| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
we discovered that mice with diabetic neuropathy had decreased sirtuin 1 (sirt1) deacetylase activity in foot skin, leading to reduced expression of brain-derived neurotrophic factor (bdnf) and subsequent loss of innervation in meissner corpuscles, a mechanoreceptor expressing the bdnf receptor trkb. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Koping Chang, Juliana Remark, Joy Barrett, Abhishikta Dasgupta, Morayo Adenegan, Mohammad Salimian, Yanni Kevas, Krish Chandrasekaran, Tibor Kristian, Rajeshwari Chellappan, Samuel Rubin, Ashley Kiemen, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. Brain : a journal of neurology. 2024-03-30. PMID:38554393. |
skin keratinocyte-derived sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2024-03-30 |
2024-04-02 |
mouse |
| Jennifer O'Brien, Peter Niehaus, Juliana Remark, Mohammad Salimian, Yanni Kevas, Samuel Rubin, Tibor Kristian, Krish Chandrasekaran, Catherine Pei-Ju Lu, James W Russell, Cheng-Ying H. Epidermal SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy. bioRxiv : the preprint server for biology. 2023-02-07. PMID:36747753. |
epidermal sirt1 and bdnf modulate mechanical allodynia in mouse models of diabetic neuropathy. |
2023-02-07 |
2023-08-14 |
mouse |
| Yan Gong, Zhan-Ping Chang, Ruo-Tong Ren, Shi-Hui Wei, Huan-Fen Zhou, Xiao-Fei Chen, Bao-Ke Hou, Xin Jin, Mao-Nian Zhan. Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats. Cellular and molecular neurobiology. vol 32. issue 3. 2021-10-21. PMID:22297541. |
data showed that over-expression of bdnf could increase alive retinal ganglion cell (rgc) number and improve its function in streptzotocin(stz)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy. |
2021-10-21 |
2023-08-12 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32671697. |
ifenprodil reduced expression of activated microglia, bdnf and dream proteins in the spinal cord following formalin injection during the early stage of painful diabetic neuropathy in rats. |
2021-10-05 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32671697. |
this study aims to determine the effect of ifenprodil, a potent noncompetitive nmdar-2b antagonist, on activated microglia, brain-derived neurotrophic factors (bdnf) and downstream regulatory element antagonist modulator (dream) protein expression in the spinal cord of streptozotocin-induced painful diabetic neuropathy (pdn) rats following formalin injection. |
2021-10-05 |
2023-08-13 |
rat |
| Bei Miao, Yue Yin, Guangtong Mao, Benhuo Zhao, Jiaojiao Wu, Hengliang Shi, Sujuan Fe. The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain. Life sciences. vol 273. 2021-04-07. PMID:33667520. |
brain-derived neurotrophic factor (bdnf) is vital in the pathogenesis of mechanical allodynia with a paucity of reports available regarding diabetic neuropathy pain (dnp). |
2021-04-07 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats. Neuropeptides. vol 79. 2020-11-23. PMID:31902597. |
this study aimed to investigate microglia activation and signalling molecules brain-derived neurotrophic factor (bdnf) and downstream regulatory element antagonist modulator (dream) proteins in spinal cord of streptozotocin-induced diabetic neuropathy rats. |
2020-11-23 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats. Neuropeptides. vol 79. 2020-11-23. PMID:31902597. |
expressions of spinal microglia activation, bdnf, and dream proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats. |
2020-11-23 |
2023-08-13 |
rat |
| Rasoul Eslami, Reza Gharakhanlou, Abdolreza Kazemi, Amir Bahador Dakhili, Ghazaleh Sorkhkamanzadeh, Ayob Sheikh. Does Endurance Training Compensate for Neurotrophin Deficiency Following Diabetic Neuropathy? Iranian Red Crescent medical journal. vol 18. issue 10. 2020-09-30. PMID:28184326. |
on the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) in diabetic neuropathy are not understood. |
2020-09-30 |
2023-08-13 |
Not clear |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Abd Aziz, Idris Lon. Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF protein expression in rat spinal cord. Journal of diabetes and metabolic disorders. vol 18. issue 1. 2020-09-30. PMID:31275889. |
minocycline attenuates the development of diabetic neuropathy by modulating dream and bdnf protein expression in rat spinal cord. |
2020-09-30 |
2023-08-13 |
rat |
| Guangju Zhou, Mingzhu Yan, Gang Guo, Nanwei Ton. Ameliorative Effect of Berberine on Neonatally Induced Type 2 Diabetic Neuropathy via Modulation of BDNF, IGF-1, PPAR-γ, and AMPK Expressions. Dose-response : a publication of International Hormesis Society. vol 17. issue 3. 2020-09-30. PMID:31360147. |
ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy via modulation of bdnf, igf-1, ppar-γ, and ampk expressions. |
2020-09-30 |
2023-08-13 |
rat |
| Kazuo Furukawa, Ichiro Fuse, Yuriko Iwakura, Hidekazu Sotoyama, Osamu Hanyu, Hiroyuki Nawa, Hirohito Sone, Nobuyuki Take. Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation. Cardiovascular diabetology. vol 16. issue 1. 2017-10-16. PMID:28178976. |
brain-derived neurotrophic factor (bdnf) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. |
2017-10-16 |
2023-08-13 |
human |
| Lei Li, Ting Yu, Liling Yu, Haijun Li, Yongjuan Liu, Dongqin Wan. Exogenous brain-derived neurotrophic factor relieves pain symptoms of diabetic rats by reducing excitability of dorsal root ganglion neurons. The International journal of neuroscience. vol 126. issue 8. 2017-03-10. PMID:26441011. |
these data provide novel information that exogenous bdnf relieved pain symptoms of diabetic rats by reducing hyperexcitability of drg neurons and might be the potential treatment of painful diabetic neuropathy. |
2017-03-10 |
2023-08-13 |
rat |
| Xue-Hong Cao, Hee-Sun Byun, Shao-Rui Chen, You-Qing Cai, Hui-Lin Pa. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557422. |
increased bdnf activity in these neurons likely contributes to the reduction in kv channel function through trkb receptor stimulation in painful diabetic neuropathy. |
2010-09-13 |
2023-08-12 |
rat |
| Praveen Anan. Neurotrophic factors and their receptors in human sensory neuropathies. Progress in brain research. vol 146. 2004-02-11. PMID:14699981. |
ngf and glial cell line-derived neurotrophic factor (gdnf) are both produced by basal keratinocytes and neurotrophin (nt-3) by suprabasal keratinocytes: relative mrna expression was significantly lower in early diabetic neuropathy skin compared to controls, for ngf (p < 0.02), bdnf (p < 0.05), nt-3 (p < 0.05), gdnf (< 0.02), but not nt4/5, trk a or p75 neurotrophin receptor (all p > 0.05). |
2004-02-11 |
2023-08-12 |
human |
| A Nitta, R Murai, N Suzuki, H Ito, H Nomoto, G Katoh, Y Furukawa, S Furukaw. Diabetic neuropathies in brain are induced by deficiency of BDNF. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200200. |
diabetic neuropathies in brain are induced by deficiency of bdnf. |
2002-12-19 |
2023-08-12 |
rat |