Wan. Single-nucleus RNA sequencing unveils critical regulators in various hippocampal neurons for anti-N-methyl-D-aspartate receptor encephalitis. Brain pathology (Zurich, Switzerland). 2023-03-21. PMID:36942475. |
anti-nmdar encephalitis mainly affects the hippocampus, however, its effect on gene expression in hippocampal neurons is unclear at present. |
2023-03-21 |
2023-08-14 |
mouse |
| Yunmeng Bai, Zhuhe Liu, Tinglin Qian, Yu Peng, Huan Ma, Hong Hu, Guangqing Cheng, Haixia Wen, Lulin Xie, Dong Zheng, Qingshan Geng, Jigang Wang, Honghao Wan. Single-nucleus RNA sequencing unveils critical regulators in various hippocampal neurons for anti-N-methyl-D-aspartate receptor encephalitis. Brain pathology (Zurich, Switzerland). 2023-03-21. PMID:36942475. |
these data involve various hippocampal neurons, which delineate a framework for understanding the hippocampal neuronal circuit and the potential molecular mechanisms of anti-nmdar encephalitis. |
2023-03-21 |
2023-08-14 |
mouse |
| Maraike K\\xc3\\xbcpper, Katrin Porath, Tina Sellmann, Christian G Bien, R\\xc3\\xbcdiger K\\xc3\\xb6hling, Timo Kirschstei. GluN2B inhibition rescues impaired potentiation and epileptogenicity at associational-commissural CA3 synapses in a model of anti-NMDAR encephalitis. Neuroscience letters. 2022-12-27. PMID:36574811. |
to this aim, we injected cerebrospinal fluid from anti-nmdar encephalitis patients into the rat hippocampus and prepared brain slices for in vitro field potential recordings. |
2022-12-27 |
2023-08-14 |
rat |
| Mehmet E Adin, David Durand, William B Zucconi, Anita J Huttner, Dennis D Spencer, Richard A Brone. Diagnostic and interventional radiology (Ankara, Turkey). 2022-08-23. PMID:35997478. |
these include temporal lobe encephaloceles, malformations of cortical development (and especially focal cortical dysplasia), hippocampal sclerosis, hippocampal malformation (also known as himal), ulegyria, autoimmune encephalitis, and rasmussen's encephalitis. |
2022-08-23 |
2023-08-14 |
Not clear |
| Gaelle Batot, Cameron S Metcalf, Laura A Bell, Alberto Pauletti, Karen S Wilcox, Sonja Br\\xc3\\xb6e. A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus. Journal of visualized experiments : JoVE. issue 184. 2022-07-11. PMID:35816000. |
furthermore, histopathological consequences of viral encephalitis and seizures such as hippocampal damage and neuroinflammation are shown, as well as long-term consequences such as spontaneous epileptic seizures. |
2022-07-11 |
2023-08-14 |
mouse |
| P Nwaubani, M Cercignani, A Colasant. In vivo Quantitative Imaging of Hippocampal Inflammation in Autoimmune Neuroinflammatory Conditions: A Systematic Review. Clinical and experimental immunology. 2022-07-08. PMID:35802780. |
the main objective of this review is to provide a current update on the characterisation of quantitative neuroimaging correlates of hippocampal neuroinflammation, by focusing on three prototypical autoimmune neuro-inflammatory conditions [multiple sclerosis (ms), systemic lupus erythematosus- (sle), autoimmune encephalitis (ae)]. |
2022-07-08 |
2023-08-14 |
human |
| Jorge Ramirez-Franco, K\\xc3\\xa9vin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian L\\xc3\\xa9v\\xc3\\xaaque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Fa. Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1. Brain : a journal of neurology. 2022-06-21. PMID:35727946. |
autoantibodies against leucine-rich glioma-inactivated 1 occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. |
2022-06-21 |
2023-08-14 |
mouse |
| Marina Cunquero, Esther Aguilar, Pablo Loza-Alvarez, Jes\\xc3\\xbas Planagum\\xc3\\xa. Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis. Journal of visualized experiments : JoVE. issue 184. 2022-06-20. PMID:35723464. |
hippocampal neuronal cultures to detect and study new pathogenic antibodies involved in autoimmune encephalitis. |
2022-06-20 |
2023-08-14 |
rat |
| Javier A L\\xc3\\xb3pez-Rivera, Victoria Smuk, Costin Leu, Gaelle Nasr, Deborah Vegh, Arthur Stefanski, Eduardo P\\xc3\\xa9rez-Palma, Robyn Busch, Lara Jehi, Imad Najm, Ingmar Bl\\xc3\\xbcmcke, Dennis La. Incidence and prevalence of major epilepsy-associated brain lesions. Epilepsy & behavior reports. vol 18. 2022-03-04. PMID:35243289. |
data were combined to generate surgical candidate incidence and prevalence estimates and the first lesion-specific estimates for hippocampal sclerosis (hs), low-grade epilepsy-associated brain tumors (leat), malformations of cortical development (mcd), glial scars, vascular malformations, and encephalitis. |
2022-03-04 |
2023-08-13 |
Not clear |
| Allison L Soung, Veronica A Dav\\xc3\\xa9, Charise Garber, Eric D Tycksen, Lauren L Vollmer, Robyn S Klei. IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34695572. |
we conclude that nsc-specific il-1 signaling within the hippocampus during viral encephalitis prevents synapse recovery and promotes spatial learning defects via altered fates of nsc progeny that maintain inflammation. |
2021-12-11 |
2023-08-13 |
Not clear |
| Gregory S Day, Brian A Gordon, Austin McCullough, Robert C Bucelli, Richard J Perrin, Tammie L S Benzinger, Beau M Ance. Flortaucipir (tau) PET in LGI1 antibody encephalitis. Annals of clinical and translational neurology. vol 8. issue 2. 2021-11-01. PMID:33410601. |
the contributors to persistent cognitive impairment and hippocampal atrophy in leucine-rich glioma-inactivated 1 antibody encephalitis (lgi1) patients are unknown. |
2021-11-01 |
2023-08-13 |
Not clear |
| Franziska Wagner, Angelika Goertzen, Orsolya Kiraly, Gregor Laube, Jakob Kreye, Otto W Witte, Harald Pr\\xc3\\xbcss, R\\xc3\\xbcdiger W Ve. Detailed morphological analysis of rat hippocampi treated with CSF autoantibodies from patients with anti-NMDAR encephalitis discloses two distinct types of immunostaining patterns. Brain research. vol 1747. 2021-10-07. PMID:32735875. |
in this study csf samples as well as monoclonal antibodies derived from patients diagnosed with nmda-r1 encephalitis were applied to rat hippocampus and visualized by immunocytochemistry. |
2021-10-07 |
2023-08-13 |
rat |
| Josephine Heine, Harald Pr\\xc3\\xbc\\xc3\\x9f, Michael Scheel, Alexander U Brandt, Stefan M Gold, Thorsten Bartsch, Friedemann Paul, Carsten Fink. Transdiagnostic hippocampal damage patterns in neuroimmunological disorders. NeuroImage. Clinical. vol 28. 2021-06-25. PMID:33396002. |
significant inversions were noted mainly on the hippocampal head, were accompanied by volume loss, and correlated with semantic fluency scores and verbal episodic memory in autoimmune encephalitis and ms. a deformation overlap analysis across disorders revealed a convergence zone on the left anterior hippocampus that corresponds to the ca1 subfield. |
2021-06-25 |
2023-08-13 |
human |
| Le-Minh Dao, Marie-Luise Machule, Petra Bacher, Julius Hoffmann, Lam-Thanh Ly, Florian Wegner, Alexander Scheffold, Harald Pr\\xc3\\xbcs. Decreased inflammatory cytokine production of antigen-specific CD4 Journal of neurology. vol 268. issue 6. 2021-06-18. PMID:33442772. |
antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong t cell infiltration into the hippocampus. |
2021-06-18 |
2023-08-13 |
mouse |