| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
we discovered that mice with diabetic neuropathy had decreased sirtuin 1 (sirt1) deacetylase activity in foot skin, leading to reduced expression of brain-derived neurotrophic factor (bdnf) and subsequent loss of innervation in meissner corpuscles, a mechanoreceptor expressing the bdnf receptor trkb. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
skin keratinocyte-derived sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
when sirt1 was depleted from skin, the mechanical allodynia worsened in diabetic neuropathy mice, likely due to retrograde degeneration of the meissner-corpuscle innervating aβ axons and aberrant formation of meissner corpuscles which may have increased the mechanosensitivity. |
2024-03-30 |
2024-04-02 |
mouse |
| Mehrdad Hashemi, Mohammad Arad Zandieh, Setayesh Ziaolhagh, Sarah Mojtabavi, Farzaneh Hasani Sadi, Zeinab Khazaei Koohpar, Maryam Ghanbarirad, Arvin Haghighatfard, Mitra Behroozaghdam, Ramin Khorrami, Noushin Nabavi, Jun Ren, Russel J Reiter, Shokooh Salimimoghadam, Mohsen Rashidi, Kiavash Hushmandi, Afshin Taheriazam, Maliheh Entezar. Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective. Biochimica et biophysica acta. Molecular basis of disease. 2023-04-07. PMID:37028606. |
sirt1 and ampk are among the predominant pathways to upregulate nrf2 expression in the amelioration of dn, dc and diabetic neuropathy. |
2023-04-07 |
2023-08-14 |
human |
| Jennifer O'Brien, Peter Niehaus, Juliana Remark, Mohammad Salimian, Yanni Kevas, Samuel Rubin, Tibor Kristian, Krish Chandrasekaran, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Epidermal SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. bioRxiv : the preprint server for biology. 2023-02-07. PMID:36747753. |
epidermal sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2023-02-07 |
2023-08-14 |
mouse |
| Anees Ahmed Syed, Mohammad Irshad Reza, Himanshu Yadav, Jiaur R Gaye. Hesperidin inhibits NOX4 mediated oxidative stress and inflammation by upregulating SIRT1 in experimental diabetic neuropathy. Experimental gerontology. 2022-12-17. PMID:36528304. |
hesperidin inhibits nox4 mediated oxidative stress and inflammation by upregulating sirt1 in experimental diabetic neuropathy. |
2022-12-17 |
2023-08-14 |
rat |
| Islauddin Khan, Kumari Preeti, Rahul Kumar, Dharmendra Kumar Khatri, Shashi Bala Sing. Activation of SIRT1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated neurotoxicity. Archives of physiology and biochemistry. 2022-08-09. PMID:35943429. |
activation of sirt1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated neurotoxicity. |
2022-08-09 |
2023-08-14 |
Not clear |
| Shivangi Patel, Hasnat Khan, Anuradha Majumda. Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy. Metabolic brain disease. 2022-05-26. PMID:35616799. |
crosstalk between sirtuins and nrf2: sirt1 activators as emerging treatment for diabetic neuropathy. |
2022-05-26 |
2023-08-13 |
Not clear |
| Preethi Bheereddy, Veera Ganesh Yerra, Anil Kumar Kalvala, Bhoomika Sherkhane, Ashutosh Kuma. SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy. Cellular and molecular neurobiology. vol 41. issue 7. 2021-09-02. PMID:32683581. |
sirt1 activation by polydatin alleviates oxidative damage and elevates mitochondrial biogenesis in experimental diabetic neuropathy. |
2021-09-02 |
2023-08-13 |
rat |
| Manisha J Oza, Yogesh A Kulkarn. Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF. Chemistry & biodiversity. vol 17. issue 6. 2021-01-22. PMID:32459048. |
in present study, we evaluated effect of fmnt as sirt1 activator in type 2 diabetic neuropathy. |
2021-01-22 |
2023-08-13 |
rat |
| Manisha J Oza, Yogesh A Kulkarn. Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF. Chemistry & biodiversity. vol 17. issue 6. 2021-01-22. PMID:32459048. |
formononetin ameliorates diabetic neuropathy by increasing expression of sirt1 and ngf. |
2021-01-22 |
2023-08-13 |
rat |
| Anil Kumar Kalvala, Veera Ganesh Yerra, Ashutosh Kuma. LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 62. 2020-06-08. PMID:31639451. |
we have previously reported mitoprotective potency of sirtuin1 (sirt1) in diabetic neuropathy (dn) via targeting mitochondrial dysfunction but its nuclear control over mitochondrial bioenergetics remains unknown. |
2020-06-08 |
2023-08-13 |
rat |
| Krish Chandrasekaran, Mohammad Salimian, Sruthi R Konduru, Joungil Choi, Pranith Kumar, Aaron Long, Nina Klimova, Cheng-Ying Ho, Tibor Kristian, James W Russel. Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. Brain : a journal of neurology. vol 142. issue 12. 2020-05-21. PMID:31754701. |
in this study, we tested whether increased expression of sirt1 protein in sensory neurons prevents and reverses experimental diabetic neuropathy induced by a high fat diet (hfd). |
2020-05-21 |
2023-08-13 |
mouse |
| Krish Chandrasekaran, Anjaneyulu Muragundla, Tyler G Demarest, Joungil Choi, Avinash R Sagi, Neda Najimi, Pranith Kumar, Anmol Singh, Cheng-Ying Ho, Gary Fiskum, Lauren G Koch, Steven L Britton, James W Russel. mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy. Annals of clinical and translational neurology. vol 4. issue 12. 2019-11-20. PMID:29296613. |
mglur2/3 activation of the sirt1 axis preserves mitochondrial function in diabetic neuropathy. |
2019-11-20 |
2023-08-13 |
Not clear |
| Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kuma. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. The Journal of nutritional biochemistry. vol 47. 2018-05-09. PMID:28528294. |
isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by sirt1 activation in experimental diabetic neuropathy. |
2018-05-09 |
2023-08-13 |
rat |
| Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kuma. Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy. The Journal of nutritional biochemistry. vol 47. 2018-05-09. PMID:28528294. |
sirtuin (sirt1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (dn) has not been yet explored. |
2018-05-09 |
2023-08-13 |
rat |